DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYO5C

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens


Alignment Length:1041 Identity:336/1041 - (32%)
Similarity:525/1041 - (50%) Gaps:149/1041 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.|||:|: :..||||::|.||:|:||||..| .||..:...|:|:.:|
Human    68 GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLP-IYGDAIIHAYSGQNMG 131

  Fly   220 SLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .:.||:||:...|:..:.   ..|.:::|||||:|||.|.:..|:|.|.|...|.:|.  :.:::
Human   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAH--VEDKV 194

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |.:.|:.||.|||:|.|||||||||||.|:.| :...|:||.::.|||||||:|.|:..|||||:
Human   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHI 259

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|.....::|.....|..|:::.|...|......|   |.:....|....:||..|..:..:.
Human   260 FYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVF 324

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVG-SDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            ::|||:||||||..    ...|.|...|. .|:.:|....||.:.:..:.:.|.:|.....:|.:
Human   325 KILAAILHLGNVQI----TAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETV 385

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQ 536
            ..|:...||::||||.||.:||.||:::|.|||..:|..|..... |.:|||:|||....|||||
Human   386 VKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQHTF-IGVLDIYGFETFDVNSFEQ 449

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNF 601
            .|||||||.||..||.|||||||.||.:|.:.||.:.:.||.|||.|:..| :||..|||:|...
Human   450 FCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLL 513

  Fly   602 PRATDLSFLEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLEL 664
            |..||.::|:|. ||:.::.  |:.:||:....|.:.|:|.:|.|..:|||:||||.:...::|:
Human   514 PHGTDENWLQKL-YNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEI 577

  Fly   665 LASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKP------------RTPTVAARFADSLQ 717
            |.:|:..|.....::        ...|....|..:|:|.            || ||.::|..||.
Human   578 LRASKFHLCANFFQE--------NPTPPSPFGSMITVKSAKQVIKPNSKHFRT-TVGSKFRSSLY 633

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            .|::::....|.:|||||||.||.....|...::||||..|:|:||:|..:.||.|..:..|..|
Human   634 LLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSR 698

  Fly   783 YRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAA 847
            |..|:.......:..:|:|:.:|..:.:   :...||.|.|::|.|......||..|.::||::.
Human   699 YGILMTKQELSFSDKKEVCKVVLHRLIQ---DSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSC 760

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR--------------------------- 885
            |.||:|:||.|.|::..|.:.||..:|..:|||:..::                           
Human   761 VMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRS 825

  Fly   886 -YERLRKGALTAQRLWRGRQARRRVQQLRSDHRR---RQEAREAAQRAREAREAKQAVLERSQLS 946
             |:.:|...:|.|...||..||||.:::..:|:.   ::.||  |..||...::.:..:...||:
Human   826 LYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYAR--AWLARRRFQSIRRFVLNIQLT 888

  Fly   947 YLDIPAELAFIYSKLQGWSPP-HGDRHLVKVLGTV----PGPPSSAVQLPEDLGQFSF------- 999
            |     .:..:..||:..:.. ||   ||:.|.::    .|......:|..:|.:.:.       
Human   889 Y-----RVQRLQKKLEDQNKENHG---LVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEE 945

  Fly  1000 ----------GKFSSVYCNGLRLQPRREPITAPL-------------LTRAASRD---------- 1031
                      .|.:.:..:...|:.::|.|...|             ||:....|          
Human   946 KGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRML 1010

  Fly  1032 ---------QDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVH-KALSSRGLRDEILVQLCNQ 1086
                     ||::..:...|     ...|||:  .||:...::|. :.::|.||:.|: .:|..|
Human  1011 LEKSFELKTQDYEKQIQSLK-----EEIKALK--DEKMQLQHLVEGEHVTSDGLKAEV-ARLSKQ 1067

  Fly  1087 V 1087
            |
Human  1068 V 1068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 263/702 (37%)
MYSc_Myo15 169..828 CDD:276838 255/681 (37%)
MyTH4 1014..1171 CDD:295320 22/107 (21%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832
MYSc 62..752 CDD:214580 265/705 (38%)
MYSc_Myo5 81..741 CDD:276831 255/681 (37%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 9/21 (43%)
IQ 810..828 CDD:197470 0/17 (0%)
COG1340 890..1150 CDD:224259 34/190 (18%)
P-loop_NTPase <910..>1163 CDD:304359 28/167 (17%)
GBP_C <927..1030 CDD:303769 12/102 (12%)
coiled coil 997..1010 CDD:293879 1/12 (8%)
coiled coil 1019..1030 CDD:293879 2/10 (20%)
Rab5-bind 1020..1345 CDD:286404 16/57 (28%)
DUF3585 1160..1326 CDD:304905
Myo5c_CBD 1369..1736 CDD:271260
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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