Protein Alignment Myo10A and MYH10

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001242941.1
• Gene: MYH10 / 4628
• HGNCID: 7568
• Length: 2007
• Species: Homo sapiens
• Alignment Length: 2228
• Identity: 530/2228 - (23%)
• Similarity: 881/2228 - (39%)
• Gaps: 515/2228 - (23%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.||:.||..|||||::|...:.:||||..| .|...:.:.|.|:...
Human    85 SKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLP-IYSENIIEMYRGKKRH 148

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVV-------------- 267
            .:|||::||..:|:..:   ...|.::.:||||:||||:||.|:||||.|.
Human   149 EMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQE 213

  Fly   268 -PGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEK 330
             |........:..|:|:|.|:||:||||:|.:|||||||||::.:.|. :|.||||.|..|||||
Human   214 SPKPVKHQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEK 278

  Fly   331 SRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWESLQ---GA 392
            ||.|.||..||.:|:||:||.|..|..:|...|...:.|.:|:.|... ..|:.|.::.|   .|
Human   279 SRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIP-IPGQQDKDNFQETMEA 342

  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457
            |.::|.|..|...:::|:::||..||:.|.:.:   ..:...:..:...:...|||.::.....|
Human   343 MHIMGFSHEEILSMLKVVSSVLQFGNISFKKER---NTDQASMPENTVAQKLCHLLGMNVMEFTR 404

  Fly   458 A-LTSRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRIS 519
            | ||.|....|  .::..|.   :||..|.:|.|||.|..||.|||.|||..:.:.....|..|.
Human   405 AILTPRIKVGRDYVQKAQTK---EQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIG 466

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHL 583
            ||||.|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|
Human   467 ILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDL 531

  Fly   584 LAK--KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWY 644
            :.:  .|.|:..|||:|..||:|||.:|:||..........:.:||  ....:|.:.||||:|.|
Human   532 IERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDY 596

  Fly   645 CVDGFLDKNRDALRGDVLELLASSRLPLVGELTK------QLRAQRDAGKTLPKGSNGRFV---- 699
            ..|.:|.||.|.|..:|..||..|....|.||.|      |..:..|:...|.:....|.|
Human   597 KADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPVDRIVGLDQ 661

  Fly   700 --------------TMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCV 750
                          |.|....||...:.:||.:|:.::...:|.|||||.||.||.|.::|...|
Human   662 VTGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLV 726

  Fly   751 LQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVE 814
            |.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::.|..::.|:.   ::
Human   727 LDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALE---LD 788

  Fly   815 GPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRG 879
            ...|::|.:::|.|..:...||..|..::....:..|...||.|.|:..|::|...:.|:..
Human   789 PNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVL--- 850

  Fly   880 QRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAR---EAAQRAREAREAKQAVLE 941
            ||....|.:||.        |:..:...:|:.|....|:.:|.:   |...:.:|.:...:..||
Human   851 QRNCAAYLKLRH--------WQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELE 907

  Fly   942 RSQLSYLDIPAELAFIYSKLQGWSPPHGD------------RHLVKVLGTVPGPPSSAVQLPEDL 994
            ..:..:..:..|...:..:||..:....:            :.|.::|..:    .|.|:..|:.
Human   908 EMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDL----ESRVEEEEER 968

  Fly   995 GQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEK 1059
            .|.              ||..::.:.|.:        ||.::.|           |:. |||::|
Human   969 NQI--------------LQNEKKKMQAHI--------QDLEEQL-----------DEE-EGARQK 999

  Fly  1060 LLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNS---GEATRLWQLLGQCLCCFQPSAAFSKYL 1121
            |..:.:..:| ..:.:.:|||: |.:|      ||   .|...:...:.:|..........:|.|
Human  1000 LQLEKVTAEA-KIKKMEEEILL-LEDQ------NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1056

  Fly  1122 MR-------FVDDEAPESLRPLLLRQLL----RQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRG 1175
            .:       .:.|......:....||.|    |:..|.|:.........::.:.
Human  1057 AKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQID----------- 1110

  Fly  1176 CDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDL 1240
             ::.|.|...:|..|                     |..:||      |.:.|..:..|..|.:|
Human  1111 -ELKLQLAKKEEELQ---------------------GALARG------DDETLHKNNALKVVREL 1147

  Fly  1241 IAE-KELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLS 1304
            .|: .||...|.:.::.  |:.|:..:..|                   .|::...:....:.|.
Human  1148 QAQIAELQEDFESEKAS--RNKAEKQKRDL-------------------SEELEALKTELEDTLD 1191

