Protein Alignment Myo10A and myo5aa

DIOPT Version :9

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_017207607.1
• Gene: myo5aa / 562188
• ZFINID: ZDB-GENE-041027-2
• Length: 1854
• Species: Danio rerio
• Alignment Length: 1630
• Identity: 431/1630 - (26%)
• Similarity: 703/1630 - (43%)
• Gaps: 358/1630 - (21%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.||::|: |..||||:.|.:|:|:|||:..| .||.::...|:|:.:|
Zfish    72 GENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYETLP-IYGADIINAYSGQNMG 135

  Fly   220 SLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .:.||:||:...|:..:...   |.:::|||||:|||.|.|..|:|.|.|  .|.::.|.:.|::
Zfish   136 DMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATV--SGSASEANVEEKV 198

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |.:.|::|:.|||:|.|||||||||||:|:.| |...|:||.:..|||||||:|.||..|||||:
Zfish   199 LASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKKYHIIGANMRTYLLEKSRVVFQADEERNYHI 263

  Fly   346 FYELLGG--LSETERSKYGLLEADKYFYLNQGATDCASGRVDWESL---QGAMQVLGVSEGEREG 405
            ||:|...  |.|.:..|.|  :|:.:.|..||......|..|.:.:   :.|..:||::|..:.|
Zfish   264 FYQLCASAHLPEFKALKLG--KANDFHYTKQGRNPVIDGVDDAKEMSTTRNAFILLGINESYQMG 326

  Fly   406 IVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAER 470
            :.::||::||||||....|.   ....:...::..:.....|:.::...:...|..:..:...|.
Zfish   327 LFQILASILHLGNVDVKDRD---SDSSIIPPNNGHLSVFCELMGVTYQDMSHWLCHKKLKTATET 388

  Fly   471 LHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR-ISILDIFGFEDLAENSF 534
            ...|:...||::||||.||.:||.||||:|..:|..:.  .|...|. |.:|||:|||....|||
Zfish   389 YIKPIPKLQAINARDALAKHIYAKLFNWIVDHVNKALH--STVKQHSFIGVLDIYGFETFEINSF 451

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDES 599
            ||.|||||||.||..||.|||||||.||.:|::.||.:.:.||.|.|:|:..| :||..|||:|.
Zfish   452 EQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIEAK-MGILDLLDEEC 515

  Fly   600 NFPRATDLSFLEKCHYNHALS-ELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLE 663
            ..|:.:|.|:.:|.:..|..: .|:.:||:..:.|.:.|:|.:|.|..||||:||:|.:..:.:.
Zfish   516 KMPKGSDDSWAQKLYNTHLKTCALFEKPRMSNKAFIIQHFADKVEYQCDGFLEKNKDTVNEEQIN 580

  Fly   664 LLASSRLPLVGEL-TKQLRAQRDAGKTLPKGSNGRFVTMKP-----------RTPTVAARFADSL 716
            :|.:|:..|:.|| ..:.:|....|.....|...| :::||           ...||..:|.:||
Zfish   581 VLKASKFDLLVELFHDEEKATSPTGAAPGPGGRTR-LSVKPDKGKSSQASKEHKKTVGLQFRNSL 644

  Fly   717 QQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVE 781
            |.|::::....|.:|||||||..|||...|....:||||..|:|:||:|...|:|.|..:|.|..
Zfish   645 QLLMETLNATTPHYVRCIKPNDYKHAFTFDPKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFS 709

  Fly   782 RYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD-YQLGATRVFLREALHRALESGRTERLRR 845
            |||.|:...... |..:..|:.:||.:    |:.|| ||.|.|::|.|......||..|.::||.
Zfish   710 RYRVLMKQKDVL-TDKKMTCKNVLEKL----VQDPDKYQFGKTKIFFRAGQVAYLEKLRADKLRA 769

  Fly   846 AAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ--QRYERLRKGALTAQRLWRGRQARRR 908
            |.:.:|:.:|..|.|::..|.:.|||.:|...||.:|:  .::.|..:.|:..|:.       :|
Zfish   770 ACIRIQKTIRCWLARKKYLRMKHAATTIQRFVRGYQARCLAKFLRRTRAAIIIQKY-------QR 827

  Fly   909 VQQLRSDHRRRQEAREAAQ---RAREAREAKQAVLERSQLSYLDIPAELAFIYSKL-QGWSPPHG 969
            :...::.::|:|.|..|.|   ||..||:..:|:|...:          |.|..|: :||.....
Zfish   828 MYIQKTCYKRKQAAALAMQCILRAYMARQLYKALLREHK----------AVIIQKMVRGWLARQW 882

