DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and myo9ab

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_021326243.1	Gene:	myo9ab / 562199	ZFINID:	ZDB-GENE-080424-6	Length:	2343	Species:	Danio rerio

Alignment Length:	2650	Identity:	641/2650 - (24%)
Similarity:	978/2650 - (36%)	Gaps:	860/2650 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PGEIQEVHRAAQVI--VVQALIKGKMRIVRFHLEPWQRGGGGSVTPSPAQSPS-LALLSPHVLRR 81
            |...::|..||:||  |::.|...:.|:  :.|...:..||.....:|:..|: ..:|.|.:...
Zfish    34 PVSARKVTTAAEVIERVIERLQLDRTRL--YVLAEVKEFGGEEWILNPSDCPAQRMMLWPRMALE 96

  Fly    82 QRPASLEDFEDL---PNLSAK-HPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPG 142
            .|... ||:..|   .||... |.......||..:.|...|.:.|.          ||..|.|
Zfish    97 NRLLG-EDYRFLLREKNLDGSIHYGSLQMWLRVTEERRRMVERGLL----------PQPPAAQ-- 148

  Fly   143 EGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGL 207
                         .|.|:..|.||:|.::|.|||.|:.:..|||:.|||||||||:|..| .|..
Zfish   149 -------------FVADLCSLPDLNEHTMLENLRGRFRQENIYTYVGSILIAVNPFKFLP-IYNP 199

  Fly   208 EVAKQYAGRPLGSLPPHLFAIG-AAAHAALP--SPQVVVISGESGSGKTESTKLVMQYLAAVVPG 269
            :..|.|....||.|.||:||:. ||.||.|.  ..|.:|||||||||||:||..::.:|.|:...
Zfish   200 KYVKMYDKHRLGQLEPHIFAVADAAYHAMLQRHRNQCIVISGESGSGKTQSTNFLIHHLTALSQK 264

  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQYLLEKSRI 333
            |.::.  :.:.||.|.|:|||||||:||.|:|||||||:::| |.:||.:.||.:.:|||||||:
Zfish   265 GFASG--VEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQESGTVRGAYVEKYLLEKSRL 327

  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQ---------------GATDCASGR 383
            |.|...||||||||.||.|.||.|||.:.||..::|.||||               ...||.|..
Zfish   328 VYQEHNERNYHVFYYLLAGASEDERSXFHLLRPEEYHYLNQITKSVHKQHWGNHCDTELDCFSVE 392

  Fly   384 V-----DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW 443
            .     |:|.||.||:::|.....|:.|..:|:|:|||||:.:.::..|  .:.:::.:...:..
Zfish   393 AEDLKHDFERLQLAMEMVGFLPTTRKQIFSLLSAILHLGNIRYKKKTFR--DDSIDICNPEVLPI 455

  Fly   444 AAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRIN-SIV 507
            .:.||.:..:.|..|||:|.|....|||..|..:.:|...||:.||:||..||:|:|.|.| :::
Zfish   456 VSELLEVKEEMLFEALTTRKTVTVGERLIVPYKLAEAGTVRDSMAKSLYCALFDWIVFRTNHALL 520

  Fly   508 QKGGTHDAHR---ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEW 569
            ......|:.:   |.:||||||||...|||||.|||:|||.||.|||:|||||||.||..|.:.|
Zfish   521 YNKDLEDSAKILSIGVLDIFGFEDYENNSFEQFCINFANETLQHYFNQHVFKLEQEEYRSEGINW 585

  Fly   570 TPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFG 634
            ..:.:.||...|:|::|||..:.||||:|.|||:|::.:.|:|....|..:.....|.:....|.
Zfish   586 HMIDYIDNTACINLISKKPTALLHLLDEECNFPQASNQTLLDKFKRQHEGNAYMEFPAVMEPAFI 650

  Fly   635 VTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELT-----------------KQLRA 682
            :.||||:|.|.|..|.:||.|.||.|::.||.|||...:..|.                 :.|.|
Zfish   651 IRHYAGKVKYSVKDFREKNTDHLRPDIVSLLKSSRKAFICGLMGLDPVASFRWAVIRAFFRALVA 715

  Fly   683 QRDAG----------------------------------------------------KTLPK--- 692
            .|.||                                                    :..|:
Zfish   716 FRHAGLQHRDNRSSGSDVHLQPQKSVDSFSFLHHPVHQRSLEILQRCKDDRYNSCVSRRSPRTPL 780

  Fly   693 ---------GSNGR-----------------FVT------------------------------- 700
                     .||||                 ||.
Zfish   781 SDLQGANTFSSNGRGWRSERVSSFAHEDEGIFVNSVNNRLLERAQGILMRNKNYKPKPSLPKHLL 845

