DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYO9A

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_011519915.1 Gene:MYO9A / 4649 HGNCID:7608 Length:2638 Species:Homo sapiens


Alignment Length:3093 Identity:696/3093 - (22%)
Similarity:1101/3093 - (35%) Gaps:1042/3093 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 PIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPW--------QRGGGGSVTPSPAQSP-SLAL 73
            |||.  ::...||:||  ::||.      :.||:..        :..||.....:|...| ...:
Human    33 PIPA--RKNSTAAEVI--ESLIN------KLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMM 87

  Fly    74 LSPHVLRRQRPASLEDFEDL---PNLSAK-HPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHP 134
            |.|.:....| .|.||:..|   .||... |.....|.||..:.|     :|:.          .
Human    88 LWPRMALENR-LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEER-----RRMM----------E 136

  Fly   135 QTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYK 199
            :.|..||.:           ...:|:..|.||:|.:||.|||.|:....|||:.|||||.:||:|
Human   137 RGFLPQPQQ-----------KDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFK 190

  Fly   200 MFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQ 261
            ..| .|..:..|.|....||.|.||::|:...|:.|:   ...|.:|||||||||||:||..::.
Human   191 FLP-IYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIH 254

  Fly   262 YLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQ 325
            :|.|:...|.::.  :.:.||.|.|:|||||||:||.|:|||||||:::| |.::|.::||.:.:
Human   255 HLTALSQKGFASG--VEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEK 317

  Fly   326 YLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQ---------------- 374
            |||||||:|.|...||||||||.||.|.||.|||.:.|.:.::|.||||                
Human   318 YLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEEYHYLNQITKKPLRQSWDDYCYD 382

  Fly   375 GATDC--ASG---RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVE 434
            ...||  ..|   |.|:|.||.||:::|.....|..|..:|:|:|||||:.:.::..|  .:.::
Human   383 SEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYR--DDSID 445

  Fly   435 VGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499
            :.:...:...:.||.:..:.|..||.:|.|....|:|..|..:.:|:..|::.||:||:.||:|:
Human   446 ICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWI 510

  Fly   500 VSRINSIV--QKGGTHDAHRISI--LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQA 560
            |.|||..:  .|...|:...:||  ||||||||...|||||.|||:|||.||.|||:|:|||||.
Human   511 VFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQE 575

  Fly   561 EYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYAR 625
            ||..|.:.|..:.:.||...|:|::|||.|:.||||:|||||:||:.:.|:|..:.|..:.....
Human   576 EYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEF 640

  Fly   626 PRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASS-----------------RLPLV 673
            |.:....|.:.||||:|.|.|..|.:||.|.:|.|::.||.||                 |..::
Human   641 PAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAIL 705

  Fly   674 GELTKQLRAQRDAGK-------------------------------------------------- 688
            ....:.:.|.|:|||                                                  
Human   706 RAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSIT 770

  Fly   689 ------------------------TLPKGSNGR-------------------------------- 697
                                    |.....|||                                
Human   771 RKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLER 835

  Fly   698 --------------------------------------------FVTMKPRTPTVAARFADSLQQ 718
                                                        .:..|.:.|:::|:|..||.:
Human   836 AHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSK 900

  Fly   719 LLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERY 783
            |::::|:..|:||:||:.|.||..||.....||:||||.|||:|::|||.||..:..||.||..:
Human   901 LMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHF 965

  Fly   784 -----RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR-------------EA 830
                 |:::||.......:|::           .:...:||:|.|.|||:             |.
Human   966 HVLLPRNIIPSKFNIQDFFRKI-----------NLNPDNYQVGKTMVFLKEQERQHLQDLLHQEV 1019

  Fly   831 LHRALESGRTER----------LRRAAVSVQRHVRGMLVRRQL----ARRQA-----AATRLQAR 876
            |.|.:...|..|          ||:|:|.:||..|..|.::|:    .::.|     ||..|||.
Human  1020 LRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQAS 1084

  Fly   877 WRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQ-RAREAREAKQAVL 940
            ||....:|||..||..|:..|:.|            |..:|||..|....| |.:..||:|:...
Human  1085 WRAHLERQRYLELRAAAIVIQQKW------------RDYYRRRHMAAICIQARWKAYRESKRYQE 1137

  Fly   941 ERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            :|.::..|...                                                      
Human  1138 QRKKIILLQST------------------------------------------------------ 1148

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKAL 1070
             |.|.|.:.|                                                   .|||
Human  1149 -CRGFRARQR---------------------------------------------------FKAL 1161

