DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and MYO15A

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_016880204.1	Gene:	MYO15A / 51168	HGNCID:	7594	Length:	3531	Species:	Homo sapiens

Alignment Length:	3240	Identity:	917/3240 - (28%)
Similarity:	1345/3240 - (41%)	Gaps:	945/3240 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PWQRGG-----GGSVTPSPAQSP-------------SLALLSPHV-----LRRQRPASLEDFEDL 93
            ||.|.|     ...:.|..|..|             ..|::.|.|     .:|..||:|:
Human  1077 PWHRWGTLPQAAAPLAPIRAPEPLPKGGERRQAAPGRFAVVMPRVQKLSSFQRVGPATLK----- 1136

  Fly    94 PNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDV------IARHPQTFALQPGEG-------- 144
            |.:.......|.:...|..|.:         |.:|.      :..|||:..|.||..
Human  1137 PQVQPIQDPKPRACSLRWSCLW---------LRADAYGPWPRVHTHPQSCHLGPGAACLSLRGSW 1192

  Fly   145 -------------------SLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGS 190
                               |:|.|:..|..||||||.|:||.|.::|.||::|:::.||||:.||
Human  1193 EEVGPPSWRNKMHSIRNLPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGS 1257

  Fly   191 ILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGK 252
            ||::||||:|| ..||.|..:||.||.||..||||||:...|.|.:   ...|.::|||||||||
Human  1258 ILVSVNPYQMF-GIYGPEQVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGK 1321

  Fly   253 TESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA 317
            ||:|||:::||||:.........||  |||||.||||:||||:|.||||||||||::|::.:.|.
Human  1322 TEATKLILRYLAAMNQKREVMQQVI--QILEATPLLESFGNAKTVRNDNSSRFGKFVEIFLEGGV 1384

  Fly   318 IVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG 382
            |.||..:||||||||||.||..|||||:|||||.||....|..:.|.||:.|:|||||.....:|
Human  1385 ISGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAG 1449

  Fly   383 RV---DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWA 444
            :.   |:..|..||:|||.|..:::.|.|:||::||||||||.:.: ...||...|.|..||:..
Human  1450 KSDADDFRRLLAAMEVLGFSSEDQDSIFRILASILHLGNVYFEKYE-TDAQEVASVVSAREIQAV 1513

  Fly   445 AHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQK 509
            |.||.||.:||.:|:|.:.||...|::.|||.::.|:|||||.||.|||.||:||::|:|::|..
Human  1514 AELLQISPEGLQKAITFKVTETMREKIFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALVSP 1578

  Fly   510 GGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAW 574
              ..|...|:||||:|||||:.||||||||||||||||..|||.||:.||.||.||:::|..:.:
Human  1579 --RQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITF 1641

  Fly   575 DDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYA 639
            .||.|.|:|::.||.||..:|||:..||:|||.:||:||||:|..:.||::|::...||.:.|||
Human  1642 ADNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYA 1706

  Fly   640 GQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPR 704
            |:|.|.|..|||||.|.:|.|||:|...||..:|..|... .|.:.|.:.|.|.|:   ||...:
Human  1707 GKVTYQVHKFLDKNHDQVRQDVLDLFVRSRTRVVAHLFSS-HAPQAAPQRLGKSSS---VTRLYK 1767

  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
            ..||||:|..||..|::.|.||:|.|:||:|||.:|.....:...|:.||||.|:|:|::||:.|
Human  1768 AHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEG 1832

  Fly   770 YPVRLRFQHFVERY------RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR 828
            :||||.||.|::||      :|.||   |.|.....:...|.:.||..      |::|.:::||:
Human  1833 FPVRLPFQGFIDRYCCLVALKHDLP---ANGDMCVSVLSRLCKVMPNM------YRVGVSKLFLK 1888

  Fly   829 EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGA 893
            |.|::.|||.|...|..||:::||.:||..::|:....:.....||:|.||..|:|||:::|:..
Human  1889 EHLYQLLESMREHVLNLAALTLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSL 1953

  Fly   894 LTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIY 958
            :..:.|.....:|||..:||::.|.:.|.  |....:|....::.|    .:.:|::|||||.:.
Human  1954 VKFRSLVHAYVSRRRYLKLRAEWRCQVEG--ALLWEQEELSKREVV----AVGHLEVPAELAGLL 2012

  Fly   959 SKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQ-----------LPEDLGQFSFGKFSSVYCN---- 1008
            ..:.|             ||....|..:.|:           ||.|:..:...||  |.|:
Human  2013 QAVAG-------------LGLAQVPQVAPVRTPRLQAEPRVTLPLDINNYPMAKF--VQCHFKEP 2062

