DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo5ab

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_009296049.2 Gene:myo5ab / 565267 ZFINID:ZDB-GENE-050411-72 Length:1800 Species:Danio rerio


Alignment Length:1743 Identity:467/1743 - (26%)
Similarity:750/1743 - (43%) Gaps:313/1743 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 SRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSS------------GVE 158
            |:|.|:....|..|.|.:.|..|.....|....|...|..|..:.||.|.            |..
Zfish     8 SKLARVWIPDPAEVWRSAELSRDYRPGDPVLHLLLEDETELEYKLDLKSGVLPPLRNPDILVGEN 72

  Fly   159 DMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            |:|.|..|||.::|.|||:|: |..||||:.|.||:|:|||:..| .||.::...|:|:.:|.:.
Zfish    73 DLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLP-IYGSDIINAYSGQNMGDMD 136

  Fly   223 PHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEA 284
            ||:||:...|:..:   ...|.:::|||||:|||.|.|..|:|.|.|......||  :.|::|.:
Zfish   137 PHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVSESSDDAS--VEEKVLAS 199

  Fly   285 APLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYE 348
            .|::||||||:|.|||||||||||:|:.| :...|:||.:..|||||||:|.||..|||||:||:
Zfish   200 NPIMEAFGNAKTTRNDNSSRFGKYIEIGFDRKHHIIGANMRTYLLEKSRVVFQASEERNYHIFYQ 264

  Fly   349 L--LGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQG---AMQVLGVSEGEREGIVR 408
            |  ...|.|.:..|.|  .||.:.|.|||.:....|..|.:.:|.   |..:||::|..:.|:.:
Zfish   265 LCACAHLPEFKPLKLG--SADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEAHQMGLFQ 327

  Fly   409 VLAAVLHLGNVYFHRRQLRHGQEGVEVGSD-AEIKWAAHLLHISADGLHRALTSRTTEARAERLH 472
            :|:|:||||||....|    |.....:..: ..:.....|..:|.:.:...|..:..:...|.|:
Zfish   328 ILSAILHLGNVEVKER----GSSSCSISDENGHLAMFCDLTEVSNESMAHWLCHKKLKTATETLN 388

  Fly   473 TPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQL 537
            .|:...:|::.|||.||.:||.||:|:||::|..:.......:. |.:|||:|||....|||||.
Zfish   389 KPVTRLEAVNGRDALAKHIYAKLFSWIVSQVNKALSTSSKPHSF-IGVLDIYGFETFELNSFEQF 452

  Fly   538 CINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFP 602
            |||||||.||..||.|||||||.||.:|::.||.:.:.||.|.|:|:..| :|:..|||:|...|
Zfish   453 CINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAK-MGLLDLLDEECTMP 516

  Fly   603 RATDLSFLEKCHYNH-ALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLA 666
            :.:|.|:.:|.:..| ..|..:.:||:..:.|.:.|:|.:|.|..||||:||:|.:..:.:.:|.
Zfish   517 KGSDDSWAQKLYNTHLKKSSHFEKPRMSNKAFIILHFADKVEYQCDGFLEKNKDTVNEEQINVLK 581

  Fly   667 SSRLPLVGELTKQLRAQRDAGKTLPKG--SNGRFV-TMKPRTPTVAARFADSLQQLLQSMGRCHP 728
            :|:..|:.||.:...:......|...|  ..||.. :.:....:|..:|.:||..|::::....|
Zfish   582 ASKFSLLLELFQDEESPAAPNTTASSGRAKFGRSTQSFREHKKSVGLQFRNSLHLLMETLNATTP 646

  Fly   729 WFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLAR 793
            .:|||||||..|....||....:||||..|:|:||:|...|:|.|..:|.|..||:.|:..    
Zfish   647 HYVRCIKPNDVKAPFMMDPHRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYQVLMTK---- 707

  Fly   794 GTPYREL-------CRALLEAMPRTGVEGPD-YQLGATRVFLREALHRALESGRTERLRRAAVSV 850
                :|:       |:::||.:    |:..| ||.|.|::|.|......||..|.::||.|.:.:
Zfish   708 ----KEILLDRKLTCQSVLERL----VQNKDKYQFGKTKIFFRAGQVAYLEKLRADKLRTACIHI 764

  Fly   851 QRHVRGMLVRRQLARRQAAATRLQARWRGQR-------------------------AQQRYERLR 890
            |:.:|..|.|.:..|.:.||..||...||.:                         |:::|.|.:
Zfish   765 QKTIRCWLARMKYLRIRQAAITLQKYTRGHQARCLCKTLRRTRATVVFQKNTRMWAARRQYLRQK 829

  Fly   891 KGALTAQRLWRGRQARRRVQQLRSDHRR---RQEAREAAQRAREAREAKQAV----------LER 942
            ..|:..||:.||..||...::|..:|:.   ::..|....|.| .|..|:||          |.|
Zfish   830 TAAVLIQRILRGYTARLEYKRLVCEHKALLIQRWVRGFLARWR-YRRIKRAVVYLQCCVRRMLAR 893

