DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and myo7ab

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_009293670.1	Gene:	myo7ab / 556141	ZFINID:	ZDB-GENE-091110-4	Length:	2204	Species:	Danio rerio

Alignment Length:	3137	Identity:	718/3137 - (22%)
Similarity:	1099/3137 - (35%)	Gaps:	1146/3137 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |||||..|.||:||.:|.||.:||:..:|||:.||||:|||||::.| .|..:..:.|..:.:|.
Zfish    66 GVEDMIRLGDLNEAGILRNLLIRYNDRVIYTYTGSILVAVNPYQLLP-IYTPDQIRLYTNKKIGE 129

  Fly   221 LPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            :|||:|.|....:.::   ...|..:||||||:||||||||::|:|||:    ....:.|.:|:|
Zfish   130 MPPHIFGIADNCYFSMQRNKKDQCCIISGESGAGKTESTKLILQFLAAI----SGQHSWIEQQVL 190

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ||.|:|||||||:|.|||||||||||::::| |.|||.||||.||||||||:..||..|||||:|
Zfish   191 EANPILEAFGNAKTIRNDNSSRFGKYVDIHFNKRGAIEGAKIEQYLLEKSRVCRQAADERNYHIF 255

  Fly   347 YELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGEREGIVR 408
            |.:|.|:|..:::|.||..|..|.||..|......||.|   :.|:..||::|..:|.|...|.:
Zfish   256 YCMLAGMSPDQKTKLGLGRATDYTYLTMGNCTVCEGRDDMKEYSSILSAMKILMFTETEYWEISK 320

  Fly   409 VLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHT 473
            :|||:||:||:.|..|..|:....|.|.| .::..||.||.:....:...||:||...|.|.:.|
Zfish   321 LLAAILHMGNLRFEARTQRNLDTCVVVRS-PDLANAASLLEVDPQDVMMCLTTRTLITRGESVST 384

  Fly   474 PLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHD----AHRISILDIFGFEDLAENSF 534
            ||.::|.||.||||.|.:|..||.|:|.:||:.:.:..:.:    ...|.:|||||||:...|||
Zfish   385 PLSVEQGLDVRDAFVKGIYGRLFVWIVDKINATIFRAPSTENRTVRRSIGLLDIFGFENFTVNSF 449

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDES 599
            ||||||:||||||.:|..|||||||.||..|.:.|..:.:.||...:.::|.||:.|..|:|:||
Zfish   450 EQLCINFANENLQQFFVHHVFKLEQEEYNLEDINWQDIEFTDNQDALDMIAIKPMNIISLIDEES 514

  Fly   600 NFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNRDALRGDVLE 663
            .||:.||.:.|.|.:..|.|:..|..|:...: :||:.|:||.|.|...|||:||||:|..|:::
Zfish   515 KFPKGTDATMLNKLNSQHKLNTNYIPPKHSHETQFGIQHFAGVVHYETKGFLEKNRDSLHSDIIQ 579

  Fly   664 LLASSRLPLVGELTKQ-----LRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSM 723
            |:.||:...:.::.:.     |....:...||.||...|     .|:||::::|..||:.|::::
Zfish   580 LVHSSKNKFIKQIFQADVAMFLCGYMEPTATLQKGMETR-----KRSPTLSSQFKRSLELLMRTL 639

  Fly   724 GRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP 788
            ..|.|:||||||||:.|..:..|....::||||.||::||:||:.|||:|..|..||:|||.|:|
Zfish   640 SVCQPFFVRCIKPNELKKPMMFDRGLCVRQLRYSGMMETIRIRRAGYPIRYTFAEFVDRYRVLMP 704

  Fly   789 --SPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQ 851
              .|..:....|..|:.::.::.   :...|:|:|.|::||::.....||..|.:.:....:.:|
Zfish   705 GVKPAHKQEDLRGTCQRIVVSVL---LRDDDWQIGKTKIFLKDHHDMLLEMERDKVITDKVILIQ 766

