Protein Alignment Myo10A and MYO6

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001355794.1
• Gene: MYO6 / 4646
• HGNCID: 7605
• Length: 1294
• Species: Homo sapiens
• Alignment Length: 971
• Identity: 307/971 - (31%)
• Similarity: 454/971 - (46%)
• Gaps: 184/971 - (18%)

  Fly   134 PQTFALQP----GEGSLR-------ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTF 187
            |.:..::|    |:..|.       |.:| ....|||...|..|:||:||.|:::||.|..|||:
Human    26 PDSLTIEPLNQKGKTFLALINQVFPAEED-SKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTY 89

  Fly   188 AGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAH---AALPSPQVVVISGESG 249
            ..:||||||||...|..|..|..|.|.|:.||:.|||:|||...|.   ..|...|.:::|||||
Human    90 VANILIAVNPYFDIPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESG 154

  Fly   250 SGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF- 313
            :||||:||.|::||......|..    |.::|:||.|||||||||:|.||:|||||||::|::|
Human   155 AGKTENTKFVLRYLTESYGTGQD----IDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFN 215

  Fly   314 KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATD 378
            :..::||..::.||||||||..|...|||||:||.|..|.||..|.|..|...|.:.|||:|.|.
Human   216 EKSSVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRYLNRGCTR 280

  Fly   379 -CASGRVDWESLQG----------------------------AMQVLGVSEGEREGIVRVLAAVL 414
             .|:...|.:.||.                            ||:.:|:.:.|:..:.||:|.||
Human   281 YFANKETDKQILQNRKSPEYLKAGSMKDPLLDDHGDFIRMCTAMKKIGLDDEEKLDLFRVVAGVL 345

  Fly   415 HLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR---TTE--ARAERLHTP 474
            ||||:.|.......|...::..|...:::.|.||.:..|.|..:||:|   ||.  .:...:..|
Human   346 HLGNIDFEEAGSTSGGCNLKNKSAQSLEYCAELLGLDQDDLRVSLTTRVMLTTAGGTKGTVIKVP 410

  Fly   475 LGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCI 539
            |.::||.:||||.||.:|:.||:.:|:|:|....  ....::.|.:|||.|||....|||||.||
Human   411 LKVEQANNARDALAKTVYSHLFDHVVNRVNQCFP--FETSSYFIGVLDIAGFEYFEHNSFEQFCI 473

  Fly   540 NYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRA 604
            ||.||.||.:||:.:.|.||..|.:|.|....:.:.||...|.|:..|.|||..:||:|:..|:.
Human   474 NYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYVDNQDCIDLIEAKLVGILDILDEENRLPQP 538

  Fly   605 TDLSFLEKCHYNH---------ALSELYARPRIGAQE-FGVTHYAGQVWYCVDGFLDKNRDALRG 659
            :|..|....|..|         ..|:|.....|...| |.:.|:||.|.|....|::||.|||..
Human   539 SDQHFTSAVHQKHKDHFRLTIPRKSKLAVHRNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHM 603

  Fly   660 DVLELLASSRLPLVGEL----------TKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFAD 714
            .:..|:..||...:.||          |||     .|||.       .|:       :|..:|..
Human   604 SLESLICESRDKFIRELFESSTNNNKDTKQ-----KAGKL-------SFI-------SVGNKFKT 649

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            .|..||..:......|:||||||.:..:...:...:|.||:..||:..:.:.|.|||.|..|...
Human   650 QLNLLLDKLRSTGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHEL 714

  Fly   780 VERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR---------------- 828
            ...|:..:|..|||..| |..|:||.:|:   |:...||:.|.|:||.|
Human   715 YNMYKKYMPDKLARLDP-RLFCKALFKAL---GLNENDYKFGLTKVFFRPGKFAEFDQIMKSDPD 775

  Fly   829 ---EALHRA---LESGRTERLR-----------------RAAVSVQRHVRGMLVRR--------- 861
               |.:.|.   |...|.::::                 .|.:.:|:.:|..|.:|
Human   776 HLAELVKRVNHWLTCSRWKKVQWCSLSVIKLKNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGL 840

  Fly   862 -----------------------------QLARRQAAATRLQARWRG-----QRAQQRYERLRKG 892
                                         |:...:.:...|.|:.:.     ::.|:.|:.|.|
Human   841 VKVGTLKKRLDKFNEVVSVLKDGKPEMNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVK- 904

  Fly   893 ALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAE 953
              :::.|....|.:::.::.....||.||..|..::.||..|.::...|..:...|::.|:
Human   905 --SSEELLSALQKKKQQEEEAERLRRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAK 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	265/716 (37%)
		PTZ00121	<828..>943	CDD:173412	28/196 (14%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO6	NP_001355794.1	MYSc_Myo6	71..759	CDD:276833	265/716 (37%)
		Responsible for slow ATPase activity. /evidence=ECO:0000250|UniProtKB:Q29122	273..317		9/43 (21%)
		Actin-binding. /evidence=ECO:0000255	665..672		5/6 (83%)
		CBD_MYO6-like	770..917	CDD:409646	18/149 (12%)
		Required for binding calmodulin. /evidence=ECO:0000250|UniProtKB:Q29122	782..810		3/27 (11%)
		Three-helix bundle. /evidence=ECO:0000250|UniProtKB:Q29122	835..916		9/83 (11%)
		SAH. /evidence=ECO:0000269|PubMed:18511944	917..984		11/47 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	934..955		5/20 (25%)
		MYO6_MIU_linker	999..1068	CDD:412090
		Interaction with TAX1BP1 and CALCOCO2/NDP52. /evidence=ECO:0000269|PubMed:31371777	1060..1285
		MyUb_Myo6	1082..1122	CDD:439319
		Interaction with OPTN. /evidence=ECO:0000250|UniProtKB:Q9I8D1	1116..1118
		Interaction with TOM1. /evidence=ECO:0000269|PubMed:31371777	1157..1285
		Myosin-VI_CBD	1177..1267	CDD:465157