DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYO10

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_036466.2 Gene:MYO10 / 4651 HGNCID:7593 Length:2058 Species:Homo sapiens


Alignment Length:1990 Identity:527/1990 - (26%)
Similarity:835/1990 - (41%) Gaps:479/1990 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 HPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNP 197
            |.:..|:.|          ....||:||..|.:||..|:::||..||.:..|||:.||||.:|||
Human    51 HQKVTAMHP----------TNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILASVNP 105

  Fly   198 YKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLV 259
            |:.....|.....:||:.|.||.||||:|||....:..|   ...|.::||||||:||||||||:
Human   106 YQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESGAGKTESTKLI 170

  Fly   260 MQYLAAVVPGGGSAS-----AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAI 318
            :::|:.:.......|     :.:...|||::|::||||||:|..|:|||||||::::.. :.|.|
Human   171 LKFLSVISQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNI 235

  Fly   319 VGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGR 383
            .|.:|..|||||:|:|.|.|||||||:||.||.||...||.::.|...:.|.||||  :.|...:
Human   236 QGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLSTPENYHYLNQ--SGCVEDK 298

  Fly   384 V--DWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW 443
            .  |.||.:   .||.|:..|:.|...:.|:||.:|||||:.|    :..|  |.:|.....:..
Human   299 TISDQESFREVITAMDVMQFSKEEVREVSRLLAGILHLGNIEF----ITAG--GAQVSFKTALGR 357

  Fly   444 AAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ 508
            :|.||.:....|..|||.|:...|.|.:.|||.:.||:|:||:.|.||||..|.|::.:|||.::
Human   358 SAELLGLDPTQLTDALTQRSMFLRGEEILTPLNVQQAVDSRDSLAMALYACCFEWVIKKINSRIK 422

  Fly   509 KGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLA 573
              |..|...|.||||||||:...|.|||..||||||.||.|||||:|.|||.||:||.|.|..:.
Human   423 --GNEDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDID 485

  Fly   574 WDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHY 638
            |.||...:.|:.|| :|:..|:::||:||:|||.:.|||.|..||.:..|.:||:....|||.||
Human   486 WIDNGECLDLIEKK-LGLLALINEESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHY 549

  Fly   639 AGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKP 703
            ||:|.|.|.|.|:||||..|.|:|.||..||...:.:|.:.: :.|:...||..||       |.
Human   550 AGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHV-SSRNNQDTLKCGS-------KH 606

  Fly   704 RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQR 768
            |.|||:::|.|||..|:.::...:|:||||||||.:|...:.|...||.||||.|||:|::||:.
Human   607 RRPTVSSQFKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKA 671

  Fly   769 GYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            ||.||..||.|.:||:.|:.: ||.....|..|.:||:....:..|   :|||.|:|||||:|.:
Human   672 GYAVRRPFQDFYKRYKVLMRN-LALPEDVRGKCTSLLQLYDASNSE---WQLGKTKVFLRESLEQ 732

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898
            .||..|.|.:..||:.::.||.|.|.|:|..:.......:|..:|....::|:..|:|.|:..|:
Human   733 KLEKRREEEVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQK 797

  Fly   899 LWRGRQARRRVQQLRSDHRRRQEAR------------EAAQRAREAREA-----------KQAVL 940
            ..||:.|||..:||.::.|.::|.:            |..:|.||.|||           ||..|
Human   798 QLRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEETRKQQEL 862

  Fly   941 ERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            |..|.|..:  |||.....|.:      .::.:.::|           :|.:::....       
Human   863 EALQKSQKE--AELTRELEKQK------ENKQVEEIL-----------RLEKEIEDLQ------- 901

  Fly  1006 YCNGLRLQPRRE-PIT-APLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK 1068
                 |::.::| .:| |.|......|||:           ||...::|...|:|.|       :
Human   902 -----RMKEQQELSLTEASLQKLQERRDQE-----------LRRLEEEACRAAQEFL-------E 943

  Fly  1069 ALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK-YLMRFV------- 1125
            :|:.    |||...:.|....|...|..::.    |.:..|..:|:..||: |....|       
Human   944 SLNF----DEIDECVRNIERSLSVGSEFSSE----LAESACEEKPNFNFSQPYPEEEVDEGFEAD 1000

  Fly  1126 DDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQ 1190
            ||...:|..|        .:.|.:.....|                          :...|::|:
Human  1001 DDAFKDSPNP--------SEHGHSDQRTSG--------------------------IRTSDDSSE 1031

  Fly  1191 ------TVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPA 1249
                  ...|.:..|.:....||.|           |.|.|.....|.|         |...|  
Human  1032 EDPYMNDTVVPTSPSADSTVLLAPS-----------VQDSGSLHNSSSG---------ESTYC-- 1074

  Fly  1250 FPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYF 1314
            .|....||                          |:..|..|..::......:.|.||......:
Human  1075 MPQNAGDL--------------------------PSPDGDYDYDQDDYEDGAITSGSSVTFSNSY 1113

