Protein Alignment Myo10A and MYO7A

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Alignment Length: 1823
• Identity: 538/1823 - (29%)
• Similarity: 785/1823 - (43%)
• Gaps: 472/1823 - (25%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |||||..|.||:||.:|.||.:||...||||:.||||:|||||::. ..|..|..:||..:.:|.
Human    96 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLL-SIYSPEHIRQYTNKKIGE 159

  Fly   221 LPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            :|||:|||....:..:   ...|..:||||||:||||||||::|:|||:    ....:.|.:|:|
Human   160 MPPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAI----SGQHSWIEQQVL 220

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ||.|:|||||||:|.|||||||||||::::| |.|||.||||.||||||||:..||..|||||||
Human   221 EATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVF 285

  Fly   347 YELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGEREGIVR 408
            |.:|.|:||.::.|.||.:|..|.||..|......||||   :.:::.||:||..::.|...|.:
Human   286 YCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISK 350

  Fly   409 VLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHT 473
            :|||:|||||:.:..|...: .:..||.....:..||.||.::...|...|||||...|.|.:.|
Human   351 LLAAILHLGNLQYEARTFEN-LDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVST 414

  Fly   474 PLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDA----HRISILDIFGFEDLAENSF 534
            ||..:||||.||||.|.:|..||.|:|.:||:.:.|..:.|.    ..|.:|||||||:.|.|||
Human   415 PLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSF 479

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDES 599
            ||||||:|||:||.:|.:|||||||.||..|.::|..:.:.||...:.::|.||:.|..|:|:||
Human   480 EQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEES 544

  Fly   600 NFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLDKNRDALRGDVLE 663
            .||:.||.:.|.|.:..|.|:..|..|:...: :||:.|:||.|:|...|||:||||.|.||:::
Human   545 KFPKGTDTTMLHKLNSQHKLNANYIPPKNNHETQFGINHFAGIVYYETQGFLEKNRDTLHGDIIQ 609

  Fly   664 LLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHP 728
            |:.|||    .:..||: .|.|    :..|:..|     .|:||::::|..||:.|::::|.|.|
Human   610 LVHSSR----NKFIKQI-FQAD----VAMGAETR-----KRSPTLSSQFKRSLELLMRTLGACQP 660

  Fly   729 WFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP--SPL 791
            :||||||||:.|..:..|....::||||.||::||:||:.|||:|..|..||||||.|||  .|.
Human   661 FFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPA 725

  Fly   792 ARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRG 856
            .:....|..|:.:.||:..|   ..|:|:|.|::||::.....||..|.:.:....:.:|:.:||
Human   726 YKQGDLRGTCQRMAEAVLGT---HDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRG 787

  Fly   857 MLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ------------------------ 897
            ...|....:.:.|||.:|..|||...::.|..:|.|.|..|
Human   788 FKDRSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQFQA 852

  Fly   898 -------------RLW---------RGRQARRRVQQLRSDH------------------------ 916
                         |||         ||..|||..|:||:::
Human   853 RCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKLRKEMSAK 917

  Fly   917 -------RRRQE-----AREAAQR---AREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSP 966
                   |:.||     |||.|:|   .:||...|:.:||:.:.:..: |...:.:..|:.|:
Human   918 KAKEEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHE-PVNHSDMVDKMFGF-- 979

  Fly   967 PHGDRHLVKVLGTVPGPPSSAVQLP-----------------------------EDLGQFSFGKF 1002
                      |||..|.|....|.|                             |||.::.|.||
Human   980 ----------LGTSGGLPGQEGQAPSGFEDLERGRREMVEEDLDAALPLPDEDEEDLSEYKFAKF 1034

  Fly  1003 SSVYCNGLRLQP-RREPITAPLLTRAASRDQDFQDALAVFKLILRWSND---------------- 1050
            ::.|..|..... .|.|:..|||......||  ..||||:..|||:..|
Human  1035 AATYFQGTTTHSYTRRPLKQPLLYHDDEGDQ--LAALAVWITILRFMGDLPEPKYHTAMSDGSEK 1097

  Fly  1051 --------------------KAL---------EGAKEKLLADYIVHKALSSR------------- 1073
                                :||         ||.|:..:...:||..|..:
Human  1098 IPVMTKIYETLGKKTYKRELQALQGEGEAQLPEGQKKSSVRHKLVHLTLKKKSKLTEEVTKRLHD 1162

