Protein Alignment Myo10A and myh7bb

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_009295034.2
• Gene: myh7bb / 560945
• ZFINID: ZDB-GENE-090311-5
• Length: 1935
• Species: Danio rerio
• Alignment Length: 2545
• Identity: 537/2545 - (21%)
• Similarity: 884/2545 - (34%)
• Gaps: 836/2545 - (32%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|:|||:|:||..||...:|||::|...:.|||||..| .|..||...|.|:....:
Zfish    88 MEDMAMLTHLNEASVLFNLSRRYSFWMIYTYSGLFCVTVNPYKWLP-VYSSEVVAAYKGKRRSDV 151

  Fly   222 PPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQY---LAAVVPGGGSASAVITEQ 280
            |||:::|...|:..:   ...|.::|:||||:|||.:||.|:||   :||:...||.....:.:|
Zfish   152 PPHIYSIADNAYNDMLKNRENQSMLITGESGAGKTVNTKRVIQYFAIIAALGEAGGKKGGTLEDQ 216

  Fly   281 ILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYH 344
            |:||.|.:||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|..|||:||
Zfish   217 IIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQQTGERSYH 281

  Fly   345 VFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQG---------AMQVLGVSE 400
            ::|::|.. .:.|.....|:.::.:.|     ..|:.|.:..:::..         ||..||.:.
Zfish   282 IYYQILSH-RKPELQDMLLVSSNPFDY-----HFCSQGVITVDNMDDGDELLATDHAMDTLGFTP 340

  Fly   401 GEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTE 465
            .|:.|..:::..::|.||:.|   :::..:|..|.........|::|:.||:..|.:.|.....:
Zfish   341 EEKYGCYKIVGGIMHFGNMKF---KVKQREEQAEADGTESADKASYLMGISSADLIKGLLHPRVK 402

  Fly   466 ARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLA 530
            ...|.:.....::|...|..|.|||.|..:|.|||.|||..:......... |.:|||.|||...
Zfish   403 VGNEYIVRGQTVEQVTYAVGALAKATYDRMFKWLVGRINKTLYTAIPRQFF-IGVLDIAGFEIFE 466

  Fly   531 ENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLL 595
            .|:|||:|||:.||.||.:||.|:|.|||.||..|.:|||.:.:..:|.....|.:||:||..:|
Zfish   467 FNNFEQMCINFTNEKLQQFFNHHMFILEQEEYKTEGIEWTFIDFGLDLQACIDLIEKPLGILSIL 531

  Fly   596 DDESNFPRATDLSFLEKCHYNHAL--SELYARPRIGAQ-----EFGVTHYAGQVWYCVDGFLDKN 653
            ::|..||:||:.||..|. |::.|  |..:.:||...:     .|.:.||||.|.|.::|:||||
Zfish   532 EEECMFPKATESSFKAKL-YDNLLGKSPNFLKPRPDKKRKYDTHFELVHYAGVVPYNINGWLDKN 595

  Fly   654 RDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRT-PTVAARFADSLQ 717
            ||.|...|:.:...|...|:..|.:.. ...|:|.....||..:  ..|..: .||:....::|.
Zfish   596 RDPLNETVVGIFQRSSNKLMSSLFENF-ISLDSGSEAKPGSKEK--RKKGASFQTVSQLHKENLN 657

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            :|:.::....|.|||||.||:.|:...|:...||.|||..|:|:.|:|.::|:|.|:.:..|.:|
Zfish   658 KLMTNLRSTQPHFVRCIIPNEAKNPGMMEPFLVLHQLRCNGVLEGIRICRKGFPNRILYAEFKQR 722

  Fly   783 YRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAA 847
            ||.|.|..:...| |.:..:|:.:.:....::...|:.|.::||.:..|...||..|.|||.:..
Zfish   723 YRILNPLAIPEDT-YVDSRKAVEKLLGSLDIDHTQYKFGHSKVFFKAGLLGQLEDMRDERLSKVL 786

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQA-RWRGQRAQQRYERLRKGALTAQRLW----------- 900
            ..:|...||.|:|.:..|.......|.. :|          .:|  |..|.:.|
Zfish   787 TLLQAFCRGKLMRMERKRMMKEKEALMVIQW----------NIR--AFYAVKNWPWMCLFFKIKP 839

