DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo10l3

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_009302795.1 Gene:myo10l3 / 555290 ZFINID:ZDB-GENE-070912-237 Length:2112 Species:Danio rerio


Alignment Length:3162 Identity:679/3162 - (21%)
Similarity:1058/3162 - (33%) Gaps:1315/3162 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            ||||||:.|.:||||:::.||.|||.|.||||..||||.|:||||.....|..|....|:...||
Zfish    63 SGVEDMSTLAELHEAAIMHNLYLRYQKDLIYTNIGSILAAMNPYKQIAGLYDSEAVDVYSRHHLG 127

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQ- 280
            .||||:||:....:..|   ...|.|:||||||:||||||||::::|:  |....|..:.::|: 
Zfish   128 ELPPHIFAVANECYRCLWKRHDSQCVLISGESGAGKTESTKLLLKFLS--VMSQNSTGSPLSERT 190

  Fly   281 ------ILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
                  |::::|::||||||:|..|:|||||||:::::| :||.|.|..|..|||||:|:|.|.|
Zfish   191 TRVEQAIVQSSPIMEAFGNAKTVYNNNSSRFGKFIQLHFSQSGNIQGGCIIDYLLEKNRVVRQNP 255

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEA-DKYFYLNQGATDCASGR-VD----WESLQGAMQVLG 397
            ||||||:||.||.|.....|..|.|.:: :.|.||||  :.|...| :|    ::|:..|::|:.
Zfish   256 GERNYHIFYALLSGAKYEHREMYVLADSPEAYHYLNQ--SGCVKDRSLDDKHLYDSVMEALKVME 318

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR 462
            .:|.|...:.::|:.||.:||:.|    :..|  |.::.:...:...:.||.:.:..|...||.|
Zfish   319 FTEEEIRDVFKLLSGVLQIGNIEF----MTAG--GAQITTKGVVSVVSDLLGLDSFQLSEVLTQR 377

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFE 527
            :...|.|.:.:||.::||:|:||:.|.|||:..|:|:::|||..::  |..:...|.||||||||
Zfish   378 SMILRGEEICSPLTVEQAIDSRDSVAMALYSQCFSWIIARINQKIK--GKDNFKSIGILDIFGFE 440

  Fly   528 DLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGIC 592
            :...|.|||..||||||.||.|||||:|.|||.||.||.:.|..:.|.||...:.|:.|| :|:.
Zfish   441 NFEVNRFEQFNINYANEKLQEYFNKHIFSLEQLEYNREGIHWEAIDWMDNAECLDLIEKK-LGML 504

  Fly   593 HLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDAL 657
            .|:::||.||:.||.:.|||.|..||.:..|.:||:...:||:.||||:|.|.|.|.|:||||..
Zfish   505 ALINEESRFPKGTDYTLLEKLHSRHATNPYYVKPRVADHQFGIKHYAGEVLYDVRGILEKNRDTF 569

  Fly   658 RGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQS 722
            |.|:|.:|..|||..:.:|.::. ..|...:||..|:       ..|.|||:::|.|||..|:.:
Zfish   570 RDDILNMLKDSRLDFIYDLFERF-GSRSGDETLKMGT-------ARRKPTVSSQFRDSLHALMAT 626

  Fly   723 MGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLL 787
            :...:|:||||||||.||:|.:.|...||.||||.|||:|::||:.|:|||..||.|:.||..:|
Zfish   627 LSASNPFFVRCIKPNMEKNANKFDSDVVLNQLRYSGMLETVKIRRAGFPVRRTFQDFLSRYTMIL 691

  Fly   788 PSPLARGTPY----RELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAV 848
                 |...:    |:.|..||   .:..|...::|||.|:|||:|||.:.||..|.|..:.|.:
Zfish   692 -----RDRNHTADERKKCADLL---TKYDVTKKEWQLGKTKVFLKEALEQRLEKEREEVRKAAGM 748