  Fly  1009 --GLRLQPRREPIT-APLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKAL 1070
              |:...|.|.|:| .|.        :...:|:::||||||:..|..|.||:|.:..:|||.|.|
Human  2063 AFGMLTVPLRTPLTQLPA--------EHHAEAVSIFKLILRFMGDPHLHGARENIFGNYIVQKGL 2119

  Fly  1071 SSRGLRDEILVQLCNQV-HGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLR 1134
            :...||||||.||.||| |.  .|:..|.|.|.||..||..|.||..|:|||::||.|......:
Human  2120 AVPELRDEILAQLANQVWHN--HNAHNAERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQ 2182

  Fly  1135 PLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS 1199
            .:...:|::..|.....   |:||.|:..|..|||.|......|||.:...:....:..|.||::
Human  2183 AVCQHRLMQAMGRAQQQ---GSGAARTLPPTQLEWTATYEKASMALDVGCFNGDQFSCPVHSWST 2244

  Fly  1200 CEEAAALAVSSLGVAS--RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGA 1262
            .||.|...:...|:|.  ||||:.:.:|.|..:..|.|||:||:::.||...||..:|
Human  2245 GEEVAGDILRHRGLADGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKS------- 2302

  Fly  1263 KFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSS 1327
                                                              ||         ...:
Human  2303 --------------------------------------------------YF---------IVGT 2308

  Fly  1328 TGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQK 1392
            .|.|.||        .|..|......||.|.:.|                           |.|.
Human  2309 EGPAASR--------GGPKVVFGNSWDSDEDMST---------------------------RPQP 2338

  Fly  1393 SQHAGRRSHAASHGSHSSKYAD---KAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFL 1454
            .:|..:...:..:.||:....:   :|:..|.:...||:...|:         ||.:.  :|.:|
Human  2339 QEHMPKVLDSDGYSSHNQDGTNGETEAQRGTATHQESDSLGEPA---------VPHKG--LDCYL 2392

  Fly  1455 DDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTS 1519
            |.||.|||.....:|....::|..::||.                      ||
Human  2393 DSLFDPVLSYGDADLEKPTAIAYRMKGGG----------------------QP------------ 2423

  Fly  1520 KDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGST 1584
                     |||.:|..|:......            ||.|: .|||..|    ||
Human  2424 ---------GGGSSSGTEDTPRRPP------------EPKPI-PGLDAST----LA--------- 2453

  Fly  1585 DSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQ-TLLSQQA 1648
                                         :|:||:..        |..|||:...|| |.|.||.
Human  2454 -----------------------------LQQAFIHK--------QAVLLAREMTLQATALQQQP 2481

  Fly  1649 AAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECK 1713
            .:||..:..:..|..|.....|:...||..|:.::||                |.|..|.||
Human  2482 LSAALRSLPAEKPPAPEAQPTSVGTGPPAKPVLLRAT----------------PKPLAPAPL--- 2527

  Fly  1714 DPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNG 1778
                          ||..|:
Human  2528 --------------AKAPRL--------------------------------------------- 2533

  Fly  1779 GMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQD 1843
                   ..:..:|..:..::...|:.:|.|   :|:|.|..........|..:.|..|..:
Human  2534 -------PIKPVAAPVLAQDQASPETTSPSP---ELVRYSTLNSEHFPQPTQQIKNIVRQYQ--- 2585

  Fly  1844 VGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAP 1908
              ||.:......|.|...::...||.|
Human  2586 --QPFRGGRPEALRKDGGKVFMKRPDP-------------------------------------- 2610

  Fly  1909 AKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVL 1973
               .:...::|:.|:..|.|:       ||..|...|.                         .|
Human  2611 ---HEEALMILKGQMTHLAAA-------PGTQVSREAV-------------------------AL 2640

  Fly  1974 LPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERD 2038
            :.|..|.|.       |||||.:..|       :||.|| |:
Human  2641 VKPVTSAPR-------PSMAPTSALP-------SRSLEP-PE----------------------- 2667

  Fly  2039 TFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGP 2103

Human  2668 ----------------------------------------------------------------- 2667

  Fly  2104 ASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLAT 2168
                         |..:.||            |::..|                          .
Human  2668 -------------ELTQTRL------------HRLINP--------------------------N 2681

  Fly  2169 FRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSG 2233
            |
Human  2682 F---------------------------------------------------------------- 2682

  Fly  2234 SGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSS-- 2296
                   ..|...|||:.:|||||.|.:....||.|||||.|:|.|... ..||||:..|:..
Human  2683 -------YGYQDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLS-EACLRISEDERLRMK 2739

  Fly  2297 ---ALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARD-WPLYFARLFAVQGAP 2357
               |.|.|       ||             ....|...|||.:|..||| |.:||:|:|...|:
Human  2740 ALFAQNQL-------DT-------------QKPLVTESVKRAVVSTARDTWEVYFSRIFPATGS- 2783

