Protein Alignment Myo10A and Myo28B1

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_723294.1
• Gene: Myo28B1 / 53515
• FlyBaseID: FBgn0040299
• Length: 2122
• Species: Drosophila melanogaster
• Alignment Length: 3154
• Identity: 719/3154 - (22%)
• Similarity: 1087/3154 - (34%)
• Gaps: 1205/3154 - (38%)

  Fly   114 RYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLR 178
            |..:..|..:.:|.|   |:.|.:.  |....|:|........||||..|.||.|.::|.||:.|
  Fly    31 RIVRTEKTQTLVCDD---RNKQFWV--PAGDVLKAMHITSQEDVEDMITLGDLQEYTILRNLQNR 90

  Fly   179 YDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAH---AALPSPQ 240
            |.|.||||:.||:|:|:|||::.|.....|: :.|..:.|..||||:|||...|.   ..|...|
  Fly    91 YAKQLIYTYTGSMLVAINPYQILPIYTNREI-QLYRNKSLAELPPHIFAISDNAFQRLQRLKENQ 154

  Fly   241 VVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRF 305
            .||||||||:||||||||::|||||:    ....:.|.:||:||.|::||||||:|.||||||||
  Fly   155 CVVISGESGAGKTESTKLILQYLAAI----SGKHSWIEQQIIEANPIMEAFGNAKTVRNDNSSRF 215

  Fly   306 GKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE--AD 367
            |||:|:.| ..|||.||:|.||||||||||.|:..|||||:||.:|.|||..||.:..|.|  ..
  Fly   216 GKYIEIRFTPQGAIQGARIQQYLLEKSRIVFQSRDERNYHIFYCMLAGLSTAERERLKLQEQSPS 280

  Fly   368 KYFYLNQGATDCASGR---VDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHG 429
            :|.||.||......||   .|:..::.||:||.....|...|:.:|||:|||||:.|...::.:
  Fly   281 QYHYLAQGGCFTLPGRGDAKDFADIRAAMKVLSFKPEEVWSILSLLAAILHLGNLRFTATEVAN- 344

  Fly   430 QEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAG 494
            ....|:.....::..|.||.|....|:.|||.||.....|.:.|.|..:.|::.||||.|:||.|
  Fly   345 LATAEIDDTPNLQRVAQLLGIPISALNAALTQRTIFVHGEHVTTSLSKEAAIEGRDAFVKSLYDG 409

  Fly   495 LFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQ 559
            :|..:|.|||..:.|......:.|.:|||||||:...||||||||||||||||.:|..|:||:||
  Fly   410 IFVRIVRRINETINKQVDQPMNSIGVLDIFGFENFDNNSFEQLCINYANENLQQFFVGHIFKMEQ 474

  Fly   560 AEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYA 624
            .||..|.:.|..:.:.||..::.|:..||:.:..|:|:||.||:.||.:.|||.|..|....:|.
  Fly   475 DEYQNEHINWQHIEFQDNQQILDLIGMKPMNLMSLIDEESKFPKGTDQTLLEKLHVQHGNRSIYV 539

  Fly   625 RPRIGAQE-FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGK 688
            :.:..... ||:.||||.|.|...|||:||||:..||:..|:                 ||...|
  Fly   540 KGKTTQTSLFGIRHYAGVVMYNPLGFLEKNRDSFSGDLRTLV-----------------QRSTNK 587

  Fly   689 TLPKGSNGRFVTMKP---------RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALR 744
            .|        |.:.|         :.||:..:|.:||..|::::.:.||:|:||||||:.|....
  Fly   588 YL--------VDIFPHEMPMDTAKKQPTLCVKFRNSLDMLMRTLSQAHPYFIRCIKPNEYKEPKN 644

  Fly   745 MDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP--SPLARGTPYRELCRALLE- 806
            .|....::||||.||::|.:||:.|||:|..::.||||||.|:|  .||.: ...|:|.|.:.|
  Fly   645 FDKELCVRQLRYSGMMETARIRRAGYPIRHAYRAFVERYRLLVPPVGPLEQ-CDCRKLARQICEV 708

