DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myo28B1

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_723294.1 Gene:Myo28B1 / 53515 FlyBaseID:FBgn0040299 Length:2122 Species:Drosophila melanogaster


Alignment Length:3165 Identity:720/3165 - (22%)
Similarity:1085/3165 - (34%) Gaps:1227/3165 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 RYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLR 178
            |..:..|..:.:|.|   |:.|.:.  |....|:|........||||..|.||.|.::|.||:.|
  Fly    31 RIVRTEKTQTLVCDD---RNKQFWV--PAGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNR 90

  Fly   179 YDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAH---AALPSPQ 240
            |.|.||||:.||:|:|:|||::.|.....|: :.|..:.|..||||:|||...|.   ..|...|
  Fly    91 YAKQLIYTYTGSMLVAINPYQILPIYTNREI-QLYRNKSLAELPPHIFAISDNAFQRLQRLKENQ 154

  Fly   241 VVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRF 305
            .||||||||:||||||||::|||||:    ....:.|.:||:||.|::||||||:|.||||||||
  Fly   155 CVVISGESGAGKTESTKLILQYLAAI----SGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRF 215

  Fly   306 GKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE--AD 367
            |||:|:.| ..|||.||:|.||||||||||.|:..|||||:||.:|.|||..||.:..|.|  ..
  Fly   216 GKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPS 280

  Fly   368 KYFYLNQGATDCASGR---VDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHG 429
            :|.||.||......||   .|:..::.||:||.....|...|:.:|||:|||||:.|...::.: 
  Fly   281 QYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVAN- 344

  Fly   430 QEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAG 494
            ....|:.....::..|.||.|....|:.|||.||.....|.:.|.|..:.|::.||||.|:||.|
  Fly   345 LATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDG 409

  Fly   495 LFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQ 559
            :|..:|.|||..:.|......:.|.:|||||||:...||||||||||||||||.:|..|:||:||
  Fly   410 IFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQ 474

  Fly   560 AEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYA 624
            .||..|.:.|..:.:.||..::.|:..||:.:..|:|:||.||:.||.:.|||.|..|....:|.
  Fly   475 DEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYV 539

  Fly   625 RPRIGAQE-FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGK 688
            :.:..... ||:.||||.|.|...|||:||||:..||:..|:                 ||...|
  Fly   540 KGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLV-----------------QRSTNK 587

  Fly   689 TLPKGSNGRFVTMKP---------RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALR 744
            .|        |.:.|         :.||:..:|.:||..|::::.:.||:|:||||||:.|....
  Fly   588 YL--------VDIFPHEMPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKN 644

  Fly   745 MDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP--SPLARGTPYRELCRALLE- 806
            .|....::||||.||::|.:||:.|||:|..::.||||||.|:|  .||.: ...|:|.|.:.| 
  Fly   645 FDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQ-CDCRKLARQICEV 708

  Fly   807 AMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAAT 871
            |:|...    |.|.|.|::|||:....:||..|::.:.::.|::||.:|.:|.||.:        
  Fly   709 ALPADS----DRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYM-------- 761

  Fly   872 RLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAK 936
                           :|.|:..:|.||.||||..||:.|.:|....|.                 
  Fly   762 ---------------KRYREAIITVQRYWRGRLQRRKYQVMRQGFHRL----------------- 794

  Fly   937 QAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK 1001
                                                         |...:|.||..        |
  Fly   795 ---------------------------------------------GACIAAQQLTT--------K 806

  Fly  1002 FSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIV 1066
            |:.|.|..::||         .|:|.....:|||              .|.||..|:        
  Fly   807 FTMVRCRTIKLQ---------ALSRGYLVRKDFQ--------------KKLLERRKQ-------- 840

  Fly  1067 HKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPE 1131
                  ..|:.|.|::|...                                        .||.|
  Fly   841 ------NQLKKEELLKLAKM----------------------------------------KEAEE 859

  Fly  1132 SLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDS 1196
            .||   |:||..|:                                         |..|....:.
  Fly   860 LLR---LQQLKEQK-----------------------------------------EREQREQQEK 880

  Fly  1197 WTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSG 1261
                                                       .:.|::...|..|.|:.|..:.
  Fly   881 -------------------------------------------RLQEEQRLKAEAAARNALAMAA 902

  Fly  1262 AKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGS 1326
            .:..|.|.|  ||:.|   |..||...:..:|                                 
  Fly   903 VQQKRRTKP--VKQEA---PKAPTLQARNSLP--------------------------------- 929

  Fly  1327 STGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQ 1391
                                 |.||......||.|                              
  Fly   930 ---------------------PPPTTLIVAAPLPT------------------------------ 943

