DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and MYO9B

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_004136.2	Gene:	MYO9B / 4650	HGNCID:	7609	Length:	2157	Species:	Homo sapiens

Alignment Length:	2340	Identity:	588/2340 - (25%)
Similarity:	924/2340 - (39%)	Gaps:	646/2340 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 HPQT----FALQP--GEGSLR-----------ARQDLGSSGV--------EDMTLLDDLHEASLL 172
            |||.    |.||.  .:|:::           |.:.|...|:        :|:..|.:|.|.:||
Human    99 HPQEDGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEGNLL 163

  Fly   173 WNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALP 237
            .||:.|:.:..|||:|||||:|:||:|..| .|..:..|.|..:.||.|.||:||:...|:..:.
Human   164 KNLKHRFLQQKIYTYAGSILVAINPFKFLP-IYNPKYVKMYENQQLGKLEPHVFALADVAYYTML 227

  Fly   238 SPQV---VVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARN 299
            ..:|   :|||||||||||:||..::..|.|:...|.::.  :...||.|.|:|||||||:||.|
Human   228 RKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASG--VERTILGAGPVLEAFGNAKTAHN 290

  Fly   300 DNSSRFGKYLEV-YFKSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL 363
            :|||||||:::| |.:||.:.||.:.:|||||||:|:|...||||||||.||.|:||.||.::.|
Human   291 NNSSRFGKFIQVSYLESGIVRGAVVEKYLLEKSRLVSQEKDERNYHVFYYLLLGVSEEERQEFQL 355

  Fly   364 LEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQ 425
            .:.:.||||||.......|   :.|:|.|:.||:::|.....::.|..||:|:|:||||.:.:|.
Human   356 KQPEDYFYLNQHNLKIEDGEDLKHDFERLKQAMEMVGFLPATKKQIFAVLSAILYLGNVTYKKRA 420

  Fly   426 LRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKA 490
            ... :||:|||....:...:.||.:..:.|...||.|.|....::|..|..:.:|:.|||:.||:
Human   421 TGR-EEGLEVGPPEVLDTLSQLLKVKREILVEVLTKRKTVTVNDKLILPYSLSEAITARDSMAKS 484

  Fly   491 LYAGLFNWLVSRIN-SIVQKGGTHDA---HRISILDIFGFEDLAENSFEQLCINYANENLQLYFN 551
            ||:.||:|:|.||| :::.|....:|   ..|.:||||||||...|||||.|||||||.||.|||
Human   485 LYSALFDWIVLRINHALLNKKDVEEAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFN 549

  Fly   552 KHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYN 616
            :|:|||||.||..|.:.|..:.:.||:..|||::|||.|:.:|||:|||||.||..:.|.|....
Human   550 QHIFKLEQEEYQGEGITWHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQ 614

  Fly   617 HALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL----- 676
            |..::.:....:....|.:.|:||:|.|.:..|.:||.|.:|.|::.||..|....|.||
Human   615 HEDNKYFLGTPVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDP 679

  Fly   677 ------------------------TKQLRAQRDAG----------KTLPKGSN------------ 695
                                    .:..||::.||          :.||:|::
Human   680 VAVFRWAVLRAAIRAMAVLREAGRLRAERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYRDLHN 744

  Fly   696 -----------------------GRF----------------------------------VTMKP 703
                                   .|.                                  :|:..
Human   745 QMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLDSKSLKLIISMTLHD 809

  Fly   704 RT-------------PTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLR 755
            ||             |:::|:|..||.:||:::|:..|:|:|||:.|.||..|..|...||||||
Human   810 RTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSNAEKKELCFDDELVLQQLR 874

  Fly   756 YLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQL 820
            |.|||:|::||:.||..:..||.|.|:::.|||..   ..|.||:...|||.|.   ::..:||:
Human   875 YTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKD---AQPCREVISTLLEKMK---IDKRNYQI 933