  Fly   701 -------------------------MKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEK 740
                                     .|.:.|:::|:|..||.:|::::|:..|:||:||:.|.||
Zfish   846 DVKSLKYLSSLTLHDRITKSLLHLHKKKKPPSISAQFNVSLNKLMETLGQSEPYFVKCIRSNAEK 910

  Fly   741 HALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPL-ARGTPYRELCRAL 804
            ..||.:...||:||||.|||:|::|||.||.|:..|:.|...:..|||:.. |.....||..|:
Zfish   911 LPLRFNDALVLRQLRYTGMLETVRIRQSGYSVKYSFKDFAHHFHVLLPAGFSASQMGIREFLRS- 974

  Fly   805 LEAMPRTGVEGPDYQLGATRVFLREALHRALE----------------SGRTE-------RLRRA 846
                  ..:|...||:|.:.|||.|.|.:.|:                |.||:       |.|||
Zfish   975 ------ADLEPSGYQVGRSMVFLHERLRQRLQDELHQEVLRRIVCLQRSFRTQRDRKHFCRQRRA 1033

  Fly   847 AVSVQRHVRGMLVRRQ-----LARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQAR 906
            |..:||..|..:.:..     |..:|.||.||||.|||.||::.|.:.|:..|..||.|
Zfish  1034 ARLIQRWWRSCISQADGSVCALELQQGAALRLQAVWRGFRARRLYLQQRRAVLIIQRCW------ 1092

  Fly   907 RRVQQLRS-------------DHRRR--QEAR-----EAAQRAREAREAKQAVLE---RSQLSY- 947
            |||...|:             .|||.  |:.|     :||.|.:::|:..:.:.|   |.|..:
Zfish  1093 RRVLNTRNTAATLIQAVWRTRTHRRSFLQQRRAAVTLQAACRGQQSRQRCRILREQQCREQSKHP 1157

  Fly   948 ------LDIPAELAFIYSKLQG-WSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
                  |....|.|   .||:. |.....|            ||..||   :|....|..|..|
Zfish  1158 STVTKSLHQNTEEA---EKLEEVWEKQTTD------------PPPKAV---DDSTLKSRNKRES- 1203

  Fly  1006 YCNGLRLQPRREPITAP---LLTRAASRDQDFQ--------------DALAVFKLI--------- 1044
                 |.|...|..|..   |..|:.|..:|.|              |:...|:|:
Zfish  1204 -----RRQRELEQATFSLELLKVRSGSNTEDAQIPPSKHHPPHQASTDSQESFELLENEDSASAK 1263

  Fly  1045 LRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLC 1109
            |..|..:.:|..:....|.:..|..:.     ||         .|.|.||...|
Zfish  1264 LELSKSEPMEVNQTSPAASFKPHFYIP-----DE---------DGSPINSAPQT----------- 1303

  Fly  1110 CFQPSAA-------FSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWL 1167
               |:.|       .|..::..:..|.|.....|   |.|..|....|:|. .|..| |.:|
Zfish  1304 ---PNRAKQIREKKESVVVIISMQKENPVDRSSL---QTLEAQDVPLSNGE-SASDC-SIIP--- 1357

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSC 1232
                               |......:|:.           ||..|:|:  .|.||
Zfish  1358 -------------------EPRTNHELDTG-----------SSFSVSSK--PLQLD--------- 1381

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPT------SSGKED 1291
                :....:.:|  |:  .|::|:.:   ||...::..::|..|.....||.      |...:|
Zfish  1382 ----LRSAASNEE--PS--EPKADVQK---KFVSQSISISMKETAANVAFPPKRSRLTFSKSDKD 1435

  Fly  1292 VPRERRS---SRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDC 1353
            :..:.||   .||...||  |..|...|     .|.......|::||..|....:.:     .||
Zfish  1436 LVNQERSLAIQREAGFRS--LKNRDVTR-----AGCKKKARMARTRSDFLSRACSTE-----ADC 1488

  Fly  1354 DSQE--------------PLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAG------- 1397
            :..|              |.|:  .|...::..:||...::  .:....|.||:..:|
Zfish  1489 EEDEDDEYEDTPVLSCTRPPHS--PSSPDIDCVFHSDSEMS--SQKEQKRIQKTMSSGDLGKMDS 1549

  Fly  1398 -RRSHAASHGS--------HSSKYADKAEYATRSSAMSDTSE--------APSLASHVRRVRVPS 1445
             |:|.:.:...        ..||:.||...:...||.|:.::        :|..|....|.|...
Zfish  1550 LRKSMSQTDSRVRGKMRFWSKSKHGDKKISSRGRSADSELTDRRNDSPPGSPEHAGVSERRRDSK 1614

  Fly  1446 QASDVDQFLDDLFSPVLDGSLDELSDARSL-AASIRGGSYEQENEAESEIDDLDDY--INDIFQP 1507
            :..:          |:|  .:..:...||| .:|:...|...:|:|...:....||  :||.
Zfish  1615 ENRE----------PML--GMMSMKRRRSLKISSVSLESTAWQNDALHILTSTADYRSMNDF--- 1664