  Fly  1392 KSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVR-VPSQASDVD---- 1451
                                                   .|  ||.|.|:. :|.....:|    
  Fly   944 ---------------------------------------RP--ASAVTRINTIPESPGTIDVESS 967

  Fly  1452 -QFLDDLF-----SPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLD-DYINDIFQPIP 1509
             |.:||:|     .|  |.:|.:|::..|      |.:........:.||..| .|:        
  Fly   968 KQMVDDVFRFLNDEP--DAALRKLNNISS------GDTIRLPKSVPNNIDTSDFSYL-------- 1016

  Fly  1510 LVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHL 1574
                        :.||...|||..::.|.:..:..:         |....|:    |::.||...
  Fly  1017 ------------KYAATYFGGGATAQHERKPLKKSL---------LKHEHPI----DEMASKAIW 1056

  Fly  1575 AVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQA 1639
            ...:|..|......:.|.||                                       :..|:.
  Fly  1057 LTILRFMGDLPDVVSSPTLH---------------------------------------VFDNEN 1082

  Fly  1640 LQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPP 1704
            |.:.|     |:..|.|.|..|                                           
  Fly  1083 LMSDL-----ASLLNTSDSYKP------------------------------------------- 1099

  Fly  1705 PMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQA 1769
                          |.|                                    :||.||:     
  Fly  1100 --------------RLF------------------------------------VRQSQRR----- 1109

  Fly  1770 QHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPM-SGQLMRSSIRLETTTTTTTSAVN 1833
                                                .|.|: ||                     
  Fly  1110 ------------------------------------IPKPLASG--------------------- 1117

  Fly  1834 NRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRST 1898
                ::|.|:..|...:|.|:.|.|..|.||.        |.:|.|                   
  Fly  1118 ----EKEAQEFYQHWLNVPTSHLEKIHFIIGH--------GIIKNS------------------- 1151

  Fly  1899 VSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPA 1963
                        |.|.....:.:||                                 .|:|..:
  Fly  1152 ------------LRDEILAQICKQL---------------------------------YLNPSRS 1171

  Fly  1964 PPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHV 2028
            ..|.||  :||                |:.....||         |.|.||            |:
  Fly  1172 SYSRGW--LLL----------------SLCLSCFPP---------SKEFEP------------HL 1197

  Fly  2029 PAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSES 2093
            .:|:::      |..:.|...|...|                                       
  Fly  1198 RSFMKQ------GTAQLQATPSLQRL--------------------------------------- 1217

  Fly  2094 VWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHR 2158
              :|..|.||.....|             |:|:..:   |..|      |.|:....||      
  Fly  1218 --ERTLVNGPRCQPPS-------------LFELHAI---RGRH------PLRLDIHLMD------ 1252

  Fly  2159 REDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELD----SMHMTTPPPVIVPAPVPPPSSTS 2219
                               ..:|:.:..|:|..||.::    .|.:|                .:
  Fly  1253 -------------------GQQRRLQVDAASTAREAVNQLCQGMGLT----------------DT 1282

  Fly  2220 PGLGVV---SGVLMGSGSGGSTACLTYNR-------VPWKLRVRKEVFQP-HEPIGPPVALDLLF 2273
            .|.|:|   :|.||..|:|........:.       .||||.:|||:|.. ::|...|.|..|::
  Fly  1283 FGFGLVMSLNGKLMPLGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIY 1347

  Fly  2274 AQVLGDV------------------------FGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNR 2314
            .|:|..:                        :|....||:.|.|.::.        |..|.|:  
  Fly  1348 KQILNGLKCGEYRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAF--------VPSDLLA-- 1402

  Fly  2315 NGSGAGGGGNGGQVRA-------LVKRHLVDMARD----------------WPLYFARLFAV--- 2353
              .|.....|..::.|       .||....|:..:                ||:..:|||.|   
  Fly  1403 --PGERAIENWSRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRK 1465

  Fly  2354 QGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALH 2418
            :|..|..|..::|::.:||:|......   |:.:..|.|:                     |.:|
  Fly  1466 EGPKLQSDELMLGINSAGLFLIDETEQ---VLASCCFSEV---------------------LKVH 1506

  Fly  2419 AARAAAIQSMV---TTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDG 2480
            ......:..|.   ..||.:           .|.|:.|.:.:|..|:.|..|.::....:..|:|
  Fly  1507 VESDDKLHVMTFQHVNFVLQ-----------CSSAQDANEVINYMLDNLRQRSSYGVALDPVVEG 1560

  Fly  2481 GSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAM--------EEQHMATDHQ---- 2533
                                                 .|||.:        |.:...|..|    
  Fly  1561 -------------------------------------DLEDCLVLNPGDLIEFEAGVTGAQLMAG 1588

