DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYH8

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_002463.2 Gene:MYH8 / 4626 HGNCID:7578 Length:1937 Species:Homo sapiens


Alignment Length:2198 Identity:509/2198 - (23%)
Similarity:856/2198 - (38%) Gaps:551/2198 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 RHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVN 196
            |..|.|.:.|.:          ...:|||.::..|||..:|:||:.||...:|||::|...:.||
Human    75 REDQVFPMNPPK----------YDKIEDMAMMTHLHEPGVLYNLKERYAAWMIYTYSGLFCVTVN 129

  Fly   197 PYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKL 258
            |||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:||.
Human   130 PYKWLP-VYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKR 193

  Fly   259 VMQYLAAVVPGG-------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KS 315
            |:||.|.:...|       |.....:.:||:.|.|||||||||:|.||||||||||::.::| .:
Human   194 VIQYFATIAVTGEKKKDESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT 258

  Fly   316 GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLN 373
            |.:..|.|..|||||||:..|...||:||:||::      |...|..|:|       ...|.:::
Human   259 GKLASADIETYLLEKSRVTFQLKAERSYHIFYQI------TSNKKPDLIEMLLITTNPYDYAFVS 317

  Fly   374 QGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GV 433
            ||.....| ..|.|.|   ..|:.:||.:..|:..|.::..||:|.||:.|.::|.....|  |.
Human   318 QGEITVPS-IDDQEELMATDSAIDILGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGT 381

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            ||...     ||:|..:::..|.:||.....:...|.:.....:.|..:|..|.|||:|..:|.|
Human   382 EVADK-----AAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYEKMFLW 441

  Fly   499 LVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAE 561
            :|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||.:||.|:|.|||.|
Human   442 MVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEE 503

  Fly   562 YARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYAR 625
            |.:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:
Human   504 YKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQK 568

  Fly   626 PRI--GAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDA 686
            |::  |..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.:..:..|.... |..:|
Human   569 PKVVKGKAEAHFSLIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTY-ASAEA 632

  Fly   687 GKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVL 751
            ..:..||:..:..:.:    ||:|.|.::|.:|:.::...||.|||||.||:.|....|:...||
Human   633 DSSAKKGAKKKGSSFQ----TVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVL 693

  Fly   752 QQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGP 816
            .|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:....::..
Human   694 HQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEG-QFIDSKKASEKLLASIDIDHT 757

  Fly   817 DYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQA--------- 868
            .|:.|.|:||.:..|...||..|.|:|.:.....|...||.|:|    :.|.||:|         
Human   758 QYKFGHTKVFFKAGLLGLLEEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVR 822

  Fly   869 -----------------------AATRLQARWRGQRAQQRYERLRKGALTAQRLWRG-------- 902
                                   |.|..:.....:..|:..:.|.|.....:.|...        
Human   823 AFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEK 887

  Fly   903 --------------RQARRRVQQL-RSDHRRRQEAREAAQRAREARE------AKQAVLERSQLS 946
                          ..|..|.:|| ::..:...:.:|..:||.|..|      ||:..|| .:.|
Human   888 NDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLE-DECS 951

  Fly   947 YL--DIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSSVYC 1007
            .|  ||. :|....:|::  ...|...:.||.|      ......|.|.:.:.|..|  ....:.
Human   952 ELKKDID-DLELTLAKVE--KEKHATENKVKNL------TEEMAGLDETIAKLSKEKKALQETHQ 1007

  Fly  1008 NGL-RLQPRREPITAPLLTRAASR-DQDFQDALAVFKLILRWSNDKALEGAKEKLLAD------- 1063
            ..| .||...:.:.  :||:|.:: :|...|.....:...:...|  ||.||.||..|       
Human  1008 QTLDDLQAEEDKVN--ILTKAKTKLEQQVDDLEGSLEQEKKLRMD--LERAKRKLEGDLKLAQES 1068

  Fly  1064 -------------------YIVHKALSSRGLRDE--ILVQLCNQVHGLPPNSGEATRLWQLLGQC 1107
                               :.:...:|.  :.||  :.:||..::..|.....|       ||:.
Human  1069 TMDMENDKQQLDEKLEKKEFEISNLISK--IEDEQAVEIQLQKKIKELQARIEE-------LGEE 1124

  Fly  1108 LCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWL 1167
            :...:.|.|            ..|..|..|.|:|..     ::.||.:|..|.....|.     .
Human  1125 IEAERASRA------------KAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKRE-----A 1172

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSC 1232
            |::...|..:.|   ||..||  .||     :..:..|.:::.||..       :|:.|::... 
Human  1173 EFQKLRRDLEEA---TLQHEA--MVA-----ALRKKHADSMAELGEQ-------IDNLQRVKQK- 1219

