Protein Alignment Myo10A and MYO7B

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_047300391.1
• Gene: MYO7B / 4648
• HGNCID: 7607
• Length: 2298
• Species: Homo sapiens
• Alignment Length: 3343
• Identity: 710/3343 - (21%)
• Similarity: 1074/3343 - (32%)
• Gaps: 1471/3343 - (44%)

  Fly     6 GDLVWFDPGMGH----PIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPWQRGGGGSVTPSPA 66
            ||.||.:|...|    .|.|.|:|. :..:|:|...  :||        |.|.|.
Human     7 GDHVWLEPPSTHKTGVAIGGIIKEA-KPGKVLVEDD--EGK--------EHWIRA---------- 50

  Fly    67 QSPSLALLSPHVLRRQRPASLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVIA 131
                                    ||...||..||
Human    51 ------------------------EDFGVLSPMHP------------------------------ 61

  Fly   132 RHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVN 196
                        .|::        ||:||..|.||:||.::.||.:||.:..|||:.||||:|||
Human    62 ------------NSVQ--------GVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSILVAVN 106

  Fly   197 PYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKL 258
            |:::.| .|.||..:.|..|.:|.||||:|||....:.::   ...|..:||||||:||||:|||
Human   107 PFQVLP-LYTLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGESGAGKTETTKL 170

  Fly   259 VMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAK 322
            ::|:||.:    ....:.|.:|:|||.|:|||||||:|.|||||||||||:::||. ||.|.||:
Human   171 ILQFLATI----SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIYFNPSGVIEGAR 231

  Fly   323 ITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQG-ATDC--ASGRV 384
            |.|:||||||:..|||.|||||:||.:|.|:|..::....|....:|.||..| .|.|  .:...
Human   232 IEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGTPSEYHYLTMGNCTSCEGLNDAK 296

  Fly   385 DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLH 449
            |:..::.||::|..|:.|...::::|||:||||||.| ...:....:..:|...........||.
Human   297 DYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGF-MASVFENLDASDVMETPAFPTVMKLLE 360

  Fly   450 ISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHD 514
            :....|...|...|...|.|.:...|.|.||.|.||||.|.:|..||.|:|.:||:.:......|
Human   361 VQHQELRDCLIKHTILIRGEFVTRSLNIAQAADRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQD 425

  Fly   515 ----AHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD 575
                ...|.:|||||||:...|||||||||:|||:||.:|.:|||.:||.||..|.:.|..:.:.
Human   426 PKNVRRAIGLLDIFGFENFENNSFEQLCINFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYT 490

  Fly   576 DNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR-IGAQEFGVTHYA 639
            ||.|.:.|||.||:.|..|||:||.||:.|||:.|:|.:..||.::.:.:|: |....||:.|:|
Human   491 DNRPTLDLLALKPMSIISLLDEESRFPQGTDLTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFA 555

  Fly   640 GQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL-------TK----QLRAQRDAGKTLPKG 693
            |:|:|..:|||:||||.|..|:|.|:.||:...:.|:       ||    .:| |..||..|.|.
Human   556 GEVYYQAEGFLEKNRDVLSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIR-QAKAGNHLFKS 619

  Fly   694 SNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLG 758
            ::.     ..|..|:.::|..||.||::.:..|.|:|:||||||:.|..|..|....|:||||.|
Human   620 ADS-----NKRPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSG 679

  Fly   759 MLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPL---ARGTPYRELCRALLEAMPRTGVEGPDYQL 820
            |::|:.||:.|:|:|..|:.|.:|:..|||:.:   .:| ..|::...:.:...||   ..|::.
Human   680 MMETVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQLQG-KLRQMTLGITDVWLRT---DKDWKA 740

  Fly   821 GATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRG------ 879
            |.|::|||:.....||..|::.|.|||:|:|:.:||...|::..|::.||..|||.|||
Human   741 GKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRKEFLRQRRAAVTLQAWWRGYCNRRN 805

  Fly   880 --------QRAQ---------QRYERLRKGALTAQRLWRGRQARRRVQQLR------SDHRRRQE 921
                    :|.|         ::|:.:|:..:..|.|.||...|::||..|      ..|.|...
Human   806 FKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGYLVRQQVQAKRRAVVVIQAHARGMA 870

  Fly   922 AREAAQRAR------------EAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSP-------- 966
            ||...|:.:            |.::::.|:..:.:.|..|...:...: .|:.|:.|
Human   871 ARRNFQQRKANGMQAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEMV-EKVFGFLPAMIGGQEG 934

  Fly   967 ---PHGD------RHLVKV-LGTVPGPPSSAVQLPED----LGQFSFGKFSSVYCNGLRLQPR-R 1016
               ||.:      :.|::| |.|||     ..:.||:    |.:::|.||:..|......... |
Human   935 QASPHFEDLESKTQKLLEVDLDTVP-----MAEEPEEDVDGLAEYTFPKFAVTYFQKSASHTHIR 994