  Fly   852 RHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDH 916
            :.||||..|.:..:.:.|...:|..|||...::.|..:|.|.|..|.|:|.|:..:..|
Zfish   767 KTVRGMKERTKFLKVRRAVMLIQRIWRGYITRKHYAVMRVGFLRLQALYRSRKLHQEYQ------ 825

  Fly   917 RRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVP 981
                     |.|.|                           .:.||.|.     |.|
Zfish   826 ---------ATRIR---------------------------VTLLQAWC-----RGL-------- 841

  Fly   982 GPPSSAVQLPEDLGQFSFGK-FSSV-----YCNGL--RLQPRREPITAPLLTRAASRDQDFQDAL 1038
                        |.:.:|.| |.:|     |..|:  |.|.:|
Zfish   842 ------------LVRRTFSKRFHAVLTIQAYARGMIARRQCKR---------------------- 872

  Fly  1039 AVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQL 1103
                  ||...|:.||..:::|..:..:...:::|..|                  .||.|
Zfish   873 ------LRLERDRRLEAERQRLAEEERLKNQMTARRAR------------------AEAAR---- 909

  Fly  1104 LGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLE 1168
                           |:..|              |.||.|:|
Zfish   910 ---------------KHQER--------------LAQLDREQ----------------------- 922

  Fly  1169 WRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCG 1233

Zfish   923 ----------------------------------------------------------------- 922

  Fly  1234 LDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRS 1298
                    .|:||     |.|:                                       |.|.
Zfish   923 --------EEREL-----AERN---------------------------------------ETRR 935

  Fly  1299 SRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLG 1363
            .:|||.:        .|||                                     .:||
Zfish   936 KKELLEQ--------MERE-------------------------------------KKEP----- 950

  Fly  1364 LSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDT 1428
                 :||
Zfish   951 -----VND--------------------------------------------------------- 953

  Fly  1429 SEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESE 1493
                                          |.::|.....|.:|.||.        ..|.||...
Zfish   954 ------------------------------SDMVDKMFGFLGNANSLP--------NLEGEAPEG 980

  Fly  1494 IDDLDD----YINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINE 1554
            .:||::    :...|.:|:||                         |:  |||   |||.:|...
Zfish   981 FEDLENAPKQFKEVIDEPLPL-------------------------PD--DEE---EDLSEYKFA 1015

  Fly  1555 LFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFL 1619
            .|                  |.:...|.:|         |..::.|
Zfish  1016 KF------------------AATYFQGNAT---------HMYVRRP------------------- 1034

  Fly  1620 QSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAA----ANNSTSPPPAPPILSSLSISPPPPQSPM 1680
                     ::|.||.....     ..|.||.|    ........|.|..  .:|||....:.|:
Zfish  1035 ---------LKQPLLFHEDE-----GDQLAALAVWITVLRFMGDLPEPKY--HISISDGSEKIPV 1083

  Fly  1681 RMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEP 1745
            ..|       :.|:|                                      ||
Zfish  1084 MTK-------IYETL--------------------------------------GK---------- 1093

  Fly  1746 QFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPM 1810
                         |.::|:                         ..|..::.|:.|:.|.
Zfish  1094 -------------RTYKRE-------------------------LQALQVDEEKHEVHSK----- 1115

  Fly  1811 SGQLMRSSIRLET-TTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVG 1874
                       :| |.:::|:.:..|:..|         ..:|:..|.|||
Zfish  1116 -----------DTYTLSSSTTDIQKRNSVR---------HKLVSLTLKKKS-------------- 1146

  Fly  1875 KLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGG 1939
              ||:.|:.:||  ..:.:|::.  ::..|.|..:.||.            |...:..|...|..
Zfish  1147 --KLTEEVTRRL--TDSDYSLQG--NSMLEDRPTSNLEK------------LHFIIGNGILRPAL 1193

  Fly  1940 VVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSP 2004
            ..:.:..:..|:.:...|.|     .:.||  :||.......||
Zfish  1194 RDEIYCQICKQLSQNASKSS-----HARGW--ILLSLCVGCFAP--------------------- 1230