  Fly  1071 SSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRP 1135
            ..:.||:            ..|..|                                        
Human  1162 KEQRLRE------------TKPEVG---------------------------------------- 1174

  Fly  1136 LLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSC 1200
                 |:..:|.|:                 ||    .:|.|.:                     
Human  1175 -----LVNIKGYGS-----------------LE----IQGSDPS--------------------- 1192

  Fly  1201 EEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFA 1265
                            ||           :.|..|..:..|.|   |       ..::.|. :.:
Human  1193 ----------------GW-----------EDCSFDNRIKAIEE---C-------KSVIESN-RIS 1219

  Fly  1266 RTTLPDAVKR-PAVPPPAPPTSSG---KEDV-PRERRSSRELLSRSSALNERYFEREPSPGPGQG 1325
            |.:..|.:|. |........:.||   :||| .|||..|.|.|.:                    
Human  1220 RESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLEDLHQ-------------------- 1264

  Fly  1326 SSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTL---------GLSESRLNDRYHSAERLAP 1381
            ...|:||..|:.:.:|              ::.:.:|         |:|.|  .||..|.| |.|
Human  1265 KKVGRAKRESRRMREL--------------EQAIFSLELLKVRSLGGISPS--EDRRWSTE-LVP 1312

  Fly  1382 VGKDTGPR----------------YQKSQHAGRRSHAASHGS---HSSKYADKAEYATRSSAMSD 1427
            .|..: ||                |::||.:...|..:..|.   .|.|.:...::.:|.:|:|.
Human  1313 EGLQS-PRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSA 1376

  Fly  1428 TSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDEL----SDARSLAASIRGGSYEQEN 1488
            ::|..| |.|::                       ||::.|:    |::.:....::        
Human  1377 SNETSS-AEHLK-----------------------DGTMKEMVVCSSESITCKPQLK-------- 1409

  Fly  1489 EAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYIN 1553
                     |.:|::.......:...:.|.:..||...|:...:.   |..|...|...||    
Human  1410 ---------DSFISNSLPTFFYIPQQDPLKTNSQLDTSIQRNKLL---ENEDTAGEALTLD---- 1458

  Fly  1554 ELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAF 1618
                       :::.|.:.|.:...:...|.::..::|:|.:|.:|..|.|......|||.::..
Human  1459 -----------INRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEERQKQLQQQNEKEM 1512

  Fly  1619 LQSAMAQNLQIQQQ---LLAQNQALQTL----LSQQAAAAAANNSTSPPPAPPILSSLSISPPPP 1676
            ::       ||:||   |..:.:|.:|:    :.:...|.::..|......|..|.||:.|....
Human  1513 ME-------QIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGE 1570

  Fly  1677 QSPM-RMKATRSSLVVMESLQPPPPPPPPPMPPPLECK-DPSETRHFLDPYGRAKTVRIG----- 1734
            .:.: .:....::|...:|.....||...|:....|.| .|.::....:   .:||.|:|     
Human  1571 LNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKE---LSKTDRMGTQLNV 1632

  Fly  1735 -----------KWRWPPPQD--------------EPQFQTEEDFFAFKM--RQHQRKTTPQAQHH 1772
                       :..:.|.|.              .|.|.|.:|..:..:  ::......||....
Human  1633 ACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIPLVSKEALNSKNPQLHKE 1697

  Fly  1773 QMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDR 1837
            ...:...:..:|||.|              |....|....:...:..|.:..|..|.:.......
Human  1698 DEPAWKPVKLAGPGQR--------------EQVARPAHKKKARMARTRSDFLTRGTFADGEGDTE 1748

  Fly  1838 DRETQDVGQPMQSVVTTKLAKKSF-EIGADRPPPGSVGKLKLS-SEM-RQRLEQVTAGHSVRSTV 1899
            :.:..|:.:|:.|     |.:.|. |:|    |..|:|:...| ||| .||...|.....:..|:
Human  1749 EDDYDDIIEPLLS-----LDQASHCELG----PAPSLGQASHSDSEMTSQRFSSVDEQAKLHKTM 1804

  Fly  1900 S----TKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSP 1960
            |    ||...|..|...|.|....:.:..      :.|..|.........|.::::..:      
Human  1805 SQGEITKLAVRQKASDSDIRPQRAKMRFW------AKGKQGEKKTTRVKPTTQSEVSPL------ 1857

  Fly  1961 PPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP--PAPPPAPQSPPTAR-----SPEPEP---- 2014
                    :.|..:.||...        |..:|.  |.||.:|:.|.:.|     :.||.|    
Human  1858 --------FAGTDVIPAHQF--------PDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKR 1906

