Protein Alignment Myo10A and myo5c

DIOPT Version :9

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_691143.2
• Gene: myo5c / 562676
• ZFINID: ZDB-GENE-131127-196
• Length: 1746
• Species: Danio rerio
• Alignment Length: 1620
• Identity: 438/1620 - (27%)
• Similarity: 692/1620 - (42%)
• Gaps: 400/1620 - (24%)

  Fly   140 QPGEGSLRARQDLGSS---------------------GVEDMTLLDDLHEASLLWNLRLRY-DKG 182
            :||:..|..:.:.|:.                     |..|:|.|..|||.::|.||::|: :..
Zfish    32 KPGDSELELQLEDGTELHYPLEGGEKLPPLRNPDILVGENDLTALSYLHEPAVLHNLKVRFVESK 96

  Fly   183 LIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALP---SPQVVVI 244
            :|||:.|.||:||||||..| .||..|...|:|:.:|.|.||:||:...|:..:.   ..|.:::
Zfish    97 IIYTYCGIILVAVNPYKQLP-IYGDAVIHAYSGQNMGDLDPHIFAVAEEAYKQMARNNKNQSIIV 160

  Fly   245 SGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYL 309
            |||||:|||.|.:..|:|.|.|...|....  :.:::|.:.|:.||.|||:|.|||||||||||.
Zfish   161 SGESGAGKTVSARYAMRYFAMVSKSGSKTR--VEDKVLASNPITEAIGNAKTTRNDNSSRFGKYT 223

  Fly   310 EVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLN 373
            |:.| |...|:||.:..|||||||:|.|:..|||||:||::....::.|.....||.|:|:.|..
Zfish   224 EISFDKRYQIIGANMRTYLLEKSRVVFQSENERNYHIFYQMCACANQPEFKGLRLLGAEKFNYTR 288

  Fly   374 QGA---TDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEV 435
            .|.   .:....|.|....:....:||:.|..:..:.:||||:||||||....:.    .|...:
Zfish   289 LGGEIEIEGVDDRADMAETRRTFNLLGLKENFQTDVFKVLAAILHLGNVIIKAKD----PEKSFI 349

  Fly   436 GS-DAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499
            || |..:.....|:.:|.:.:.|.|..|......|.:..|...::|::||||.||.:||.||||:
Zfish   350 GSRDPHLAIFCDLMGVSTENMSRWLCHRRIVLSTETVVKPQPRERAVNARDALAKHIYAHLFNWV 414

  Fly   500 VSRIN-SIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYA 563
            :.:|| :::..|..|..  |.:|||:|||....|||||.|||||||.||..||.|||||||.||.
Zfish   415 IHKINHALMVPGKQHSF--IGVLDIYGFETFEINSFEQFCINYANEKLQQQFNLHVFKLEQEEYM 477

  Fly   564 RERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSE-LYARPR 627
            :|.:.||.:.:.||.|||.|:..| :||..|||:|..||:.||.::|:|. ||...|: |:.:||
Zfish   478 KEDIPWTLIDFYDNQPVIDLIEAK-MGILDLLDEECLFPQGTDKNWLQKL-YNFLGSKPLFEKPR 540

  Fly   628 IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG----K 688
            :....|.:.|:|.:|.|...|||:||||.|..::::::.:|:..|:....|:..|  |:|    |
Zfish   541 LSNDSFMIQHFADKVEYQCKGFLEKNRDTLYEELVDIMRASQFALLAGFFKEEEA--DSGHKIIK 603

  Fly   689 TLP-----KGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748
            ..|     |.||      |....||..:|..||..|::::....|.:|||||||:||.....|..
Zfish   604 VTPAQPRVKASN------KQLRSTVGDKFRSSLYLLMETLNATTPHYVRCIKPNEEKLPFEYDSR 662

  Fly   749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGV 813
            .|:||||..|:|:||:|..:.||.|..:..|..||..|:.....:....::.||.:|:.:.
Zfish   663 RVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRYSILMSQSELKLGEKKQTCRTVLQRLI---- 723

  Fly   814 EGPD---YQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQ-LARRQAA----- 869
              ||   |:.|.|::|.|......||..|.:.||.|.|::|:||||...||. |..||||
Zfish   724 --PDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAACVTIQKHVRGWRQRRSFLNIRQAALIIQL 786

