Protein Alignment Myo10A and myh10

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_009300420.1
• Gene: myh10 / 555454
• ZFINID: ZDB-GENE-030616-162
• Length: 2014
• Species: Danio rerio
• Alignment Length: 2258
• Identity: 521/2258 - (23%)
• Similarity: 886/2258 - (39%)
• Gaps: 540/2258 - (23%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|...:.:.|.|:...
Zfish    88 SKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLP-IYSENIIEMYRGKKRH 151

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAV-----------VPGG 270
            .:|||::||..:|:..:   ...|.::.:||||:||||:||.|:||||.|           :| .
Zfish   152 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIP-P 215

  Fly   271 GSASAV-----------ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKI 323
            .|..||           :..|:|:|.|:||:||||:|.:|||||||||::.:.|. :|.||||.|
Zfish   216 ESPKAVKLQNGILFYGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI 280

  Fly   324 TQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWES 388
            ..|||||||.:.||..||.:||||:||.|..|..||...|...:.|.:|:.|... ..|:.|.::
Zfish   281 ETYLLEKSRAIRQAKDERTFHVFYQLLAGAGEHLRSDLLLEGFNSYRFLSNGNIP-IPGQQDKDN 344

  Fly   389 LQGAMQVLGVSEGEREGI---VRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHI 450
            .|..|:.:.:.....|.|   ::|::|||..||:.|.:.:   ..:...:..:...:...|||.:
Zfish   345 FQETMEAMHIMSFNHEEILSMLKVVSAVLQFGNIVFKKER---NTDQASMPENTAAQKLCHLLGM 406

  Fly   451 SADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDA 515
            :.....||:.|...:...:.:......:||..|.:|.|||.|..||.|||.|||..:.:.....|
Zfish   407 NVMEFTRAILSPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGA 471

  Fly   516 HRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLP 579
            ..|.||||.|||....||||||||||.||.||..||..:|.|||.||.||.:||:.:.:. |..|
Zfish   472 SFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQP 536

  Fly   580 VIHLLAK--KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAG 640
            .|.|:.:  .|.|:..|||:|..||:|||.:|::|..........:.:||  ....:|.:.||||
Zfish   537 CIDLIERPANPPGVLALLDEECWFPKATDKTFVDKLVQEQGTHGKFQKPRQLKDKADFCIIHYAG 601

  Fly   641 QVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQ-----LRA---------------QRD 685
            :|.|..|.:|.||.|.|..:|..||..|....|.||.|.     .||               .|.
Zfish   602 RVDYKADEWLMKNMDPLNDNVATLLHQSTDKFVAELWKDEIQNFQRASFYDVSSLHESPGEVDRI 666

  Fly   686 AGKTLPKGSN-----GRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRM 745
            .|.....|.|     ..:.|.|....||...:.:||.:|:.::...:|.|||||.||.||.|.::
Zfish   667 VGLDQVAGMNETAFGAAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKL 731

  Fly   746 DMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMP 809
            :...||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::.|..::.|:.
Zfish   732 EPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALE 796

  Fly   810 RTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQ 874
               ::...|::|.:::|.|..:...||..|..::....:..|...||.|.|:..|::|...:.|:
Zfish   797 ---LDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDIIIYFQSVCRGYLARKAFAKKQQQLSALK 858

  Fly   875 ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAV 939
            ..   ||....|.:||.        |:..:...:|:.|....|:.:|.:...:...:.:|.:..|
Zfish   859 VL---QRNCAAYLKLRH--------WQWWRLFTKVKPLLQVTRQEEEMQAKDEELIKVKERQVKV 912

  Fly   940 ------LERSQLSYLDIPAELAFIYSKLQGWSPPHGD------------RHLVKVLGTVPGPPSS 986
                  :||.....|:   |...:..:||..:....:            :.|.::|..:    .|
Zfish   913 ENELVEMERKHQQLLE---EKNILAEQLQAETELFAEAEEMRARLVAKKQELEEILHDL----ES 970

  Fly   987 AVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDK 1051
            .|:..|:..|              .||..::        :..|..||.::.|           |:
Zfish   971 RVEEEEERNQ--------------SLQNEKK--------KMQSHIQDLEEQL-----------DE 1002

  Fly  1052 ALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAA 1116
            . |.|::||..:.:..:|...:...|.:|::..|
Zfish  1003 E-EAARQKLQLEKVTAEAKIKKMEEDILLLEDQN------------------------------- 1035

  Fly  1117 FSKYL--MRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMA 1179
             ||:|  .:.::|...|     :..||..::....:.|.|
Zfish  1036 -SKFLKEKKLLEDRVGE-----MTSQLAEEEEKAKNLGKV------------------------- 1069

  Fly  1180 LPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEK 1244
                ...:....|.::.....||...   ..|..|.|.......|.|        |.:.:|.|:.
Zfish  1070 ----KNKQEMMMVDLEERLKKEEKTR---QELEKAKRKLDAETTDLQ--------DQIAELQAQI 1119

  Fly  1245 ELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSAL 1309
            :......|.:.:.|:  |..||                     |.|:|.::..:.::|....:.|
Zfish  1120 DELKIQLAKKEEELQ--AVLAR---------------------GDEEVAQKNNALKQLRELQAQL 1161

