DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myh11a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_021332550.1 Gene:myh11a / 554168 ZFINID:ZDB-GENE-050531-1 Length:1983 Species:Danio rerio


Alignment Length:2217 Identity:527/2217 - (23%)
Similarity:877/2217 - (39%) Gaps:489/2217 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            |:::....|:...:|..|                 |.||||..|..|:|||:|.|||.||..|||
Zfish    66 KKITVNKDDIQKMNPPKF-----------------SKVEDMAELTCLNEASVLHNLRERYYSGLI 113

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||::|...:.||||||.| .|..::.:.|.|:....:|||:::|...|:..:   ...|.::.:|
Zfish   114 YTYSGLFCVVVNPYKMLP-IYSEKIIEMYKGKKRHEVPPHIYSITDNAYRNMMQDREDQSILCTG 177

  Fly   247 ESGSGKTESTKLVMQYLAAVV-------------PGGGSASAVITEQILEAAPLLEAFGNARTAR 298
            |||:||||:||.|:||||.|.             .|...|...:.:|:|:|.|:|||||||:|.:
Zfish   178 ESGAGKTENTKKVIQYLAVVASSHKGKKDMSAQQSGQQFAYGELEKQLLQANPILEAFGNAKTIK 242

  Fly   299 NDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYG 362
            |||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:|:||.::.|..:..|.:..
Zfish   243 NDNSSRFGKFIRINFDVTGFIVGANIETYLLEKSRCIRQAKTERAFHIFYYMVAGTKDKLREELL 307

  Fly   363 LLEADKYFYLNQGATDCASGRVD--WESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQ 425
            |...:.|.:|:.|.......:.|  ::....||:::|.|..||..:::|::.||.|||:.|.:.:
Zfish   308 LENFNNYRFLSAGHVQIPGNQDDEMYDETMEAMEIMGFSVEERADVLKVVSTVLQLGNIEFKKER 372

  Fly   426 LRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKA 490
               .||...:..:...:...||..|:.....||:.:...:...|.:......:||..|.:|.|||
Zfish   373 ---NQEQATMPDNTAAQKVCHLQGINVTDFTRAILTPRIKVGREVVQKAQTKEQADFAIEALAKA 434

  Fly   491 LYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVF 555
            :|..||.|::.|:|..:.|.....|..:.||||.|||....||||||||||.||.||..||..:|
Zfish   435 MYERLFRWILLRVNKALDKTKRQGASFLGILDIAGFEIFENNSFEQLCINYTNEKLQQLFNHTMF 499

  Fly   556 KLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPVGICHLLDDESNFPRATDLSFLEKCHYNH 617
            .|||.||.||.:||..:.:. |..|.|.|:.:  .|.||..|||:|..||:|||:||:||....|
Zfish   500 ILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGILALLDEECWFPKATDVSFVEKLCNTH 564

  Fly   618 ALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQL 680
            |....:|:|:  ....||.|.||||:|.|....:|.||.|.|..:|..||.:|..|.|.:|.|. 
Zfish   565 ANHTKFAKPKQLKDKTEFSVQHYAGRVDYNAVAWLTKNMDPLNDNVTALLNNSSNPFVQDLWKD- 628

  Fly   681 RAQRDAG-KTLPKGSN----GRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEK 740
             |.|..| :|:.|.|:    ....|.|....||...:.:||.:|:.::....|.|||||.||.||
Zfish   629 -ADRVVGLETIAKMSDSLAPSASKTKKGMFRTVGQLYKESLAKLMTTLHNTQPNFVRCIIPNHEK 692

  Fly   741 HALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRAL 804
            .|.::|...||:|||..|:|:.|:|.::|:|.|:.||.|.:||..|..:.:.:| ...::.|..:
Zfish   693 RAGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACCLM 757

