DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and MYO7A

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_011543348.2 Gene:MYO7A / 4647 HGNCID:7606 Length:2258 Species:Homo sapiens


Alignment Length:1823 Identity:538/1823 - (29%)
Similarity:785/1823 - (43%) Gaps:472/1823 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |||||..|.||:||.:|.||.:||...||||:.||||:|||||::. ..|..|..:||..:.:|.
Human    96 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLL-SIYSPEHIRQYTNKKIGE 159

  Fly   221 LPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            :|||:|||....:..:   ...|..:||||||:||||||||::|:|||:    ....:.|.:|:|
Human   160 MPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAI----SGQHSWIEQQVL 220

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ||.|:|||||||:|.|||||||||||::::| |.|||.||||.||||||||:..||..|||||||
Human   221 EATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVF 285

  Fly   347 YELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGEREGIVR 408
            |.:|.|:||.::.|.||.:|..|.||..|......||||   :.:::.||:||..::.|...|.:
Human   286 YCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISK 350

  Fly   409 VLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHT 473
            :|||:|||||:.:..|...: .:..||.....:..||.||.::...|...|||||...|.|.:.|
Human   351 LLAAILHLGNLQYEARTFEN-LDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVST 414

  Fly   474 PLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDA----HRISILDIFGFEDLAENSF 534
            ||..:||||.||||.|.:|..||.|:|.:||:.:.|..:.|.    ..|.:|||||||:.|.|||
Human   415 PLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSF 479

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDES 599
            ||||||:|||:||.:|.:|||||||.||..|.::|..:.:.||...:.::|.||:.|..|:|:||
Human   480 EQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEES 544

  Fly   600 NFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNRDALRGDVLE 663
            .||:.||.:.|.|.:..|.|:..|..|:...: :||:.|:||.|:|...|||:||||.|.||:::
Human   545 KFPKGTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQ 609

  Fly   664 LLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHP 728
            |:.|||    .:..||: .|.|    :..|:..|     .|:||::::|..||:.|::::|.|.|
Human   610 LVHSSR----NKFIKQI-FQAD----VAMGAETR-----KRSPTLSSQFKRSLELLMRTLGACQP 660

  Fly   729 WFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP--SPL 791
            :||||||||:.|..:..|....::||||.||::||:||:.|||:|..|..||||||.|||  .|.
Human   661 FFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPA 725

  Fly   792 ARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRG 856
            .:....|..|:.:.||:..|   ..|:|:|.|::||::.....||..|.:.:....:.:|:.:||
Human   726 YKQGDLRGTCQRMAEAVLGT---HDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRG 787

  Fly   857 MLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ------------------------ 897
            ...|....:.:.|||.:|..|||...::.|..:|.|.|..|                        
Human   788 FKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQA 852

  Fly   898 -------------RLW---------RGRQARRRVQQLRSDH------------------------ 916
                         |||         ||..|||..|:||:::                        
Human   853 RCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAK 917

  Fly   917 -------RRRQE-----AREAAQR---AREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSP 966
                   |:.||     |||.|:|   .:||...|:.:||:.:.:..: |...:.:..|:.|:  
Human   918 KAKEEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHE-PVNHSDMVDKMFGF-- 979

  Fly   967 PHGDRHLVKVLGTVPGPPSSAVQLP-----------------------------EDLGQFSFGKF 1002
                      |||..|.|....|.|                             |||.::.|.||
Human   980 ----------LGTSGGLPGQEGQAPSGFEDLERGRREMVEEDLDAALPLPDEDEEDLSEYKFAKF 1034

  Fly  1003 SSVYCNGLRLQP-RREPITAPLLTRAASRDQDFQDALAVFKLILRWSND---------------- 1050
            ::.|..|..... .|.|:..|||......||  ..||||:..|||:..|                
Human  1035 AATYFQGTTTHSYTRRPLKQPLLYHDDEGDQ--LAALAVWITILRFMGDLPEPKYHTAMSDGSEK 1097

  Fly  1051 --------------------KAL---------EGAKEKLLADYIVHKALSSR------------- 1073
                                :||         ||.|:..:...:||..|..:             
Human  1098 IPVMTKIYETLGKKTYKRELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHD 1162

  Fly  1074 ---------------------------------GLRDEILVQLCNQVHGLPPNSGEATRLWQLLG 1105
                                             .|||||..|:..|:...|..|..| |.|.|:.
Human  1163 GESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYA-RGWILVS 1226

  Fly  1106 QCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWR 1170
            .|:.||.||..|.|||..|:.. .|....|....:|.|....||          |:..|:|||.:
Human  1227 LCVGCFAPSEKFVKYLRNFIHG-GPPGYAPYCEERLRRTFVNGT----------RTQPPSWLELQ 1280

  Fly  1171 AWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASR-GWTL---VLDDGQQLTDS 1231
            |......:.||:|..|..::|:..||.|:.:|........:.:..| |::|   :.|....|  .
Human  1281 ATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSL--G 1343

  Fly  1232 CGLDYVMDLIAE----------------------KELCPAFPAPRSDLLRS---------GAKFA 1265
            .|.|:|||.|::                      ||:...:.:|..|.:.:         |.||.
Human  1344 SGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG 1408

  Fly  1266 R-----------------------------------TTLPD------------------AVKRPA 1277
            .                                   |.:||                  |.|:..
Human  1409 EYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKTLEKWAQLAIAAHKKGI 1473

  Fly  1278 VPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSS--------TGQ--AK 1332
            ...........||||....|....||.      .|::|.....||....:        ||.  ..
Human  1474 YAQRRTDAQKVKEDVVSYARFKWPLLF------SRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVD 1532

  Fly  1333 SRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVG-----------KDT 1386
            .:.:.|.:|...:|:.|.:..:.:..| :||.|:......:.....|.|.|           |.|
Human  1533 EQEQVLLELSFPEIMAVSSSRECRVWL-SLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTT 1596

  Fly  1387 GPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRV-------- 1443
            .|.:..:...|                  .||...||...|..:.  :.:.:..:|.        
Human  1597 APSFTLATIKG------------------DEYTFTSSNAEDIRDL--VVTFLEGLRKRSKYVVAL 1641

  Fly  1444 ---PSQASDVDQFLD----DLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYI 1501
               |:.|.:...||.    ||.  :||....|    :.:.:....|..|:..:.       .|:.
Human  1642 QDNPNPAGEESGFLSFAKGDLI--ILDHDTGE----QVMNSGWANGINERTKQR-------GDFP 1693

  Fly  1502 NDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDE----------ESEIE----DLDDYI 1552
            .|....:|.|....:     ::.|:     |...|::|.:          |.|:.    .|:::.
Human  1694 TDSVYVMPTVTMPPR-----EIVAL-----VTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEFS 1748

  Fly  1553 NELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLM-QLPGETESGPALYQQQVQR 1616
            .:.|.|.|      |.|....:....||.....|:..:||...|: :|.|..|     ..|:...
Human  1749 YDYFRPPP------KHTLSRVMVSKARGKDRLWSHTREPLKQALLKKLLGSEE-----LSQEACL 1802

  Fly  1617 AFL 1619
            ||:
Human  1803 AFI 1805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 314/693 (45%)
MYSc_Myo15 169..828 CDD:276838 304/672 (45%)
MyTH4 1014..1171 CDD:295320 57/248 (23%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYO7AXP_011543348.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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