DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo15aa

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_021330383.1 Gene:myo15aa / 560592 ZFINID:ZDB-GENE-080425-2 Length:2394 Species:Danio rerio


Alignment Length:3074 Identity:883/3074 - (28%)
Similarity:1338/3074 - (43%) Gaps:783/3074 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 RARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAK 211
            ||.:|    ||||||.|::|||.::|.||:.|:::.||||:.||||::||||||| :.||.::..
Zfish    15 RAEED----GVEDMTQLEELHEGAVLLNLKKRFERNLIYTYIGSILVSVNPYKMF-NIYGTDMVL 74

  Fly   212 QYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSA 273
            |:.|..||..|||||||..|::..:   ...|.::|||||||||||:||||::||||:     ..
Zfish    75 QHKGHALGENPPHLFAIANASYTKMMDAKENQCIIISGESGSGKTETTKLVLRYLAAI-----HH 134

  Fly   274 SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYLLEKSRIVTQAP 338
            ...||:|||||.||||:||||:|.|||||||||||:|::.:.|.|.||..:||||||||||.||.
Zfish   135 KQNITQQILEATPLLESFGNAKTVRNDNSSRFGKYMEIFMEEGVISGAITSQYLLEKSRIVFQAK 199

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCA----SGRVDWESLQGAMQVLGVS 399
            .|||||:|||:|.||...::..:.|.:|:.|:|||||. ||.    |...|:..|..||::|..|
Zfish   200 DERNYHIFYEMLAGLPSQQKQSFYLQDAETYYYLNQGG-DCVIVGKSDGEDFRRLLSAMEILHFS 263

  Fly   400 EGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTT 464
            ..::.||.|||:::||||||:|.|.: ...||...|.|..||:..|.||.||.:||.:::|.:.|
Zfish   264 AEDQSGIFRVLSSILHLGNVFFERYE-TESQEVASVVSAQEIRVVAELLQISPEGLQKSITFKVT 327

  Fly   465 EARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDL 529
            |...|:::|||.::.|:|||||.||.||:.||:||..|||..|..  .::|..||||||:|||||
Zfish   328 ETMREKIYTPLTVESAIDARDAVAKILYSLLFSWLTDRINKQVYP--RNEALSISILDIYGFEDL 390

  Fly   530 AENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHL 594
            ..|||||||||||||.||.:||:.:||.||.||.||::.|..:.:.||...|.|:|.||.||..:
Zfish   391 TFNSFEQLCINYANEYLQFFFNRVIFKEEQDEYNREQIIWEEVPFSDNQACIDLIAAKPHGILRI 455

  Fly   595 LDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRG 659
            |||:|.||:|||.:||:||||:|..:.||::|::...||.:.||||:|.|.|..|||||.|.:|.
Zfish   456 LDDQSGFPQATDHTFLQKCHYHHGNNPLYSKPKMPLPEFTIKHYAGKVSYQVHKFLDKNYDQVRQ 520

  Fly   660 DVLELLASSRLPLV-------GELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQ 717
            |||:|...|:..:|       .|...|.|:|.....|         ||.:.:..||||:|..||.
Zfish   521 DVLDLFIQSKNKMVAYLFMNYAEALNQQRSQIGKNST---------VTRRHQASTVAAKFQQSLL 576

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            :|::.|.|.:|:|||||||||.|.....||..|..||.|.|:|:|::||:.|||:|:.|..|:.|
Zfish   577 ELIEKMERANPYFVRCIKPNQNKEPAVFDMELVSAQLCYSGILETVRIRREGYPIRMPFDVFLFR 641

  Fly   783 YRHLL----PSPLARGTPYRELCRALLEAM--PRTGVEGPDYQLGATRVFLREALHRALESGRTE 841
            |:.||    |.| |.|    |.|..:|..:  .|.|.    :|:|.|::|::|.::..|||.| :
Zfish   642 YKSLLGLKQPPP-ANG----ENCVIMLRKLCPVRPGA----FQVGVTKLFMKEEIYFLLESKR-D 696