  Fly   805 LEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAA 869
            ::.:   .::...|::|.:::|.|..:...||..|..::....::.|...||.|.|:..|:||..
Zfish   758 IKHL---DIDPNLYRIGQSKIFFRTGVLAQLEEERDLKITVIIIAFQSQARGFLARKAFAKRQQQ 819

  Fly   870 ATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQE---AREAAQRARE 931
            .|.::..   ||....|.:||.        |:..:...:|:.|....|:.:|   ..|..|:|:|
Zfish   820 LTAMKVI---QRNCAAYLKLRN--------WQWWRLFTKVKPLLQVTRQEEEMSLKEEELQKAKE 873

  Fly   932 AREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQ 996
            :.:..:..|:...|.:..:..|...:..|||..:..:.:...::|     ...|...:|.|.|.:
Zfish   874 SAQKFEIELKDIALKHTQLMDERNQLQEKLQAETELYAEAEEMRV-----RLASKKQELEEILHE 933

  Fly   997 FSFGKFSSVYCNGLRLQPRREPITAPL--LTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEK 1059
            .. .:.......|..||..::.:...:  |......::|.:..|.:         :|....||.|
Zfish   934 ME-ARLEEEEDRGAALQMEKKKMHEQIKDLEEHLEEEEDARQKLQL---------EKVTCDAKIK 988

  Fly  1060 LLADYIV------HKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFS 1118
            .|.|.|:      :|....|.:.:|.:....:.:......|...|:|..         :..:..|
Zfish   989 KLEDDILIMDDQNNKLQKERKILEERIADFSSNLAEEEEKSKNLTKLKN---------KHESMIS 1044

  Fly  1119 KYLMRFVDDEAPESLRPLLLRQL------LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCD 1177
            :..:|...:|..........|:|      |::|.....:                      :..|
Zfish  1045 ELEVRLKKEEKTRQELDKAKRKLEAESNDLQEQIADLQA----------------------QIAD 1087

  Fly  1178 MALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCG--------- 1233
            :...|...:|..|             ||||                   :|.|..|         
Zfish  1088 LKAQLAKKEEELQ-------------AALA-------------------RLEDETGQKNNALKKI 1120

  Fly  1234 -------LDYVMDLIAEKELCPAFPAPRSDLLRSGAKF--ARTTLPDAVKRPAVPPPAPPTSSGK 1289
                   .|...||.:|:.........:.||   |.:.  .::.|.|.:          .|::.:
Zfish  1121 RELEGHISDLQEDLESERAARNKAEKTKRDL---GEELEALKSELEDTL----------DTTATQ 1172

  Fly  1290 EDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLL----AGDIVPVP 1350
            :::..:|.....||.|:.....|..|.:...         ..:..:::|::|.    ....|.|.
Zfish  1173 QELRAKREQEVTLLKRAIEDESRVHEAQVQE---------MRQKHTQALEELTEQLEQSKRVKVN 1228

  Fly  1351 TDCDSQ------EPLHT--LGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGS 1407
            .:...|      ..||.  ..|::.: .|..|..::|.....|...|:..|:.     |.|..|.
Zfish  1229 LEKAKQALEKETSELHVELRSLTQGK-QDVEHKKKKLEGQLADLQSRFNDSER-----HKAELGD 1287

  Fly  1408 HSSKYADKAEYATR-------------------SSAMSDTSEAPSLASHVR-RVRVPSQASDVDQ 1452
            ..||...:.|..|.                   ||.:.||.|.  ||...| ::::.::...:: 
Zfish  1288 RVSKITVELESVTNLLNEAEGKNIKLSKDVASLSSQVQDTQEL--LAEETRQKLQLSTKLRQIE- 1349

  Fly  1453 FLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKL 1517
              ||  ...|...|||.::|:              ...|..:..|:..::|      ..:.||::
Zfish  1350 --DD--RNALQEQLDEEAEAK--------------RNVERHVSTLNIQLSD------FKKKLEEM 1390

