Protein Alignment Myo10A and myo16

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_001920958.3
• Gene: myo16 / 563752
• ZFINID: ZDB-GENE-070912-470
• Length: 1910
• Species: Danio rerio
• Alignment Length: 1953
• Identity: 448/1953 - (22%)
• Similarity: 688/1953 - (35%)
• Gaps: 645/1953 - (33%)

  Fly    26 VHRAA---QVIVVQALIKGKMRIVRFHLEPWQRGGGGSVTPSPAQSPSLALLSPHV--------- 78
            :|.||   |..:|..|:|.|       .:|       ::.......||....:.|:
Zfish   280 LHLAAKYGQTHIVSQLLKHK-------ADP-------TLLNCNQDKPSDIAATEHIAEMLLRAEE 330

  Fly    79 --LRRQRPASLEDFEDLPNLSAKHPA-------LPSSRLRRLKCRYPQVVKRLSTLC-----SDV 129
              ::|||..|..     |..|..|.|       ||              ||:|:|:.     .|.
Zfish   331 FWVQRQRDPSAS-----PPQSEDHSAEANQDDNLP--------------VKKLATMALPISRRDS 376

  Fly   130 IARHPQTFALQPGEGSLRARQDLGSSGV-------------------EDMTLLDDLHEASLLWNL 175
            :......|....|..:.:|..|.|..|.                   :|:..|.:|.::|||:.:
Zfish   377 LLEKEAMFRDSGGALTQQASLDNGLDGSYPSAAGKLEQVKLMPPAPNDDLASLSELTDSSLLYEM 441

  Fly   176 RLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQY---AGRPLGSLPPHLFAIGAAA-HAAL 236
            :.|:....|||:.|.||:.:||||..| .|...|::.|   :||...|||||:|:....| |...
Zfish   442 QKRFANDQIYTYIGHILLLINPYKDLP-IYSNLVSQLYLSSSGRLCSSLPPHIFSSAERAFHMMF 505

  Fly   237 PS--PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARN 299
            ..  ||..:|||||||||:.:.|.::::|||.....|.|   :..::.....:|||||:|:|..|
Zfish   506 QERRPQCFIISGESGSGKSVACKHILKHLAARSSPKGFA---LEPRMKHVNVILEAFGHAKTQMN 567

  Fly   300 DNSSRFGKYLEVYF--KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYG 362
            .:.|||.|.:.:.:  |...::..::..|:|||||::...|.::|:::||.:..|||..|:|:..
Zfish   568 TSGSRFIKLISLQYCDKRKTLLRGRLYTYMLEKSRVICMPPHQQNFNIFYLMAEGLSAEEKSQLY 632

  Fly   363 LLEADKYFYLNQG--------ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNV 419
            |.....:..||..        |:.|...|....:|:.|::.||.::.|.|.:..:::|:||||::
Zfish   633 LNNVLAHRCLNTAAPGESPAVASACPQSREKLLALKQALRALGFNKLEVENVFVLISALLHLGDL 697

  Fly   420 YFHRRQLRHGQEGVEVGSDAEIKW---------AAHLLHISADGLHRALTSRTTEARAE---RLH 472
            .|            ...:||:..:         .|.:|.:|::.|..||||.....:.:   |.|
Zfish   698 RF------------TALTDADTAFVSDLQLLDRVAGMLQVSSEDLSSALTSDVQCFKGDVITRRH 750

  Fly   473 TPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ--KGGTHD-AHRISILDIFGFEDLAENSF 534
            |   ::.:...||...||||..||:.||:.||..:|  :..|.| |..||||||||||:...|::
Zfish   751 T---VEMSNHHRDLLTKALYGRLFSLLVNNINFYLQGHEETTGDPALEISILDIFGFEEFQRNAY 812

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPL-AWDDNLPVIHLLAKKPVGICHLLDDE 598
            ||||||..||.:..:..:.:|:.||.|..:|.:....| :......|:....:||.|:..::|:|
Zfish   813 EQLCINMVNERIHQFTAEVLFQQEQHECLQEGVAMETLRSLGSQTAVLDFFFQKPQGVLCIIDEE 877

  Fly   599 SNFPRATDLSFLEKCHYNHALSELYAR-------------------------PRIGAQEFGVTHY 638
            |        ..|..|..|     ||.|                         |:.....|.|||:
Zfish   878 S--------QSLRPCEVN-----LYKRLQIQLDSSATDAVSLTTKDGNGNPPPKDQGPSFTVTHF 929

  Fly   639 AGQVWYCVDGFLDKNRDALRGDVLELLASS-----------RLPLVGELTKQ------------- 679
            ||::.|.:.|.||:|:|.|..::|.::.:|           :|...|.|..|
Zfish   930 AGKMTYDLTGSLDRNKDVLPQNILFVMKTSENVLIHQMFQCKLTQTGSLVPQHQRMKLRGPKGTL 994

  Fly   680 ------LRAQRDAGKTL-------PKGSNGRFVTMKPRTP-TVAARFADSLQQLLQSMGRCHPWF 730
                  |...|||.|.:       .||::.....::...| |||.:..:||.::...:..|.|.|
Zfish   995 INKSTTLNPARDAKKYVELNKLLKKKGASSFLQRLERCGPITVAVQLKNSLCEITSKLQSCTPHF 1059

  Fly   731 VRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLA--R 793
            ::|::||........|...|..||:|:|:|:.:::.:.||||||.|..|:.|||.|:.:.:.  :
Zfish  1060 IQCVRPNNASKPDVFDSFHVSSQLQYVGVLEMVRMIRYGYPVRLSFSSFLSRYRELVDTIITDRK 1124