  Fly   842 RLRR-AAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQA 905
            |:|. ||:::||:.|...||::....:....||||..||...::||.::|...:..:.|......
Zfish   697 RVRHVAALTLQRYTRMFFVRKRYTAFRMKIIRLQAHCRGFLTRKRYVKMRVSLVKFRSLVHMYVD 761

  Fly   906 RRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGD 970
            |:|..:||.:.||:.|..   ||..|...:|:.|:   .:::|.|||||..:.....|....|.|
Zfish   762 RKRYIRLRYEARRKAEEE---QRRIEMELSKREVV---NVTHLVIPAELGALLQAAAGGRELHSD 820

  Fly   971 RHLVKVLGTVPGPP---SSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQ 1032
                 .|..|..|.   .:.:.||.|:..::..|...::..    :|:...:||||.|.....|.
Zfish   821 -----CLALVQAPTVQVETQLTLPLDINNYTISKLVQIHFK----EPKFGMLTAPLKTPLTHVDD 876

  Fly  1033 DF-QDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGE 1096
            |. .:||.||.:|||:..|..|.||:|.|..:||:.|.|::..||||||.|:.||| ...||...
Zfish   877 DLTHEALDVFVMILRFMGDPHLNGAQENLFGNYIIQKGLTNLNLRDEILCQIANQV-WRNPNPDN 940

  Fly  1097 ATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRS 1161
            :.|.|.||..||..|.|||...|||::||.|.|....:.:...:|::    .......|....|:
Zfish   941 SERGWLLLLACLSAFAPSAKVEKYLLKFVSDHAYNEFKAVGQHKLIQ----AMQKSLYGPETART 1001

  Fly  1162 FVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV--ASRGWTLVLDD 1224
            :..:.|||.|..:..:|.|.:...|..|....|.||||.||.|...:...||  |.:|.::::.:
Zfish  1002 YPLSLLEWTANRKKANMVLQVHCFDGTSFLCPVHSWTSGEELAGDILQHRGVTEAWKGCSVIMKE 1066

  Fly  1225 GQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGK 1289
            ..|..:..|.||||||||:.||...||..:|..:.|.....||                      
Zfish  1067 HGQWAELAGHDYVMDLIADMELMRNFPKQKSYFIISAESPTRT---------------------- 1109

  Fly  1290 EDVPRERRSSRELLSRSSALNERYFEREPSPGP---GQGSSTGQAKSRSKSLDDLLAGDIVPVPT 1351
                                       .|:.|.   |.|                       ..:
Zfish  1110 ---------------------------RPNAGLALFGSG-----------------------FDS 1124

  Fly  1352 DCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKA 1416
            |.||     :|.|.::.|                                       ||...|..
Zfish  1125 DDDS-----SLLLPQTML---------------------------------------SSSLPDSD 1145

  Fly  1417 EYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRG 1481
            .|  .|.|.||.||||:             ...:|::||.||.|||.....:...:.|:::.::|
Zfish  1146 GY--YSHAESDFSEAPT-------------QKGMDRYLDSLFDPVLSDGNGDFEKSSSMSSRMKG 1195

  Fly  1482 -GSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEI 1545
             |....||                                         |.:...|..|      
Zfish  1196 AGGIGGEN-----------------------------------------GDLEKPPSGR------ 1213

  Fly  1546 EDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALY 1610
                          |...||..                    ||.|:|    .:.|.|...|   
Zfish  1214 --------------PYPPGLQP--------------------GAVPVL----PVMGGTMMPP--- 1237

  Fly  1611 QQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPP 1675
                                    ....|:.::...||:||.       |..||:       |..
Zfish  1238 ------------------------IPMPAMPSVPHAQASAAV-------PSVPPM-------PAM 1264

  Fly  1676 PQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPP 1740
            |..|           .|.::.|.|..|..|..|.:...||:                        
Zfish  1265 PSMP-----------AMPAMLPLPALPNVPPMPDMSGVDPA------------------------ 1294

  Fly  1741 PQDEPQFQTEEDFFAFKMRQHQRKTTPQ-----AQHHQMTSNGGMMESGPGARGASATAIEWEEF 1800
                            .:.|||:....|     ||  |||              ..|.|::.:.:
Zfish  1295 ----------------VLAQHQQAIINQQAIILAQ--QMT--------------MQAMALQQQMY 1327