  Fly  1310 NERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYH 1374
            .|...:.|         |...|:::::.|...|:.::..:.|:.:.     ||..:.::...|..
Zfish  1162 AELQEDLE---------SEKAARNKAEKLKRDLSEELEALKTELED-----TLDTTAAQQELRSK 1212

  Fly  1375 SAERLAPVGK--DTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATR---------SSAMSDT 1428
            ..:.:|.:.|  |...|..:||....|..   ||:...:.:::.|.|.|         .:..||.
Zfish  1213 REQEVAELKKAIDDETRNHESQIQEMRQR---HGTALEEISEQLEQAKRVKGNLEKNKQTLESDN 1274

  Fly  1429 SEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESE 1493
            .|   |.:.|:.::.....|:..:       ..|:..|.|:....|....::|...::.::.::|
Zfish  1275 KE---LTNEVKSLQQAKSESEHKR-------KKLEAQLQEVMARFSEGEKVKGELADRTHKIQTE 1329

  Fly  1494 IDDLDDYINDIFQP-IPLVQNLEKLTSKDQ---------------LAAIIK-----GGGVASKPE 1537
            :|::...:.|..:. |.|.:::..|.|:.|               |::.|:     ...:..:.|
Zfish  1330 LDNVSCLLEDAEKKGIKLTKDVSSLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQE 1394

  Fly  1538 ERDE-----ESEIEDLDDYINE----LFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLL 1593
            |.:|     |.::..|...:.|    |.:.:...|||:::..|                     |
Zfish  1395 EEEESRKNLEKQLATLQAQLVETKKKLEDDVGALEGLEEVKRK---------------------L 1438

  Fly  1594 HQLMQLPGETESGPAL-----------YQQQVQRAFL----QSAMAQNLQIQQ----QLLAQNQA 1639
            .:.|::..:.....|:           .||::....:    |..:..||:.:|    |:||:.:.
Zfish  1439 QKDMEVTSQKLEEKAIAFDKLEKTKNRLQQELDDLMVDLDHQRQIVSNLEKKQKKFDQMLAEEKT 1503

  Fly  1640 LQTLLSQQ---AAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPP 1701
            :....:::   |.|.|....|         .:||::          :|...:|...|..:.....
Zfish  1504 ISARYAEERDRAEAEAREKDT---------KALSMA----------RALDEALEAKEEFERLNKQ 1549

  Fly  1702 PPPPMPPPLECKDP-SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKT 1765
            ....|...:..||. .:..|.|:...|....::.:.|....:.|.:.|..||   .|:|......
Zfish  1550 LRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVEEMRTQLEELEDELQATED---AKLRLEVNMQ 1611

  Fly  1766 TPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTS 1830
            ..:||                             |:.:.......:.:..|:.::
Zfish  1612 AMKAQ-----------------------------FDRDLQARDEQNEEKKRALVK---------- 1637

  Fly  1831 AVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEI----------GADRPPPGSVGKL-KLSSEMRQ 1884
              ..|:.:.|.:|..:.....|.   |||..|:          .|::....::.:| ||.::|:.
Zfish  1638 --QVREMEAELEDERKQRALAVA---AKKKLEMDLKDVEAQIEAANKARDEAIKQLRKLQAQMKD 1697

  Fly  1885 RLEQVTAGHSVRSTVSTKS-EQRAPAKLEDTRKLMLQQQLGG--------------LFASVSGGN 1934
            ...::....:.|..:.|:| |.....|..:...|.||:.|..              |...:|...
Zfish  1698 YQRELEEARTSRDEIFTQSKENEKKLKSLEAEILQLQEDLASSERARRHAEQERDELADEISNSA 1762

  Fly  1935 SGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPP 1999
            ||...::|....:..:|.::|.:|....:               ::.......|..:|
Zfish  1763 SGKAALLDEKRRLEARIAQLEEELEEEQS---------------NMELLNDRFRKTTM------- 1805

  Fly  2000 APQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSS 2064
                           ...|.::::..|...|  |:.|.......||.:.:.|....||....|..
Zfish  1806 ---------------QVDTLNTELAGERSAA--QKSENARQQLERQNKDLKSKLQELEGSVKSKF 1853

  Fly  2065 PA-VAA-----------WEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRE 2117
            .| :||           .||..:||:.:....|..|...:.|:.:.|.|    ...:::.:|:.|
Zfish  1854 KASIAALEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVEDE----RRHADQYKEQME 1914

  Fly  2118 RERERLYEIRQVERERESHKVYQPAPPRVIQASMD----TTGGHRREDRT-------GGLATFRT 2171
            :...|:.::::...|.|.......|..|.:|..:|    .:.|..||..|       ||..:|
Zfish  1915 KANSRMKQLKRQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTLKNRLRRGGPVSF-- 1977

  Fly  2172 HMAQKYEHERKRKSSASSGMR----------EELDS----MHMTTPPP 2205
                         ||:.||.|          ::.||    ::...|||
Zfish  1978 -------------SSSRSGRRQLQMEGDFSDDDADSKASDLNENQPPP 2012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	259/718 (36%)
		PTZ00121	<828..>943	CDD:173412	25/120 (21%)
		MyTH4	1014..1171	CDD:470587	22/158 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	11/66 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myh10	XP_009300420.1	Myosin_N	34..79	CDD:460670
		MYSc_Myh10	102..812	CDD:276952	259/718 (36%)
		Myosin_tail_1	889..1969	CDD:460256	221/1377 (16%)