DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYH9

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_002464.1 Gene:MYH9 / 4627 HGNCID:7579 Length:1960 Species:Homo sapiens


Alignment Length:2236 Identity:530/2236 - (23%)
Similarity:875/2236 - (39%) Gaps:504/2236 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGS-----------------SGVEDMTLLDDLH 167
            |:|..:.||.....|.:...:.||.::....:.|.                 |.||||..|..|:
Human    29 KKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLN 93

  Fly   168 EASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAA 232
            |||:|.||:.||..|||||::|...:.:||||..| .|..|:.:.|.|:....:|||::||...|
Human    94 EASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLP-IYSEEIVEMYKGKKRHEMPPHIYAITDTA 157

  Fly   233 HAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSA--SAVITEQILEAAPLLEAFG 292
            :.::   ...|.::.:||||:||||:||.|:||||.|.....|.  ...:..|:|:|.|:|||||
Human   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFG 222

  Fly   293 NARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSET 356
            ||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:|:||.||.|..|.
Human   223 NAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEH 287

  Fly   357 ERSKYGLLEADKYFYLNQGATDCASGRVDWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGN 418
            .::...|...:||.:|:.|.. ...|:.|.:..|   .||:::|:.|.|:.|::||::.||.|||
Human   288 LKTDLLLEPYNKYRFLSNGHV-TIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGN 351

  Fly   419 VYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-LTSRTTEAR--AERLHTPLGIDQA 480
            :.|.:.:   ..:...:..:...:..:|||.|:.....|. ||.|....|  .::..|.   :||
Human   352 IVFKKER---NTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTK---EQA 410

  Fly   481 LDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANEN 545
            ..|.:|.|||.|..:|.|||.|||..:.|.....|..|.||||.|||....||||||||||.||.
Human   411 DFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEK 475

  Fly   546 LQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAKK--PVGICHLLDDESNFPRATDL 607
            ||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.|.  |.||..|||:|..||:|||.
Human   476 LQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDK 540

  Fly   608 SFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRL 670
            ||:||..........:.:|:  ....:|.:.||||:|.|..|.:|.||.|.|..::..||..|..
Human   541 SFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSD 605

  Fly   671 PLVGELTKQ----LRAQRDAGKT---LPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHP 728
            ..|.||.|.    :...:.||.:   ||    |.|.|.|....||...:.:.|.:|:.::...:|
Human   606 KFVSELWKDVDRIIGLDQVAGMSETALP----GAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNP 666

  Fly   729 WFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLAR 793
            .|||||.||.||.|.::|...||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:
Human   667 NFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPK 731

  Fly   794 G-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGM 857
            | ...::.|..:::|:.   ::...|::|.::||.|..:...||..|..::....:..|...||.
Human   732 GFMDGKQACVLMIKALE---LDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGY 793

  Fly   858 LVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEA 922
            |.|:..|:||...|.::..   ||....|.:||.        |:..:...:|:.|....|:.:|.
Human   794 LARKAFAKRQQQLTAMKVL---QRNCAAYLKLRN--------WQWWRLFTKVKPLLQVSRQEEEM 847

  Fly   923 REAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSA 987
            .        |:|.:...:...||:..:...|:..:.|:|.                      :..
Human   848 M--------AKEEELVKVREKQLAAENRLTEMETLQSQLM----------------------AEK 882

  Fly   988 VQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKA 1052
            :||.|.|      :..:..|      ...|.:.|    |..::.|:.::.....:..:....::.
Human   883 LQLQEQL------QAETELC------AEAEELRA----RLTAKKQELEEICHDLEARVEEEEERC 931

  Fly  1053 --LEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSA 1115
              |:..|:|:                .:.:.:|..|:.                       :..:
Human   932 QHLQAEKKKM----------------QQNIQELEEQLE-----------------------EEES 957

  Fly  1116 AFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMAL 1180
            |..|..:..|..||  .|:.|...|::.:.                            :.|.:|.
Human   958 ARQKLQLEKVTTEA--KLKKLEEEQIILED----------------------------QNCKLAK 992

  Fly  1181 PLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLT---------------- 1229
            ...|.::.......:.....|::.:||    .:.::...::.|..::|.                
Human   993 EKKLLEDRIAEFTTNLTEEEEKSKSLA----KLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053

  Fly  1230 --DSCGL-DYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKED 1291
              ||..| |.:.:|.|:........|.:.:.|:  |..||.....|.|..|:             
Human  1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ--AALARVEEEAAQKNMAL------------- 1103

