Protein Alignment Myo10A and myh14

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_005157988.2
• Gene: myh14 / 563011
• ZFINID: ZDB-GENE-100921-1
• Length: 2060
• Species: Danio rerio
• Alignment Length: 2367
• Identity: 557/2367 - (23%)
• Similarity: 893/2367 - (37%)
• Gaps: 656/2367 - (27%)

  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            ::|:.|..::...:|..|                 |.||||..|..|:|||:|.|||.||..|||
Zfish    74 RKLTLLREELQRMNPPRF-----------------SKVEDMADLTCLNEASVLHNLRERYYSGLI 121

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||::|...:.:||||..| .|...:.:.|.|:....:|||::||..||:.::   ...|.::.:|
Zfish   122 YTYSGLFCVVINPYKNLP-IYTESIIEMYRGKKRHEMPPHIYAISEAAYRSMLQDREDQSILCTG 185

  Fly   247 ESGSGKTESTKLVMQYLAAVVPG----------------------GGSASAV--------ITEQI 281
            |||:||||:||.|:||||.|...                      |..:|||        :..|:
Zfish   186 ESGAGKTENTKKVIQYLAHVASSHKSGTLGRPKDTVVQMDGTRSLGRGSSAVNRTVQYGELERQL 250

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:|:
Zfish   251 LQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDERTFHI 315

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESL---QGAMQVLGVSEGEREGIV 407
            ||:||.|.:|..|.:..|..||:|.:|..|:.. ..|:.|.|:.   ..:|.::|.::.|...::
Zfish   316 FYQLLSGATEAMRKELLLGGADQYRFLCGGSLP-VPGQSDSENFTQTMDSMTIMGFTQEESTSML 379

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLH 472
            :|:::||..||:.||:.:   ..:...:..|...:...|||.||.....||:.:...:...|.:.
Zfish   380 KVISSVLQFGNITFHKEK---NTDQASMPDDTAAQKLCHLLGISVLEFSRAILTPRIKVGREYVQ 441

  Fly   473 TPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQL 537
            ......||..|.:|.|||.|..||.|||.|||..:.:.....|..|.||||.|||....||||||
Zfish   442 KAQTKQQADFAVEALAKATYERLFRWLVHRINRALDRRQRQGASFIGILDIAGFEIFQLNSFEQL 506

  Fly   538 CINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPVGICHLLDDES 599
            ||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.:  .|.|:..|||:|.
Zfish   507 CINYTNEKLQQLFNHTMFVLEQEEYQREGIEWNFIDFGLDLQPCIDLIERPAHPPGVLALLDEEC 571

  Fly   600 NFPRATDLSFLEKCHYNHALSELYARPRIGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVL 662
            .||||||.||::|..........:.|||...:|  |.:.||||:|.|..:.:|.||.|.|..:|.
Zfish   572 WFPRATDRSFVDKLSAEQGSHSKFMRPRQLKEEADFSIIHYAGKVDYKANEWLVKNMDPLNDNVA 636

  Fly   663 ELLASSRLPLVGELTKQLRAQRDAGKTLPK----------GSNG-----RFV------------- 699
            .||..|..|.:.||      .|:..:|||:          .:||     |.|
Zfish   637 SLLHQSSDPFISEL------WREDIQTLPRVYFFDSYATLQTNGCDSMERIVGLDQVSSGENSGP 695

  Fly   700 ---------TMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLR 755
                     |.|....||...:.:||.:|:.::...:|.|:|||.||.||.|.::....||.|||
Zfish   696 VSFGAAGLKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFLRCIIPNHEKRAGKLSPHLVLDQLR 760

  Fly   756 YLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD--- 817
            ..|:|:.|:|.::|:|.|:.||.|.:||..|.|:                 |:|||.::|..
Zfish   761 CNGVLEGIRICRQGFPNRIPFQEFRQRYEILTPN-----------------AIPRTFMDGKHASE 808

