Protein Alignment Myo10A and MYO1C

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1021
• Identity: 343/1021 - (33%)
• Similarity: 519/1021 - (50%)
• Gaps: 161/1021 - (15%)

  Fly   143 EGSLRARQDLGSSGVEDMTLLDDL-HEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYG 206
            |.:|.||..:   ||:|..||::. .||:.:.|||.|:.:.||||:.|.:|::||||:.. ..|.
Human    37 ESALTARDRV---GVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDL-QIYS 97

  Fly   207 LEVAKQYAGRPLGSLPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVP 268
            .:..::|.|.....:||||||:....:.||.:   .|.|:||||||:||||:||.::|:.|...|
Human    98 RQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCP 162

  Fly   269 G---GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLE 329
            .   ||:    :.:::|::.|:|||||||:|.|||||||||||::|.|. .||.||..|..||||
Human   163 APERGGA----VRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLE 223

  Fly   330 KSRIVTQAPGERNYHVFYELL-GGLSETERSKYGL-LEADKYFYLNQGATDCA-----SGRVDWE 387
            |||:|.|..||||:|:||:|| ||..||.| :.|| .....|.||.:|  .||     :.:.||:
Human   224 KSRVVHQNHGERNFHIFYQLLEGGEEETLR-RLGLERNPQSYLYLVKG--QCAKVSSINDKSDWK 285

  Fly   388 SLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISA 452
            .::.|:.|:..:|.|.|.::.::|:||||||::|...:    :...:|.::.::|:...||.:..
Human   286 VVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANE----ESNAQVTTENQLKYLTRLLSVEG 346

  Fly   453 DGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRIN-SIVQKGGTHDAH 516
            ..|..|||.|...|:.|.|.:||.::||..||||.|||:|:..|.|||.:|| |:..|.....:.
Human   347 STLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSW 411

  Fly   517 R----ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDN 577
            |    :.:|||:|||....|||||.||||.||.||..|.:...|.||.||..|.:.|.|:.:.:|
Human   412 RSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNN 476

  Fly   578 LPVIHLLAKKPVGICHLLDDESNFP-RATDLSFLEKC--------HY-NHALSELYARPRIGAQE 632
            ..:..|:.:|..||..:||:|...| .||||:||||.        |: .|.|::...|..:|..|
Human   477 KIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGE 541

  Fly   633 FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGR 697
            |.:.||||:|.|.|.||||||.|.|..::.|.:.||:.|::.:...:..
Human   542 FRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSE---------------- 590

  Fly   698 FVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDT 762
             ::.|.|..|||.:|..||.||::.:....|.:|||||||..|...|.|...:..|::|||:|:.
Human   591 -LSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLEN 654

  Fly   763 IQIRQRGYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRV 825
            :::|:.|:..|.:::.|::||:.|.|.  |...|.|...:  |:|  :...|.:..:|::|.|::
Human   655 LRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGV--AVL--VRHLGYKPEEYKMGRTKI 715

  Fly   826 FLR-----EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR 885
            |:|     .|...|||                           .|||:.||::||.|||...:|:
Human   716 FIRFPKTLFATEDALE---------------------------VRRQSLATKIQAAWRGFHWRQK 753

  Fly   886 YERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDI 950
            :.|:::.|:..|..|||...||:.       .:|:.|.:..:|.......:.|........:||
Human   754 FLRVKRSAICIQSWWRGTLGRRKA-------AKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLD- 810

  Fly   951 PAELAFIYSKLQGWSPPHGDRHLVKVLGTV-PGPPSSAVQLPEDLGQFSFGKFSSVYCNGL---- 1010
            ....:|:.: |:...|.:       ||.|. |.||.:..:..|.|.:.........||..:
Human   811 HVRTSFLLN-LRRQLPQN-------VLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEW 867

  Fly  1011 --RLQPR------------REPITAPLL---TRAASRD-----------QDFQDALAVFK----- 1042
              :||.:            ..|.:.|.|   ||..:.:           :..|.|:.|.|
Human   868 KQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKG 932

  Fly  1043 -------LILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
                   |:|..:....:|.||.|...||.....:|...|.|.:.|
Human   933 YKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFV 978

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	267/689 (39%)
		PTZ00121	<828..>943	CDD:173412	28/119 (24%)
		MyTH4	1014..1171	CDD:470587	21/106 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	266/688 (39%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		10/21 (48%)
		IQCG	751..781	CDD:467744	9/36 (25%)
		Myosin_TH1	874..1055	CDD:461801	21/105 (20%)