  Fly  2358 LYPDVSIMGVSHSGLYLAR------RDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLA 2416
            :...|.::.|||.|:.|.|      .....|.|::|.||.:| ..||:|....|:.||.:.| :.
Human  2784 VGTGVQLLAVSHVGIKLLRMVKGGQEAGGQLRVLRAYSFADI-LFVTMPSQNMLEFNLASEK-VI 2846

  Fly  2417 LHAARAAAIQSMVTTFVQEFRKSQSKASTLSS-------------GARAAAQTLNVP-------- 2460
            |.:|||..::::|..|:.|.:|.......:.:             |.....|.|..|
Human  2847 LFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRVGYSAGC 2911

  Fly  2461 --------LERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQ 2517
                    ||.|..|         |.|.|.|
Human  2912 VVRRKVVYLEELRRR---------GPDFGWR---------------------------------- 2933

  Fly  2518 QLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVH---- 2578
                                  .|...|:..||  ....:..|...:..|.|:....|:..
Human  2934 ----------------------FGTIHGRVGRF--PSELVQPAAAPDFLQLPTEPGRGRAAAVAA 2974

  Fly  2579 --HQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDAD--- 2638
              ......|:..::.:..|.....|::.:|..  ..||    |::|:||.::||:.|.|..|
Human  2975 AVASAAAAQEVGRRREGPPVRARSADHGEDAL--ALPP----YTMLEFAQKYFRDPQRRPQDGLR 3033

  Fly  2639 -RHHERHQSAANRSYAELVKWQGHAIRLPLLRL-PNDLAPLALECFDCILRYCGDIPL--DPDLT 2699
             :..|..:|   |:..:::.:....::..|:.| .:.|:.:|.:.|..::|:.||.||  ..||
Human  3034 LKSKEPRES---RTLEDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDAPLKGQSDL- 3094

  Fly  2700 EVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYL 2764
            :|.|  .:|..|..:..:|||.|||::||.|.|.|...||.||.||||.|:.||..||:.|.|:|
Human  3095 DVLC--NLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHL 3157

  Fly  2765 MEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAE 2829
            ...|...:........|.|..|..||:||.|.|||..:||..|:.|:.||||::||::.||||.|
Human  3158 TRFLQDVSRTPGLPFQGIAKACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFLLPGGLE 3222

  Fly  2830 RVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLKSG 2894
            |.:..:..||..||:.|:||.:.:.......|:.::.:........||:...|||||.:|:.:..
Human  3223 RHLKIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQHVCPLSRRAYILDVASEMEQVD 3287

  Fly  2895 QPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVPVPEMVRDMARIAA 2959
            ..:.|.|.|.:|...||.|   ..|||.:.:|||.||||:||...:|.:. |..::::.::::|:
Human  3288 GGYMLWFRRVLWDQPLKFE---NELYVTMHYNQVLPDYLKGLFSSVPASR-PSEQLLQQVSKLAS 3348

  Fly  2960 LLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLNVLAT 3024
            |.|||.|..::|:::|::..:  ||...|....:.|:.||.....|...|||.|.:||||.:|:.
Human  3349 LQHRAKDHFYLPSVREVQEYI--PAQLYRTTAGSTWLNLVSQHRQQTQALSPHQARAQFLGLLSA 3411

  Fly  3025 WPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTR 3089
            .|:||||||.::..          ::..:....|||:|..|:.||...|||.:..:...|:.|||
Human  3412 LPMFGSSFFFIQSC----------SNIAVPAPCILAINHNGLNFLSTETHELMVKFPLKEIQSTR 3466

  Fly  3090 KVR--SEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQISQRDKR 3142
            ..|  :.....::::.:|::..||.:::|.||..|:.|:|..::... :|..:||
Human  3467 TQRPTANSSYPYVEIALGDVAAQRTLQLQLEQGLELCRVVAVHVENL-LSAHEKR 3520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	339/691 (49%)
		MYSc_Myo15	169..828	CDD:276838	326/670 (49%)
		MyTH4	1014..1171	CDD:295320	62/158 (39%)
		MyTH4	2704..2810	CDD:279165	44/105 (42%)
		B41	2823..3033	CDD:214604	72/209 (34%)
		FERM_B-lobe	2920..3025	CDD:271216	37/104 (36%)
		FERM_C_MyoXV	3029..3138	CDD:270022	29/110 (26%)
MYO15A	XP_016880204.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147859
Domainoid	1	1.000	609	1.000	Domainoid score	I191
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1223	1.000	Inparanoid score	I189
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52622
OrthoDB	1	1.010	-	-		D10566at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		oto88484
orthoMCL	1	0.900	-	-		OOG6_100101
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5032
SonicParanoid	1	1.000	-	-		X4354
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.940