Protein Alignment Myo10A and MYO5C

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_061198.2
• Gene: MYO5C / 55930
• HGNCID: 7604
• Length: 1742
• Species: Homo sapiens
• Alignment Length: 1041
• Identity: 336/1041 - (32%)
• Similarity: 525/1041 - (50%)
• Gaps: 149/1041 - (14%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.|||:|: :..||||::|.||:|:||||..| .||..:...|:|:.:|
Human    68 GENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLP-IYGDAIIHAYSGQNMG 131

  Fly   220 SLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .:.||:||:...|:..:.   ..|.:::|||||:|||.|.:..|:|.|.|...|.:|.  :.:::
Human   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGSNAH--VEDKV 194

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |.:.|:.||.|||:|.|||||||||||.|:.| :...|:||.::.|||||||:|.|:..|||||:
Human   195 LASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHI 259

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|.....::|.....|..|:::.|...|......|   |.:....|....:||..|..:..:.
Human   260 FYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVF 324

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVG-SDAEIKWAAHLLHISADGLHRALTSRTTEARAERL 471
            ::|||:||||||..    ...|.|...|. .|:.:|....||.:.:..:.:.|.:|.....:|.:
Human   325 KILAAILHLGNVQI----TAVGNERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETV 385

  Fly   472 HTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQ 536
            ..|:...||::||||.||.:||.||:::|.|||..:|..|..... |.:|||:|||....|||||
Human   386 VKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQHTF-IGVLDIYGFETFDVNSFEQ 449

  Fly   537 LCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNF 601
            .|||||||.||..||.|||||||.||.:|.:.||.:.:.||.|||.|:..| :||..|||:|...
Human   450 FCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLL 513

  Fly   602 PRATDLSFLEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLEL 664
            |..||.::|:|. ||:.::.  |:.:||:....|.:.|:|.:|.|..:|||:||||.:...::|:
Human   514 PHGTDENWLQKL-YNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEI 577

  Fly   665 LASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKP------------RTPTVAARFADSLQ 717
            |.:|:..|.....::        ...|....|..:|:|.            || ||.::|..||.
Human   578 LRASKFHLCANFFQE--------NPTPPSPFGSMITVKSAKQVIKPNSKHFRT-TVGSKFRSSLY 633

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            .|::::....|.:|||||||.||.....|...::||||..|:|:||:|..:.||.|..:..|..|
Human   634 LLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSR 698

  Fly   783 YRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAA 847
            |..|:.......:..:|:|:.:|..:.:   :...||.|.|::|.|......||..|.::||::.
Human   699 YGILMTKQELSFSDKKEVCKVVLHRLIQ---DSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSC 760

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR--------------------------- 885
            |.||:|:||.|.|::..|.:.||..:|..:|||:..::
Human   761 VMVQKHMRGWLQRKKFLRERRAALIIQQYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRS 825

  Fly   886 -YERLRKGALTAQRLWRGRQARRRVQQLRSDHRR---RQEAREAAQRAREAREAKQAVLERSQLS 946
             |:.:|...:|.|...||..||||.:::..:|:.   ::.||  |..||...::.:..:...||:
Human   826 LYQLIRMATITMQAYSRGFLARRRYRKMLEEHKAVILQKYAR--AWLARRRFQSIRRFVLNIQLT 888

  Fly   947 YLDIPAELAFIYSKLQGWSPP-HGDRHLVKVLGTV----PGPPSSAVQLPEDLGQFSF------- 999
            |     .:..:..||:..:.. ||   ||:.|.::    .|......:|..:|.:.:.
Human   889 Y-----RVQRLQKKLEDQNKENHG---LVEKLTSLAALRAGDVEKIQKLEAELEKAATHRRNYEE 945

  Fly  1000 ----------GKFSSVYCNGLRLQPRREPITAPL-------------LTRAASRD---------- 1031
                      .|.:.:..:...|:.::|.|...|             ||:....|
Human   946 KGKRYRDAVEEKLAKLQKHNSELETQKEQIQLKLQEKTEELKEKMDNLTKQLFDDVQKEERQRML 1010

  Fly  1032 ---------QDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVH-KALSSRGLRDEILVQLCNQ 1086
                     ||::..:...|     ...|||:  .||:...::|. :.::|.||:.|: .:|..|
Human  1011 LEKSFELKTQDYEKQIQSLK-----EEIKALK--DEKMQLQHLVEGEHVTSDGLKAEV-ARLSKQ 1067

  Fly  1087 V 1087
            |
Human  1068 V 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	255/681 (37%)
		PTZ00121	<828..>943	CDD:173412	37/145 (26%)
		MyTH4	1014..1171	CDD:470587	22/107 (21%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO5C	NP_061198.2	MYSc_Myo5	81..741	CDD:276831	255/681 (37%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	632..654		9/21 (43%)
		IQ	810..828	CDD:197470	0/17 (0%)
		IQ	831..851	CDD:459869	9/19 (47%)
		SMC_prok_B	<886..>1356	CDD:274008	37/199 (19%)
		Myo5c_CBD	1369..1736	CDD:271260