  Fly  1017 EPITAPLLTRAASRDQDFQDALAVFKLILRWSND------------------------------- 1050
            .|:..|||..  ..|.|...||.::.:|||:..|
Human   995 RPLRYPLLYH--EDDTDCLAALVIWNVILRFMGDLPEPVLYARSSQQGSSVMRQIHDTLGREHGA 1057

  Fly  1051 --------KALEGAKEK-----------------------------------LLAD--------- 1063
                    ....|.|:|                                   |.||
Human  1058 QVPQHSRSAQRSGCKDKGTKDISSMKLKRSSRITGQVASQLNIGEEALEPDGLGADRPMSNLEKV 1122

  Fly  1064 -YIVHKALSSRGLRDEILVQLCNQVHGLPPN--SGEATRLWQLLGQCLCCFQPSAAFSKYLMRFV 1125
             :||..|:....|||||..|:|.|   |..|  :....|.|.||..||.||.||..|.|||:.|:
Human  1123 HFIVGYAILRPSLRDEIYCQICKQ---LSENFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFI 1184

  Fly  1126 DDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQ 1190
             .:.|.:..|....:|.|....|.          |:..|.|||.:|......:.:.:.|....|.
Human  1185 -GQGPATYGPFCAERLRRTYANGV----------RAEPPTWLELQAVKSKKHIPIQVILATGESL 1238

  Fly  1191 TVAVDSWTSCEEAAALAVSSLGVASR-GWTL---VLDDGQQLTDSCGLDYVMDLIAEKELCPAFP 1251
            ||.|||.::..|.........|::.. |::|   |.|....|  ..|.|::||.||.   |
Human  1239 TVPVDSASTSREMCMHIAHKQGLSDHLGFSLQVAVYDKFWSL--GSGRDHMMDAIAR---C---- 1294

  Fly  1252 APRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFER 1316
                                                  |.:.:||..|:    |.|.. ..||.:
Human  1295 --------------------------------------EQMAQERGESQ----RQSPW-RIYFRK 1316

  Fly  1317 EPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAP 1381
            |
Human  1317 E---------------------------------------------------------------- 1317

  Fly  1382 VGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQ 1446
                                                                             
Human  1318 ----------------------------------------------------------------- 1317

  Fly  1447 ASDVDQFLDDLFSPVLDGSLDELSDA---RSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPI 1508
                      .|:|..|...|.:|..   |.:...:..|.|..|.|.|
Human  1318 ----------FFTPWHDSREDPVSTELIYRQVLRGVWSGEYSFEKEEE----------------- 1355

  Fly  1509 PLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEH 1573
                                                                             
Human  1356 ----------------------------------------------------------------- 1355

  Fly  1574 LAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQ 1638
                                  |::|                       :|::..:|....|:::
Human  1356 ----------------------LVEL-----------------------LARHCYVQLGASAESK 1375

  Fly  1639 ALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPP 1703
            |:|.||                              |...|.::..|:                |
Human  1376 AVQELL------------------------------PSCIPHKLYRTK----------------P 1394

  Fly  1704 PPMPPPLECKD---PSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKT 1765
            |..|..|..|.   |.|:|                | |.||
Human  1395 PDRPHTLRSKSHHWPCESR----------------W-WTPP------------------------ 1418

  Fly  1766 TPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTS 1830
                                                                             
Human  1419 ----------------------------------------------------------------- 1418

  Fly  1831 AVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSV 1895
                                                                             
Human  1419 ----------------------------------------------------------------- 1418

  Fly  1896 RSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSP 1960
                                             :.||..|.||....||:.|... :|.:|
Human  1419 ---------------------------------ACSGRCSSPGSSKSSHSQVMAS-DRGQG---- 1445

  Fly  1961 PPAPPSG-GWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVV 2024
                 :| ||            ||..|::|.......|.|        |.|      :|.....|
Human  1446 -----AGMGW------------APRGPMQPSHCRLSWPGP--------RLP------KTQLILAV 1479

  Fly  2025 KEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDRED 2089
            ......|:.:||:
Human  1480 NWKGLCFLDQQEK---------------------------------------------------- 1492

  Fly  2090 YSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTT 2154
                                            .|.|:               :.|.|:
Human  1493 --------------------------------MLLEL---------------SFPEVM------- 1503

  Fly  2155 GGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTS 2219
                      ||||.|               .|..|.|..|.:||
Human  1504 ----------GLATNR---------------EAQGGQRLLLSTMH-------------------- 1523

  Fly  2220 PGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGP-PVALDLLFAQVLGDVFGV 2283
                                                  :.:|.:.| .||:..|.|..|
Human  1524 --------------------------------------EEYEFVSPSSVAIAELVALFL------ 1544

  Fly  2284 TPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFA 2348
                                                         ..|.:|.:..|
Human  1545 ---------------------------------------------EGLKERSIFAM--------- 1555

  Fly  2349 RLFAVQGAPLYPDVSIMGVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGK 2413
               |:|......|.::         ||.:..|.|::.:       :..:.......|..|.|.||
Human  1556 ---ALQDRKATDDTTL---------LAFKKGDLLVLTK-------KQGLLASENWTLGQNDRTGK 1601