  Fly  2005 PTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAA 2069
                           |.:.|| ::..||.                            |..|..|.
Zfish  1231 ---------------SEKFVK-YLRTFIN----------------------------SGPPGYAP 1251

  Fly  2070 WEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERE 2134
            :.: ||.|....:::|.:               |.|....:..:.|:
Zfish  1252 YCE-ERLRRTFANKTRTQ---------------PPSWLELQATKSKK------------------ 1282

  Fly  2135 SHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELD-SM 2198
                    |..:....||           |...|..|..|...| |.....|...|:::... |:
Zfish  1283 --------PIMLPVTFMD-----------GTTKTLLTDSATTAE-ELCNALSDKIGLKDRFGFSL 1327

  Fly  2199 HMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGS----GGSTACLTY--------NRVPWKLR 2251
            ::.....|         ||            :|||.    ...:.|..|        ...||:|.
Zfish  1328 YIALFDKV---------SS------------LGSGKDHVMDAVSQCEQYAKEQGAQERNAPWRLF 1371

  Fly  2252 VRKEVFQP-HEPIGPPVALDLLFAQVL-GDVFGVTPCLR-------------------------- 2288
            .|||:|.| |.|....||.:|::.|:: |..||...|.|
Zfish  1372 FRKEIFTPWHNPAEDGVATNLIYQQIVRGVKFGEYRCDREEDLAELASQQYYVDYGPEILPERLL 1436

  Fly  2289 -----------ITPQ---EK-SSALNMLHGHGVSVDTL--SNRNGSGAGGGGNGGQVRALVKRHL 2336
                       |||.   || :..:..:|..|:.....  |.|                 ||..:
Zfish  1437 SLIQSYIPDREITPSKTVEKWAQMIIAIHIKGIYTQKRFDSQR-----------------VKEEV 1484

  Fly  2337 VDMAR-DWPLYFARL---FAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAV 2397
            ||.|| .|||.|:|.   |...|..|..:..|:.|:.:|:|........|:   .:||.|| :||
Zfish  1485 VDFARFKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLL---DLSFPEI-TAV 1545

  Fly  2398 TLPRPAALQ-----LNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTL 2457
            :..|...||     |....|......:..|..|:.:|..|
Zfish  1546 SSSRGGKLQGQSFTLATIKGDEYTFTSNNAEDIRDLVVAF------------------------- 1585

  Fly  2458 NVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDA 2522
               ||.|.||....                               ......|:...|....|..:
Zfish  1586 ---LEGLRSRSKFV-------------------------------VAMMDSHYPAGQDASFLRFS 1616

  Fly  2523 MEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPS-------SLTNGQVHHQ 2580
            ..:.....:|..:|....|...|...|..|:            |..|:       ::|..|....
Zfish  1617 KGDLIFLDEHTGEQVLTSGWAHGVNDRTKKR------------GDFPADNVYVLPTITRPQYDIV 1669

  Fly  2581 EQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQ 2645
            ..::....|:..|:   :|....|.|...     .|..|:|.:|:..||             |..
Zfish  1670 SLIIMSPDQRKDSV---NLSQQNLLDSGE-----KVQPYTLEEFSYDHF-------------RPP 1713

  Fly  2646 SAANRSYAELVKWQG---------HAIRLPLLR---LPNDLAPLALECFDCILRYCGDIPLDPDL 2698
            |.:..|...:.|.:|         ..::.|||:   ...:|:..|.:.|..||:|.||.|.....
Zfish  1714 SKSTLSRVIINKGRGKDKIWCCTREPLKQPLLKKILSHEELSQDACQAFIAILKYMGDYPSKRSR 1778

  Fly  2699 TEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPY 2763
            :..:....:.....|...|:||:|||::||.|.|.  ...|.::.|.||.:....|..|:.|.|:
Zfish  1779 SVNELTDQIFEGALKAEPLKDEIYCQIIKQLTENH--VKYSEEKGWELLWLCTGLFPPSNMLLPH 1841

