Protein Alignment Myo10A and MYH11

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001035203.1
• Gene: MYH11 / 4629
• HGNCID: 7569
• Length: 1979
• Species: Homo sapiens
• Alignment Length: 2205
• Identity: 532/2205 - (24%)
• Similarity: 886/2205 - (40%)
• Gaps: 537/2205 - (24%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.|||.||..|||||::|...:.|||||..| .|..::...|.|:...
Human    85 SKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLP-IYSEKIVDMYKGKKRH 148

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLA------------AVVPG 269
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||            ::..|
Human   149 EMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQG 213

  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRI 333
            ...|...:.:|:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.
Human   214 PSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRA 278

  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD--WESLQGAMQVL 396
            :.||..||.:|:||.::.|..|..||...|...:.|.:|:.|.....:.:.|  ::....||.::
Human   279 IRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIM 343

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-LT 460
            |.||.|:..|::|:::||.|||:.|.:.:   ..:...:..:...:...||:.|:.....|: ||
Human   344 GFSEEEQLSILKVVSSVLQLGNIVFKKER---NTDQASMPDNTAAQKVCHLMGINVTDFTRSILT 405

  Fly   461 SRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDI 523
            .|....|  .::..|.   :||..|.:|.|||.|..||.|:::|:|..:.|.....|..:.||||
Human   406 PRIKVGRDVVQKAQTK---EQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDI 467

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK- 586
            .|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.:
Human   468 AGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERP 532

  Fly   587 -KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDG 648
             .|.|:..|||:|..||:|||.||:||..........:.:|:  ....||.:.||||:|.|....
Human   533 NNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASA 597

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG---------KTLPKGSNGRFVTMKPR 704
            :|.||.|.|..:|..||.:|....|.:|.|.:  .|..|         .:||..|.    |.|..
Human   598 WLTKNMDPLNDNVTSLLNASSDKFVADLWKDV--DRIVGLDQMAKMTESSLPSASK----TKKGM 656

  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
            ..||...:.:.|.:|:.::....|.|||||.||.||.:.::|...||:|||..|:|:.|:|.::|
Human   657 FRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQG 721

  Fly   770 YPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            :|.|:.||.|.:||..|..:.:.:| ...::.|..:::|:.   ::...|::|.:::|.|..:..
Human   722 FPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALE---LDPNLYRIGQSKIFFRTGVLA 783

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQR 898
            .||..|..::....::.|...||.|.|:..|:||...|.::..   ||....|.:||.     .:
Human   784 HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVI---QRNCAAYLKLRN-----WQ 840

  Fly   899 LWR-------GRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAF 956
            .||       ..|..|:.:::::.....|:.:|..|:|.  .|.|:...:.|||:     .|...
Human   841 WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAE--NELKELEQKHSQLT-----EEKNL 898

  Fly   957 IYSKLQGWSPPHGDRHLVKV--------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQ 1013
            :..:||..:..:.:...::|        |..:.....:.::..||.||              :||
Human   899 LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ--------------QLQ 949

  Fly  1014 PRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDE 1078
            ..|:.:...:|        |.::.|            :..|.|::||..:.:..:| ..:.|.||
Human   950 AERKKMAQQML--------DLEEQL------------EEEEAARQKLQLEKVTAEA-KIKKLEDE 993

  Fly  1079 ILVQ-------------LCNQVHGLPPNSGE----ATRLWQLLGQCLCCFQPSAAFSKYLMRFVD 1126
            |||.             |..::..|..|..|    |..|.:|..      :..:..|:..:|...
Human   994 ILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN------KHESMISELEVRLKK 1052

  Fly  1127 DEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQT 1191
            :|........|.|:|              .|....|.....:.:|  :..::.:.|...:|..|
Human  1053 EEKSRQELEKLKRKL--------------EGDASDFHEQIADLQA--QIAELKMQLAKKEEELQ- 1100

  Fly  1192 VAVDSWTSCEEAAALAVSSLGVASRGWTLV--------LDDGQQLTDSCGLDYVMDLIAEK---E 1245
                        ||||.....:|.:...|.        :.|.|:..||   :......|||   :
Human  1101 ------------AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS---ERAARNKAEKQKRD 1150

  Fly  1246 LCPAFPAPRSDL------------LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERR- 1297
            |.....|.:::|            ||:..:...|.|..|:..        .|.|.:..|...|:
Human  1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE--------ETRSHEAQVQEMRQK 1207

