DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myo15a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_008766109.1 Gene:Myo15a / 501699 RGDID:1561873 Length:3512 Species:Rattus norvegicus


Alignment Length:3241 Identity:937/3241 - (28%)
Similarity:1374/3241 - (42%) Gaps:952/3241 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 WQRGGGGSVTP---SPAQSPSLALLSPHVLRRQRPA----------SLEDFE---DLPNLSAKH- 100
            |.|....|.||   :|.::|. :||......|.:|.          .|..|:   ..|....:| 
  Rat  1062 WHRWKTVSRTPAPLAPTRAPG-SLLKAGKQLRDKPGRFAVVMPQVRGLSSFQQKGSAPLQPPEHS 1125

  Fly   101 -------PALPSSRLRRLKCRYPQVVK---------RLSTLCSDVIAR-------HPQTFALQPG 142
                   ||..:..|     |:|::..         |:.||.|....|       .|:....:.|
  Rat  1126 DQDPEHGPATQACSL-----RWPRLWSPADTHSPWPRIHTLSSPSPLRGHGGDCQSPKDLWKKTG 1185

  Fly   143 E-------------GSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIA 194
            .             .|:|:|:.....||||||.|:||.|.::|.||:.|:::.||||:.||||::
  Rat  1186 SRSWQNKMHSIRNLPSVRSREQHREDGVEDMTQLEDLQETTVLTNLKTRFERNLIYTYIGSILVS 1250

  Fly   195 VNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTEST 256
            ||||:||. .||.|..:||:||.||..|||||||...|.|.:   ...|.|:|||||||||||:|
  Rat  1251 VNPYRMFA-IYGPEQVQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEAT 1314

  Fly   257 KLVMQYLAAVVPGGGSASAVITE-QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVG 320
            ||:::.|||:    .....|:.: :||||.|||||||||:|.||||||||||::|::.:.|.|.|
  Rat  1315 KLLLRCLAAM----NQRRDVMQQIKILEATPLLEAFGNAKTVRNDNSSRFGKFVEIFLEGGVICG 1375

  Fly   321 AKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV- 384
            |..:||||||||||.||..|||||:|||||.||....|..:.|.||:.|:|||||.....:|:. 
  Rat  1376 AITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSD 1440

  Fly   385 --DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHL 447
              |:..|..||:|||.:..:::.|.|:||::||||||||.:.: ...||...|.|..||:..|.|
  Rat  1441 ADDFRRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHE-TDAQEVASVVSAREIQAVAEL 1504

  Fly   448 LHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT 512
            |.:|.:||.:|:|.:.||...|::.|||.::.|:|||||.||.|||.||.||::|:|::|..  .
  Rat  1505 LQVSPEGLQKAITFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITRVNALVSP--K 1567

  Fly   513 HDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDN 577
            .|...|:||||:|||||:.||||||||||||||||..|||.||:.||.||.||:::|..:|:.||
  Rat  1568 QDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQMDWREIAFADN 1632

  Fly   578 LPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQV 642
            .|.|:|::.||.||..:|||:..||:|||.:||:||||:|..:.||.:|::...||.:.||||:|
  Rat  1633 QPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYCKPKMPLPEFTIKHYAGKV 1697

  Fly   643 WYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPT 707
            .|.|..|||||.|.:|.|||:|...||..:|..|.....|| .|...|.|.|:   :|...:..|
  Rat  1698 TYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFSSHAAQ-TAPPRLGKSSS---ITRLYKAHT 1758

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            |||:|..||..|::.|.||:|.||||:|||.:|.....:...::.||||.|:|:|::||:.|:||
  Rat  1759 VAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPV 1823

  Fly   773 RLRFQHFVERYRHLLPSPL---ARGTPYRELCRALLEAMPRTGVEGPD-YQLGATRVFLREALHR 833
            ||.||.|::|||.|:...|   |.|    ::|.:||.   |.....|| |::|.:::||:|.||:
  Rat  1824 RLPFQVFIDRYRCLVALKLNVPADG----DMCVSLLS---RLCTVTPDMYRVGVSKLFLKEHLHQ 1881

