Protein Alignment Myo10A and MYO1D

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_056009.1
• Gene: MYO1D / 4642
• HGNCID: 7598
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 344/1076 - (31%)
• Similarity: 512/1076 - (47%)
• Gaps: 175/1076 - (16%)

  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212
            |.|:....|..|..|:|.:.....:.|||||::||.||||.|.::::|||||:. :.||.:..:|
Human     2 AEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLL-NIYGRDTIEQ 65

  Fly   213 YAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-PGGGSA 273
            |.||.|...|||||||..||:.|:   .....:|||||||:||||::|.:|||:||:. |...:.
Human    66 YKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAE 130

  Fly   274 SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQA 337
            ...:...:|::..:|||||||:|.|||||||||||:::.|. .|..:|..|..|||||||::.|.
Human   131 VERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQ 195

  Fly   338 PGERNYHVFYELL-GGLSETERSKYGLLEADKYFYLNQGA------TDCASGRVDWESLQGAMQV 395
            ||||::|.||:|| ||..:..||.:.......|.|::.||      .|.|..||    :..||:|
Human   196 PGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRV----VADAMKV 256

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEG-VEVGSDAEIKWAAHLLHISADGLHRAL 459
            :|....|.:.:.::|||:|||||:.|    :..|... :|.|....|  .|.||....|.:.:||
Human   257 IGFKPEEIQTVYKILAAILHLGNLKF----VVDGDTPLIENGKVVSI--IAELLSTKTDMVEKAL 315

  Fly   460 TSRTTEAR---AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ-KGGTHDAHR--- 517
            ..||....   .::.||.   .:|...|||||||:|..||.|:|:|||.|:: |......|.
Human   316 LYRTVATGRDIIDKQHTE---QEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNT 377

  Fly   518 -ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVI 581
             |.:|||:|||....|||||.||||.||.||..|.:.|.|.||.||.||.:.|..:.:.:|..::
Human   378 VIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIV 442

  Fly   582 HLLAKKPVGICHLLDDE-SNFPRATDLSFLEKC------HYNHALSELYARPRI--GAQEFGVTH 637
            .|:.::..||..:|||. .|..:.||..|||..      |.:.:..:|.|..:|  ..::|.:.|
Human   443 DLVEQQHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRH 507

  Fly   638 YAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGS-NGRFVTM 701
            |||.|.|.|.||:|||:|.|..|...|:.:|..|::..:             .|:|. :...||.
Human   508 YAGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNM-------------WPEGKLSITEVTK 559

  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIR 766
            :|.  |.|..|.:|:..|:.::....|::|||||||.:|.....|......|:.|||:|:.:::|
Human   560 RPL--TAATLFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVR 622

  Fly   767 QRGYPVRLRFQHFVERYR---------HLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGA 822
            :.|:..|..::.|:.||:         |.|||.       :|..:.|:|   |.|.: .|...|.
Human   623 RAGFAFRQTYEKFLHRYKMISEFTWPNHDLPSD-------KEAVKKLIE---RCGFQ-DDVAYGK 676

  Fly   823 TRVFLREALHRALESGRT----ERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQ 883
            |::|:|        :.||    |.||..          ||:|..|.        ||..|||..|:
Human   677 TKIFIR--------TPRTLFTLEELRAQ----------MLIRIVLF--------LQKVWRGTLAR 715

  Fly   884 QRYERLRKGALTAQRLWRG-------RQARRRVQQLRS--DHRRRQEAREAAQRAREAREAKQAV 939
            .||:| .|.|||..|.:|.       .:..||...:::  |:.:..:.....:..|...||.|.:
Human   716 MRYKR-TKAALTIIRYYRRYKVKSYIHEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTI 779

  Fly   940 LERSQLSYL--DIPA-ELAFIYSKLQGWSPPHGDRHLV--------KVLGTVPGPPSSA---VQL 990
            ..|.:.|.|  .||| :|..:.:|:.......|.|..:        ..|.:.|..|.::   |.:
Human   780 FNRWRASQLIKSIPASDLPQVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPV 844

  Fly   991 PEDLGQ--------FS-----FGKFSSVYCNGL--------RLQPRRE---PITAPLLTRAASRD 1031
            ..:|.:        ||     ..:||.|....:        ::.|.::   ..|.||........
Human   845 ANELKRKDKYMNVLFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSV 909

  Fly  1032 QDFQDALAVFK-------LILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHG 1089
            .:.:|.|.||.       ::..:|.....|....:|:...:.|.....|.|:..:...:...:||
Human   910 SNGKDQLVVFHTKDNKDLIVCLFSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSLHG 974

  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFV 1125
            ........|||          .||...|:|....|:
Human   975 KKCTVSVETRL----------NQPQPDFTKNRSGFI 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	262/698 (38%)
		PTZ00121	<828..>943	CDD:173412	32/127 (25%)
		MyTH4	1014..1171	CDD:470587	24/122 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1D	NP_056009.1	MYSc_Myo1	24..682	CDD:276829	262/697 (38%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	572..594		8/21 (38%)
		Myosin_TH1	803..996	CDD:461801	36/202 (18%)