  Fly  1298 ---------SSRELLSRSSA---LNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVP 1350
                     ...|...|:.|   .|::..|:|.:...|:....||||...:.....|...:..:.
Human  1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272

  Fly  1351 TDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASH-GSHSSKYAD 1414
            :.|...|      .:.:.|||:.|..:.  .|...||   ..::..|:....|.. .|.||:..|
Human  1273 SKCSDGE------RARAELNDKVHKLQN--EVESVTG---MLNEAEGKAIKLAKDVASLSSQLQD 1326

  Fly  1415 KAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDD-------------LFSPVLDGSL 1466
                 |:.....:|.:..::::.:|::.  .:.:.:...||:             ..:..|..|.
Human  1327 -----TQELLQEETRQKLNVSTKLRQLE--EERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384

  Fly  1467 DELSDARSLAASIRGG-------------SYEQENEAESEID--------DLDDYINDIFQPIPL 1510
            .:|.|..|...::..|             .||::..|..:::        :|||.:.|:.....|
Human  1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL 1449

  Fly  1511 VQNLEKLTSK-DQLAAIIKGGGVASK-PEERDE-ESEIEDLDDYINELFEPIPVAEGLDK-LTSK 1571
            |.||||...| |||.|..|  .::|| .:|||. |:|..:.:.      :.:.:|..|:: |.:|
Human  1450 VSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKET------KALSLARALEEALEAK 1506

  Fly  1572 EHLAVSIRGGGSTDSNGADPLLHQLMQ--LPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLL 1634
            |.|            ...:.:|...|:  :..:.:.|..:::.:..:..|::.|.:.....::|.
Human  1507 EEL------------ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

  Fly  1635 AQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPP 1699
            .:.||.:                                   .:.:|::      |.|::|:
Human  1560 DELQATE-----------------------------------DAKLRLE------VNMQALK--- 1580

  Fly  1700 PPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRK 1764
                                                     .|.|...|..::....|.||.||
Human  1581 -----------------------------------------GQFERDLQARDEQNEEKRRQLQR- 1603

  Fly  1765 TTPQAQHHQMTSNGGMMESGPGARGASATA---IEWEEFEIESPTPPPMSGQLMRSSIRLETTTT 1826
                 |.|:..:.   :|.....|..:|.|   :|.:..::|......:.|       |.|....
Human  1604 -----QLHEYETE---LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKG-------REEAIKQ 1653

  Fly  1827 TTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLK-LSSEMRQRLEQVT 1890
            ........:|..||.:|.......:..|  ||::.:            |.| |.:::.|..|.:.
Human  1654 LRKLQAQMKDFQRELEDARASRDEIFAT--AKENEK------------KAKSLEADLMQLQEDLA 1704

  Fly  1891 AGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERME 1955
            |....|             |..|..|..|.::|.   :|:||.|:    :.|....:..:|.::|
Human  1705 AAERAR-------------KQADLEKEELAEELA---SSLSGRNA----LQDEKRRLEARIAQLE 1749

  Fly  1956 GKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSS 2020
            .:|.                                                   |.:.:....|
Human  1750 EELE---------------------------------------------------EEQGNMEAMS 1763

  Fly  2021 SQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSR 2085
            .:|.|                |.:|.:.:|:   .|....:::....:|.:|.||:....||:..
Human  1764 DRVRK----------------ATQQAEQLSN---ELATERSTAQKNESARQQLERQNKELRSKLH 1809

  Fly  2086 DREDYSESVWDR--AEVEGPASGSGSEKEREKRERER---------ERLYEI-RQVERERESHKV 2138
            :.|...:|.:..  |.:|...:....:.|:|.||::.         ::|.|| .|||.||:..:.
Human  1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

  Fly  2139 YQPAPPRVIQASMDTTGGHRREDRTGGLATFR--THMAQKYEHERKRKSSASSGMREELD 2196
            |                   :|....|.|..:  ....::.|.|.:|.::....::.|||
Human  1875 Y-------------------KEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	255/694 (37%)
		PTZ00121	<828..>943	CDD:173412	28/121 (23%)
		MyTH4	1014..1171	CDD:470587	30/173 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/77 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYH11	NP_001035203.1	Myosin_N	31..76	CDD:460670
		MYSc_class_II	99..778	CDD:276951	255/694 (37%)
		Actin-binding. /evidence=ECO:0000250	668..690		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	769..783		3/13 (23%)
		Myosin_tail_1	855..1935	CDD:460256	248/1411 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	865..889		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1751..1807		14/125 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1873..1979		10/62 (16%)
		C-terminal	1942..1979