  Fly  1292 VPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQ 1356
                 :..|||.|:.|.|.|..        ..:.:|..:|:.:.:.|.:.|......:....|| 
Human  1104 -----KKIRELESQISELQEDL--------ESERASRNKAEKQKRDLGEELEALKTELEDTLDS- 1154

  Fly  1357 EPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATR 1421
                |....|.|     ...|:...:.|.|.....|:..|..:.....|.....:.|::.|...|
Human  1155 ----TAAQQELR-----SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210

  Fly  1422 SSAMSD------TSEAPSLASHV------------RRVRVPSQASDV-------DQFLDDLFSPV 1461
            ..|..:      .:|...||:.|            :|.:|.:|..::       ::...:|...|
Human  1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKV 1275

  Fly  1462 --LDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLA 1524
              |...||.::...|.:.|......:..:..||::.|..:.:.:        :|.:||:...:|.
Human  1276 TKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE--------ENRQKLSLSTKLK 1332

  Fly  1525 AIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNG- 1588
            .:            .||::...:      :|.|.......|:|..:..|..|:.......||.| 
Human  1333 QV------------EDEKNSFRE------QLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379

  Fly  1589 ---ADPLLHQLMQ----LPGETESGPALY----------QQQVQRAFL----QSAMAQNLQIQQ- 1631
               |:.:..:|.:    |....|...|.|          ||::....:    |...|.||:.:| 
Human  1380 LETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444

  Fly  1632 ---QLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSL---- 1689
               ||||:.:.:....:::...|.|........|..:..:|       :..|..||....|    
Human  1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL-------EEAMEQKAELERLNKQF 1502

  Fly  1690 -VVMESLQPPPPPPPPPMPPPLECKDP-SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEED 1752
             ..||.|              :..||. .::.|.|:...||...::.:.:....:.|.:.|..||
Human  1503 RTEMEDL--------------MSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553

  Fly  1753 FFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRS 1817
               .|:|........:||..:...  |..|.....:......:...|.|:|............|.
Human  1554 ---AKLRLEVNLQAMKAQFERDLQ--GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK 1613

  Fly  1818 SIR--LETTTTTTTSAVNNRD-------------RD--RETQDVGQPMQSVVTTKLAKKSFEIGA 1865
            .:.  |:.......||..|||             :|  ||..|.....:.::..  ||::.:   
Human  1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ--AKENEK--- 1673

  Fly  1866 DRPPPGSVGKLK-LSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFAS 1929
                     ||| :.:||.|..|::.|.            :||        |...||:...| |.
Human  1674 ---------KLKSMEAEMIQLQEELAAA------------ERA--------KRQAQQERDEL-AD 1708

  Fly  1930 VSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP 1994
            ....:||.|      |....:..|:|.:::                                   
Human  1709 EIANSSGKG------ALALEEKRRLEARIA----------------------------------- 1732

  Fly  1995 PAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHV-PAFIQRQERDTFGAVRQQQMISSHHLHLED 2058
                          ..|.|.:....:::::.:.: .|.:|..:.:|             .|:||.
Human  1733 --------------QLEEELEEEQGNTELINDRLKKANLQIDQINT-------------DLNLER 1770

  Fly  2059 HSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDR---------AEVEGPASGSGSEKE-- 2112
            ..|..:.  .|.:|.||:....:.:.::.|...:|.:..         |::|........|::  
Human  1771 SHAQKNE--NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAA 1833

  Fly  2113 -REKRERERERLYEIRQVERERESHKVYQ----PAPPRVIQASMDTTGGHRREDRTGGLATFRTH 2172
             ::.|..|::....:.||:.||.:.:.|:    .|..|:.|.............|...       
Human  1834 CKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA------- 1891

  Fly  2173 MAQKYEHERKRKSSASSGMREELDSM 2198
            ..:|.:.|.:..:..:..|..|:.|:
Human  1892 SRRKLQRELEDATETADAMNREVSSL 1917

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 275/704 (39%)
MYSc_Myo15 169..828 CDD:276838 267/683 (39%)
MyTH4 1014..1171 CDD:295320 17/158 (11%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYH9NP_002464.1 Mediates interaction with LIMCH1. /evidence=ECO:0000269|PubMed:28228547 2..838 303/834 (36%)
Myosin_N 29..68 CDD:367160 8/38 (21%)
Motor_domain 95..764 CDD:354959 267/683 (39%)
Actin-binding 654..676 9/21 (43%)
Myosin_tail_1 841..1921 CDD:366712 226/1398 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1035..1057 1/21 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1137 3/26 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1877..1960 6/48 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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