DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh13

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001074719.1 Gene:Myh13 / 544791 MGIID:1339967 Length:1938 Species:Mus musculus


Alignment Length:2255 Identity:512/2255 - (22%)
Similarity:862/2255 - (38%) Gaps:583/2255 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 VVKRLS----TLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLR 178
            :||.|.    ||.||      |.|.:.|.:          ...:|||.::..|||.::|:||:.|
Mouse    61 IVKTLDDRELTLNSD------QVFPMNPPK----------FDKIEDMAMMTHLHEPAVLYNLKER 109

  Fly   179 YDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---Q 240
            |...:|||::|...:.|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |
Mouse   110 YAAWMIYTYSGLFCVTVNPYKWLP-VYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQ 173

  Fly   241 VVVISGESGSGKTESTKLVMQYLAAVVPGG--------GSASAVITEQILEAAPLLEAFGNARTA 297
            .::|:||||:|||.:||.|:||.|.:...|        |.....:.:||::|.|||||||||:|.
Mouse   174 SILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEQQPGKMQGTLEDQIIQANPLLEAFGNAKTV 238

  Fly   298 RNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKY 361
            ||||||||||::.::| .:|.:..|.|..|||||||:..|...||:||:||:::.. .:.|....
Mouse   239 RNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMSN-KKPELIDL 302

  Fly   362 GLLEADKYF--YLNQGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYF 421
            .|:..:.:.  :::||....|| ..|.|.|   ..|:.:||.|..|:.||.::..||:|.||:.|
Mouse   303 LLISTNPFDFPFVSQGEVTVAS-IDDSEELLATDNAIDILGFSPEEKVGIYKLTGAVMHYGNMKF 366

  Fly   422 HRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDAR 484
            .::|.....|  |.||...     |.:|:.:::..:.:.|.....:...|.:.....:.|..::.
Mouse   367 KQKQREEQAEPDGTEVADK-----AGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQVTNSV 426

  Fly   485 DAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQ 547
            .|.|||:|..:|.|:|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||
Mouse   427 GALAKAVYEKMFLWMVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQ 488

  Fly   548 LYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEK 612
            .:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:||..:|::|..||:|||.||..|
Mouse   489 QFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNK 553

  Fly   613 CHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPL 672
            .:..| ..|..:.:|:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.|.|
Mouse   554 LYDQHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKL 618

  Fly   673 VGELTKQLRAQRDAGKTL-------PKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWF 730
            :..|.... |..:||.:.       .|||:.:         ||:|.|.::|.:|:.::...||.|
Mouse   619 LSFLFSNY-AGAEAGDSAGGKKGGKKKGSSFQ---------TVSAVFRENLNKLMTNLRSTHPHF 673

  Fly   731 VRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG- 794
            |||:.||:.|....||...|:.|||..|:|:.|:|.::|:|.|:.:..|.:|||.|..|.:..| 
Mouse   674 VRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQ 738

  Fly   795 -TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGML 858
             ...:.....||.::   .|:...::.|.|:||.:..|...||..|.|:|.......|...||.|
Mouse   739 FIDSKNASEKLLNSI---DVDREQFRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTRTQAVCRGYL 800

  Fly   859 VR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQ 911
            :|   :::..|:.:...:|         ..|.......:.:.|.|.|          :|.:.:..
Mouse   801 MRVEFKKMMERRESIFCIQYNVRSFMNVKHWPWMNLFFKIKPLLKSA----------EAEKEMAT 855

  Fly   912 LRSDHRRRQE--AREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLV 974
            ::.|..|.:|  ||..|:| :|..|...::|:..                               
Mouse   856 MKEDFERAKEDLARSEARR-KELEEKMVSLLQEK------------------------------- 888

  Fly   975 KVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALA 1039
                                             |.|:||             ..|..::..||  
Mouse   889 ---------------------------------NDLQLQ-------------VQSETENLMDA-- 905

  Fly  1040 VFKLILRWSNDKALEG-AKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQL 1103
                      ::..|| .|.|:..:..| |.|:.|...:|.:            ||....:...|
Mouse   906 ----------EERCEGLIKSKIQLEAKV-KELNERLEEEEEM------------NSELVAKKRNL 947

  Fly  1104 LGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLE 1168
            ..:|           ..|.|.:||                                         
Mouse   948 EDKC-----------SSLKRDIDD----------------------------------------- 960

  Fly  1169 WRAWTRGCDMALPLTLPDEASQTVAVDS--------WTSCEEAAALAVSSLGVASRGWTLVLDDG 1225
                       |.|||.....:..|.::        .|:.||..:................|||.
Mouse   961 -----------LELTLTKVEKEKHATENKVKNLSEEMTALEETISKLTKEKKSLQEAHQQTLDDL 1014

  Fly  1226 Q-----------------QLTDSCGLDYVMDLIAEKELCPAFPAPRSDL------LRSGAKFART 1267
            |                 |.||    |....|..||:|       |:||      |....|.::.
Mouse  1015 QVEEDKVNGLIKINVKLEQQTD----DLEGSLEQEKKL-------RADLERVKRKLEGDLKMSQE 1068

  Fly  1268 TLPD----------AVKRPAVPPPAPPTSSGKEDV--PRERRSSRELLSRSSALNERYFEREPSP 1320
            ::.|          .:|:.........|....|.|  .:.::..:||.:|:..|.|..       
Mouse  1069 SIMDLENDTQQLEEKLKKKEFEMSQLQTRIDDEQVLSLQLQKKIKELQARTEELEEEI------- 1126