  Fly  2764 LMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYR---LP 2825
            :.:.|.|      :..|..|..|:..|:|..|.|.||..|.:.||.|:   :....||:.   .|
Zfish  1842 VQKFLQS------KKHHPVAPDCMQRLQKALRNGSRKYPPHLVEVEAI---QHKTTQIFHKVYFP 1897

  Fly  2826 GGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTEL 2890
            ...:.......||...|....:...:.:.|   .:.|||:..:.....::|  ..::..|....|
Zfish  1898 DDTDEAFEVESSTKAKDFCRNIAGRMMLHS---SEGFSLFVKISDKVISVP--EGDFFFDFVRHL 1957

  Fly  2891 ---------LKSGQ----PFYLIFCRSVWHFALKREPAPMPLYVEVLFN--QVAPDYLEGLLLEL 2940
                     :|.|.    .:.:.|.:.:|   ....|...|: .:.:|:  |..|.||.|.
Zfish  1958 TDWIKKARAVKDGTVPSLTYQVFFMKKLW---TNTFPGKDPM-ADSIFHYFQELPKYLRGY---- 2014

  Fly  2941 PGNGVPVPEMVRDMARIAALLHRA---ADLSH-VPAMKEIKFLLPKPALGIREIRPAQWVGLVQS 3001
                  ....|.:..::|||::|.   .|.|| |...|..|.|||:..  |.::.|..|...|.:
Zfish  2015 ------HKCSVEEAFQLAALIYRVRFEEDKSHFVHFSKMQKELLPQDL--IHQLSPDDWKRSVVT 2071

  Fly  3002 AWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGV 3066
            .:.:.|..|..:.|..||.::..||.|||:||.||:        ..|.|.|  ..|::|:|:.||
Zfish  2072 HFNKHAGKSREEAKLMFLEIIYKWPTFGSAFFEVKQ--------SSDPHFP--EVLLIAINKLGV 2126

  Fly  3067 LFLDPNTHETLQHWSFMEVISTRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYI 3131
            ..:||.|.:.|....|.::.:.     ..|..:..:.:|||::...:..:|...:::..|:..||
Zfish  2127 TLIDPKTKDILGTHPFTKISNW-----SSGHTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYI 2186

  Fly  3132 TM---AQISQRDKRELN 3145
            :.   ....||..|..|
Zfish  2187 SQMLTTMTKQRSSRTNN 2203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	298/698 (43%)
		MYSc_Myo15	169..828	CDD:276838	288/677 (43%)
		MyTH4	1014..1171	CDD:295320	19/156 (12%)
		MyTH4	2704..2810	CDD:279165	33/105 (31%)
		B41	2823..3033	CDD:214604	51/231 (22%)
		FERM_B-lobe	2920..3025	CDD:271216	29/110 (26%)
		FERM_C_MyoXV	3029..3138	CDD:270022	27/111 (24%)
myo7ab	XP_009293670.1	MYSc	60..755	CDD:214580	300/702 (43%)
		MYSc_Myo7	79..743	CDD:276832	288/677 (43%)
		IQ	780..801	CDD:197470	5/20 (25%)
		MyTH4	1030..1279	CDD:214535	71/521 (14%)
		B41	1285..1500	CDD:214604	58/264 (22%)
		FERM_N	1288..>1327	CDD:286467	10/50 (20%)
		FERM_B-lobe	1389..1489	CDD:271216	21/116 (18%)
		FERM_C1_MyoVII	1494..1592	CDD:270019	29/129 (22%)
		SH3	1593..1657	CDD:302595	11/106 (10%)
		MyTH4	1736..1884	CDD:214535	46/158 (29%)
		B41	1891..2103	CDD:214604	51/232 (22%)
		FERM_M	2001..2103	CDD:278785	34/113 (30%)
		FERM_C2_MyoVII	2099..2193	CDD:270020	27/108 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.800