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLR 913
            .::.|:...:.|:...|.|::...:|..:|....:|.:.|.|..|:..|:..||:.||:..:||.
Zfish   749 VIRAHILSYVARKHYKRVQSSTVTIQKNYRAYFWRQAFLRFRSAAVVLQKHLRGQIARQLYRQLL 813

  Fly   914 SDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLG 978
            .:.:||:| .|..:|..|.|..::               ||.                       
Zfish   814 EEKQRREE-EERIRREEEERRRQE---------------ELR----------------------- 839

  Fly   979 TVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKL 1043
                                            |||..::                          
Zfish   840 --------------------------------RLQEEKQ-------------------------- 846

  Fly  1044 ILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCL 1108
              |...::..|..:.:||.:                                |..|         
Zfish   847 --RQEEERRKEEERLRLLEE--------------------------------EKKR--------- 868

  Fly  1109 CCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWT 1173
                             .:|..|:||       |:|:                            
Zfish   869 -----------------REEEQETLR-------LQQE---------------------------- 881

  Fly  1174 RGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVM 1238
                                                                             
Zfish   882 ----------------------------------------------------------------- 881

  Fly  1239 DLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELL 1303
                |:||                                                 :|...||.
Zfish   882 ----EEEL-------------------------------------------------KRRQEELK 893

  Fly  1304 SRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESR 1368
            |:                              :.|:|..||.                   |.|.
Zfish   894 SK------------------------------QILEDREAGH-------------------SRSL 909

  Fly  1369 LNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHS-SKYADKAEYATRSSAMSDTSEAP 1432
            :...:|:.:      ||.                    ||| .:|:.:.|    |..|.:.    
Zfish   910 VGKNHHNHK------KDV--------------------SHSLCQYSSEEE----SRQMEEI---- 940

  Fly  1433 SLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDL 1497
                    :|:..:...:.:..|:..|.:.|.|.|||               .|:.:||      
Zfish   941 --------LRLEREIERLQKQRDEGVSLLNDSSRDEL---------------RQKRDAE------ 976

  Fly  1498 DDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVA 1562
                         :..|||..|:           ||         :|..::.|:           
Zfish   977 -------------IYRLEKEASR-----------VA---------TEFLEMLDF----------- 997

  Fly  1563 EGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNL 1627
                              ||...|..::..||.    |.||.:  .|.:::|...|         
Zfish   998 ------------------GGLEQSLSSEENLHD----PSETTA--PLAEEEVDEGF--------- 1029

  Fly  1628 QIQQQLLAQNQALQTLLSQQAAAAAANNSTSP-PPAPP---------ILSSLSISPPPP------ 1676
                                    .|.:...| |..||         :||||  .||||      
Zfish  1030 ------------------------HAEDECIPLPDFPPLAAVPLDKEVLSSL--PPPPPAFAEGP 1068

  Fly  1677 ---QSPMRMKATRSSLVV----MESLQPPPPPPPPPMPPPL---------ECKDPSETRHFLDPY 1725
               .||.||:..:||..:    :..:.||||..|||.||.|         ..|.|.:|...|   
Zfish  1069 VGTSSPARMERPKSSSSIKHNRLSDIPPPPPTAPPPPPPTLISSRVDFEVVYKSPRKTEILL--- 1130

  Fly  1726 GRAKTVRIGKWRWPPPQDEPQF----QTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPG 1786
                           |::|..|    .||.|:                                 
Zfish  1131 ---------------PEEETSFSILPDTESDY--------------------------------- 1147

  Fly  1787 ARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSV 1851
                     :.||||                                                  
Zfish  1148 ---------DQEEFE-------------------------------------------------- 1153

  Fly  1852 VTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRK 1916
                                                                             
Zfish  1154 ----------------------------------------------------------------- 1153

