Protein Alignment Myo10A and MYO5A

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001369277.1
• Gene: MYO5A / 4644
• HGNCID: 7602
• Length: 1904
• Species: Homo sapiens
• Alignment Length: 1767
• Identity: 463/1767 - (26%)
• Similarity: 732/1767 - (41%)
• Gaps: 445/1767 - (25%)

  Fly    73 LLSPHVLRRQRPASLEDFEDLPNLSAKHPALPSSRLR--RLKCRYPQVVKRLSTLCSDVIARHPQ 135
            :||...::||        ..:|:|.:....|..:.|:  |:....|:.|.:.:.|..|
Human     5 MLSIVTVQRQ--------SKIPHLQSMLTCLDETALKFARVWIPDPEEVWKSAELLKD------- 54

  Fly   136 TFALQPGEGSLRARQDLGSS----------------------GVEDMTLLDDLHEASLLWNLRLR 178
               .:||:..|....:.|..                      |..|:|.|..|||.::|.|||:|
Human    55 ---YKPGDKVLLLHLEEGKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVR 116

  Fly   179 Y-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP--- 239
            : |..||||:.|.:|:|:|||:..| .||.::...|:|:.:|.:.||:||:...|:..:...
Human   117 FIDSKLIYTYCGIVLVAINPYEQLP-IYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERN 180

  Fly   240 QVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSR 304
            |.:::|||||:|||.|.|..|:|.|.|  .|.::.|.:.|::|.:.|::|:.|||:|.|||||||
Human   181 QSIIVSGESGAGKTVSAKYAMRYFATV--SGSASEANVEEKVLASNPIMESIGNAKTTRNDNSSR 243

  Fly   305 FGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADK 368
            ||||:|:.| |...|:||.:..|||||||:|.||..|||||:||:|.......|.....|..||.
Human   244 FGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNADN 308

  Fly   369 YFYLNQGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQL---- 426
            :.|..||.:....|..|.:.:   :.|..:||:||..:.||.|:||.:||||||.|..|..
Human   309 FNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILHLGNVGFTSRDADSCT 373

  Fly   427 ---RHGQ-----EGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDA 483
               :|..     |.:.|..:....|..          ||.|.:.|     |....|:...||.:|
Human   374 IPPKHEPLCIFCELMGVDYEEMCHWLC----------HRKLATAT-----ETYIKPISKLQATNA 423

  Fly   484 RDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR----ISILDIFGFEDLAENSFEQLCINYANE 544
            |||.||.:||.||||:|..:|..:     |.|.:    |.:|||:|||....|||||.|||||||
Human   424 RDALAKHIYAKLFNWIVDNVNQAL-----HSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANE 483

  Fly   545 NLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSF 609
            .||..||.|||||||.||.:|::.||.:.:.||.|.|:|:..| :||..|||:|...|:.||.::
Human   484 KLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESK-LGILDLLDEECKMPKGTDDTW 547

  Fly   610 LEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPL 672
            .:|. ||..|::  |:.:||:..:.|.:.|:|.:|.|..:|||:||:|.:..:.:::|.||:..:
Human   548 AQKL-YNTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKM 611

  Fly   673 VGELTKQLRAQRDAGKTLPKG--SNGRFVTMKPRTP-----------------TVAARFADSLQQ 718
            :.||     .|.|.....|..  |:||  |...|||                 ||..:|.:||..
Human   612 LPEL-----FQDDEKAISPTSATSSGR--TPLTRTPAKPTKGRPGQMAKEHKKTVGHQFRNSLHL 669

  Fly   719 LLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERY 783
            |::::....|.:|||||||..|.....|....:||||..|:|:||:|...|:|.|..:|.|..||
Human   670 LMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRY 734

  Fly   784 RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAV 848
            |.|:...... :..::.|:.:||.:.   ::...||.|.|::|.|......||..|.::||.|.:
Human   735 RVLMKQKDVL-SDRKQTCKNVLEKLI---LDKDKYQFGKTKIFFRAGQVAYLEKLRADKLRAACI 795

  Fly   849 SVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ--QRYERLRKGALTAQRLWRGRQARRRVQQ 911
            .:|:.:||.|:|::..|.:.||..:|...||.:|:  .::.|..|.|...|:.||....|||
Human   796 RIQKTIRGWLLRKKYLRMRKAAITMQRYVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRR--- 857

