|
Fly 53 WQRGGGGSVTP---SPAQSPSLALLSPHVLRRQRPA----------SLEDFE---DLPNLSAKH- 100
|.|....|.|| :|.::|. :||......|.:|. .|..|: ..|....:|
Rat 1062 WHRWKTVSRTPAPLAPTRAPG-SLLKAGKQLRDKPGRFAVVMPQVRGLSSFQQKGSAPLQPPEHS 1125
Fly 101 -------PALPSSRLRRLKCRYPQVVK---------RLSTLCSDVIAR-------HPQTFALQPG 142
||..:..| |:|::.. |:.||.|....| .|:....:.|
Rat 1126 DQDPEHGPATQACSL-----RWPRLWSPADTHSPWPRIHTLSSPSPLRGHGGDCQSPKDLWKKTG 1185
Fly 143 E-------------GSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIA 194
. .|:|:|:.....||||||.|:||.|.::|.||:.|:::.||||:.||||::
Rat 1186 SRSWQNKMHSIRNLPSVRSREQHREDGVEDMTQLEDLQETTVLTNLKTRFERNLIYTYIGSILVS 1250
Fly 195 VNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTEST 256
||||:||. .||.|..:||:||.||..|||||||...|.|.: ...|.|:|||||||||||:|
Rat 1251 VNPYRMFA-IYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEAT 1314
Fly 257 KLVMQYLAAVVPGGGSASAVITE-QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVG 320
||:::.|||: .....|:.: :||||.|||||||||:|.||||||||||::|::.:.|.|.|
Rat 1315 KLLLRCLAAM----NQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEIFLEGGVICG 1375
Fly 321 AKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV- 384
|..:||||||||||.||..|||||:|||||.||....|..:.|.||:.|:|||||.....:|:.
Rat 1376 AITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSD 1440
Fly 385 --DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHL 447
|:..|..||:|||.:..:::.|.|:||::||||||||.:.: ...||...|.|..||:..|.|
Rat 1441 ADDFRRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHE-TDAQEVASVVSAREIQAVAEL 1504
Fly 448 LHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT 512
|.:|.:||.:|:|.:.||...|::.|||.::.|:|||||.||.|||.||.||::|:|::|.. .
Rat 1505 LQVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSP--K 1567
Fly 513 HDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDN 577
.|...|:||||:|||||:.||||||||||||||||..|||.||:.||.||.||:::|..:|:.||
Rat 1568 QDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADN 1632
Fly 578 LPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQV 642
.|.|:|::.||.||..:|||:..||:|||.:||:||||:|..:.||.:|::...||.:.||||:|
Rat 1633 QPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYCKPKMPLPEFTIKHYAGKV 1697
Fly 643 WYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPT 707
.|.|..|||||.|.:|.|||:|...||..:|..|.....|| .|...|.|.|: :|...:..|
Rat 1698 TYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQ-TAPPRLGKSSS---ITRLYKAHT 1758
Fly 708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
|||:|..||..|::.|.||:|.||||:|||.:|.....:...::.||||.|:|:|::||:.|:||
Rat 1759 VAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPV 1823
Fly 773 RLRFQHFVERYRHLLPSPL---ARGTPYRELCRALLEAMPRTGVEGPD-YQLGATRVFLREALHR 833
||.||.|::|||.|:...| |.| ::|.:||. |.....|| |::|.:::||:|.||:
Rat 1824 RLPFQVFIDRYRCLVALKLNVPADG----DMCVSLLS---RLCTVTPDMYRVGVSKLFLKEHLHQ 1881
Fly 834 ALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898
.|||.|...|.|||:::||::||...:|:....:.....||:|.||..|:|||:::|:..|..:.
Rat 1882 LLESMRERVLNRAALTLQRYLRGFFTQRRFRSLRQKIILLQSRARGFLARQRYQQMRQSLLKFRS 1946
Fly 899 LWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQG 963
|......|||..:||::.||| |:||..|.:|....::.|..| :|::|||:|.:.....|
Rat 1947 LVHTYVNRRRYLKLRAERRRR--AQEAWLREQEELSKREVVPVR----HLEVPAEVAGLLQAAAG 2005
Fly 964 WSPPHGDRHLVKVLGTVPGPPSSA---VQLPEDLGQFSFGKFSSVYCN------GLRLQPRREPI 1019
..|.. |..:..|..|...| |.||.|:..:...|| :.|: |:...|.:.|:
Rat 2006 LKPSS-----VPQVAIVRAPRLQAEPCVTLPLDINNYPMAKF--IRCHFKEPSFGMLTVPLKMPL 2063
Fly 1020 TAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLC 1084
|..|:...| :|::|||||||:..|..|.|.:|.:|.:||||:.|....||||||.||.