  Fly  1518 TSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKL-TSKEHLAVSIRGG 1581
            |...:|   ::.|   .|..:||.|:        .|..||  ..|...||| .:|..|       
Zfish  1391 TGNVEL---LEEG---KKRLQRDLEA--------ANTQFE--EKAAAYDKLEKTKNRL------- 1432

  Fly  1582 GSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFL----QSAMAQNLQIQQ----QLLAQNQ 1638
                                         ||:::...:    |..:..||:.:|    |:||:.:
Zfish  1433 -----------------------------QQELEDTLMDLDNQRQLVSNLEKKQKKFDQMLAEEK 1468

  Fly  1639 ALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRM-KATRSSLVVMESLQPPPPPP 1702
            ::.:..:.:...|.|........|..:..:|..:....:...|. ||.|:.   ||.|       
Zfish  1469 SISSKYADERDRAEAEAREKETKALSLARALEEAQEAREEFERANKALRAE---MEDL------- 1523

  Fly  1703 PPPMPPPLECKDP-SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTT 1766
                   :..||. .:..|.|:...|....::.:.:....:.|.:.|..||   .|:|.......
Zfish  1524 -------VSSKDDVGKNVHELEKSKRGLEAQVEEMKTQLEELEDELQAAED---AKLRLEVNMQA 1578

  Fly  1767 PQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIE---------SPTPPPMSGQLMRSSIRLE 1822
            .:||..:...  |..|.|...:......:...|.|:|         :.:...:.|.|.....::|
Zfish  1579 LKAQFERDLQ--GRDEQGEEKKRQLVKQVRELETELEDERKQRTALAASKKKLEGDLKDLEGQIE 1641

  Fly  1823 TTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLE 1887
            |         :|:.||...:.:                               .||.::|:....
Zfish  1642 T---------SNKGRDEAIKQL-------------------------------RKLQAQMKDFQR 1666

  Fly  1888 QVTAGHSVRSTV-STKSEQRAPAKLEDTRKLMLQQQLGG--------------LFASVSGGNSGP 1937
            ::...|:.|..| |:..|....||..:...|.||:.|..              |...::...||.
Zfish  1667 ELDDAHAAREEVLSSAKENERKAKTLEAELLQLQEDLAAAERAKKQVEAERDELADELASNASGK 1731

  Fly  1938 GGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQ 2002
            ..:.|....:..:|:::|.:|.....                        ....:.......|.|
Zfish  1732 SALSDEKRRLEAKIQQLEEELEEEQG------------------------NMEMLNDRLRKSAQQ 1772

  Fly  2003 SPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVR--QQQMISSHHLHLEDHSASSSP 2065
            ........:.|   ||:|.:  .|.....::||.::....::  :.|:.|.....:   ||..:.
Zfish  1773 VDQLTNELQAE---RTTSQK--NESARQLMERQNKELKAKLQEMENQVKSKFKSSI---SALEAK 1829

  Fly  2066 AVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVE 2130
            .....||.|:|       |||:::.:::|                ::::|:.:|.     :.|||
Zfish  1830 VAQLEEQLEQE-------SRDKQNTAKAV----------------RQKDKKLKEM-----MTQVE 1866

  Fly  2131 RERESHKVYQ----PAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGM 2191
            .||:..:.|:    .|..||.|.............|.       |...:|.:.|....:..:..|
Zfish  1867 DERKQAEQYKDQADKATARVKQLKRQLEESEEESQRI-------TAARRKLQRELDEATETNDAM 1924

  Fly  2192 REELDSM 2198
            ..|::|:
Zfish  1925 SREVNSL 1931

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 268/709 (38%)
MYSc_Myo15 169..828 CDD:276838 260/688 (38%)
MyTH4 1014..1171 CDD:295320 23/170 (14%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh11aXP_021332550.1 Myosin_N 32..71 CDD:308391 1/4 (25%)
MYSc_class_II 98..778 CDD:276951 260/688 (38%)
Myosin_tail_1 855..1935 CDD:307627 234/1391 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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