  Fly   901 --RGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQA--VLERSQLSYLDIPAELAFIYSKL 961
              |.....:.:..|:.:.::.:||.|.::..|:..|.||.  |.|::.|| |.:.||
Zfish   840 LLRSAATEKELATLKEEFQKLKEALERSEVKRKELEEKQVSLVQEKNDLS-LQLQAE-------- 895

  Fly   962 QGWSPPHGDR--HLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLL 1024
            |.......||  .|:|....:.|.....::..||                      .|.:.|.:|
Zfish   896 QDNLADAEDRCNLLIKAKIQMEGKIKELMERLED----------------------EEEMNATIL 938

  Fly  1025 TRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHG 1089
            .:                                             .|.|.||
Zfish   939 AK---------------------------------------------KRKLEDE----------- 947

  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAV 1154
                                |.:        |.:.:||
Zfish   948 --------------------CIE--------LKKDLDD--------------------------- 957

  Fly  1155 GAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAAL--AVSSLGVAS 1215
                                     |.:||.....:..|.::...  .||.|||  .:|.|....
Zfish   958 -------------------------LEITLAKVEKEKHATENKVKNLVEEMAALDETISRLSKEK 997

  Fly  1216 RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPP 1280
            :    .|.|..|
Zfish   998 K----ALQDAHQ----------------------------------------------------- 1005

  Fly  1281 PAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL---- 1341
                  ...||:..|......|......|.::..:.|           |..:...|...||
Zfish  1006 ------QALEDLQSEENKVNMLSKAKIKLEQQVDDLE-----------GSLEQEKKVRMDLERVK 1053

  Fly  1342 --LAGDI---VPVPTDCD-SQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRS 1400
              |.||:   |....|.| |::.|      |.||..:.|...::       |.:.::.|....:.
Zfish  1054 RKLEGDLKLSVESSMDLDNSKQQL------EERLKKKDHEMVQI-------GAKIEEEQALVIQL 1105

  Fly  1401 HAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGS 1465
            |...           .|..||...:.:..||...|    |.:...|.|||.:            .
Zfish  1106 HKKI-----------KELQTRIEELEEELEAERAA----RSKSEKQRSDVSR------------E 1143

  Fly  1466 LDELSDARSLAASIRGGSYEQENEAESEI----DDLDD---------------YINDIFQPIPLV 1511
            |:|||:....|........|...:.|::.    .||::               :.:.:.:....:
Zfish  1144 LEELSERLEEAGGATTAQIEMNKKREADFIKLRRDLEEASLHHETTIAMLRRKHADTVAEMGEQL 1208

  Fly  1512 QNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGL-----DKLT-S 1570
            .||:::..|             .:.|:.:...|.|||...:..|.......|.:     |:|. |
Zfish  1209 DNLQRVKQK-------------LEKEKAETRMECEDLASNVEHLSRAKTTTEKMCRMYEDQLNES 1260

  Fly  1571 KEHLAVSIRGGGSTDSNGADPLLHQLMQLP-----GETESGPALYQQQVQRAFLQSAMAQNLQIQ 1630
            |..:               :.|..|||.:.     .:|||.      :|.|. |:......:|:|
Zfish  1261 KTKI---------------EELQRQLMDVTSQKARAQTESA------EVSRR-LEEKEVLVMQLQ 1303

  Fly  1631 QQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESL 1695
            :..:|.:|.::.|..|....:.|.||.:                        .|.:||....:.|
Zfish  1304 RTKIAFSQTVEELKKQLEEESKAKNSLA------------------------HAVQSSRHDCDLL 1344

  Fly  1696 QPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQ 1760
            :.             :.::..|.:..|........:.|.:||.....|..| :|:|      :..
Zfish  1345 RE-------------QFEEEQEAKSELQRALSKANIEIAQWRTKYETDAIQ-RTDE------LED 1389

  Fly  1761 HQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTT 1825
            .::|...:.|                   .|..|:|....:..|         |.::..||:|
Zfish  1390 AKKKLVARLQ-------------------GSEEAVEASNAKCAS---------LEKTKHRLQT-- 1424