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898
            .|||.|...|.|||:::||::||...:|:....:.....||:|.||..|:|||:::|:..|..:.
  Rat  1882 LLESMRERVLNRAALTLQRYLRGFFTQRRFRSLRQKIILLQSRARGFLARQRYQQMRQSLLKFRS 1946

  Fly   899 LWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQG 963
            |......|||..:||::.|||  |:||..|.:|....::.|..|    :|::|||:|.:.....|
  Rat  1947 LVHTYVNRRRYLKLRAERRRR--AQEAWLREQEELSKREVVPVR----HLEVPAEVAGLLQAAAG 2005

  Fly   964 WSPPHGDRHLVKVLGTVPGPPSSA---VQLPEDLGQFSFGKFSSVYCN------GLRLQPRREPI 1019
            ..|..     |..:..|..|...|   |.||.|:..:...||  :.|:      |:...|.:.|:
  Rat  2006 LKPSS-----VPQVAIVRAPRLQAEPCVTLPLDINNYPMAKF--IRCHFKEPSFGMLTVPLKMPL 2063

  Fly  1020 TAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLC 1084
            |..|:...|       :|::|||||||:..|..|.|.:|.:|.:||||:.|....||||||.||.
  Rat  2064 TQMLVEHHA-------EAISVFKLILRFMGDPHLHGTQEMILGNYIVHQGLVEPALRDEILAQLA 2121

  Fly  1085 NQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGT 1149
            ||| ...||:..|.|.|.||..||..|.||:...|:|::||.|......:.:...:||:      
  Rat  2122 NQV-WRNPNAYNAKRGWLLLAACLSGFAPSSHLDKFLLKFVSDYGQNGFQAVCQHRLLQ------ 2179

  Fly  1150 SSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVA 1214
               |:|:||.|:|.|..|||.|......|||.::..:....:..|..|::.|..|...:...|:|
  Rat  2180 ---AMGSGAARTFPPTQLEWTAIQEKASMALDVSCFNGDQFSCPVHPWSTGEAVAGDILKHRGLA 2241

  Fly  1215 S--RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPA 1277
            .  ||||:.:.:|.|..:..|.|||:||:::.||...||..:|..: .||:              
  Rat  2242 DGWRGWTVAMKNGVQWAELAGHDYVLDLVSDLELLRDFPRQKSYFI-VGAE-------------- 2291

  Fly  1278 VPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLL 1342
                                                     .|..|:|.:.|             
  Rat  2292 -----------------------------------------GPLAGRGDTRG------------- 2302

  Fly  1343 AGDIVPVPTDC-DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHG 1406
                  |..:| ||.|                           ||..|.|...|..:......:.
  Rat  2303 ------VFGNCWDSDE---------------------------DTPTRPQPQDHVAKMPDFDGYC 2334

  Fly  1407 SHSSKYAD----KAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLD 1467
            ||.....:    ...:|:...|:.:|.| |:         ||.:  ::|.:||.||.|||     
  Rat  2335 SHKEDGTNGETAAQRWASNRQAVDNTGE-PA---------VPPR--ELDGYLDSLFDPVL----- 2382

  Fly  1468 ELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGV 1532
                                  |..::|                  |||.|:   :|..:||||.
  Rat  2383 ----------------------ACGDVD------------------LEKPTA---IAYRMKGGGQ 2404

  Fly  1533 ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLM 1597
            .......|....:.:      ...:|||   |||..|    ||                      
  Rat  2405 PGSSASEDTPRRLPE------PKLKPIP---GLDAST----LA---------------------- 2434

  Fly  1598 QLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPP-P 1661
                            :|:||:..        |..|||:...||.|..||...:|.:....|. |
  Rat  2435 ----------------LQQAFIHR--------QAVLLAREMTLQALALQQQPLSATSRPQLPERP 2475

  Fly  1662 APPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYG 1726
            .||.....::...||..|:.::.|..|| ...|:...|..|..|:..|:..:|            
  Rat  2476 LPPEARPKTVGTGPPAKPVLVRPTPQSL-APGSVAKSPKIPSKPVAAPILARD------------ 2527