  Fly  1801 -EIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVG----QPMQSVVTTKLAKKS 1860
             .:..|     ..:|:.::...:.:.|              .||:|    :|.......|.:::.
Zfish  1328 NSVHHP-----HSELLPAARSSQYSPT--------------KQDIGPVSYKPAPVSPPQKSSQRH 1373

  Fly  1861 FEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGG 1925
            :......||||.|.:..:|:     .|.:...|:::..:  |..|..|.|               
Zfish  1374 YSPPRREPPPGEVVRATVSN-----TEYLEPSHNIKDII--KQYQTNPVK--------------- 1416

  Fly  1926 LFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPP 1990
                                                                             
Zfish  1417 ----------------------------------------------------------------- 1416

  Fly  1991 SMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLH 2055
                ||..|..::...::.|:|..:    :..::|:.:.|..|:::                   
Zfish  1417 ----PAEIPRREAKVFSKKPDPHDE----AMMILKDQMSAPPQQRK------------------- 1454

  Fly  2056 LEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERER 2120
                                                                             
Zfish  1455 ----------------------------------------------------------------- 1454

  Fly  2121 ERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKS 2185
                            |.|.|.||        ::.|                          ::.
Zfish  1455 ----------------KTYTPVPP--------SSSG--------------------------KEF 1469

  Fly  2186 SASSGMREELDSMHMTTPPPV-IVPAPVPPPSSTSPGLGVV-SGVLMGSGSGGSTACLTYNRVPW 2248
            |...|..:.:.|:.....||| .|....|.|:..|..|.|. ..:........|....||..|||
Zfish  1470 SYDGGPMKPVKSITTKRSPPVPAVSQRFPAPAPVSRDLPVEDENIQTQLHKRSSEEHYTYTNVPW 1534

  Fly  2249 KLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVD-TLS 2312
            |:.:|||||.|.:....|:.|||||.|::.|.|. ..|:|||.:|:....::...|.:... |:.
Zfish  1535 KIYLRKEVFYPKDSFNHPLILDLLFKQIVHDTFS-EACIRITTEERQKMKSIFAEHSIDASATIQ 1598

  Fly  2313 NRNGSGAGGGGNGGQVRALVKRHLVDMARD-WPLYFARLFAVQGAPLYPDVSIMGVSHSG---LY 2373
            :.|                ||:.:|..|:| |.:||:|||...|: :...|.::.|||.|   |.
Zfish  1599 DEN----------------VKKKVVVAAKDTWDIYFSRLFPASGS-VGTGVQVLSVSHRGIKLLK 1646

  Fly  2374 LARRDA---DYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQE 2435
            :.|..|   ||..|::..|:.:|. .||:|....|:.||.|.| |.|.:|:|..:::|:..|:.|
Zfish  1647 MVRSSAVAPDYFRVLRPYSYTDIM-FVTIPSKNMLEFNLNNEK-LILFSAKAPQVKTMIDYFITE 1709

  Fly  2436 FRKSQSKASTLSSGARAAAQTLN------VPLERLESRQAHAQRNEHGVDGGSRQN--------- 2485
            .:|.......:.:........|:      :.|:::|           |:|.|....         
Zfish  1710 LKKDSDYVVAVRNYITDDRTLLSFHKGDIIRLQKME-----------GLDAGQYYGCIVKKKVIL 1763

  Fly  2486 -EQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQR 2549
             |:|::.......:......:......:..|.....|.:   ::..|.:::.:.:.|:.      
Zfish  1764 LEELKRDTPDFGWKFGAIHGRSGVFPVEFVQPVAAPDFI---NIPVDKKEEPKNKQGRV------ 1819

  Fly  2550 FLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHH------DLDANYLQDES 2608
                        .::|....:..:....|..::.::.....|:....:      |:|...|||  
Zfish  1820 ------------AASAAVAVAVGSAAAAHELDRTIEVASPVSEYTEAYTDSTDMDIDERILQD-- 1870

  Fly  2609 NGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHER--HQSAANRSYAELVKWQGHAIRLPLLRLP 2671
                    .:|::::||.::||..|.::....:::  .:|...|..:|:||:....|:..|:...
Zfish  1871 --------VQYNMVEFAKKYFRGAQRKNGGDSYKKKSKKSKEPRDPSEMVKFSKSPIQESLIEFT 1927