Rat 2064 TQMLVEHHA-------EAISVFKLILRFMGDPHLHGTQEMILGNYIVHQGLVEPALRDEILAQLA 2121
Fly 1085 NQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGT 1149
||| ...||:..|.|.|.||..||..|.||:...|:|::||.|......:.:...:||:
Rat 2122 NQV-WRNPNAYNAKRGWLLLAACLSGFAPSSHLDKFLLKFVSDYGQNGFQAVCQHRLLQ------ 2179
Fly 1150 SSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVA 1214
|:|:||.|:|.|..|||.|......|||.::..:....:..|..|::.|..|...:...|:|
Rat 2180 ---AMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHPWSTGEAVAGDILKHRGLA 2241
Fly 1215 S--RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPA 1277
. ||||:.:.:|.|..:..|.|||:||:::.||...||..:|..: .||:
Rat 2242 DGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFI-VGAE-------------- 2291
Fly 1278 VPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLL 1342
.|..|:|.:.|
Rat 2292 -----------------------------------------GPLAGRGDTRG------------- 2302
Fly 1343 AGDIVPVPTDC-DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHG 1406
|..:| ||.| ||..|.|...|..:......:.
Rat 2303 ------VFGNCWDSDE---------------------------DTPTRPQPQDHVAKMPDFDGYC 2334
Fly 1407 SHSSKYAD----KAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLD 1467
||.....: ...:|:...|:.:|.| |: ||.: ::|.:||.||.|||
Rat 2335 SHKEDGTNGETAAQRWASNRQAVDNTGE-PA---------VPPR--ELDGYLDSLFDPVL----- 2382
Fly 1468 ELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGV 1532
|..::| |||.|: :|..:||||.
Rat 2383 ----------------------ACGDVD------------------LEKPTA---IAYRMKGGGQ 2404
Fly 1533 ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLM 1597
.......|....:.: ...:||| |||..| ||
Rat 2405 PGSSASEDTPRRLPE------PKLKPIP---GLDAST----LA---------------------- 2434
Fly 1598 QLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPP-P 1661
:|:||:.. |..|||:...||.|..||...:|.:....|. |
Rat 2435 ----------------LQQAFIHR--------QAVLLAREMTLQALALQQQPLSATSRPQLPERP 2475
Fly 1662 APPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYG 1726
.||.....::...||..|:.::.|..|| ...|:...|..|..|:..|:..:|
Rat 2476 LPPEARPKTVGTGPPAKPVLVRPTPQSL-APGSVAKSPKIPSKPVAAPILARD------------ 2527
Fly 1727 RAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGAS 1791
|..|:. :.|.|
Rat 2528 -----------WTAPES-------------------------------------ISSSP------ 2538
Fly 1792 ATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKL 1856
:|:| .|.:|:....:.||.: :|::
Rat 2539 ---------------------ELVR------------YSTLNSEHFPQPTQQI----KSII---- 2562
Fly 1857 AKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGH-SVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
|.:: :|| .||| ..|.|...|..:|.|...|:. ||:.
Rat 2563 --KQYK----QPP--------------------WAGHPEARRTDGGKVFRRPPDPHEEA--LMIL 2599
Fly 1921 QQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPP 1985
:......|.|.| ||:.|. ...|:.|..|.|
Rat 2600 KGQKTQLAVVPG----------------TQVSRE---------------AVALVKPVTSAP---- 2629
Fly 1986 PIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMIS 2050
||...|.|..| :||.||..| |. |.|:
Rat 2630 --RPCMGAAPVQP--------SRSLEPPED-------------PV--------------QTQL-- 2655
Fly 2051 SHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK 2115
Rat 2656 ----------------------------------------------------------------- 2655
Fly 2116 RERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHE 2180
|::..| .|
Rat 2656 --------------------HRLVNP--------------------------NF----------- 2663
Fly 2181 RKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNR 2245
..|..