  Fly   818 ------------YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAA 870
                        :::|.::||.|..:...||..|..::....:..|...||.|.|:...::|...
Zfish   809 LMISALELDKNLFRVGQSKVFFRAGVLAHLEEERDLKITDTIIRFQSAARGYLARKAFHKKQQQL 873

  Fly   871 TRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREA 935
            :.|:..   ||....|.:||.        |:..:...:|:.|....|:.:|.     :||||:..
Zfish   874 SALRVM---QRNCAAYLKLRN--------WQWWRLFTKVKPLLQVTRQDEEI-----QAREAQLQ 922

  Fly   936 KQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFG 1000
            |    .:.:||.|::  :...:..|.|                          ||.|:
Zfish   923 K----AKDKLSKLEL--DFTELDKKNQ--------------------------QLIEE------- 948

  Fly  1001 KFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL------------ 1053
              .||..:.|:.:.........:..|.|:|.|:.:|.|...:..|....::.:
Zfish   949 --KSVLTDQLQAEAELFAEAEEMRARLANRKQELEDVLGELESRLEEEEERTVQLTNEKKRIQQH 1011

  Fly  1054 -----------EGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQC 1107
                       ||.:::|..:.:..:: ..:.|..|.|. |..|...|   |.|..:|.:.|.:
Zfish  1012 VQDLEEQLEEEEGTRQRLQLEKVTLES-KVKSLEAETLT-LAEQRDRL---SKEKKQLEERLNE- 1070

  Fly  1108 LCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQ----------LLRQQGGGTSSGAVGAGACRSF 1162
                     .:..|..  ::|..:||..|..:|          |.|::.|.
Zfish  1071 ---------VTDQLTE--EEEKVKSLNKLKNKQEAVIADIEERLKREEQGR-------------- 1110

  Fly  1163 VPAWLEWRAWTRG------------CDMALPLT-------------------LPDEASQTVAVDS 1196
                ||...|.|.            .||:|.:|                   |.:|.::.
Zfish  1111 ----LEQEKWKRRMEGEAVEAQEQLSDMSLLVTELRGSLSQREKEITTLQTRLEEEGARR----- 1166

  Fly  1197 WTSCEEAAALAVSSL-----------GVASRGWTLVLDDGQQL----TDSCGLDYVMDLIA---- 1242
             |..:.|...|:|.:           |:..|......|.|::|    |:   |:..:|..|
Zfish  1167 -TEAQRALREAMSQVSELKEEVENERGMRERAEKQRRDLGEELEALRTE---LEDTLDTTAAQQE 1227

  Fly  1243 -----EKEL-----CPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERR 1297
                 |.||     |......|.:...|..:...|...|::               :|.:...:|
Zfish  1228 LRSRREAELGELQRCLEEETRRHEAQLSELRIKHTAAIDSL---------------QEQLDNAKR 1277

  Fly  1298 SSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTL 1362
            |.:.|....:.|.|............||......:.|.::...|              ||
Zfish  1278 SRQSLEKAKAVLEEERLNLSAELKTLQGGKMESERGRKRAEGQL--------------QE----- 1323

  Fly  1363 GLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSD 1427
                  ||.|...|||         .|.::.:..|:.               ::|..:.||::|
Zfish  1324 ------LNARLSQAER---------EREEREERLGKL---------------QSELESLSSSLS- 1357

  Fly  1428 TSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIR------GGSYEQ 1486
            :|::.|...|.....:.||..||.:.|.           :|.....:|.:.:|      .|..|:
Zfish  1358 SSDSKSHRLHKEVSSLESQLHDVQELLQ-----------EETRQKLALGSRVRALEEEKAGLMER 1411

  Fly  1487 ENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERD----------- 1540
            ..|.|.:..:|...|.:..|.:   .:|::.|  :::.:.::.|....:..:||
Zfish  1412 LEEEEEKTRELTRQIQNHTQQL---ADLKRQT--EEVNSAVEAGEETRRKMQRDLENAVQREKSK 1471