  Fly  1315 EREPSP----GPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDR--- 1372
            ..:.||    ..|..:|:|..:..|:.......          ||:|...:...::..|:.|   
Human  1114 GSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFE----------DSEEDFDSRFDTDDELSYRRDS 1168

  Fly  1373 ---------YHS------------AERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYA--- 1413
                     :||            ..|...:..:|...::..|.|.::......|..||..:   
Human  1169 VYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRN 1233

  Fly  1414 -DKAEYATRSSAM----SDTSEAPSLASHVRRVRV----PSQASDVDQFLDDLFSPVLDGSLDEL 1469
             .|..:..|.|.:    :|:.|.......||..:.    .::.:.:|..:.|....::..|.::.
Human  1234 WKKRWFVLRQSKLMYFENDSEEKLKGTVEVRTAKEIIDNTTKENGIDIIMADRTFHLIAESPEDA 1298

  Fly  1470 SDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQ--LAAIIKGGGV 1532
            |...|:.:.:...:.::..|...|..:..:.:..:  .:.|:.::....|.|:  ...||....|
Human  1299 SQWFSVLSQVHASTDQEIQEMHDEQANPQNAVGTL--DVGLIDSVCASDSPDRPNSFVIITANRV 1361

  Fly  1533 ----ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLL 1593
                |..|||         :..:|..|..    ::|..::..:|.:   :||           .|
Human  1362 LHCNADTPEE---------MHHWITLLQR----SKGDTRVEGQEFI---VRG-----------WL 1399

  Fly  1594 HQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQ--TLLSQQAAAAAANNS 1656
            |:      |.::.|.:...::::.:.  .:..| .:.....::..||:  ||             
Human  1400 HK------EVKNSPKMSSLKLKKRWF--VLTHN-SLDYYKSSEKNALKLGTL------------- 1442

  Fly  1657 TSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHF 1721
                    :|:||....||.:...:                                   ||.::
Human  1443 --------VLNSLCSVVPPDEKIFK-----------------------------------ETGYW 1464

  Fly  1722 -LDPYGRAKTVRI------GKWRW----------PPPQDEPQFQTEEDFFAFKMRQ------HQR 1763
             :..|||....|:      ...||          ..|.|.|..|..:|.....:..      ::|
Human  1465 NVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKR 1529

  Fly  1764 KTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTT 1828
            ....:..||                            .:.||..|...|.:..:.::.:..||..
Human  1530 NPILRYTHH----------------------------PLHSPLLPLPYGDINLNLLKDKGYTTLQ 1566

  Fly  1829 TSAVNNRDRDRETQDVGQP---MQSVVTT-------------KLAKKSFEIGADRPPPGSVGKL- 1876
            ..|:...:..::.:.:..|   :|.::.|             :|.|::.::    |.|||||.| 
Human  1567 DEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKV----PHPGSVGNLY 1627

  Fly  1877 --------------------KLSSEMRQRLEQVTAGH-------SVRSTVSTKSEQRAPAKLEDT 1914
                                .|...:::..||.....       :..|...||..:..|:: ::.
Human  1628 SWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKYALFTYESLKKTKCREFVPSR-DEI 1691

  Fly  1915 RKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERM 1954
            ..|:.:|::........||:...  .::||.|....:|::
Human  1692 EALIHRQEMTSTVYCHGGGSCKI--TINSHTTAGEVVEKL 1729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 306/693 (44%)
MYSc_Myo15 169..828 CDD:276838 295/672 (44%)
MyTH4 1014..1171 CDD:295320 33/166 (20%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYO10NP_036466.2 MYSc 58..739 CDD:214580 309/713 (43%)
MYSc_Myo10 77..727 CDD:276840 295/672 (44%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 619..641 10/21 (48%)
SAH. /evidence=ECO:0000250|UniProtKB:F8VQB6, ECO:0000250|UniProtKB:P79114 815..908 22/123 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 819..840 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..866 4/18 (22%)
Mediates antiparallel dimerization. /evidence=ECO:0000269|PubMed:23012428 883..933 12/83 (14%)
MYO10_CC 883..933 CDD:293340 12/83 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1090 33/211 (16%)
PH-like 1181..>1223 CDD:302622 4/41 (10%)
PH2_MyoX 1215..1316 CDD:270108 15/100 (15%)
PH 1215..1308 CDD:278594 15/92 (16%)
PH3_MyoX-like 1381..1506 CDD:270109 28/207 (14%)
PH 1396..1495 CDD:278594 24/174 (14%)
MyTH4 1549..1695 CDD:214535 23/150 (15%)
B41 1704..1958 CDD:214604 6/28 (21%)
UBQ 1705..>1753 CDD:294102 6/27 (22%)
FERM_M 1796..1958 CDD:278785
FERM_C_MyoX 1954..2042 CDD:270023
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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