  Fly   807 AMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAAT 871
            |:|...    |.|.|.|::|||:....:||..|::.:.::.|::||.:|.:|.||.:
  Fly   709 ALPADS----DRQYGKTKLFLRDEDDASLELQRSQLMLKSIVTIQRGIRRVLFRRYM-------- 761

  Fly   872 RLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAK 936
                           :|.|:..:|.||.||||..||:.|.:|....|.
  Fly   762 ---------------KRYREAIITVQRYWRGRLQRRKYQVMRQGFHRL----------------- 794

  Fly   937 QAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK 1001
                                                         |...:|.||..        |
  Fly   795 ---------------------------------------------GACIAAQQLTT--------K 806

  Fly  1002 FSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIV 1066
            |:.|.|..::||         .|:|.....:|||              .|.||..|:
  Fly   807 FTMVRCRTIKLQ---------ALSRGYLVRKDFQ--------------KKLLERRKQ-------- 840

  Fly  1067 HKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPE 1131
                  ..|:.|.|::|...                                        .||.|
  Fly   841 ------NQLKKEELLKLAKM----------------------------------------KEAEE 859

  Fly  1132 SLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDS 1196
            .||   |:||..|:                                         |..|....:.
  Fly   860 LLR---LQQLKEQK-----------------------------------------EREQREQQEK 880

  Fly  1197 WTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSG 1261
                                                       .:.|::...|..|.|:.|..:.
  Fly   881 -------------------------------------------RLQEEQRLKAEAAARNALAMAA 902

  Fly  1262 AKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGS 1326
            .:..|.|.|  ||:.|   |..||...:..:|
  Fly   903 VQQKRRTKP--VKQEA---PKAPTLQARNSLP--------------------------------- 929

  Fly  1327 STGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQ 1391
                                 |.||......||.|
  Fly   930 ---------------------PPPTTLIVAAPLPT------------------------------ 943

  Fly  1392 KSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDD 1456
                                  ..|...||.:.:.::.....:.|..:.|      .||.:||:|
  Fly   944 ----------------------RPASAVTRINTIPESPGTIDVESSKQMV------DDVFRFLND 980

  Fly  1457 LFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLD-DYINDIFQPIPLVQNLEKLTSK 1520
              .|  |.:|.:|::..|      |.:........:.||..| .|:
  Fly   981 --EP--DAALRKLNNISS------GDTIRLPKSVPNNIDTSDFSYL------------------- 1016

  Fly  1521 DQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTD 1585
             :.||...|||..::.|.:..:..:         |....|:    |::.||......:|..|...
  Fly  1017 -KYAATYFGGGATAQHERKPLKKSL---------LKHEHPI----DEMASKAIWLTILRFMGDLP 1067

  Fly  1586 SNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAA 1650
            ...:.|.||                                       :..|:.|.:.|     |
  Fly  1068 DVVSSPTLH---------------------------------------VFDNENLMSDL-----A 1088

  Fly  1651 AAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDP 1715
            :..|.|.|..|
  Fly  1089 SLLNTSDSYKP------------------------------------------------------ 1099

  Fly  1716 SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGM 1780
               |.|                                    :||.||:
  Fly  1100 ---RLF------------------------------------VRQSQRR---------------- 1109

  Fly  1781 MESGPGARGASATAIEWEEFEIESPTPPPM-SGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDV 1844
                                     .|.|: ||                         ::|.|:.
  Fly  1110 -------------------------IPKPLASG-------------------------EKEAQEF 1124

  Fly  1845 GQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPA 1909
            .|...:|.|:.|.|..|.||.        |.:|.|
  Fly  1125 YQHWLNVPTSHLEKIHFIIGH--------GIIKNS------------------------------ 1151

  Fly  1910 KLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLL 1974
             |.|.....:.:||                                 .|:|..:..|.||  :||
  Fly  1152 -LRDEILAQICKQL---------------------------------YLNPSRSSYSRGW--LLL 1180