  Fly   970 DRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVY--CNGLRLQPRREPITAPLLTRAASRDQ 1032
            .:..:|.:                           ||  |...|::.:||
Zfish   883 FKRSLKAI---------------------------VYLQCCIRRMRAKRE--------------- 905

  Fly  1033 DFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEA 1097
                        |:          |.|:.|..:.|....:.|:.::|:
Zfish   906 ------------LK----------KLKIEARSVEHFKKLNIGMENKIM----------------- 931

  Fly  1098 TRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSF 1162
                                  .|.|.:||:..|:      |.:..:.....:|.||.:...|:.
Zfish   932 ----------------------QLQRRIDDQNKEN------RSMSERLNTLETSHAVESERMRAE 968

  Fly  1163 VPAWLEWRAWTRGCD-----MALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVL 1222
            |..       .||.:     .|..:|...|..:.:..|...:.:|..|:         ..|....
Zfish   969 VTR-------LRGAEEDAKNNANKVTSLLEELERLRKDLQNTQKEKKAI---------EDWAQTY 1017

  Fly  1223 DDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSS 1287
            .|..:       ..:.:|..:.:|........:.|::..::.....:..|:|.        .|..
Zfish  1018 QDEME-------KMISELKEQNQLLKTEKNNLNQLIQEQSQQWTDKMQRALKE--------ETQQ 1067

  Fly  1288 GKEDVPRERRSSRELLSRSSALNERYFERE---------PSPGPGQGSSTGQAKSRSKSLDDLLA 1343
            .:.|:..||...:.||:....|.|:|.:.:         |.||..:..||
Zfish  1068 LENDLNEERSRYQNLLTEHLRLEEKYDDLKEEITLAVNVPKPGHRRTDST--------------- 1117

  Fly  1344 GDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGP---------RYQK------- 1392
                            |:...||...|..:..:|..:.||:|...         :.||
Zfish  1118 ----------------HSSNESECTYNSEFAESEEGSRVGEDVSKSILDMSLFLKLQKRVSELEQ 1166

  Fly  1393 -----------SQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQ 1446
                       .:...:|:.|.....|......:.||        ::.:...|.|..::::
Zfish  1167 EKQSLQNELDRREEQFQRARARDDEEHKKARGAELEY--------ESLKRQELESENKKLK---- 1219

  Fly  1447 ASDVDQFLDDLFSPVLDGS-----------LDELS------DARSLAASIRGGSYEQENEAESEI 1494
             .|::|....|...|..||           ||:|:      :.|.....|.......:.||....
Zfish  1220 -HDLNQMRQSLRGSVEAGSGAPGSPAYTVLLDQLNASNEELEVRKEEVLILRSQLVSQKEAMQHK 1283

  Fly  1495 DDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDY--INELFE 1557
            |:.    ..:.:|:|.:::::|||...:::....|          .:::......||  :||..|
Zfish  1284 DEK----TTMTEPLPYIEDVQKLTDAKEISQAYMG----------LKDTNRSPFPDYHKLNEDGE 1334

  Fly  1558 PIPVAEGLDKLT------------SKEHLAVSIRG---GGSTDSNGADPLLHQLMQLPGETESGP 1607
            ...|.|||.:..            |.::....:||   ....::|....||.|.:|||.|.....
Zfish  1335 LWLVYEGLKETNRLLESQLQAQRRSHDNEVEVLRGELHSLKEENNRQQQLLAQNLQLPPEARIEA 1399

  Fly  1608 ALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANN------------STSPP 1660
            :| |.::.|     ...:||.:.:||..|::.::.|..|....|...|            .|:..
Zfish  1400 SL-QHEITR-----LTNENLDLMEQLEKQDKTVRKLKKQLKVFAKKINDLEGGQMDVSPGQTADE 1458

  Fly  1661 PAPPI 1665
            |..|:
Zfish  1459 PVHPV 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	267/704 (38%)
		MYSc_Myo15	169..828	CDD:276838	259/683 (38%)
		MyTH4	1014..1171	CDD:295320	20/156 (13%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo5aa	XP_017207607.1	MYSc_Myo5	85..752	CDD:276831	259/683 (38%)
		IQ	766..787	CDD:197470	7/20 (35%)
		IQ	789..811	CDD:197470	8/21 (38%)
		SMC_N	<920..1279	CDD:330553	70/478 (15%)
		SMC_N	<1156..>1445	CDD:330553	61/321 (19%)
		Myo5a_CBD	1480..1854	CDD:271262

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810