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDL------LRSGA-----------KFARTTLPDAVKRPAVPP 1280
                     .|||        :|:|      |.|.|           |..| :|.|.|       
Human  1220 ---------LEKE--------KSELKMETDDLSSNAEAISKAKGNLEKMCR-SLEDQV------- 1259

  Fly  1281 PAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGD 1345
                 |..|.....::|...:|.::.:.|..                  :|...|:.||:     
Human  1260 -----SELKTKEEEQQRLINDLTAQRARLQT------------------EAGEYSRQLDE----- 1296

  Fly  1346 IVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQH----------AGRRS 1400
                 .|....:...:...|..::.:..|..|.............|.|:|          ..:..
Human  1297 -----KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEG 1356

  Fly  1401 HAASHGSHSSKYADKAEYATR--SSAMSDTSE----APSLASHVRRVR-----VPSQASDVDQFL 1454
            .|....:.|...::.|::.|:  :.|:..|.|    ...||..::...     |.::.:.:::..
Human  1357 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTK 1421

  Fly  1455 DDLFSPVLDGSLD-ELSDARSLAASIRGGSYE----------QENEAESEIDDLD--DYINDIFQ 1506
            ..|.:.|.|..|| |.|:|...|...:..:::          :|.:||.|....:  ....::|:
Human  1422 QRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFK 1486

  Fly  1507 PIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSK 1571
                |:|:.: .|.|||..:        :.|.::.:.||.||.:.|.|..:.|...|.:.|...:
Human  1487 ----VKNVYE-ESLDQLETL--------RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQ 1538

  Fly  1572 EHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQ----QVQRAFLQSAMAQNLQIQQQ 1632
            |...:      ......|:..|        |.|.|..|..|    ||:....:....::.:|.|.
Human  1539 EKCEI------QAALEEAEASL--------EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL 1589

  Fly  1633 LLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISP--PPPQSPMRMKATRSSLVVMESL 1695
            .....:.::|:.|...|...:.|           .:|.:..  ....:.|.::...::.:..|||
Human  1590 KRNHTRVVETMQSTLDAEIRSRN-----------DALRVKKKMEGDLNEMEIQLNHANRLAAESL 1643

  Fly  1696 QPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQ 1760
                                   |::.:..|..|..::        ..:...:.:||........
Human  1644 -----------------------RNYRNTQGILKETQL--------HLDDALRGQEDLKEQLAIV 1677

  Fly  1761 HQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTT 1825
            .:|....||:..::                      |...|....:......:|:.:|.|::...
Human  1678 ERRANLLQAEIEEL----------------------WATLEQTERSRKIAEQELLDASERVQLLH 1720

  Fly  1826 TTTTSAVNNRDR-DRETQDVGQPMQSVV-----TTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQ 1884
            |..||.:|.:.: :.:...:...::.|:     ..:.|||:....|           .::.|:::
Human  1721 TQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAA-----------MMAEELKK 1774

  Fly  1885 RLEQVTAGHSVRSTVSTKSEQRAPAKLEDT-----RKLMLQQQLGGLFASVSGGNSGPGGVVDSH 1944
              ||.|:.|.          :|....||.|     .:|...:||     ::.||           
Human  1775 --EQDTSAHL----------ERMKKNLEQTVKDLQHRLDEAEQL-----ALKGG----------- 1811

  Fly  1945 ATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARS 2009
               :.||:::|.::                                               ....
Human  1812 ---KKQIQKLEARV-----------------------------------------------RELE 1826

  Fly  2010 PEPEPDYRTSSSQV--VKEH---VPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAA 2069
            .|.|.:.:.::..|  :::|   |.....:.|.|....:|.|.::......::.:...:      
Human  1827 GEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQA------ 1885

  Fly  2070 WEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK-RERERE 2121
             |:||.:.:.:.|:.|..:...|...:||::        :|.:..| |.:.||
Human  1886 -EEAEEQSNANLSKFRKLQHELEEAEERADI--------AESQVNKLRVKSRE 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 256/709 (36%)
MYSc_Myo15 169..828 CDD:276838 249/688 (36%)
MyTH4 1014..1171 CDD:295320 35/190 (18%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYH8NP_002463.2 Myosin_N 38..75 CDD:280832 509/2198 (23%)
Myosin_head 90..769 CDD:278492 255/700 (36%)
MYSc_Myh8 102..769 CDD:276882 249/688 (36%)
Actin-binding 658..680 10/21 (48%)
Actin-binding 760..774 5/13 (38%)
Myosin_tail_1 849..1926 CDD:279860 231/1387 (17%)
eIF-4B <1042..1099 CDD:283846 9/60 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1146 6/31 (19%)
COG6 1375..>1510 CDD:303003 28/147 (19%)
DUF342 <1505..1581 CDD:302792 19/89 (21%)
TMPIT 1741..>1828 CDD:285135 22/175 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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