  Fly  1975 PPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDT 2039
                            |:.....||         |.|.||            |:.:|:::
  Fly  1181 ----------------SLCLSCFPP---------SKEFEP------------HLRSFMKQ----- 1203

  Fly  2040 FGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPA 2104
             |..:.|...|...|                                         :|..|.||.
  Fly  1204 -GTAQLQATPSLQRL-----------------------------------------ERTLVNGPR 1226

  Fly  2105 SGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATF 2169
            ....|             |:|:..:   |..|      |.|:....||
  Fly  1227 CQPPS-------------LFELHAI---RGRH------PLRLDIHLMD----------------- 1252

  Fly  2170 RTHMAQKYEHERKRKSSASSGMREELD----SMHMTTPPPVIVPAPVPPPSSTSPGLGVV---SG 2227
                    ..:|:.:..|:|..||.::    .|.:|                .:.|.|:|   :|
  Fly  1253 --------GQQRRLQVDAASTAREAVNQLCQGMGLT----------------DTFGFGLVMSLNG 1293

  Fly  2228 VLMGSGSGGSTACLTYNR-------VPWKLRVRKEVFQP-HEPIGPPVALDLLFAQVLGDV---- 2280
            .||..|:|........:.       .||||.:|||:|.. ::|...|.|..|::.|:|..:
  Fly  1294 KLMPLGAGQEHVLDAISECEQRQLDAPWKLYIRKEMFATWYDPSMDPKATQLIYKQILNGLKCGE 1358

  Fly  2281 --------------------FGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNG 2325
                                :|....||:.|.|.::.        |..|.|:    .|.....|.
  Fly  1359 YRCRSEKDIAMVCALACFVEYGPGEILRLKPSEITAF--------VPSDLLA----PGERAIENW 1411

  Fly  2326 GQVRA-------LVKRHLVDMARD----------------WPLYFARLFAV---QGAPLYPDVSI 2364
            .::.|       .||....|:..:                ||:..:|||.|   :|..|..|..:
  Fly  1412 SRLIAATYEKSSYVKEEQNDLLLEAQKRAKEDICLFAHLSWPMRHSRLFEVVRKEGPKLQSDELM 1476

  Fly  2365 MGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMV 2429
            :|::.:||:|......   |:.:..|.|:                     |.:|......:..|.
  Fly  1477 LGINSAGLFLIDETEQ---VLASCCFSEV---------------------LKVHVESDDKLHVMT 1517

  Fly  2430 ---TTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQS 2491
               ..||.:           .|.|:.|.:.:|..|:.|..|.::....:..|:|
  Fly  1518 FQHVNFVLQ-----------CSSAQDANEVINYMLDNLRQRSSYGVALDPVVEG----------- 1560

  Fly  2492 ELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAM--------EEQHMATDHQ----QQQQQQLGQQQ 2544
                                      .|||.:        |.:...|..|    ..|....|...
  Fly  1561 --------------------------DLEDCLVLNPGDLIEFEAGVTGAQLMAGNAQDCYRGCVN 1599

  Fly  2545 GQQQRFLKQQSYLHSARKSNAG--QQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDE 2607
            ||..:||             ||  :..::||......|:.:   ::.:.|..|.....|||.:..
  Fly  1600 GQWGQFL-------------AGNVRVLATLTKPSEKLQDIL---REGRFQEPPKPTPRANYSRRR 1648

  Fly  2608 SNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLRLPN 2672
                      ::::.|.|..|||  :..|:|:             |.|.|:....::.|||:...
  Fly  1649 ----------QHNISQLAESHFR--EPLDSDK-------------APLSKFSPEPLKAPLLKAVV 1688

  Fly  2673 DLAPL---ALECFDCILRYCGDI-----PLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQT 2729
            .:.||   ||.....||:|.|||     |::.||        :.....::..|.||:|||||||.
  Fly  1689 KVPPLFQQALVMHHHILKYMGDIARSNLPVNTDL--------IFQPALQHPLLCDELYCQLMKQL 1745