  Fly   821 GATRVFLR--------EALHR---------------ALESGRTERLRRAAVSVQRHVRGMLVRRQ 862
            |.|:|||:        |.|||               .||.....:::||||::|...|...|||.
Human   934 GKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLERRHFLQMKRAAVTIQACWRSYRVRRA 998

  Fly   863 LARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQ 927
            |.|.| ||..|||.|||...::.|...::..:..|.|.||...|:...|:.|      |.::|.:
Human   999 LERTQ-AAVYLQASWRGYWQRKLYRHQKQSIIRLQSLCRGHLQRKSFSQMIS------EKQKAEE 1056

  Fly   928 RAREAREAKQAVLE---RSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQ 989
            :.|||.||.:|..|   :.|.:.....||        ||..|.....||..         ...||
Human  1057 KEREALEAARAGAEEGGQGQAAGGQQVAE--------QGPEPAEDGGHLAS---------EPEVQ 1104

  Fly   990 LPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALE 1054
             |.|.....       :.:..:..|..|....|..|.||.                  |::| :.
Human  1105 -PSDRSPLE-------HSSPEKEAPSPEKTLPPQKTVAAE------------------SHEK-VP 1142

  Fly  1055 GAKEKLLADYIVHKALSSRGLR----DEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSA 1115
            .::||       .::...|||.    ....:|.|.:...|.                    :||
Human  1143 SSREK-------RESRRQRGLEHVKFQNKHIQSCKEESALR--------------------EPS- 1179

  Fly  1116 AFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMAL 1180
                                   |::.::||                 .:.||.:..:|. |..|
Human  1180 -----------------------RRVTQEQG-----------------VSLLEDKKESRE-DETL 1203

  Fly  1181 PLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKE 1245
             |.:..||..|   ......|:..|:||   |..|......|..|......  |:....|..:..
Human  1204 -LVVETEAENT---SQKQPTEQPQAMAV---GKVSEETEKTLPSGSPRPGQ--LERPTSLALDSR 1259

  Fly  1246 LCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPP---PAPPTSSGKEDVPR----ERRSS---- 1299
            :.|  |||.|         |..| |:...:|...|   ..|.:..|...:.|    ||.:|
Human  1260 VSP--PAPGS---------APET-PEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVEL 1312

  Fly  1300 ------------RELLSRSSALNERY----------FEREPS----------PG-----PGQGSS 1327
                        ..:||:|..|::|:          .||..|          |.     |...::
Human  1313 WRGKKLVAAASPSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETT 1377

  Fly  1328 TGQAKSRSKSLDDLLAGDIVPVP-------TDCDSQEPLHTLGLSESRLNDRYHS---AERL--- 1379
            .|:..::..::.....||...:|       :..||:.....|.|.:::  |:.:|   ||.|
Human  1378 DGERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTK--DKKYSLEGAEELENA 1440

  Fly  1380 -----------------APVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYAD-KAEYATRSSAMS 1426
                             ||.|       |:.:||.........|....|..: |....|.|....
Human  1441 VSGHVVLEATTMKKGLEAPSG-------QQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVSEKWR 1498

  Fly  1427 DTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAE 1491
            :        |..|::...::...:|:||           |::::|.||....|.....|...:..
Human  1499 E--------SVFRQITNANELKYLDEFL-----------LNKINDLRSQKTPIESLFIEATEKFR 1544

  Fly  1492 SEIDDLDDYINDIFQPIP----------LVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIE 1546
            |.|..:        ..:|          |::|.:.:.|           .:|::..::|....:.
Human  1545 SNIKTM--------YSVPNGKIHVGYKDLMENYQIVVS-----------NLATERGQKDTNLVLN 1590

  Fly  1547 DLDDYINEL--------FEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGET 1603
            .....::|.        |||:..::. .|...|:..||.       :.||.....:| :.:|...
Human  1591 LFQSLLDEFTRGYTKNDFEPVKQSKA-QKKKRKQERAVQ-------EHNGHVFASYQ-VSIPQSC 1646

