Protein Alignment Myo10A and MYO1E

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_004989.2
• Gene: MYO1E / 4643
• HGNCID: 7599
• Length: 1108
• Species: Homo sapiens
• Alignment Length: 847
• Identity: 277/847 - (32%)
• Similarity: 433/847 - (51%)
• Gaps: 149/847 - (17%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |||:||.||..:.|.|::.||:.||....|:|:.||:||:|||:|..| .:|.:..:.|.|....
Human    19 SGVDDMVLLSKITENSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMP-YFGEKEIEMYQGAAQY 82

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            ..|||::|:....:..:   ...|.|:||||||:|||.:.|.:|.|::. |.|||:....:.:.|
Human    83 ENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISR-VSGGGTKVQHVKDII 146

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIV-GAKITQYLLEKSRIVTQAPGERNYHV 345
            |::.|||||||||:|.||:||||||||.|:.|..|... |.||:.:||||||:|.:.||||::|:
Human   147 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHI 211

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|:.|.|..::...|:...|.|:||:...:   |....|.:::....||.|:|:...|:..::
Human   212 FYQLIEGASAEQKHSLGITSMDYYYYLSLSGSYKVDDIDDRREFQETLHAMNVIGIFAEEQTLVL 276

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRALTSRTTEA 466
            :::|.:|||||:.|.           |||:.|.::      :.|:||.|:.|.|...||||..::
Human   277 QIVAGILHLGNISFK-----------EVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDS 330

  Fly   467 ----RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFE 527
                ::|.:|..|.::||...|||.||||:|.:|::||..||..::|  .|:.:.|.:|||:|||
Human   331 KWGGKSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSINKAMEK--DHEEYNIGVLDIYGFE 393

  Fly   528 DLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKK--PVG 590
            ...:|.|||.|||:.||.||..|.:...|.||.||.:|.:.|||:.:.:|..|..|:..|  |.|
Human   394 IFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPG 458

  Fly   591 ICHLLDDESNFPRATDLSFLEKCHYNHALSE-------LYARPRIGAQE--------FGVTHYAG 640
            |..:|||              .|...||:.|       ...:.:||:.|        |.:.||||
Human   459 IMSILDD--------------VCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQGFIIHHYAG 509

  Fly   641 QVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL-TKQLRAQRDAGKTLPKGSNGRFVTMKPR 704
            :|.|.:|||.::|||.|..|::||:.||.||.:..| .:.|:|.:                 |.|
Human   510 KVSYDMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADK-----------------KGR 557

  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
            ..|..::.......|:.::.:|.|.::||||||:.|.....:...|..|:.|||:.:.|::|:.|
Human   558 PTTAGSKIKKQANDLVSTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAG 622

  Fly   770 YPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EA 830
            |..|..||.|::||..|..:  |..:|    |..:.:|..:....::...:|||.::||::  |:
Human   623 YAYRRIFQKFLQRYAILTKATWPSWQG----EEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPES 683

  Fly   831 LHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALT 895
            |. .||..|                                        :|....|.|:
Human   684 LF-LLEEMR----------------------------------------ERKYDGYARV------ 701

  Fly   896 AQRLWRGRQARRRVQQLRSDH-----RRRQEAREAAQR--------AREAREAKQAVLERSQLSY 947
            .|:.||...||::..|:|.:.     .:::..|.:..|        ..|..|.:|.|.:|.::.:
Human   702 IQKSWRKFVARKKYVQMREEASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDF 766

  Fly   948 LD 949
            .|
Human   767 AD 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	246/695 (35%)
		PTZ00121	<828..>943	CDD:173412	21/129 (16%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1E	NP_004989.2	MYSc_Myo1	33..679	CDD:276829	246/695 (35%)
		Actin-binding. /evidence=ECO:0000255	581..591		6/9 (67%)
		Myosin_TH1	719..920	CDD:461801	9/50 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..966
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	993..1053
		SH3_MyoIe_If_like	1056..1107	CDD:212761