  Fly  1305 RSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRL 1369
            .::|..|...:||......:.:...:.|:....:.|:               ...|...|.|  |
Human  1192 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM---------------RQRHATALEE--L 1239

  Fly  1370 NDRYHSAERLA------PVGKDTGPR------------YQKSQHAGRRSHAASHGSHSS------ 1410
            :::...|:|..      ..|.:|..:            ..:|:|..::..|.....|:.
Human  1240 SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1304

  Fly  1411 ---KYADKAEYATRS----SAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDE 1468
               :.|:||......    |.:.:.:|...:........:.||..|..:.|.           :|
Human  1305 LRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ-----------EE 1358

  Fly  1469 LSDARSLAASIR-----GGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEK--LTSKDQLAAI 1526
            .....:|::.||     ..|.:::.|.|.|..                :||||  |..:.|||
Human  1359 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR----------------KNLEKQVLALQSQLA-- 1405

  Fly  1527 IKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADP 1591
                  .:|.:..|:...||.|::...:|.:.   ||.|.:...::.||.      .......:.
Human  1406 ------DTKKKVDDDLGTIESLEEAKKKLLKD---AEALSQRLEEKALAY------DKLEKTKNR 1455

  Fly  1592 LLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQ----QLLAQNQALQTLLSQQ---AA 1649
            |..:|..|..:.:     :|:||         |.||:.:|    ||||:.:::....:::   |.
Human  1456 LQQELDDLTVDLD-----HQRQV---------ASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1506

  Fly  1650 AAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKD 1714
            |.|....|         .:||::          :|...:|...|..:.........|...:..||
Human  1507 AEAREKET---------KALSLA----------RALEEALEAKEEFERQNKQLRADMEDLMSSKD 1552

  Fly  1715 P-SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNG 1778
            . .:..|.|:...||...::.:.|....:.|.:.|..||   .|:|........:||
Human  1553 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATED---AKLRLEVNMQAMKAQ-------- 1606

  Fly  1779 GMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQD 1843
                                 ||.:..|....:.:..|..|:            ..|:.:.|.:|
Human  1607 ---------------------FERDLQTRDEQNEEKKRLLIK------------QVRELEAELED 1638

  Fly  1844 VGQPMQSVVTTKLAKKSFEI----------GADRPPPGSVGKL-KLSSEMR---QRLEQVTAGHS 1894
            ..:.....|.   :||..||          .|::.....:.:| ||.::|:   :.||:..|...
Human  1639 ERKQRALAVA---SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1700

  Fly  1895 VRSTVSTKSEQRAPAKLEDTRKLMLQQQLGG--------------LFASVSGGNSGPGGVVDSHA 1945
            .....|.:||::  .|..:...|.||::|..              |...::...||...::|...
Human  1701 EIFAQSKESEKK--LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKR 1763

  Fly  1946 TVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP-------PAPPPAPQS 2003
            .:..:|.::|.:|....:               ::.......|..::..       .|...|.|.
Human  1764 RLEARIAQLEEELEEEQS---------------NMELLNDRFRKTTLQVDTLNAELAAERSAAQK 1813

  Fly  2004 PPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHL-----HLEDHSASS 2063
            ...||            .|:.:::.....:.||.:  |||:.:...:...|     .||:.
Human  1814 SDNAR------------QQLERQNKELKAKLQELE--GAVKSKFKATISALEAKIGQLEEQ---- 1860

  Fly  2064 SPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQ 2128
                  .||..:||:.:....|..|...:.::.:.|.|    ...:::.:|:.|:...|:.::::
Human  1861 ------LEQEAKERAAANKLVRRTEKKLKEIFMQVEDE----RRHADQYKEQMEKANARMKQLKR 1915

  Fly  2129 VERERESHKVYQPAPPRVIQASMD----TTGGHRRED-------RTGGLATFRTHMAQKYEHERK 2182
            ...|.|.......|..|.:|..:|    ...|..||.       |.||..:|
Human  1916 QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISF------------- 1967

  Fly  2183 RKSSASSGMREELDSMHM 2200
              ||:.||.|:    :|:
Human  1968 --SSSRSGRRQ----LHL 1979

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	261/713 (37%)
		PTZ00121	<828..>943	CDD:173412	26/117 (22%)
		MyTH4	1014..1171	CDD:470587	29/170 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	13/67 (19%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYH10	NP_001242941.1	Myosin_N	31..76	CDD:460670
		MYSc_Myh10	99..802	CDD:276952	261/713 (37%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	692..714		9/21 (43%)
		Myosin_tail_1	879..1959	CDD:460256	231/1371 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1158..1178		4/40 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1728..1759		3/30 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1903..2007		21/96 (22%)