  Fly  1604 ESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTL-------LSQQAAAAAANNSTSPPP 1661
            |...: |...:.:|.|.|........:.....|:....|.       :.........::.||...
Human  1647 EQCLS-YIWLMDKALLCSVCKMTCHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKA 1710

  Fly  1662 APPI-----LSSLSISPPPPQSPMRMK-ATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRH 1720
            :.||     |..:.:.....:...|.. |...:..:.::||                .||:..:
Human  1711 SVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQ----------------TDPAAVK- 1758

  Fly  1721 FLDPYG-RAKTVRIGKWRWPPPQDEPQFQTEEDFF-AFKMRQHQRKTT---------PQAQHHQM 1774
             |:.:. .|.|..:.:|....|:....|....||. |.::.:.|.:..         |:|.|:.:
Human  1759 -LENFPIHAITGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSL 1822

  Fly  1775 TS------NGGMMES----GPGARGASATAIEWEEFEIESP-TPPPMSGQLMRSSIRLETTTTTT 1828
            ..      ...::|.    .||     |.||.:....:..| ...|::.  |:..:::   ||..
Human  1823 ERLIFHLVKVALLEDVNRMSPG-----ALAIIFAPCLLRCPDNSDPLTS--MKDVLKI---TTCV 1877

  Fly  1829 TSAVNNRDRDRET--QDVGQ--PMQSVVTTKL------AKKSFEIGADRPPPGSVGKLKLSSEMR 1883
            ...:..:.|..:.  :::.|  ..:|:...:|      |....::|...|..|.:.|...:.:::
Human  1878 EMLIKEQMRKYKVKMEEISQLEAAESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQ 1942

  Fly  1884 QR-----LEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSG-----GNSGPG 1938
            :.     ||:..||..                 ||..|.:|.:::..:......     ....|.
Human  1943 EEELEVLLEEEAAGGD-----------------EDREKEILIERIQSIKEEKEDITYRLPELDPR 1990

  Fly  1939 GV----VDSHATVRTQ--IERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAP 1997
            |.    :||..:..|:  :|...|:         |...|   ||||::|           .|.||
Human  1991 GSDEENLDSETSASTESLLEERAGR---------GASEG---PPAPALP-----------CPGAP 2032

  Fly  1998 PPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSAS 2062
            .|:|.  ||..:|   |..|.||...|:...|              |:..::.:.::.|.....|
Human  2033 TPSPL--PTVAAP---PRRRPSSFVTVRVKTP--------------RRTPIMPTANIKLPPGLPS 2078

  Fly  2063 SSPAVAAWEQAERERS---RSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLY 2124
            ..|   .|....||.:   |.|.....|.|...||:.....:.|..|:....|.:.:....:|.|
Human  2079 HLP---RWAPGAREAAAPVRRREPPARRPDQIHSVYITPGADLPVQGALEPLEEDGQPPGAKRRY 2140

Fly 2125 2124
Human 2141 2140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	302/842 (36%)
		MYSc_Myo15	169..828	CDD:276838	292/790 (37%)
		MyTH4	1014..1171	CDD:295320	23/160 (14%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO9B	NP_004136.2	Myosin_IXb_RA	7..112	CDD:176374	6/12 (50%)
		MYSc	141..950	CDD:214580	297/818 (36%)
		MYSc_Myo9	160..941	CDD:276836	292/790 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..734		6/24 (25%)
		Actin-binding. /evidence=ECO:0000305	844..855		5/10 (50%)
		Neck or regulatory domain. /evidence=ECO:0000305	940..1044		33/104 (32%)
		IQ	978..999	CDD:197470	9/20 (45%)
		IQ	1000..1022	CDD:197470	10/22 (45%)
		Tail. /evidence=ECO:0000305	1045..2157		249/1383 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1298		75/391 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1410		14/89 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1484		8/35 (23%)
		C1	1633..1681	CDD:237996	8/49 (16%)
		RhoGAP_myosin_IXB	1698..1883	CDD:239872	35/212 (17%)
		Interaction with RHOA. /evidence=ECO:0000269\|PubMed:26529257	1739..1744		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1980..2157		46/206 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810