  Fly  1917 LMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVP 1981
                :.||      |.|::  |...|.|.|....:.|                            
Zfish  1154 ----EALG------SCGDA--GSTNDGHLTDEEVLRR---------------------------- 1178

  Fly  1982 APPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQ 2046
                                 |..|..|.:   .:|.||...:..:       .|.|  |.|...
Zfish  1179 ---------------------SSCTYNSTD---SFRGSSDSFIDSN-------DEND--GYVDTD 1210

  Fly  2047 QMISSHHLHLEDHSA---------SSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEG 2102
            :.:|:..:||.:.|.         ..|..:..|        |.|......|.:   :|.||:.:.
Zfish  1211 EEVSNGRVHLLNGSGPPYFHSYLYMKSGLMIPW--------RRRWCVLKDETF---MWFRAKQDS 1264

  Fly  2103 PASG----SGSEKEREKRERERERLYEIRQVER---ERESHKVYQPAPPRVIQASMDTTGGHRRE 2160
            ..||    .|.......|...:.|.:.:|..:.   |.:|.:..:....  |:|:.:....|.:|
Zfish  1265 LKSGWLYKKGGGMSTLSRRNWKMRWFVLRDSKLMYFENDSEEKLKGTID--IRAAKEIVDNHEKE 1327

  Fly  2161 DRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPG---L 2222
            :....:...||:.......|      .:||....|..:|..||..::...........:.|   :
Zfish  1328 NALNIVTEDRTYQIYAESPE------DASGWFNVLSRVHSATPDQLLQMQHEQANPKNAVGTLDV 1386

  Fly  2223 GVVSGVLMGSGSG--GSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTP 2285
            |::..|.......  .|...:|.||                                     |..
Zfish  1387 GLIDSVCASDNPDRPNSFVIITANR-------------------------------------VIH 1414

  Fly  2286 CLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFARL 2350
            |...||:|      |.|..|:    |....|.....|          :..:|   |.|       
Zfish  1415 CNTDTPEE------MHHWIGL----LQKPKGDSRIDG----------QEFIV---RGW------- 1449

  Fly  2351 FAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHL 2415
                   |:.::...|.|.| |.|.:|  .:::...::.:                         
Zfish  1450 -------LHKEMKSSGKSTS-LKLKKR--WFVLTNNSLDY------------------------- 1479

  Fly  2416 ALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDG 2480
                                ::.|:..||.|.:....:..::..|.|::.....:.....||   
Zfish  1480 --------------------YKSSERSASKLGTLVLNSLCSVVQPDEKVYKETGYWNIIVHG--- 1521

  Fly  2481 GSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAM---EEQHMATDHQ---QQQQQQ 2539
                                       :.|..:...:.|.:||   ....:|.|::   :...||
Zfish  1522 ---------------------------RKHSYRLYTKLLNEAMRWASAIQVAIDNKVPIETPTQQ 1559

  Fly  2540 LGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYL 2604
            |       .|.:|:.|.                   .|...|||                     
Zfish  1560 L-------IRDIKESSL-------------------NVEAVEQM--------------------- 1577

  Fly  2605 QDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLR 2669
                                   ::||..||                |.:      |.:..|||.
Zfish  1578 -----------------------YWRNPILR----------------YTQ------HPLHSPLLP 1597

  Fly  2670 LP--------------NDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDE 2720
            ||              ..|...|::.|:.:...  :...||    :..:..:|..|....|||||
Zfish  1598 LPYGEVNINLQKEKGYTSLQDEAVKIFNSLQEM--EAVSDP----MPIIQGILQTCQDLRALRDE 1656

  Fly  2721 VYCQLMKQTTANRSPCPDS-SQRA-WRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTA 2783
            |||||:|||  |..|.|:| :.|| |.||:.::..|..|..:..||..||     .|.:.....|
Zfish  1657 VYCQLIKQT--NHVPQPNSPANRAHWHLLTCMSCTFLPSRGILRYLRFHL-----KRIKELFPGA 1714

