DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myh9b

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_001920098.4 Gene:myh9b / 561431 ZFINID:ZDB-GENE-030131-998 Length:1698 Species:Danio rerio


Alignment Length:1666 Identity:461/1666 - (27%)
Similarity:709/1666 - (42%) Gaps:343/1666 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|..|:...|.|:...
Zfish    79 SKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLP-IYSEEIVDMYKGKKRH 142

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPG----GGSASAVI 277
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||.|...    ...:|:|:
Zfish   143 EMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKTKKDQSSSVL 207

  Fly   278 T-----EQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQ 336
            :     :|:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.|
Zfish   208 SHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQ 272

  Fly   337 APGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD----WESLQGAMQVLG 397
            |..||.:|:||.:|.|:.:..||:..|...:||.:|:.|.. ...|:.|    .|::: ||:::|
Zfish   273 AKEERTFHMFYYMLTGVGDKLRSELCLEGYNKYRFLSNGNV-TIPGQQDRDMYVETVE-AMRIMG 335

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR 462
            .||.|..|::||:::||.|||:.|.:.  ||..: ..:..|...:...||:.::.....||:.|.
Zfish   336 FSEEEHVGLLRVISSVLQLGNMSFKKE--RHSDQ-ASMPDDTAAQKVCHLMGMNVTDFTRAILSP 397

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFE 527
            ..:...:.:......:||..|.:|.|||.|..:|.|||.|||..:.|.....|..|.||||.|||
Zfish   398 RIKVGRDYVQKAQTQEQAEFAVEALAKATYERMFRWLVMRINKALDKTKRQGASFIGILDIAGFE 462

  Fly   528 DLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPV 589
            ....||||||||||.||.||..||..:|.|||.||.||.:||:.:.:. |..|.|.|:.|  .|.
Zfish   463 IFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIDLIEKPASPP 527

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQE--FGVTHYAGQVWYCVDGFLDK 652
            ||..|||:|..||:|||.||:||..........:.:|:....|  |.:.||||:|.|..|.:|.|
Zfish   528 GILALLDEECWFPKATDKSFVEKVLQEQGTHPKFHKPKKLKDEADFCIIHYAGKVDYKADEWLMK 592

  Fly   653 NRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSN---GRFVTMKPRTPTVAARFAD 714
            |.|.|..:|..||..|....|.||.|.:  .|..|.....|.:   |.|.|.|....||...:.:
Zfish   593 NMDPLNDNVATLLNQSTDRFVSELWKDV--DRIVGLDKVAGMSELPGAFKTRKGMFRTVGQLYKE 655

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            .|.:|:.::...:|.|||||.||.||.|.::|...||.|||..|:|:.|:|.::|:|.|:.||.|
Zfish   656 QLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEF 720

  Fly   780 VERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            .:||..|.|:.:.:| ...::.|..::.|:.   ::...|::|.::||.|..:...||..|..::
Zfish   721 RQRYEILTPNSIPKGFMDGKQACMLMIRALE---LDPNLYRIGQSKVFFRAGVLAHLEEERDMKI 782

  Fly   844 RRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWR------- 901
            ....::.|...||.:.|:..|:||...|.::..   ||....|.:||.     .:.||       
Zfish   783 TDVIINFQAWCRGYVARKAFAKRQQQLTAMRVI---QRNCAAYLKLRN-----WQWWRLFTKVKP 839

  Fly   902 GRQARRRVQQLRSDHRRRQEAREAAQRARE---AREAKQAVLERSQLSY-------LDIPAELAF 956
            ..|..|:.:::::......:.||..|.|.:   ..|.||..|...:::.       :|:.||...
Zfish   840 LLQVSRQEEEMQAKEEELSKVREKQQVAEQQLVEMEVKQQQLNAEKMALQEQLQAEMDLCAEADE 904

  Fly   957 IYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPR------ 1015
            :.::|..     ..:.|.::|..:    .:.|:..|:.......:...:..|...|:.:      
Zfish   905 MRNRLVA-----KKQELEEILHDL----EARVEEEEERANHLQAEKKKMQQNIADLEQQLDEEEA 960

  Fly  1016 -REPITAPLLTRAAS-----------RDQD---------FQDALAVFKLILRWSNDKA-----LE 1054
             |:.:....:|..|.           .||:         .::.:|.|...|....:|:     |:
Zfish   961 ARQKLQLEKVTMEAKLKKTEEEVMVLDDQNNKLSKEKKLMEERIAEFTTNLAEEEEKSKSLQKLK 1025