  Fly  1508 IPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEI---EDLDDYINELFEPIPVAEGLD--- 1566
              |::.:..|.::|               .::|...::   :.|.::...:|.....|..:|
Zfish  1665 --LMKKISDLDAED---------------GQKDTAVDVVFKKALKEFRLNIFNSYSTALAMDDGR 1712

  Fly  1567 KLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQL-PGETESGPALYQQQVQRAFLQSAMAQNLQIQ 1630
            .:..|:..|:            .:.:|.:.|:| ..:....|........:.||...|.:
Zfish  1713 SIRYKDLYAL------------FEHILEKSMRLEQRDWSESPVKVWVNTFKVFLDEFMTE----- 1760

  Fly  1631 QQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMR-------------- 1681
                                           ..|:..::|.:|.|.:...|
Zfish  1761 -------------------------------YKPMDGTISKAPKPERKKRRKKESDTVEEHMGHI 1794

  Fly  1682 MKATR----------SSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAK------T 1730
            .|:|:          |||:.|             |.....||        |..|...|      |
Zfish  1795 FKSTQYSIPTYCEFCSSLIWM-------------MDKACVCK--------LCRYACHKKCCLRMT 1838

  Fly  1731 VRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQR-------KTTPQAQHHQMTSNGGMMESGPGAR 1788
            .:..| ::.|.....||..|    ..::...:|       |.....:.|.:.:.|...:||...:
Zfish  1839 TKCSK-KFDPELSSRQFGVE----LSRLTSDERSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNK 1898

  Fly  1789 --------GASATAIEWEEFEI------------ESPTPPPMSGQLMRSSIRLETTTTTTTSAVN 1833
                    ...|.::..:::.|            :.|. |.|:.:|....:|          |:.
Zfish  1899 IKELKQGLDTDANSVNLDDYNIHVIASVLKQWLRDLPN-PLMTFELYEEFLR----------AMG 1952

  Fly  1834 NRDRDRETQDVGQPMQSVVTT----------KLAKKSFEIGADRPPPGSVG-------------- 1874
            .:|:....|.|...:..:..|          .|.:.||:...:|....::.
Zfish  1953 LQDKREVVQGVYSIIDQLSRTHLNTLERLIFHLVRISFQEETNRMSANALAIVFAPCILRCPDTT 2017

  Fly  1875 ----------------KLKLSSEMRQ---RLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
                            :|.:..:||:   ||:.:       :|:.. :|.:|.::|...|:.|..
Zfish  2018 DPLQSVRDISKTTACVELIICEQMRKYKARLKDI-------NTLEF-AENKAKSRLTHIRRSMKP 2074

  Fly  1921 QQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPP 1985
            ..:...|..:|                ||.......|.....|..||.            ..|.|
Zfish  2075 VLIAVRFIGIS----------------RTVTSPNAAKKGKSRARKSGH------------HTPSP 2111

  Fly  1986 PIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQ---- 2046
            |:.|                  |:.|.|......:..|:.|...|.:|::|:    .:.||
Zfish  2112 PLSP------------------RASEREEPVDEGAEPVLSEQQQAAMQQEEK----VLTQQIENL 2154

  Fly  2047 ---------------------QMI----------SSHHLHLEDHSASSSP------AVAA--WEQ 2072
                                 :|:          ||.:| :|...|:|.|      ||:|  |.:
Zfish  2155 QKEKEELTYEMLALEPRASDDEMLESEASIGTADSSENL-MESEGAASDPWEKSPGAVSASRWRK 2218

  Fly  2073 AERERSRSRSRSRDREDYSESVWD----------------RAEVEGPASGSGSE-------KERE 2114
            :|   |:||...|.:.:..:||..                |:...||...|.|.       .:.|
Zfish  2219 SE---SKSRRCLRRQPESLDSVDSAVASLSSVSSTPHYRFRSSSSGPLFSSSSPTGDLHILPDPE 2280

  Fly  2115 KRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTG 2164
            ..|:...........|:.|...:..:..||:..:..  .|||.|||...|
Zfish  2281 SCEQASLSARCASSSEKTRPRPRANRSCPPKPREPG--DTGGRRREHEFG 2328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	303/862 (35%)
		MYSc_Myo15	169..828	CDD:276838	294/841 (35%)
		MyTH4	1014..1171	CDD:295320	37/189 (20%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo9ab	XP_021326243.1	UBQ	7..111	CDD:320785	20/79 (25%)
		MYSc_Myo9	163..991	CDD:276836	293/839 (35%)
		C1	1793..1841	CDD:237996	13/68 (19%)
		RhoGAP_myosin_IXA	1854..2039	CDD:239871	25/199 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810