  Fly   943 SQLSYLDIPAELAFIYSKLQGWSPPHG-DRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVY 1006
            .:|..|.|.|.....|.||.     :| :..::::...:........:|.|.:|  :....|.|.
Zfish   894 RELKKLKIEARSVEHYKKLN-----YGMENKIMQLQRKLDEQHKENRELSEQIG--AIESHSVVE 951

  Fly  1007 CNGLRLQ------------PRREPITA-----PLLTRAASRDQDFQDALAVFKLILRWSNDK--A 1052
            ...|.:|            .|.:.:|:     .|:.|...::::.     |.:|     |:|  .
Zfish   952 LEKLHVQLKTLQEAEEEARHREDLVTSLQEELDLVRRELEKNKEM-----VVEL-----NEKNTM 1006

  Fly  1053 LEGAKE---KLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPS 1114
            |:..||   :|:.:........|....:::...|..|:      :.|..|...||.:.|      
Zfish  1007 LKSEKEEMNRLIQEQEQQIREKSEATNEDVTENLQTQL------NEERFRYQNLLTEHL------ 1059

  Fly  1115 AAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMA 1179
                |...|:.|.::.:.:..:......|...|.:||.:....:            :...|.:::
Zfish  1060 ----KLEERYADLKSEKEVAEISTAGDSRADSGYSSSQSESIHS------------SMLTGSEVS 1108

  Fly  1180 LPLTLPDEASQTVAVDSWTSCE---EAAALAVSSLGVASRGWT----LVLDDGQQLTD---SCGL 1234
               :|..|.:..||.|.....:   ..|.|...::.:.|...|    |:|:..::|.|   :.|.
Zfish  1109 ---SLEKEDAVQVAADVSLLLKLQRRVAELEKENMDMQSEMDTKEEQLILEKAKELEDCRKTLGA 1170

  Fly  1235 DYVMDLIAEKELCPAFPAPRSD--LLRSGAKFARTTLPDAVKRPAVPPPA-------PPTSSGKE 1290
            :...:.:..:||       .||  .|:...:..|.:|..........|..       ...:|..|
Zfish  1171 ERDYEALKRQEL-------ESDNKKLKKDLQELRQSLSKGTGSKVTSPGGRAYNVILEQLNSTNE 1228

  Fly  1291 DVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDS 1355
            ::  |.|....|:.||..::...|:.:.....|....:    |||.:||.....:...:....:|
Zfish  1229 EL--EVRKEEVLILRSQLVSHEAFKHKELGTVGDSGDS----SRSPTLDLTELNEDGELWMAYES 1287

  Fly  1356 QEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYAT 1420
            .:..:.:.:|:.:.....|.        |:|.....:.||.                  |||...
Zfish  1288 LKETNRILVSQLQTQREMHE--------KETESLRVELQHL------------------KAELDQ 1326

  Fly  1421 RSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYE 1485
            :...:|.:.|.|    |..|:    |||     |....|.:...::|.|               |
Zfish  1327 QQQMLSQSLELP----HDARI----QAS-----LQHEISRLTQQNMDLL---------------E 1363

  Fly  1486 QENEAESEI----DDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIE 1546
            |..:.:..:    ..|..|:....:|..:  :.|:.:.::.||.  .|..|:...:|||.:..:|
Zfish  1364 QMGKQDKMVRKLKKQLKIYMKKFGEPEGV--HFEQSSPENMLAE--SGRTVSIVRKERDFQGMLE 1424

  Fly  1547 DLDDYINELF-------EPIPVAEGL--------------------DKLTSKEHLAVSIRGGGST 1584
            ...:..|:||       :|..||..|                    |.|.....|..||....:|
Zfish  1425 YRREDENKLFKTLITDLKPRGVAVNLVPGLPAYILFMCLRHADYANDDLRVSTLLNTSINSIKNT 1489

  Fly  1585 DSNGAD------------PLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQ- 1636
            .....|            ..||.|.|..||.........:|.:.......:::..|:...|..| 
Zfish  1490 LKKRGDFESISFWLANTCRFLHCLKQYSGEEGYSKHNTPRQNEHCLTNFDLSEYRQVLSDLAIQI 1554

  Fly  1637 -NQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSS 1688
             .|.::.:          .|...|..||.:|...:|.......|..|:...||
Zfish  1555 YQQLIRVI----------ENILQPMIAPAMLEQETIQGVMGVKPTGMRKRTSS 1597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 264/702 (38%)
MYSc_Myo15 169..828 CDD:276838 256/681 (38%)
MyTH4 1014..1171 CDD:295320 27/166 (16%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myo5abXP_009296049.2 Myosin_head 7..1324 CDD:332202 405/1426 (28%)
MYSc_Myo5 83..742 CDD:276831 256/681 (38%)
Myo5-like_CBD 1427..1800 CDD:322280 35/181 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.810

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