  Fly  2730 TANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTA 2794
            :.|  |..:|.:|.|.||.:.......|..:...|:..|       |......|..||..|:::.
  Fly  1746 SDN--PSSESEKRGWDLLYLATGLVAPSVLVMRELIILL-------RMRADALADACLKRLKRSL 1801

  Fly  2795 RCGGRKNVPSVEEVTAVSAGRSARRQIYR---LPGGAERVVNTRCSTVVADVIAELCALLGVESE 2856
            ..|.||..|.:.||..:   :.....||.   .|............|..|::||::...|.::|.
  Fly  1802 AQGQRKKAPHLIEVEGI---QQRCLHIYHKIYFPDDTVEAFEIESHTRGAELIADIAQRLELKSP 1863

  Fly  2857 AEQQEFSLYCIVQGDAFTMPLAADEYILDVTTEL------------LKSGQPFYLIFCRSVWHFA 2909
            .   .:|::.......:.||  .:|::.|..|:|            :..|| :.|.|.|.:|
  Fly  1864 V---GYSIFLKTGDRVYAMP--EEEFVFDFITQLIYWLRQQRTIRSISDGQ-YQLHFMRKLW--- 1919

  Fly  2910 LKREPAPMPLYVEVLFN--QVAPDYLEGLLLELPGNGVPVPEMVRDMARIAALLHRA---ADLSH 2969
            |...|.. .|..:::|:  |....||:|.          .|......:|:|.|::.|   ..|..
  Fly  1920 LNNHPGE-DLNGDMIFSYPQELHKYLKGY----------YPIDCEQASRLAILVYSADHDVSLQR 1973

  Fly  2970 VPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQV--ANLSPGQVKAQFLNVLATWPLFGSSF 3032
            :|.:  :..|:|:..:.::.:  |:|   .|...|:|  .:|:....|..||..|:.:..|||:|
  Fly  1974 LPEV--LTRLIPEDLIPLQTV--AEW---RQQILPKVHRDHLTEDHAKILFLQELSHFACFGSTF 2031

  Fly  3033 FAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDGA 3097
            |.||          :.|...:...|::|:|..|...|||.|.|.|:.:.:.::    .:.| .|.
  Fly  2032 FVVK----------QQNDDALPETLLIAINSTGFHMLDPTTKEILRSYEYSQL----GIWS-SGK 2081

  Fly  3098 LFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYI 3131
            ....::.||::....:...|.|.:::..|:..|:
  Fly  2082 NHFHIRFGNMIGASKLLCSTTQGYKMDDLLASYV 2115

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	290/680 (43%)
		PTZ00121	<828..>943	CDD:173412	25/114 (22%)
		MyTH4	1014..1171	CDD:470587	22/156 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	3/66 (5%)
		MyTH4	2704..2810	CDD:459939	31/105 (30%)
		FERM_B-lobe	2920..3025	CDD:271216	24/111 (22%)
		FERM_C_MyoXV	3029..3138	CDD:270022	25/103 (24%)
Myo28B1	NP_723294.1	MYSc_Myo7	81..726	CDD:276832	290/680 (43%)
		IQ	765..785	CDD:197470	10/19 (53%)
		Atrophin-1	<820..>946	CDD:460830	45/391 (12%)
		MyTH4	1031..1239	CDD:470587	73/597 (12%)
		FERM1_F1_Myosin-VII	1243..1334	CDD:340612	27/131 (21%)
		B41	1248..1429	CDD:214604	44/233 (19%)
		PH-like	1454..1547	CDD:473070	25/127 (20%)
		MyTH4	1674..1819	CDD:214535	47/164 (29%)
		FERM2_F1_Myosin-VII	1825..1919	CDD:340613	21/99 (21%)
		B41	1827..2032	CDD:214604	50/231 (22%)
		FERM_C2_MyoVII	2028..2121	CDD:270020	25/103 (24%)