  Fly  2672 ND-LAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSP 2735
            :: |..:|.|.|..|:::.||.|:... .|...:.|:|....:|..:|||.|||:::|.|.|.|.
Zfish  1928 DENLNKVAAEIFLAIMKFMGDYPMKGQ-AEQDVISTILRLSGEYGLMRDEAYCQVLRQITGNTSS 1991

  Fly  2736 CPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRK 2800
            ..:|.||.||||.|..||:.||:.|:|||:::|....:.......|.|..|..|||||.:.|||.
Zfish  1992 KTESCQRGWRLLYIFTAYYKCSEVLKPYLLKYLQDVCASPGVHFQGIAKACEQNLRKTFQYGGRI 2056

  Fly  2801 NVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLY 2865
            ..|:..|:.|:.||||::||::.||||.||.:..:..:|..|.|.|||..:|:.......|::::
Zfish  2057 EHPNGMELKAMLAGRSSKRQLFLLPGGIERHLKIKTCSVALDAIEELCYEMGLHKLEALDEYAVF 2121

  Fly  2866 CIVQGDAFTMPLAADEYILDVTTELLKSGQPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAP 2930
            .:........||...|||||:|||.......:.|.|.|.:|...||.:   ..|.|.:.:|||.|
Zfish  2122 VVTNRGQNVRPLNKREYILDITTEAEHVDSNYSLWFRRVIWTQPLKFD---NELGVTMHYNQVYP 2183

  Fly  2931 DYLEGLLLELPGNGVPVPEMVRDMARIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQW 2995
            |||:|||..|| .|....:.::.:|::|||.|||.|..::|.:.|::..:|....|::  |..||
Zfish  2184 DYLKGLLTVLP-QGKASEQQLQQVAKLAALQHRAKDSLYLPTIHEVQEYIPTQLSGLQ--RAQQW 2245

  Fly  2996 VGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILA 3060
            :.:......||..|||.|.|||||.:::.:|:||||||.:          :..::|.:....:||
Zfish  2246 LNMATQHMQQVQPLSPHQAKAQFLGLVSAFPMFGSSFFYI----------LSSSNSAVDTPCVLA 2300

  Fly  3061 LNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGAL--FLDMKVGNLMQQRVIRVQTEQAHEI 3123
            :|:.|:.||...|||.:..:...||.|||..|...|:.  ::::.:|:||.||:.::|.||:.|:
Zfish  2301 VNQNGLNFLSKETHEPMVKFPLKEVQSTRTQRPTAGSSYPYVEIMLGDLMSQRITQLQLEQSLEL 2365

  Fly  3124 SRLVRQYITMAQISQRDKR 3142
            .|:|..::... :|.|:||
Zfish  2366 CRVVAMHMENL-LSVREKR 2383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 337/699 (48%)
MYSc_Myo15 169..828 CDD:276838 326/678 (48%)
MyTH4 1014..1171 CDD:295320 60/157 (38%)
MyTH4 2704..2810 CDD:279165 43/105 (41%)
B41 2823..3033 CDD:214604 76/209 (36%)
FERM_B-lobe 2920..3025 CDD:271216 40/104 (38%)
FERM_C_MyoXV 3029..3138 CDD:270022 33/110 (30%)
myo15aaXP_021330383.1 Motor_domain 34..684 CDD:328930 326/677 (48%)
IQ 723..742 CDD:279006 6/18 (33%)
MyTH4 866..1013 CDD:214535 58/151 (38%)
Atrophin-1 <1205..1505 CDD:331285 85/699 (12%)
SH3_MYO15A 1716..1795 CDD:213000 8/89 (9%)
MyTH4 1914..2068 CDD:214535 55/154 (36%)
FERM_B-lobe 2176..2273 CDD:271216 39/99 (39%)
FERM_C_MyoXV 2279..2380 CDD:270022 34/111 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 602 1.000 Domainoid score I189
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1190 1.000 Inparanoid score I188
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10566at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm24502
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - LDO PTHR13140
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5032
SonicParanoid 1 1.000 - - X4354
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1212.000

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