  Fly  1727 RAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGAS 1791
                       |..|:.                                     :.|.|      
  Rat  2528 -----------WTAPES-------------------------------------ISSSP------ 2538

  Fly  1792 ATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKL 1856
                                 :|:|            .|.:|:....:.||.:    :|::    
  Rat  2539 ---------------------ELVR------------YSTLNSEHFPQPTQQI----KSII---- 2562

  Fly  1857 AKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGH-SVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
              |.::    :||                    .||| ..|.|...|..:|.|...|:.  ||:.
  Rat  2563 --KQYK----QPP--------------------WAGHPEARRTDGGKVFRRPPDPHEEA--LMIL 2599

  Fly  1921 QQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPP 1985
            :......|.|.|                ||:.|.               ...|:.|..|.|    
  Rat  2600 KGQKTQLAVVPG----------------TQVSRE---------------AVALVKPVTSAP---- 2629

  Fly  1986 PIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMIS 2050
              ||...|.|..|        :||.||..|             |.              |.|:  
  Rat  2630 --RPCMGAAPVQP--------SRSLEPPED-------------PV--------------QTQL-- 2655

  Fly  2051 SHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK 2115
                                                                             
  Rat  2656 ----------------------------------------------------------------- 2655

  Fly  2116 RERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHE 2180
                                |::..|                          .|           
  Rat  2656 --------------------HRLVNP--------------------------NF----------- 2663

  Fly  2181 RKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNR 2245
                                                                        ..|..
  Rat  2664 ------------------------------------------------------------YGYQD 2668

  Fly  2246 VPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSS-----ALNMLHGHG 2305
            .||::.:|||||.|.:....||.|||||.|:|.|... ..||||:..|:..     |.|.|    
  Rat  2669 APWRIFLRKEVFYPKDNYSHPVQLDLLFRQILHDTLS-EACLRISEDERLQMKALFAQNQL---- 2728

  Fly  2306 VSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARD-WPLYFARLFAVQGAPLYPDVSIMGVSH 2369
               ||             ....|...|||..::|||| |.:||:|||...|: :...|.|:.|||
  Rat  2729 ---DT-------------QRPLVTESVKRAAINMARDSWEIYFSRLFPAMGS-VGTGVQILAVSH 2776

  Fly  2370 SGLYLAR-----RDAD-YLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSM 2428
            :|:.|.|     |:|. .|.|:.|.||.:| ..||:|....|:.||.|.| :.|.:|||..::::
  Rat  2777 TGVKLLRMAKGNREASRRLRVLCAYSFADI-LFVTMPSQNMLEFNLTNEK-VILFSARARQVKTL 2839

  Fly  2429 VTTFVQEFRKSQS-------------KASTLSSGARAAAQTLNVP----------------LERL 2464
            |.||:.|.:|...             :..:...|.....|:|..|                ||.|
  Rat  2840 VDTFILELKKDSDYVVAVRNFLSEDPELLSFHKGDIIHLQSLEPPRIGYSAGCVVRKKLVYLEEL 2904

  Fly  2465 ESRQAHAQRNEHGVDGGSR-----------QNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQ 2518
            ..|         |.|.|.|           .:|.:|.:.....||...:        ..:.:...
  Rat  2905 RRR---------GPDFGWRFGAVHGRVGRFPSELVQPAAAPDFLQLPAE--------PGRGRAAA 2952

  Fly  2519 LEDAMEEQHMATDHQQQQQQQLG-QQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQ 2582
            :..|:.....|        :::| :::|...|          ||.:::|:...:|          
  Rat  2953 VAAAVASAAAA--------REVGRRREGPPVR----------ARSADSGEDSVAL---------- 2989

  Fly  2583 MLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDAD----RHHER 2643
                                          |||    ::|:||.::||:.:.|..|    :..|.
  Rat  2990 ------------------------------PPS----TMLEFAQKYFRDPRRRPRDGLKLKSKED 3020

  Fly  2644 HQSAANRSYAELVKWQGHAIRLPLLRL-PNDLAPLALECFDCILRYCGDIPLDPDLTEVKCVYTV 2707
            .:|   ::..:::.:....|:..|:.| .::|..:|::.|..::|:.||.||... .|:..:.|:
  Rat  3021 RES---KTLEDMLCFTKVPIQESLIELSDSNLNKMAVDMFVAVMRFMGDAPLKGQ-NELDVLCTL 3081