  Fly  1541 --EESEIEDLDDYINELFEPIPVA--------EGLDKLTSK------EHLAVSIRGGGSTDSNGA 1589
              |:..||...:.:.|..|.:.:|        ..|:|...|      |..|||.|
Zfish  1472 EEEKERIERQKERLREEIEDMTIALQRERQNCTALEKRQKKFDQCLAEEKAVSAR---------- 1526

  Fly  1590 DPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAAN 1654
                                .|::..|     |.|::.:.:.:.|:.::|||....|:......|
Zfish  1527 --------------------LQEERDR-----AEAESREKETRFLSLSRALQEATEQRDELERTN 1566

  Fly  1655 NSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSL-VVMESLQPPPPPPPPPMPPPLECKDPSET 1718
            ..........:.:...:.    ::...::.:|.:| ...:||:                   .:|
Zfish  1567 KQLRLEMEQLVNAQDDVG----KNVHELERSRRALETEAQSLK-------------------EQT 1608

  Fly  1719 RHFLDPYGRAKTVRIG---KWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGM 1780
            :...|..|.|:..|:.   ..:....|.|.:..|:|:    |..:.:|....|.:..:.     |
Zfish  1609 QELEDELGEAENARLRLEVTLQALRAQFEREISTKEE----KGEEKRRALNKQVRELET-----M 1664

  Fly  1781 MESGPGARGASATA---IEWEEFEIESPTPPPMSG--QLMRSSIRLETTTTTTTSAVNNRDRDRE 1840
            :|.....|..:.|.   :|.|..|.|:.......|  :..|...||:|         ..::..||
Zfish  1665 LEEEKTQRAQALTVKKQLETELQEAEAQVEAASRGREEAFRQMKRLQT---------QMKELIRE 1720

  Fly  1841 TQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLE----QVTAGHSVRSTVST 1901
            ..:          ||||:...           |.:.|.|.:..|.||    |:|...||
Zfish  1721 LDE----------TKLARDEI-----------VAQSKDSEKRLQTLEAELLQLTEDLSV------ 1758

  Fly  1902 KSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPS 1966
                      .:.:|...||:...:...:....:|...:.|....:.|:|.:||.:|....:...
Zfish  1759 ----------SERQKRQAQQERDEMADEIINNATGKSALFDEKRRLETRITQMEEELEEAQSNAE 1813

  Fly  1967 GGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAF 2031
                  ||                               ..|..:......|.:.|:..|...|.
Zfish  1814 ------LL-------------------------------AERQRKSTLQIETLTVQLSGERTLAQ 1841

  Fly  2032 IQRQERDTF---------------GAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSR 2081
            .....|:|.               |||:.:..:|...|..:..|.....     ||..:||:.:.
Zfish  1842 KSESARETLERQNKELKTRLSEMEGAVKGKHRLSVAALEAKIESMEEQV-----EQERQERAMAN 1901

  Fly  2082 SRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIR----QVERERESHKVYQPA 2142
            ...|..|...:.|..:.|.|    ...:::.||:.::...||.:::    :||.|.......:..
Zfish  1902 KLVRKTEKKLKEVLMQVEDE----RRHADQYREQLDKSMGRLRQLKRQLEEVEEENSRSNAQRRK 1962

  Fly  2143 PPRVIQASMDTTGGHRREDRTGGLATFRTHMA----QKYEHERKRKSSASSGMREELDSMHM--- 2200
            ..|.::...|:.....||     |.|.|:.::    ||.|.......|..:|.|..:|.:..
Zfish  1963 LQRELEEMSDSMQSMNRE-----LNTLRSQLSITERQKSEQRAPLPLSMRAGRRALVDDLSQENS 2022

  Fly  2201 ------TTPPPVIVPAPVPPPSSTSPG 2221
                  .:|.|...|...|.||..:.|
Zfish  2023 DSEDPGASPTPSSGPPGTPTPSDNALG 2049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	270/752 (36%)
		PTZ00121	<828..>943	CDD:173412	26/114 (23%)
		MyTH4	1014..1171	CDD:470587	31/189 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	19/109 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myh14	XP_005157988.2	None