  Fly  2784 AVCL------TNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGA-------------- 2828
            .:.:      .:|:||.   .|:.|||.||:.|:...|.....:|...||:              
Zfish  1715 EIEMFAVFIGDSLKKTK---AREFVPSQEEIIALLNRREMTTTVYCHGGGSCKISINSHTTAGEV 1776

  Fly  2829 --------------------------ERVVNTRCSTVVADVIAELCALLGVESEAE---QQEFSL 2864
                                      :|.|.:|  .:||||:|:...|.|.|.|.:   :..|.|
Zfish  1777 VEKLIRGLAMEDSRNMFALFEHNNTIDRAVESR--VIVADVLAKFERLTGSELEEDGPWKLYFKL 1839

  Fly  2865 YCIVQGDAFTMPLAADEYI--LDVTTELLKSGQPFYLIFCRSVWHFALKREPAP--MPLYVEVLF 2925
            ||.:  |..:||....|::  .:...|.|.||            ||....:...  ..|.::.|:
Zfish  1840 YCFL--DVESMPKEGVEFVFMFEQAHESLISG------------HFPAHEDTLQHLAALRLQYLY 1890

  Fly  2926 NQVA-----------PDYLEGLLLEL------PGNGVPVPEMVRDMARIAALLHR---AADLSHV 2970
            ..|:           ...|...:|:.      .|:|..:..  |..:.:...|.|   ...:...
Zfish  1891 GDVSRVNWSLDSIYPTGCLRSRILQFTKVGGAAGSGQTLER--RRTSFLDGTLRRGLKTGTMKKQ 1953

  Fly  2971 PAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSSFFAV 3035
            .:|:|.:.|    .:.|:|...|....:::. |.::..|...|...:::|::..||.:||:.|.|
Zfish  1954 RSMQEEQML----EMWIKEETSATRASIMEK-WSRLHGLDQHQAMVKYMNIIKEWPGYGSTLFDV 2013

  Fly  3036 KRIWAEEG--PHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVI-------STRKV 3091
            :   .:||  ||          ||.|:::...|........:.|:.:.:..::       ||.|:
Zfish  2014 E---CKEGGFPH----------DLWLSVSAENVSVYKRGEAKPLETFPYEHIVFFGAPHASTYKI 2065

  Fly  3092 RSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITM 3133
            ..:...:|.               :|.|..||:::::.||.|
Zfish  2066 TVDGRDMFF---------------ETPQVGEITKIMKAYINM 2092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 298/700 (43%)
MYSc_Myo15 169..828 CDD:276838 285/679 (42%)
MyTH4 1014..1171 CDD:295320 12/156 (8%)
MyTH4 2704..2810 CDD:279165 41/113 (36%)
B41 2823..3033 CDD:214604 52/276 (19%)
FERM_B-lobe 2920..3025 CDD:271216 19/124 (15%)
FERM_C_MyoXV 3029..3138 CDD:270022 24/114 (21%)
myo10l3XP_009302795.1 MYSc 64..740 CDD:214580 300/704 (43%)
MYSc_Myo10 77..728 CDD:276840 285/679 (42%)
MYO10_CC 933..983 CDD:293340 16/99 (16%)
PH-like <1236..>1263 CDD:302622 8/37 (22%)
PH2_MyoX 1266..1367 CDD:270108 21/108 (19%)
PH 1266..1359 CDD:278594 18/100 (18%)
PH3_MyoX-like 1432..1557 CDD:270109 26/229 (11%)
PH 1447..1547 CDD:278594 21/191 (11%)
MyTH4 1640..1744 CDD:279165 41/113 (36%)
UBQ 1752..>1805 CDD:294102 3/52 (6%)
B41 1755..2011 CDD:214604 53/278 (19%)
FERM_M 1850..2011 CDD:278785 31/179 (17%)
FERM_C_MyoX 2007..2095 CDD:270023 24/114 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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