  Fly  2015 --------------DYRTSSSQVVK-----EHVPAFIQRQ---------ERDTF------GAVRQ 2045
                          .::..|.|::.     :.:..|:.::         ::||.      .|:::
Human  1907 KRSVKISNVALDSMHWQNDSVQIIASVSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKE 1971

  Fly  2046 --QQMIS--SHHLHLED-HSASSSPAVAAWEQAERERSRSRSRSRDREDYSES---VW------- 2095
              |.:.|  |..|.::| .|.......|.:||.    .....|...|:...||   ||       
Human  1972 FRQNIFSFYSSALAMDDGKSIRYKDLYALFEQI----LEKTMRLEQRDSLGESPVRVWVNTFKVF 2032

  Fly  2096 -DRAEVEGPASGSGSEK----EREKRERERERLYEIRQVERERESH--KVYQPAPPRVIQAS--- 2150
             |....|...|...:.|    ||:||.::...|.|      |...|  |..|.:.|...:..   
Human  2033 LDEYMNEFKTSDCTATKVPKTERKKRRKKETDLVE------EHNGHIFKATQYSIPTYCEYCSSL 2091

  Fly  2151 ---MDTTGGHRREDRTGGLATFRTH----------MAQKYEHERKRKSSASSGMR-EELDSMHMT 2201
               ||.....:       |..:..|          .::||:.|   .||...|:. ..|.|...|
Human  2092 IWIMDRASVCK-------LCKYACHKKCCLKTTAKCSKKYDPE---LSSRQFGVELSRLTSEDRT 2146

  Fly  2202 TPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPP 2266
            .  |::|...:  ......|| ...|:...|||        .|::       ||:.|..:.....
Human  2147 V--PLVVEKLI--NYIEMHGL-YTEGIYRKSGS--------TNKI-------KELRQGLDTDAES 2191

  Fly  2267 VALDLLFAQVLGDVFGVTPCLRITP------------------QEKSSALNMLHGHGVSVDTLSN 2313
            |.||.....|:..||  ...||..|                  ||:...:..::.   .:|.||.
Human  2192 VNLDDYNIHVIASVF--KQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYS---VIDQLSR 2251

  Fly  2314 RNGSGAGGGGNGGQVRALVKR--HLVDMA--RDWPLYFARLFAVQGAPLY---PDV-----SIMG 2366
            .:            :..|.:.  |||.:|  .|.....|...|:..||..   ||.     |:..
Human  2252 TH------------LNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQD 2304

  Fly  2367 VSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTT 2431
            :|.:...:.      ||||:                   |:|        .:.||...|.|:   
Human  2305 ISKTTTCVE------LIVVE-------------------QMN--------KYKARLKDISSL--- 2333

  Fly  2432 FVQEFRKSQSKASTLSSGAR-------AAAQTLNVPLERLESRQAHAQRNEHG--------VDGG 2481
               ||  :::||.|..|..|       .|.:.:|:....:..:....:.|..|        :...
Human  2334 ---EF--AENKAKTRLSLIRRSMKPVLIAVRFMNITRNSVSGKGRIRRGNYPGPSSPVVVRLPSV 2393

  Fly  2482 SRQNEQLQQSE--LHHHLQQQQQQQQQQQHH---------QQQQQQQQLEDAMEEQHMATDHQQQ 2535
            |..:|:...||  :...:.:|||...||:..         |:::::...|..:.|...:.|...:
Human  2394 SDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLE 2458

  Fly  2536 QQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSL-TNGQVHHQEQMLQQQQQQSQSLPHHDL 2599
            .:..:|.....:.  |..:|....:.||......||| |.|:.....::.:|.::|..||...|.
Human  2459 SEASIGTADSSEN--LNMESEYAISEKSERSLALSSLKTAGKSEPSSKLRKQLKKQQDSLDVVDS 2521

  Fly  2600 DANYL---QDESNGGTPPSVTKYSLLQFAMQHFRNDQL 2634
            ..:.|   ...|:.||......||...|......|:.|
Human  2522 SVSSLCLSNTASSHGTRKLFQIYSKSPFYRAASGNEAL 2559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 292/893 (33%)
MYSc_Myo15 169..828 CDD:276838 283/859 (33%)
MyTH4 1014..1171 CDD:295320 13/156 (8%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYO9AXP_011519915.1 UBQ 6..110 CDD:294102 22/87 (25%)
MYSc 143..1014 CDD:214580 290/897 (32%)
MYSc_Myo9 160..1004 CDD:276836 283/859 (33%)
C1 2072..2120 CDD:237996 8/54 (15%)
RhoGAP_myosin_IX 2133..2318 CDD:239842 47/227 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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