DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and MYO10

DIOPT Version :10

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens


Alignment Length:1990 Identity:527/1990 - (26%)
Similarity:835/1990 - (41%) Gaps:479/1990 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 HPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNP 197
            |.:..|:.|          ....||:||..|.:||..|:::||..||.:..|||:.||||.:|||
Human    51 HQKVTAMHP----------TNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNP 105

  Fly   198 YKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLV 259
            |:.....|.....:||:.|.||.||||:|||....:..|   ...|.::||||||:||||||||:
Human   106 YQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLI 170

  Fly   260 MQYLAAVVPGGGSAS-----AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAI 318
            :::|:.:.......|     :.:...|||::|::||||||:|..|:|||||||::::.. :.|.|
Human   171 LKFLSVISQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNI 235

  Fly   319 VGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGR 383
            .|.:|..|||||:|:|.|.|||||||:||.||.||...||.::.|...:.|.||||  :.|...:
Human   236 QGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYHYLNQ--SGCVEDK 298

  Fly   384 V--DWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW 443
            .  |.||.:   .||.|:..|:.|...:.|:||.:|||||:.|    :..|  |.:|.....:..
Human   299 TISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEF----ITAG--GAQVSFKTALGR 357

  Fly   444 AAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ 508
            :|.||.:....|..|||.|:...|.|.:.|||.:.||:|:||:.|.||||..|.|::.:|||.::
Human   358 SAELLGLDPTQLTDALTQRSMFLRGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIK 422

  Fly   509 KGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLA 573
              |..|...|.||||||||:...|.|||..||||||.||.|||||:|.|||.||:||.|.|..:.
Human   423 --GNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDID 485

  Fly   574 WDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHY 638
            |.||...:.|:.|| :|:..|:::||:||:|||.:.|||.|..||.:..|.:||:....|||.||
Human   486 WIDNGECLDLIEKK-LGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHY 549

  Fly   639 AGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKP 703
            ||:|.|.|.|.|:||||..|.|:|.||..||...:.:|.:.: :.|:...||..||       |.
Human   550 AGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHV-SSRNNQDTLKCGS-------KH 606

  Fly   704 RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQR 768
            |.|||:::|.|||..|:.::...:|:||||||||.:|...:.|...||.||||.|||:|::||:.
Human   607 RRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKA 671

  Fly   769 GYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            ||.||..||.|.:||:.|:.: ||.....|..|.:||:....:..|   :|||.|:|||||:|.:
Human   672 GYAVRRPFQDFYKRYKVLMRN-LALPEDVRGKCTSLLQLYDASNSE---WQLGKTKVFLRESLEQ 732

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898
            .||..|.|.:..||:.::.||.|.|.|:|..:.......:|..:|....::|:..|:|.|:..|:
Human   733 KLEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQK 797

  Fly   899 LWRGRQARRRVQQLRSDHRRRQEAR------------EAAQRAREAREA-----------KQAVL 940
            ..||:.|||..:||.::.|.::|.:            |..:|.||.|||           ||..|
Human   798 QLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQEL 862

  Fly   941 ERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            |..|.|..:  |||.....|.:      .::.:.::|           :|.:::....       
Human   863 EALQKSQKE--AELTRELEKQK------ENKQVEEIL-----------RLEKEIEDLQ------- 901

  Fly  1006 YCNGLRLQPRRE-PIT-APLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK 1068
                 |::.::| .:| |.|......|||:           ||...::|...|:|.|       :
Human   902 -----RMKEQQELSLTEASLQKLQERRDQE-----------LRRLEEEACRAAQEFL-------E 943

  Fly  1069 ALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK-YLMRFV------- 1125
            :|:.    |||...:.|....|...|..::.    |.:..|..:|:..||: |....|       
Human   944 SLNF----DEIDECVRNIERSLSVGSEFSSE----LAESACEEKPNFNFSQPYPEEEVDEGFEAD 1000

  Fly  1126 DDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQ 1190
            ||...:|..|        .:.|.:.....|                          :...|::|:
Human  1001 DDAFKDSPNP--------SEHGHSDQRTSG--------------------------IRTSDDSSE 1031

  Fly  1191 ------TVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPA 1249
                  ...|.:..|.:....||.|           |.|.|.....|.|         |...|  
Human  1032 EDPYMNDTVVPTSPSADSTVLLAPS-----------VQDSGSLHNSSSG---------ESTYC-- 1074

  Fly  1250 FPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYF 1314
            .|....||                          |:..|..|..::......:.|.||......:
Human  1075 MPQNAGDL--------------------------PSPDGDYDYDQDDYEDGAITSGSSVTFSNSY 1113