  Fly  2708 LMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAA 2772
            |..|..:..:|||.|||::||.|.|.|...||.||.||||.|||||:.||:...|||:..|...:
  Rat  3082 LKFCGDHEVMRDECYCQIVKQITDNTSSKQDSCQRGWRLLYILAAYYSCSEVFYPYLIRFLQHVS 3146

  Fly  2773 SDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPGGAERVVNTRCS 2837
            ........|.|..|..||:||.|.|||...||..|:.|:.||||::||::.||||.||.:..:..
  Rat  3147 WTPGLPFQGIAKACEQNLQKTLRFGGRLEFPSSMELRAMLAGRSSKRQLFLLPGGLERHLKIKTC 3211

  Fly  2838 TVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELLKSGQPFYLIFC 2902
            ||..|||..||:.:.:.......|:.::.:........||:...|||||.:.:.:....:.|.|.
  Rat  3212 TVALDVIEGLCSEMALTRPEAFDEYVIFVVTNRGQHVCPLSCQAYILDVASGMEQVDGGYTLWFR 3276

  Fly  2903 RSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGNGVPVPEMVRDMARIAALLHRAADL 2967
            |.:|...||.|   ..|||.:.:|||.||||:||...:|.: .|..:.::.::::|:|.|||.|.
  Rat  3277 RVLWDQPLKFE---NELYVTMHYNQVLPDYLKGLFSSVPAS-QPTEQQLQQVSKLASLQHRAKDH 3337

  Fly  2968 SHVPAMKEIKFLLPKPALGIREIRPAQ---------WVGLVQSAWPQVANLSPGQVKAQFLNVLA 3023
            .::|:::|           ::|..|||         |:.||.....|...|||.|.:||||.:|:
  Rat  3338 FYLPSVRE-----------VQEYIPAQLYHTTAGDTWLNLVSQHRQQTQALSPHQARAQFLGLLS 3391

  Fly  3024 TWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVIS- 3087
            .:||||||||.::.......|      :|    .|||:|..|:.||...|||.:......|:.| 
  Rat  3392 AFPLFGSSFFFIQSCSNVLVP------AP----CILAVNHNGLNFLSTKTHELIVKIPLKEIQST 3446

  Fly  3088 -TRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQISQRDKR 3142
             |::..:.....::::.:|::..||.:::|.||..|:.|:|..::. :.:|.|::|
  Rat  3447 WTQQPTANSSYPYVEISLGDVAAQRTMQLQLEQGLELCRVVAVHVE-SMLSAREER 3501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 342/690 (50%)
MYSc_Myo15 169..828 CDD:276838 328/669 (49%)
MyTH4 1014..1171 CDD:295320 63/156 (40%)
MyTH4 2704..2810 CDD:279165 47/105 (45%)
B41 2823..3033 CDD:214604 73/218 (33%)
FERM_B-lobe 2920..3025 CDD:271216 38/113 (34%)
FERM_C_MyoXV 3029..3138 CDD:270022 29/110 (26%)
Myo15aXP_008766109.1 MYSc 1206..1888 CDD:214580 345/700 (49%)
MYSc_Myo15 1225..1876 CDD:276838 328/669 (49%)
MyTH4 2054..2200 CDD:214535 64/162 (40%)
SH3 2853..2932 CDD:302595 13/87 (15%)
MyTH4 3032..3186 CDD:214535 60/154 (39%)
B41 3196..3401 CDD:214604 73/219 (33%)
FERM_B-lobe 3291..3391 CDD:271216 37/111 (33%)
FERM_C_MyoXV 3397..3498 CDD:270022 30/111 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166341717
Domainoid 1 1.000 608 1.000 Domainoid score I182
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1248 1.000 Inparanoid score I164
OMA 1 1.010 - - QHG52622
OrthoDB 1 1.010 - - D10566at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - oto95624
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - LDO PTHR13140
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X4354
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.910

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