  Fly   870 -------------ATRLQARW---------RGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQL 912
                         |..|:..|         ||...::.|:.:.:.|:|.|...||..||:|.:::
Zfish   787 YVRGKKQIRCTVTAQALKQGWAAIVIQRHCRGFLVRRIYQLVLRAAVTIQAFTRGWMARKRYKKM 851

  Fly   913 RSDHRR---RQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLV 974
            .::|:.   ::.||  |...|...:..:.::...||||     .:..:..|::..:..:..  |:
Zfish   852 VAEHKALVLQKYAR--AWLVRRRFQTMRRLVINVQLSY-----RVQQLRKKVEEQNKENCG--LM 907

  Fly   975 KVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALA 1039
            :.|.::....:..::..:.| :...||.::.              .:.|:.||.:..::...|:.
Zfish   908 EKLTSLSNARAQGLEKIQAL-EAELGKLTNE--------------MSALVQRAKTNSEEANQAID 957

  Fly  1040 VFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLL 1104
            |            |:..||||:.:   :||| .|.|:| ..||:.:|
Zfish   958 V------------LQNDKEKLVEE---NKAL-ERKLKD-TTVQMQDQ------------------ 987

  Fly  1105 GQCLCCFQPSAAFSKYLMRFVDD-EAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLE 1168
                        |.....:.::| |..|.||.:
Zfish   988 ------------FEDVKRKLMEDLEREERLRKV-------------------------------- 1008

  Fly  1169 WRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCG 1233
                   .:....|...|...:.||:.     ||...|....:    |..|.|.:|.:..|:
Zfish  1009 -------AEHNSELQKEDSDKEIVAIK-----EENRRLREERI----RLQTQVEEDVKTNTE--- 1054

  Fly  1234 LDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRE--- 1295
                   :.|:.|                        ...|...|.|          |:.:|
Zfish  1055 -------LQEQML------------------------QLTKHVKVIP----------DLRKEINN 1078

  Fly  1296 ---RRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQE 1357
               :|:..|...|:..|                    ||:::...:...|.|       |...|:
Zfish  1079 LQIQRAEAEKTLRAQNL--------------------QARAKMNLITRQLLG-------DATEQD 1116

  Fly  1358 PLHTLGLSESRLND-------RYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADK 1415
            .:..|....|..||       .:...||.|.| .:|..|.||..|..:.........|.||..::
Zfish  1117 LIQRLNEEASDNNDDGADLITAFDGMERAAKV-METQLREQKDAHESQLEALIFKNEHLSKENEQ 1180

  Fly  1416 AEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIR 1480
            .:...:..  ||.::  |:...|.|:..           :::..|.|...:.||:
Zfish  1181 LQALFQEK--SDINQ--SIGQEVTRLTA-----------ENMVIPELKQQVSELN---------- 1220

  Fly  1481 GGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEI 1545
                ..::|.||::.|         |...:...|::|:|...||.             .:|:|:.
Zfish  1221 ----RHKHELESQLQD---------QTAEMSAKLKELSSALHLAV-------------EEEQSQR 1259

  Fly  1546 EDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALY 1610
            ..|                      :|.|..|.|....||        .|:.:|..|.:.   |.
Zfish  1260 RRL----------------------QEELTESQRRREETD--------RQISELQEENQQ---LK 1291

  Fly  1611 QQQVQRAFLQSAM--------AQNLQIQQQLLAQNQALQTLLSQQAAA---AAANNSTSP 1659
            :.|:..:..::.:        |:|:..::||..:::.::.|..|..|.   ||||...:|
Zfish  1292 KAQITESQAKNTLRLETSRLTAENMDFEEQLDMKDRLIKRLQDQIKALQTHAAANQKAAP 1351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	271/702 (39%)
		MYSc_Myo15	169..828	CDD:276838	263/681 (39%)
		MyTH4	1014..1171	CDD:295320	25/157 (16%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo5c	XP_691143.2	MYSc	63..750	CDD:214580	273/711 (38%)
		MYSc_Myo5	82..739	CDD:276831	263/681 (39%)
		IQ	808..826	CDD:197470	2/17 (12%)
		IQ	830..849	CDD:197470	8/18 (44%)
		Laminin_I	1068..1314	CDD:283627	63/367 (17%)
		GBP_C	<1176..1291	CDD:303769	32/198 (16%)
		coiled coil	1280..1291	CDD:293879	2/13 (15%)
		Myo5c_CBD	1366..1740	CDD:271260

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810