  Fly  1315 EREPSP----GPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDR--- 1372
            ..:.||    ..|..:|:|..:..|:.......          ||:|...:...::..|:.|   
Human  1114 GSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFE----------DSEEDFDSRFDTDDELSYRRDS 1168

  Fly  1373 ---------YHS------------AERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYA--- 1413
                     :||            ..|...:..:|...::..|.|.::......|..||..:   
Human  1169 VYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRN 1233

  Fly  1414 -DKAEYATRSSAM----SDTSEAPSLASHVRRVRV----PSQASDVDQFLDDLFSPVLDGSLDEL 1469
             .|..:..|.|.:    :|:.|.......||..:.    .::.:.:|..:.|....::..|.::.
Human  1234 WKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTKENGIDIIMADRTFHLIAESPEDA 1298

  Fly  1470 SDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQ--LAAIIKGGGV 1532
            |...|:.:.:...:.::..|...|..:..:.:..:  .:.|:.::....|.|:  ...||....|
Human  1299 SQWFSVLSQVHASTDQEIQEMHDEQANPQNAVGTL--DVGLIDSVCASDSPDRPNSFVIITANRV 1361

  Fly  1533 ----ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLL 1593
                |..|||         :..:|..|..    ::|..::..:|.:   :||           .|
Human  1362 LHCNADTPEE---------MHHWITLLQR----SKGDTRVEGQEFI---VRG-----------WL 1399

  Fly  1594 HQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQ--TLLSQQAAAAAANNS 1656
            |:      |.::.|.:...::::.:.  .:..| .:.....::..||:  ||             
Human  1400 HK------EVKNSPKMSSLKLKKRWF--VLTHN-SLDYYKSSEKNALKLGTL------------- 1442

  Fly  1657 TSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHF 1721
                    :|:||....||.:...:                                   ||.::
Human  1443 --------VLNSLCSVVPPDEKIFK-----------------------------------ETGYW 1464

  Fly  1722 -LDPYGRAKTVRI------GKWRW----------PPPQDEPQFQTEEDFFAFKMRQ------HQR 1763
             :..|||....|:      ...||          ..|.|.|..|..:|.....:..      ::|
Human  1465 NVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKR 1529

  Fly  1764 KTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTT 1828
            ....:..||                            .:.||..|...|.:..:.::.:..||..
Human  1530 NPILRYTHH----------------------------PLHSPLLPLPYGDINLNLLKDKGYTTLQ 1566

  Fly  1829 TSAVNNRDRDRETQDVGQP---MQSVVTT-------------KLAKKSFEIGADRPPPGSVGKL- 1876
            ..|:...:..::.:.:..|   :|.::.|             :|.|::.::    |.|||||.| 
Human  1567 DEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKV----PHPGSVGNLY 1627

  Fly  1877 --------------------KLSSEMRQRLEQVTAGH-------SVRSTVSTKSEQRAPAKLEDT 1914
                                .|...:::..||.....       :..|...||..:..|:: ::.
Human  1628 SWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSR-DEI 1691

  Fly  1915 RKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERM 1954
            ..|:.:|::........||:...  .::||.|....:|::
Human  1692 EALIHRQEMTSTVYCHGGGSCKI--TINSHTTAGEVVEKL 1729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc_Myo15 169..828 CDD:276838 295/672 (44%)
PTZ00121 <828..>943 CDD:173412 42/137 (31%)
MyTH4 1014..1171 CDD:470587 33/166 (20%)
Ubl1_cv_Nsp3_N-like 1178..>1245 CDD:475130 13/72 (18%)
MyTH4 2704..2810 CDD:459939
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYO10NP_036466.2 SH3_19 7..58 CDD:465815 2/6 (33%)
MYSc_Myo10 77..727 CDD:276840 295/672 (44%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 10/21 (48%)
SMC_N 727..>958 CDD:481474 69/283 (24%)
SAH. /evidence=ECO:0000269|PubMed:23012428 814..883 19/76 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 2/20 (10%)
PTZ00108 <846..1161 CDD:240271 79/463 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 4/18 (22%)
DUF5401 <848..967 CDD:375164 33/171 (19%)
MYO10_CC 883..933 CDD:465249 12/83 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 33/211 (16%)
PH-like 1181..>1223 CDD:473070 4/41 (10%)
PH2_MyoX 1215..1316 CDD:270108 15/100 (15%)
PH3_MyoX-like 1381..1506 CDD:270109 28/207 (14%)
MyTH4 1549..1695 CDD:214535 23/150 (15%)
FERM_F1_Myosin-X 1697..1792 CDD:340726 7/35 (20%)
B41 1704..1958 CDD:214604 6/28 (21%)
FERM_C_MyoX 1954..2042 CDD:270023
Blue background indicates that the domain is not in the aligned region.

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