  Fly  1321 GPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKD 1385
               :...|.:||...:..|  ||.::..:                ..||.:...:......:.|.
Mouse  1127 ---EAEHTVRAKIEKQRSD--LARELEEI----------------SERLEEASGATSAQIEMNKK 1170

  Fly  1386 TGPRYQKSQ---HAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRV--RVPS 1445
            ....:||.:   ......|.|:..:...|:||            ..:|......:::||  ::..
Mouse  1171 RESEFQKLRRDLEEATLQHEATAATLRKKHAD------------TVAELGEQIDNLQRVKQKLEK 1223

  Fly  1446 QASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPL 1510
            :.|::...:||:.|     :::.:|.::|....:.....:|.||.:::.|.....|:|:      
Mouse  1224 EKSELKMEIDDMAS-----NIETVSKSKSNMERMCRSVEDQFNEIKAKDDQQTQLIHDL------ 1277

  Fly  1511 VQNLEKLTSKDQLAAIIKGGGVASKPEERD---------EESEIEDLDDYINELFEPIPVAEGL- 1565
              |::|...:.|      .|.::.:.||::         :::..:.|::...:|.|.......| 
Mouse  1278 --NMQKARLQTQ------NGELSHQVEEKESLVSQLTKSKQALTQQLEELKRQLEEETKAKNALA 1334

  Fly  1566 DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ-QQVQRAFLQSAMAQNLQI 1629
            ..|.|..|....:|.....:..|...|...|.:...|.......|: ..:||       .:.|:.
Mouse  1335 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR-------TEELEE 1392

  Fly  1630 QQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMES 1694
            .::.|||.      |.:......|:||.        .:||.      ::..|::.....|:    
Mouse  1393 AKKKLAQR------LQEAEENTEASNSK--------CASLE------KTKQRLQGEVDDLM---- 1433

  Fly  1695 LQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEE-------- 1751
                           |:.:..:.....||...|.....:.:|:  ...||.|.:.|.        
Mouse  1434 ---------------LDLERANTACATLDKKQRNFDKVLAEWK--QKLDESQAELEAAQKESRSL 1481

  Fly  1752 DFFAFKMR----------QHQRKTTPQAQHHQMTSNGGMMESGPGARGASAT--AIEWEEFEIES 1804
            ....||||          :..|:.....|.........:.|:|...:....|  .:|.|:.::::
Mouse  1482 STEIFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEVEKTKKQVEQEKSDLQA 1546

  Fly  1805 PTPPPMSGQL-------MRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLA 1857
            .. ..:.|.|       :|..:.|....:.....|..:|.:     |.:|...:.||||:..::.
Mouse  1547 AL-EEVEGSLEHEESKILRVQLELSQVKSELDRKVTEKDEEIEQIKRNSQRAVEAMQSVLDAEIR 1610

  Fly  1858 KKSFEIGADRPPPGSVG--KLKLSSEMRQRLE-----QVTAGHSVRSTVSTKSEQRAPAKLEDTR 1915
            .::..:...:...|.:.  :::||...||..|     :...|....|.:.....||:...|::  
Mouse  1611 SRNDALRLKKKMEGDLNEMEIQLSHANRQVAETQKHLRTVQGQLKDSQLHLDDAQRSNEDLKE-- 1673

  Fly  1916 KLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSV 1980
            :|.:.::..||                    ::.::|.|:..|.                     
Mouse  1674 QLAIVERRNGL--------------------LQEELEEMKVALE--------------------- 1697

  Fly  1981 PAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQV------------VKEHVPAFIQ 2033
                                 |:..|.|..|.|  ...||.:|            .|:.:.|.:.
Mouse  1698 ---------------------QTERTRRLSEQE--LLDSSDRVQLLHSQNTSLINTKKKLEADLA 1739

  Fly  2034 RQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWD-- 2096
            :.:.:...::::     |.:...:...|.:..|:.| |:.::|:..|....|.:::..::|.|  
Mouse  1740 QCQAEVENSIQE-----SRNAEEKAKKAITDAAMMA-EELKKEQDTSAHLERMKKNLEQTVKDLQ 1798

  Fly  2097 -RAEVEGPASGSGSEKEREKRE-RERERLYEI-----RQVERERESHKVYQPAPPRVIQASMDTT 2154
             |.:.....:..|.:|:.:|.| |.||...|:     |..|..:.:||..:.......||..|..
Mouse  1799 HRLDEAEQLALKGGKKQIQKLEARVRELESELDAEQKRGAEALKGAHKYERKVKEMTYQAEEDRK 1863

  Fly  2155 GGHRREDRTGGL-ATFRTHMAQKYEHERKRKSSASSGMR--EELD 2196
            ...|.:|....| |..:::..|..|.|.:..:..|...|  .||:
Mouse  1864 NILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELE 1908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 256/714 (36%)
MYSc_Myo15 169..828 CDD:276838 249/693 (36%)
MyTH4 1014..1171 CDD:295320 20/157 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh13NP_001074719.1 Myosin_N 36..73 CDD:280832 4/11 (36%)
Myosin_head 88..770 CDD:278492 255/705 (36%)
MYSc_Myh13 100..770 CDD:276887 249/693 (36%)
Myosin_tail_1 850..1927 CDD:279860 229/1416 (16%)
DUF342 <1506..1582 CDD:302792 11/76 (14%)
TMPIT 1744..>1837 CDD:285135 19/98 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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