  Fly  1826 TTTTSAVNNRDRDRETQD--VGQPMQSVVTTKLAKK--SFEIGADRPPPGSVGKLKLSSEMRQRL 1886
                          |.:|  |.....:.|...|.||  :|:              |:.||.||:.
Zfish  1425 --------------EIEDLMVDLERSNAVAIALDKKQRNFD--------------KVLSEWRQKF 1461

  Fly  1887 EQVTA---GHSVRS-TVSTK------SEQRAPAKLEDTRK--LMLQQQLGGLFASVSGGNSGPGG 1939
            |:..:   |....| ::||:      |.:.|..:||..::  ..||:::..|...:|.||.
Zfish  1462 EETQSELEGSQKESRSLSTELFKLKNSYEEALDQLETIKRENKNLQEEITDLTDQISQGNK---- 1522

  Fly  1940 VVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSP 2004
                  |:. ::|:|:..|
Zfish  1523 ------TIH-ELEQMKKVL---------------------------------------------- 1534

  Fly  2005 PTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAA 2069
                      |:.....|...|.....::.:|..|   :|.|..:|.....:|...|
Zfish  1535 ----------DHEKCDIQAALEEAEGTLEHEESKT---LRVQLELSQTKTEVEKKLA-------- 1578

  Fly  2070 WEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERE 2134
             |:.|...:..|:..|..|....::.........|.....:.|.:..|.|....:..||..   |
Zfish  1579 -ERDEEIDNLRRNHQRTLEGMQTTLDAETRARNEAIRVKKKMENDMNEMEIHLNHANRQAV---E 1639

  Fly  2135 SHKVYQPAPPRV--IQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDS 2197
            |.|:.:....::  :|..:|.:..|..|.:.....|.|.:.....|.|..|      |:.|:.|
Zfish  1640 SQKMVRNLQLQIKDLQVELDESMHHCEELKEQVAVTERRNTLLSAELEELR------GVAEQTD- 1697

  Fly  2198 MHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEP 2262
                                                                 |:||  ...||.
Zfish  1698 -----------------------------------------------------RMRK--VAEHEL 1707

  Fly  2263 IGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQ 2327
            :                             |.|..:|:||....
Zfish  1708 L-----------------------------ESSERVNLLHAQNT--------------------- 1722

  Fly  2328 VRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGE 2392
                                  :...|...|..|:|::.                        ||
Zfish  1723 ----------------------VMLNQKKKLESDLSMLS------------------------GE 1741

  Fly  2393 IQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTL 2457
            :..|         |...||.:..|..|...||:.:      :|.:|.|..:|.|....|...||:
Zfish  1742 VDDA---------QQECRNAEEKAKKAITDAAMMA------EELKKEQDTSSHLERMKRNMEQTI 1791

  Fly  2458 NVPLERLESRQAHAQRNEHGVDGGSRQNE--QLQQSELHHHLQQQQQQQQQQQH----------- 2509
            .....||:..:..|      :.||.:|.:  :::..||...|..:|::..:.|.
Zfish  1792 KDLQNRLDEAEQIA------LKGGKKQIQKMEIRVRELETELDCEQKKSAEFQKGIRKYERRIKE 1850

  Fly  2510 --HQQQQQQQ---QLEDAMEE-QHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQ 2568
              :|.::.::   :::|.::: |......::|.:....|......||.|.|..|..|      ::
Zfish  1851 LTYQTEEDRKTLLRMQDLIDKLQAKVKSFKRQAEDAEEQVNCNMTRFRKIQHDLDEA------EE 1909

  Fly  2569 PSSLTNGQVH 2578
            .:.:...||:
Zfish  1910 RADMAESQVN 1919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	238/682 (35%)
		PTZ00121	<828..>943	CDD:173412	30/130 (23%)
		MyTH4	1014..1171	CDD:470587	11/156 (7%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	14/70 (20%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myh7bb	XP_009295034.2	Myosin_N	33..77	CDD:460670
		Motor_domain	100..767	CDD:473979	238/682 (35%)
		Myosin_tail_1	847..1924	CDD:460256	273/1758 (16%)