Protein Alignment Myo10A and MYO1A

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_005370.1
• Gene: MYO1A / 4640
• HGNCID: 7595
• Length: 1043
• Species: Homo sapiens
• Alignment Length: 804
• Identity: 301/804 - (37%)
• Similarity: 441/804 - (54%)
• Gaps: 80/804 - (9%)

  Fly   153 GSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRP 217
            ||.||||:.||:.|.|.|||.||:|||:...|||:.|:::|:||||:..| .||.|...:|....
Human     6 GSVGVEDLVLLEPLVEESLLKNLQLRYENKEIYTYIGNVVISVNPYQQLP-IYGPEFIAKYQDYT 69

  Fly   218 LGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITE 279
            ...|.||::|:...|:.:|   ...|.::|:|||||||||::||||.|:|||. |.|.....:.|
Human    70 FYELKPHIYALANVAYQSLRDRDRDQCILITGESGSGKTEASKLVMSYVAAVC-GKGEQVNSVKE 133

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |:|::.|:|||||||:|.||:||||||||:::.|. .|:.:|..||.|||||||:|.|..||||:
Human   134 QLLQSNPVLEAFGNAKTIRNNNSSRFGKYMDIEFDFKGSPLGGVITNYLLEKSRLVKQLKGERNF 198

  Fly   344 HVFYELLGGLSETERSKYGLLEADK--YFYLN------QGATDCASGRVDWESLQGAMQVLGVSE 400
            |:||:||.|..| :..|...||.|.  |.|||      .|..|.:|.|    ::|.||.|:|.||
Human   199 HIFYQLLAGADE-QLLKALKLERDTTGYAYLNHEVSRVDGMDDASSFR----AVQSAMAVIGFSE 258

  Fly   401 GEREGIVRVLAAVLHLGNVY---------FHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLH 456
            .|...::.|.:.||.||||.         .....:|.|:...|:|         .::.::::.:.
Human   259 EEIRQVLEVTSMVLKLGNVLVADEFQASGIPASGIRDGRGVREIG---------EMVGLNSEEVE 314

  Fly   457 RALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISIL 521
            |||.|||.|...|::.|.|.:.||..||||.||.:|:.||:|:|:|||..::.|.......:.:|
Human   315 RALCSRTMETAKEKVVTALNVMQAQYARDALAKNIYSRLFDWIVNRINESIKVGIGEKKKVMGVL 379

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||:|||.|.:|||||..|||.||.||..|.:...|.||.||.||.:.||.:.:.||..:..|:..
Human   380 DIYGFEILEDNSFEQFVINYCNEKLQQVFIEMTLKEEQEEYKREGIPWTKVDYFDNGIICKLIEH 444

  Fly   587 KPVGICHLLDDESNFPR-ATDLSFLEKC--------HYNHALSELYARP---RIGAQEFGVTHYA 639
            ...||..:||:|...|. .:|.:||.|.        ||...:::...|.   .:|...|.:.|||
Human   445 NQRGILAMLDEECLRPGVVSDSTFLAKLNQLFSKHGHYESKVTQNAQRQYDHTMGLSCFRICHYA 509

  Fly   640 GQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPR 704
            |:|.|.|..|:|||.|.|..|:|:.:..::.||:..|             .|:| |.:..::| |
Human   510 GKVTYNVTSFIDKNNDLLFRDLLQAMWKAQHPLLRSL-------------FPEG-NPKQASLK-R 559

  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
            .||..|:|..|:..|::::....|.::||||||:.:...:.....|..|.||||:|:.:::|:.|
Human   560 PPTAGAQFKSSVAILMKNLYSKSPNYIRCIKPNEHQQRGQFSSDLVATQARYLGLLENVRVRRAG 624

  Fly   770 YPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EA 830
            |..|..:..|:||||.|..|  |...|.....:.:.|.|....:|    :...|.|::|:|  :.
Human   625 YAHRQGYGPFLERYRLLSRSTWPHWNGGDREGVEKVLGELSMSSG----ELAFGKTKIFIRSPKT 685

  Fly   831 LHRALESGRTERLRRAAVSVQRHVRGMLVRR--QLARRQAAATRLQARW-RGQRAQQRYERLRKG 892
            |. .||..|..||::.|..:|:..||...|.  ||.|:...   |.:.| ||...::.|.:::..
Human   686 LF-YLEEQRRLRLQQLATLIQKIYRGWRCRTHYQLMRKSQI---LISSWFRGNMQKKCYGKIKAS 746

  Fly   893 ALTAQRLWRGRQARRRVQQ-LRSD 915
            .|..|...||.:||:..:: .||:
Human   747 VLLIQAFVRGWKARKNYRKYFRSE 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	263/693 (38%)
		PTZ00121	<828..>943	CDD:173412	28/94 (30%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1A	NP_005370.1	MYSc_Myo1	22..681	CDD:276829	263/693 (38%)
		Actin-binding. /evidence=ECO:0000255	571..593		7/21 (33%)
		IQ	742..764	CDD:197470	6/21 (29%)
		Myosin_TH1	847..1042	CDD:461801