Rat 2664 ------------------------------------------------------------YGYQD 2668
Fly 2246 VPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSS-----ALNMLHGHG 2305
.||::.:|||||.|.:....||.|||||.|:|.|... ..||||:..|:.. |.|.|
Rat 2669 APWRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTLS-EACLRISEDERLQMKALFAQNQL---- 2728
Fly 2306 VSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARD-WPLYFARLFAVQGAPLYPDVSIMGVSH 2369
|| ....|...|||..::|||| |.:||:|||...|: :...|.|:.|||
Rat 2729 ---DT-------------QRPLVTESVKRAAINMARDSWEIYFSRLFPAMGS-VGTGVQILAVSH 2776
Fly 2370 SGLYLAR-----RDAD-YLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSM 2428
:|:.|.| |:|. .|.|:.|.||.:| ..||:|....|:.||.|.| :.|.:|||..::::
Rat 2777 TGVKLLRMAKGNREASRRLRVLCAYSFADI-LFVTMPSQNMLEFNLTNEK-VILFSARARQVKTL 2839
Fly 2429 VTTFVQEFRKSQS-------------KASTLSSGARAAAQTLNVP----------------LERL 2464
|.||:.|.:|... :..:...|.....|:|..| ||.|
Rat 2840 VDTFILELKKDSDYVVAVRNFLSEDPELLSFHKGDIIHLQSLEPPRIGYSAGCVVRKKLVYLEEL 2904
Fly 2465 ESRQAHAQRNEHGVDGGSR-----------QNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQ 2518
..| |.|.|.| .:|.:|.:.....||...: ..:.:...
Rat 2905 RRR---------GPDFGWRFGAVHGRVGRFPSELVQPAAAPDFLQLPAE--------PGRGRAAA 2952
Fly 2519 LEDAMEEQHMATDHQQQQQQQLG-QQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQ 2582
:..|:.....| :::| :::|...| ||.:::|:...:|
Rat 2953 VAAAVASAAAA--------REVGRRREGPPVR----------ARSADSGEDSVAL---------- 2989
Fly 2583 MLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDAD----RHHER 2643
||| ::|:||.::||:.:.|..| :..|.
Rat 2990 ------------------------------PPS----TMLEFAQKYFRDPRRRPRDGLKLKSKED 3020
Fly 2644 HQSAANRSYAELVKWQGHAIRLPLLRL-PNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTV 2707
.:| ::..:::.:....|:..|:.| .::|..:|::.|..::|:.||.||... .|:..:.|:
Rat 3021 RES---KTLEDMLCFTKVPIQESLIELSDSNLNKMAVDMFVAVMRFMGDAPLKGQ-NELDVLCTL 3081
Fly 2708 LMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAA 2772
|..|..:..:|||.|||::||.|.|.|...||.||.||||.|||||:.||:...|||:..|...:
Rat 3082 LKFCGDHEVMRDECYCQIVKQITDNTSSKQDSCQRGWRLLYILAAYYSCSEVFYPYLIRFLQHVS 3146
Fly 2773 SDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCS 2837
........|.|..|..||:||.|.|||...||..|:.|:.||||::||::.||||.||.:..:..
Rat 3147 WTPGLPFQGIAKACEQNLQKTLRFGGRLEFPSSMELRAMLAGRSSKRQLFLLPGGLERHLKIKTC 3211
Fly 2838 TVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLKSGQPFYLIFC 2902
||..|||..||:.:.:.......|:.::.:........||:...|||||.:.:.:....:.|.|.
Rat 3212 TVALDVIEGLCSEMALTRPEAFDEYVIFVVTNRGQHVCPLSCQAYILDVASGMEQVDGGYTLWFR 3276
Fly 2903 RSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVPVPEMVRDMARIAALLHRAADL 2967
|.:|...||.| ..|||.:.:|||.||||:||...:|.: .|..:.::.::::|:|.|||.|.
Rat 3277 RVLWDQPLKFE---NELYVTMHYNQVLPDYLKGLFSSVPAS-QPTEQQLQQVSKLASLQHRAKDH 3337
Fly 2968 SHVPAMKEIKFLLPKPALGIREIRPAQ---------WVGLVQSAWPQVANLSPGQVKAQFLNVLA 3023
.::|:::| ::|..||| |:.||.....|...|||.|.:||||.:|:
Rat 3338 FYLPSVRE-----------VQEYIPAQLYHTTAGDTWLNLVSQHRQQTQALSPHQARAQFLGLLS 3391
Fly 3024 TWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVIS- 3087
.:||||||||.::.......| :| .|||:|..|:.||...|||.:......|:.|
Rat 3392 AFPLFGSSFFFIQSCSNVLVP------AP----CILAVNHNGLNFLSTKTHELIVKIPLKEIQST 3446
Fly 3088 -TRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQISQRDKR 3142
|::..:.....::::.:|::..||.:::|.||..|:.|:|..::. :.:|.|::|
Rat 3447 WTQQPTANSSYPYVEISLGDVAAQRTMQLQLEQGLELCRVVAVHVE-SMLSAREER 3501
| 