  Fly  1055 GAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPN----SGEATRLWQLLGQCLCCFQPSA 1115
            ...|.::.|      |..|..|:|      .|...|..|    .|::|.|...:.:    .|...
Zfish  1026 NKHEAMITD------LEDRLRREE------KQRQELEKNRRKLEGDSTELHDQIAE----LQAQI 1074

  Fly  1116 A------------FSKYLMRFVDDEAPESLRPLLLRQL------LRQQGGGTSSGAVGAGACRSF 1162
            |            ..:.|.|..::.|.::|....:|:|      |::......:....|...|..
Zfish  1075 AELKAQLAKKEEELQEALARIEEEAAQKNLAQKKIRELESQLSELQEDLELERAARTKAEKHRRD 1139

  Fly  1163 VPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQ 1227
            :...||          ||...|.|....|.|.....:..|.   .|:.|..|       |::..:
Zfish  1140 LGEELE----------ALKTELEDTLDSTAAQQELRTKRET---EVAQLKKA-------LEEDAK 1184

  Fly  1228 LTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDV 1292
            :.:.     ||..|.:|. ..||......|             :.|||..|     .....|:.:
Zfish  1185 VHEQ-----VMAEIRQKH-SQAFDELNEQL-------------EQVKRNKV-----SVEKSKQAL 1225

  Fly  1293 PRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL-------------LA- 1343
            ..||             ||...|.: :...|:|.|..:.|.....|.:|             || 
Zfish  1226 ESER-------------NELQIELQ-TLMQGKGESEHRRKKAEAQLQELQVKHTESERQRIELAE 1276

  Fly  1344 --------------------GDIVPVPTDC--------DSQEPLH-------TLGLSESRLNDRY 1373
                                |..:....||        |.||.|.       .|.....:|.|..
Zfish  1277 RLTKMQAELDNVNTLLSDAEGKSIKASKDCSTVESQLQDVQEVLQEETRQKLALNTRLRQLEDEQ 1341

  Fly  1374 HS-AERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASH 1437
            || .|:|            :.:...:|:.....|:..::..|..:...:.|...:.:|.      
Zfish  1342 HSLREQL------------EEEEEAKRNLEKQIGTMQAQLVDMKKKMEQESGSLECAEE------ 1388

  Fly  1438 VRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDL---DD 1499
             .|.||......|.|.||:     .:.:.|:|...::              ..:.|:||:   .|
Zfish  1389 -SRKRVQRDLEAVSQRLDE-----RNAAFDKLDKTKT--------------RLQQELDDMLVDQD 1433

  Fly  1500 YINDIFQPIPLVQNLEKLTSK-DQLAAIIKGGGVASKPEERDEES---------------EIEDL 1548
            ::..|      |.||||...| ||:.|..|... |...||||...               |:|.|
Zfish  1434 HLRQI------VSNLEKKQKKFDQMLAEEKSIS-ARYAEERDRAEAEAREKETRMLALARELETL 1491

  Fly  1549 DDYINEL--FEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ 1611
            .|...||  ...:..||..|.::||:.:..|:               |.|      .:|..|:.|
Zfish  1492 TDMKEELDRTNKLLRAEMEDLVSSKDDVGKSV---------------HDL------EKSKRAMEQ 1535

  Fly  1612 QQVQRAFLQSAMAQNLQIQQQLLAQNQA-LQTLLSQQAAAA 1651
            |      |:....|..:::.:|.|...| |:..::.||..|
Zfish  1536 Q------LEEMKTQLEELEDELQATEDAKLRLEVNMQAMKA 1570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 276/705 (39%)
MYSc_Myo15 169..828 CDD:276838 268/684 (39%)
MyTH4 1014..1171 CDD:295320 35/210 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh9bXP_001920098.4 Myosin_N 28..66 CDD:280832
Myosin_head 81..767 CDD:278492 275/696 (40%)
Motor_domain 93..767 CDD:277568 268/684 (39%)
KASH_CCD 937..1120 CDD:291334 32/198 (16%)
Sec1 <943..>1076 CDD:301618 25/148 (17%)
Dor1 1018..>1175 CDD:302817 34/185 (18%)
Filament 1034..1341 CDD:278467 70/380 (18%)
Rab5-bind 1306..1606 CDD:286404 73/337 (22%)
GrpE 1532..>1640 CDD:295646 12/45 (27%)
GBP_C <1596..1689 CDD:303769
coiled coil 1660..1669 CDD:293879
coiled coil 1678..1689 CDD:293879
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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