  Fly   794 GTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EALHRALESGRTERLRRAAVSVQRHVRG 856
            .....|.||.:|......|     :|:|.::||||  :|.|.   :.|..:|.|..:..|:.:||
Zfish  1125 KATTEEKCRHILLHCKLQG-----WQMGNSKVFLRYWQADHL---NDRCHQLHRKIIICQKVMRG 1181

  Fly   857 MLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRL--WRGRQARRRVQQLRSDHRRR 919
            .|.|:|:.||  ..:|.|.....||..|..|.|  |..|...|  .......|...:||. |...
Zfish  1182 WLARQQVRRR--LTSRKQELCNVQRFLQGAEDL--GLRTYDNLVIQNAADIARENDRLRG-HISA 1241

  Fly   920 QEAREAAQRAREAREAKQAVLERS------------------QLSYLDIPAEL---------AFI 957
            ....|..:...:..::.:.|:|:|                  :.|.:.:|..:         |.|
Zfish  1242 PPLGERPEPVGKEEDSPKRVVEKSGRGNDVANRGGNRPIRHFRSSSVPLPLVMDSLVHSSIGASI 1306

  Fly   958 YSKLQGWSPPHGDRHLVKVLGTVPG-----------PPSSAVQLPEDLGQFSFGKFSSVYCNGLR 1011
            .:.||  ..||         .|..|           ||....:.|......|:...|:    ||.
Zfish  1307 KAALQ--PTPH---------STDEGNGGSLSSPRKQPPPKPKRDPNTRLSASYEAVSA----GLS 1356

  Fly  1012 LQPRREPIT-------APLLTRAASRD-----QDFQDALAVFKLI-----LRWSNDKALEGAKEK 1059
            :.|:..|..       :|..|:.:..|     :...|..:..|.|     .|..|.| |.|:.|:
Zfish  1357 IAPKDSPAEGQASPSGSPPNTQLSPSDSLAKPRPHSDDYSTMKKIPPPKPKRSPNTK-LTGSYEE 1420

  Fly  1060 LLADY--------------------IVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLL 1104
            :....                    ::.:|.|:.|....:|        .|.|...|.....:::
Zfish  1421 ISVPSPARPTDMKLVSLVRGGHCLGLIQRAASADGPHSSVL--------SLYPCQDEEDVYIEMV 1477

  Fly  1105 GQCLCCF-------QPSAAFSKYLMRFVDDE-------APESLRPLLLR----------QLLRQQ 1145
            |......       :|..|..:.:..|.:||       .||::.|..|.          .|:.|.
Zfish  1478 GASRALSLADTHSPEPGEAVYEEMKYFPNDEIVSTPVVKPEAVNPTPLPAPVLEIKRPVTLIEQS 1542

  Fly  1146 G--GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPL--TLPDEASQTVAVDSWTSCEEAA-- 1204
            |  ||...|..|       :|           ||:..|.  .||......|...|..:|..|:
Zfish  1543 GTLGGKQQGKDG-------MP-----------CDIPAPFPNLLPHRPPLLVFPPSPVTCSPASDE 1589

  Fly  1205 ----ALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFA 1265
                .|.|..|.|..........||                 ...|.|.:...|:|    .:...
Zfish  1590 SPLTPLEVKKLPVFETNLNYSSQDG-----------------GSPLSPQYTRQRAD----SSPSL 1633

  Fly  1266 RTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQ 1330
            ...:||....|..|||.||                     .:.|...|  |.||..|
Zfish  1634 SILMPDKSTPPLTPPPPPP---------------------PAVLPPPY--RPPSHFP-------- 1667

  Fly  1331 AKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQH 1395
                           ..|.|                     .:.:..|.|.|.....|:.
Zfish  1668 ---------------FPPEP---------------------NFLALTRAASVASTESPKV----- 1691

  Fly  1396 AGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSP 1460
                ||...||                     .:|.|           ||.:...       |||
Zfish  1692 ----SHKMGHG---------------------LAETP-----------PSSSKPP-------FSP 1713

  Fly  1461 VLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSK-DQLA 1524
            | ..|..|...|.|.::|..                       :|.|    .|...|||. |:|.
Zfish  1714 V-KTSRPEPRRAHSCSSSPL-----------------------LFNP----ANGRPLTSPLDELN 1750

  Fly  1525 AIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGA 1589
            .|...|                                   ..|..|......||..|.::||
Zfish  1751 TIFSSG-----------------------------------RSLLRKSTTGRKIRDSGLSNSN-- 1778

  Fly  1590 DPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAAN 1654
                   :.|||..:.||               ::.:.|:|.:                   .||
Zfish  1779 -------INLPGREDQGP---------------ISPSAQLQDK-------------------NAN 1802

  Fly  1655 NSTSP---PPAP-------------------PILSSLS-----ISPPPPQSPMRMKATRSSLVVM 1692
            |.|||   .|||                   |:.||.|     :.....|.|.|.:|.......:
Zfish  1803 NHTSPNSSNPAPIENGNQISNGTLEDEGHPKPMASSSSTLHRHMDSHHTQVPQRSRACGEQRATL 1867

  Fly  1693 ESL 1695
            :.|
Zfish  1868 QEL 1870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	225/755 (30%)
		PTZ00121	<828..>943	CDD:173412	31/118 (26%)
		MyTH4	1014..1171	CDD:470587	39/219 (18%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	13/74 (18%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo16	XP_001920958.3	ANKYR	83..330	CDD:440430	12/63 (19%)
		ANK repeat	113..144	CDD:293786
		ANK repeat	146..207	CDD:293786
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786	9/39 (23%)
		Motor_domain	435..1154	CDD:473979	225/755 (30%)
		NYAP_N	1242..1672	CDD:464717	94/538 (17%)
		NYAP_C	1726..>1772	CDD:464724	16/107 (15%)