  Fly  2534 QQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAG--QQPSSLTNGQVHHQEQMLQQQQQQSQSLPH 2596
            ..|....|...||..:||             ||  :..::||......|:.:   ::.:.|..|.
  Fly  1589 NAQDCYRGCVNGQWGQFL-------------AGNVRVLATLTKPSEKLQDIL---REGRFQEPPK 1637

  Fly  2597 HDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGH 2661
            ....|||.:..          ::::.|.|..|||  :..|:|:             |.|.|:...
  Fly  1638 PTPRANYSRRR----------QHNISQLAESHFR--EPLDSDK-------------APLSKFSPE 1677

  Fly  2662 AIRLPLLRLPNDLAPL---ALECFDCILRYCGDI-----PLDPDLTEVKCVYTVLMHCHKYLALR 2718
            .::.|||:....:.||   ||.....||:|.|||     |::.||        :.....::..|.
  Fly  1678 PLKAPLLKAVVKVPPLFQQALVMHHHILKYMGDIARSNLPVNTDL--------IFQPALQHPLLC 1734

  Fly  2719 DEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTA 2783
            ||:|||||||.:.|  |..:|.:|.|.||.:.......|..:...|:..|       |......|
  Fly  1735 DELYCQLMKQLSDN--PSSESEKRGWDLLYLATGLVAPSVLVMRELIILL-------RMRADALA 1790

  Fly  2784 AVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYR---LPGGAERVVNTRCSTVVADVIA 2845
            ..||..|:::...|.||..|.:.||..:   :.....||.   .|............|..|::||
  Fly  1791 DACLKRLKRSLAQGQRKKAPHLIEVEGI---QQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIA 1852

  Fly  2846 ELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTEL------------LKSGQPFY 2898
            ::...|.::|..   .:|::.......:.||  .:|::.|..|:|            :..|| :.
  Fly  1853 DIAQRLELKSPV---GYSIFLKTGDRVYAMP--EEEFVFDFITQLIYWLRQQRTIRSISDGQ-YQ 1911

  Fly  2899 LIFCRSVWHFALKREPAPMPLYVEVLFN--QVAPDYLEGLLLELPGNGVPVPEMVRDMARIAALL 2961
            |.|.|.:|   |...|.. .|..:::|:  |....||:|.          .|......:|:|.|:
  Fly  1912 LHFMRKLW---LNNHPGE-DLNGDMIFSYPQELHKYLKGY----------YPIDCEQASRLAILV 1962

  Fly  2962 HRA---ADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQV--ANLSPGQVKAQFLNV 3021
            :.|   ..|..:|.:  :..|:|:..:.::.:  |:|   .|...|:|  .:|:....|..||..
  Fly  1963 YSADHDVSLQRLPEV--LTRLIPEDLIPLQTV--AEW---RQQILPKVHRDHLTEDHAKILFLQE 2020

  Fly  3022 LATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVI 3086
            |:.:..|||:||.||          :.|...:...|::|:|..|...|||.|.|.|:.:.:.:: 
  Fly  2021 LSHFACFGSTFFVVK----------QQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQL- 2074

  Fly  3087 STRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYI 3131
               .:.| .|.....::.||::....:...|.|.:::..|:..|:
  Fly  2075 ---GIWS-SGKNHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 300/701 (43%)
MYSc_Myo15 169..828 CDD:276838 290/680 (43%)
MyTH4 1014..1171 CDD:295320 22/156 (14%)
MyTH4 2704..2810 CDD:279165 31/105 (30%)
B41 2823..3033 CDD:214604 50/231 (22%)
FERM_B-lobe 2920..3025 CDD:271216 24/111 (22%)
FERM_C_MyoXV 3029..3138 CDD:270022 25/103 (24%)
Myo28B1NP_723294.1 MYSc 62..737 CDD:214580 302/710 (43%)
MYSc_Myo7 81..726 CDD:276832 290/680 (43%)
IQ 765..785 CDD:197470 10/19 (53%)
DUF4355 827..>887 CDD:290964 23/214 (11%)
MyTH4 1031..1239 CDD:295320 73/597 (12%)
B41 1248..1429 CDD:214604 44/233 (19%)
FERM_N 1248..>1288 CDD:286467 11/80 (14%)
FERM_B-lobe 1342..1429 CDD:271216 17/98 (17%)
PH-like 1454..1547 CDD:302622 25/127 (20%)
MyTH4 1674..1819 CDD:214535 47/164 (29%)
B41 1827..2032 CDD:214604 50/231 (22%)
FERM_N 1829..>1877 CDD:286467 8/50 (16%)
FERM_M 1936..2032 CDD:278785 26/112 (23%)
FERM_C2_MyoVII 2028..2121 CDD:270020 25/103 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466264
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
65.750

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