  Fly   912 LRSDHRRRQEAREAAQ---RAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGW-SPPHGDRH 972
                ::.|:.|....|   |...||...:.:|...         :...|..:::|| :..|..|.
Human   858 ----YKIRRAATIVLQSYLRGFLARNRYRKILREH---------KAVIIQKRVRGWLARTHYKRS 909

  Fly   973 LVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDA 1037
            :..::                          .:.|...|:..:||.....:..|:..|
Human   910 MHAII--------------------------YLQCCFRRMMAKRELKKLKIEARSVER------- 941

  Fly  1038 LAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQ 1102
               :|        |...|.:.|::.   :.:.:..:....:.||:....:.|
Human   942 ---YK--------KLHIGMENKIMQ---LQRKVDEQNKDYKCLVEKLTNLEG------------- 979

  Fly  1103 LLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWL 1167
                                  :.:...|.||..|.|..|.::....::|.|
Human   980 ----------------------IYNSETEKLRSDLERLQLSEEEAKVATGRV------------- 1009

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSC 1232
                          |:|.:|.::.
Human  1010 --------------LSLQEEIAKL----------------------------------------- 1019

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDL--LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRE 1295
                                 |.||  .||..|..                       :|...|.
Human  1020 ---------------------RKDLEQTRSEKKCI-----------------------EEHADRY 1040

  Fly  1296 RRSSRELLS-----------RSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPV 1349
            ::.:.:|:|           ...|||.|..:              |||..:::::..|..:...:
Human  1041 KQETEQLVSNLKEENTLLKQEKEALNHRIVQ--------------QAKEMTETMEKKLVEETKQL 1091

  Fly  1350 PTDCDSQEPLHTLGLSE-SRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYA 1413
            ..|.:.:...:...|:| |||.:||          .|.........|..:..|..:..:|||
Human  1092 ELDLNDERLRYQNLLNEFSRLEERY----------DDLKEEMTLMVHVPKPGHKRTDSTHSS--- 1143

  Fly  1414 DKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLD--------DLFSPVLDGSLDELS 1470
            :::||.. ||.:::..:.||........:||   .|:..||.        :....|:...||...
Human  1144 NESEYIF-SSEIAEMEDIPSRTEEPSEKKVP---LDMSLFLKLQKRVTELEQEKQVMQDELDRKE 1204

  Fly  1471 D--ARSLA-----ASIRGGSYEQEN----EAESEIDDLDDYINDIFQPI-----PLVQN------ 1513
            :  .||.|     ..|||...|.|:    |.|||...|.:.:|::.:.:     |.|..
Human  1205 EQVLRSKAKEEERPQIRGAELEYESLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAY 1269

  Fly  1514 ---LEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLA 1575
               :|:|||..:...:.|...:..:.:...::..|:..||. |.:.:...:.|.:.|:..|..:|
Human  1270 RVLMEQLTSVSEELDVRKEEVLILRSQLVSQKEAIQPKDDK-NTMTDSTILLEDVQKMKDKGEIA 1333

  Fly  1576 VSIRGGGSTD-SNGADPLLHQLMQLPGE-------TESGPALYQQQVQ-------------RAFL 1619
            .:..|...|: |:..|  .|:|.: .||       .:....|.:.|:|             |..:
Human  1334 QAYIGLKETNRSSALD--YHELNE-DGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEI 1395

  Fly  1620 QSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKA 1684
            ||...:|.: ||||||||  ||.....:..|:..:..|...........|....|......|:..
Human  1396 QSLKEENNR-QQQLLAQN--LQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYRISL 1457

  Fly  1685 TRSSLVVMESLQ 1696
            .:..:.:||.|:
Human  1458 YKRMIDLMEQLE 1469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	267/703 (38%)
		PTZ00121	<828..>943	CDD:173412	35/119 (29%)
		MyTH4	1014..1171	CDD:470587	19/156 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	3/66 (5%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO5A	NP_001369277.1	COG5022	35..1472	CDD:227355	455/1729 (26%)
		MYSc_Myo5	107..775	CDD:276831	267/703 (38%)
		Myo5a_CBD	1530..1904	CDD:271262