DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo10A and LOC556989

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_685035.4	Gene:	LOC556989 / 556989	-ID:	-	Length:	1124	Species:	Danio rerio

Alignment Length:	938	Identity:	329/938 - (35%)
Similarity:	485/938 - (51%)	Gaps:	138/938 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            ||:..|.:|.|..||..|..|:.:.||||:.|.||:|:||:| :...|..||:::|......|||
Zfish    42 EDLANLSELDEKCLLEVLTGRFTQNLIYTYIGDILVAINPFK-YLSIYEKEVSQRYKCHEKKSLP 105

  Fly   223 PHLFAIGAAAHAAL-------PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQ 280
            ||:||:...|:.::       |..|.:|||||||:||||||||:::::..:.    .|::.:.:|
Zfish   106 PHIFAVADRAYQSMLGRLAMGPKNQCIVISGESGAGKTESTKLLLRHIMELC----KANSQLEQQ 166

  Fly   281 ILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            ||:..|||||||||:|..||||||||||:::.|::.::.||||.:|||||||:|.|..||:|:|:
Zfish   167 ILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRFQNSSVKGAKINEYLLEKSRVVHQDQGEQNFHI 231

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQ--GATDCA-SGRVDWESLQGAMQVLGVSEGEREGIV 407
            ||.:|.|:|..::..||||:...|.|||.  |..|.. :.||.:..:..||.::|..|.|:..::
Zfish   232 FYLMLAGISLEDKEIYGLLDPTLYRYLNGRFGQEDVVQTWRVKYAEVCNAMDMVGFEEQEKVDMM 296

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW---AAHLLHISADGLHRALTSRTTEARAE 469
            .:||.:|.|||:.|....    .:.::| |:|...|   .|....:..:.|.::||..|:..|.|
Zfish   297 TILAGILSLGNITFETTD----SDALKV-SEASRGWLKATAGQFGVQEEDLLKSLTCTTSMTRGE 356

  Fly   470 ---RLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDA--HRISILDIFGFEDL 529
               |||..   .||.||||:.||..|..:|.|:||:||..:......|.  :.|.||||||||:.
Zfish   357 AIQRLHNQ---QQAEDARDSIAKVAYGRVFGWIVSKINEQLAPKVDFDVELNEIGILDIFGFENF 418

  Fly   530 AENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHL 594
            |.|.|||||||.|||.||.:||.|:|.:||.||..|.:.|..:.:.||.|::.|...||:||..|
Zfish   419 AVNRFEQLCINLANEQLQYFFNHHIFLMEQKEYKEEGITWETITYKDNKPILDLFLMKPIGILSL 483

  Fly   595 LDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRG 659
            ||::|.||:|||..|::|.:.....:..:...|.....|.|.||||:|.|...|||:||||.:..
Zfish   484 LDEQSAFPQATDRDFVDKLNSKFKSAPNFEVVRNHTPLFTVVHYAGKVQYNASGFLEKNRDTIPA 548

  Fly   660 DVLELLASSRLPLVGELTKQLRAQRDAGKTLPKG-----SNGRFVTMKPRTPTVAARFADSLQQL 719
            .:.||..:|..||:..|.....::  .|..:|:.     |:..|  ...|..:|.|:|..||..|
Zfish   549 SIRELFINSVTPLLSVLFAATISR--TGTLMPRKAKLQVSDDNF--NSTRKQSVGAQFKHSLAVL 609

  Fly   720 LQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYR 784
            ::.|....|.||||||||:.|...::|...||.||||.|:::||:||:.|:..|..|:.|.|||.
Zfish   610 MEKMFAASPHFVRCIKPNRSKQPDQLDSKLVLDQLRYNGLMETIRIRRDGFSWRPTFREFAERYN 674

  Fly   785 HLLPSPLARGTPY-RELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAV 848
            .||..|   ..|. :..|.::|.:...:|     ::.|::|:|.: ..|:...:...:||.|||:
Zfish   675 ILLLKP---DLPTDKSSCMSILNSTELSG-----WKCGSSRLFFK-LCHQVELANLLDRLGRAAL 730

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLR 913
            .:|::.|....||:..                            .|.|: |.|.|||:|..::..
Zfish   731 VIQKNFRARTCRRKYL----------------------------CLLAE-LRRQRQAQREREERE 766

  Fly   914 SDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLG 978
            .:.|||||..:..|:.:||...::..:|:..|.    ||            |||
Zfish   767 EEERRRQEEEKRRQQQQEAERKRRLEVEQENLR----PA------------SPP----------- 804

  Fly   979 TVPGP--------PSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAP--LLTRAASRDQD 1033
             ||.|        |.|.:.        |..|.:||           .|:..|  .|..|...|.|
Zfish   805 -VPLPRKKKPEPRPRSVLS--------SISKTASV-----------APVPRPRSKLLEATPFDND 849

  Fly  1034 FQDALAVFKLILRWSNDKALEGAKEKLL 1061
            ..:...:...::....|:  |..|||.|
Zfish   850 LNENFHLDASLMLQPIDE--ERIKEKHL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	276/701 (39%)
		MYSc_Myo15	169..828	CDD:276838	270/682 (40%)
		MyTH4	1014..1171	CDD:295320	12/50 (24%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC556989	XP_685035.4	MYSc	34..711	CDD:214580	275/693 (40%)
		MYSc_Myo28	53..711	CDD:276854	270/682 (40%)
		SH2	895..992	CDD:301589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810