  Fly  1074 ---------------------------------GLRDEILVQLCNQVHGLPPNSGEATRLWQLLG 1105
                                             .|||||..|:..|:...|..|..| |.|.|:.
Human  1163 GESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYA-RGWILVS 1226

  Fly  1106 QCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWR 1170
            .|:.||.||..|.|||..|:.. .|....|....:|.|....||          |:..|:|||.:
Human  1227 LCVGCFAPSEKFVKYLRNFIHG-GPPGYAPYCEERLRRTFVNGT----------RTQPPSWLELQ 1280

  Fly  1171 AWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASR-GWTL---VLDDGQQLTDS 1231
            |......:.||:|..|..::|:..||.|:.:|........:.:..| |::|   :.|....|  .
Human  1281 ATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNALADKISLKDRFGFSLYIALFDKVSSL--G 1343

  Fly  1232 CGLDYVMDLIAE----------------------KELCPAFPAPRSDLLRS---------GAKFA 1265
            .|.|:|||.|::                      ||:...:.:|..|.:.:         |.||.
Human  1344 SGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHSPSEDNVATNLIYQQVVRGVKFG 1408

  Fly  1266 R-----------------------------------TTLPD------------------AVKRPA 1277
            .                                   |.:||                  |.|:..
Human  1409 EYRCEKEDDLAELASQQYFVDYGSEMILERLLNLVPTYIPDREITPLKTLEKWAQLAIAAHKKGI 1473

  Fly  1278 VPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSS--------TGQ--AK 1332
            ...........||||....|....||.      .|::|.....||....:        ||.  ..
Human  1474 YAQRRTDAQKVKEDVVSYARFKWPLLF------SRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVD 1532

  Fly  1333 SRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVG-----------KDT 1386
            .:.:.|.:|...:|:.|.:..:.:..| :||.|:......:.....|.|.|           |.|
Human  1533 EQEQVLLELSFPEIMAVSSSRECRVWL-SLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTT 1596

  Fly  1387 GPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRV-------- 1443
            .|.:..:...|                  .||...||...|..:.  :.:.:..:|.
Human  1597 APSFTLATIKG------------------DEYTFTSSNAEDIRDL--VVTFLEGLRKRSKYVVAL 1641

  Fly  1444 ---PSQASDVDQFLD----DLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYI 1501
               |:.|.:...||.    ||.  :||....|    :.:.:....|..|:..:.       .|:.
Human  1642 QDNPNPAGEESGFLSFAKGDLI--ILDHDTGE----QVMNSGWANGINERTKQR-------GDFP 1693

  Fly  1502 NDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDE----------ESEIE----DLDDYI 1552
            .|....:|.|....:     ::.|:     |...|::|.:          |.|:.    .|:::.
Human  1694 TDSVYVMPTVTMPPR-----EIVAL-----VTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEFS 1748

  Fly  1553 NELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLM-QLPGETESGPALYQQQVQR 1616
            .:.|.|.|      |.|....:....||.....|:..:||...|: :|.|..|     ..|:...
Human  1749 YDYFRPPP------KHTLSRVMVSKARGKDRLWSHTREPLKQALLKKLLGSEE-----LSQEACL 1802

  Fly  1617 AFL 1619
            ||:
Human  1803 AFI 1805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	304/672 (45%)
		PTZ00121	<828..>943	CDD:173412	43/199 (22%)
		MyTH4	1014..1171	CDD:470587	57/248 (23%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	20/92 (22%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	304/672 (45%)
		CBD_MYO6-like	<796..>839	CDD:409646	12/42 (29%)
		tolA	<826..>996	CDD:236545	35/182 (19%)
		MAP7	<887..963	CDD:461709	16/75 (21%)
		MyTH4	1047..1283	CDD:214535	58/249 (23%)
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612	22/99 (22%)
		B41	1289..1504	CDD:214604	40/222 (18%)
		FERM_C1_MyoVII	1498..1634	CDD:270019	29/162 (18%)
		SH3	1635..1699	CDD:473055	13/76 (17%)
		MyTH4	1793..1926	CDD:214535	4/18 (22%)
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613
		B41	1933..2145	CDD:214604