  Fly  2414 HLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGV 2478
                     ..:..|...:            |:.:..:.:||.|::.....|.|:..|
Human  1602 ---------TGLVPMACLY------------TIPTVTKPSAQLLSLLAMSPEKRKLAA------- 1638

  Fly  2479 DGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQ 2543
                                               |:.|..|...||
Human  1639 -----------------------------------QEGQFTEPRPEE------------------ 1650

  Fly  2544 QGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDES 2608
                                                                             
Human  1651 ----------------------------------------------------------------- 1650

  Fly  2609 NGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGH-------AIRLP 2666
                ||....::|.:|:.:.||..:           :...:.:...|.:.:||       .:|.|
Human  1651 ----PPKEKLHTLEEFSYEFFRAPE-----------KDMVSMAVLPLARARGHLWAYSCEPLRQP 1700

  Fly  2667 LLRLPN---DLAPLALECFDCILRYCGDIPLD---PDLTEVKCVYTVLMHCHKYLALRDEVYCQL 2725
            ||:..:   ||..:|.:.|..||||.||.|..   |.|.....::|:.:   ::.||:||||||:
Human  1701 LLKRVHANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLAL---QHPALQDEVYCQI 1762

  Fly  2726 MKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNL 2790
            :||.|.|.:  ..|.:|.|:||.:....|..|..|.|:..:.:     |.||. ...|..|...:
Human  1763 LKQLTHNSN--RHSEERGWQLLWLCTGLFPPSKGLLPHAQKFI-----DTRRG-KLLAPDCSRRI 1819

  Fly  2791 RKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRL--PGGAERVVNTRCSTVVADVIAELCALLGV 2853
            :|..|.|.||..|...||.|  |.::..|..:::  |.....::....:|.|.||...:...|.:
Human  1820 QKVLRTGPRKQPPHQVEVEA--AEQNVSRICHKIYFPNDTSEMLEVVANTRVRDVCDSIATRLQL 1882

  Fly  2854 ESEAEQQEFSLYCIV--------QGDAFTMPLAADEYILDVTTELLKSGQPFYLIFCRSVWHFAL 2910
               |..:..||:..:        :||.|...|..       .::.:|..:|
Human  1883 ---ASWEGCSLFIKISDKVISQKEGDFFFDSLRE-------VSDWVKKNKP-------------- 1923

  Fly  2911 KREPAPMPLYVEVLFNQVAPDYLEGLLLEL-PGNGV----------PVPEMVR--------DMAR 2956
            ::|.||:.|..:|.|       :..|.|.: ||..|          .:|:.:|        |...
Human  1924 QKEGAPVTLPYQVYF-------MRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAIH 1981

  Fly  2957 IAALLHRA------ADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVK 3015
            :|.|:::|      :.|:.||  |.::.|:|:..  .|.:...:|...:..|:.:..:.:..:.|
Human  1982 LAGLIYKAQFNNDRSQLASVP--KILRELVPENL--TRLMSSEEWKKSILLAYDKHKDKTVEEAK 2042

  Fly  3016 AQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLIL-ALNRRGVLFLDPNTHETLQH 3079
            ..||..:..||.|||:||.||:           ...|.:.|:|| |:||.|||.:.|.|.:.|..
Human  2043 VAFLKWICRWPTFGSAFFEVKQ-----------TSEPSYPDVILIAINRHGVLLIHPKTKDLLTT 2096

  Fly  3080 WSFMEVISTRKVRSEDGALFLDMKVGNL 3107
            :.|.::.|.     ..|:.:..|.:|:|
Human  2097 YPFTKISSW-----SSGSTYFHMALGSL 2119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	281/684 (41%)
		PTZ00121	<828..>943	CDD:173412	41/155 (26%)
		MyTH4	1014..1171	CDD:470587	57/243 (23%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	20/70 (29%)
		MyTH4	2704..2810	CDD:459939	35/105 (33%)
		FERM_B-lobe	2920..3025	CDD:271216	25/129 (19%)
		FERM_C_MyoXV	3029..3138	CDD:270022	25/80 (31%)
MYO7B	XP_047300391.1	MYSc_Myo7	79..748	CDD:276832	281/684 (41%)
		IQ	785..807	CDD:197470	9/21 (43%)
		MyTH4	992..1221	CDD:214535	58/244 (24%)
		FERM1_F1_Myosin-VII	1225..1323	CDD:340612	32/288 (11%)
		FERM_C1_MyoVII	1467..1550	CDD:270019	31/336 (9%)
		SH3	1551..1611	CDD:473055	14/96 (15%)
		MyTH4	1692..1839	CDD:214535	52/157 (33%)
		FERM2_F1_Myosin-VII	1846..1943	CDD:340613	22/127 (17%)
		B41	1848..2060	CDD:214604	49/246 (20%)
		FERM_C2_MyoVII	2056..>2131	CDD:270020	25/80 (31%)