Protein Alignment Myo10A and MYH7

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_000248.2
• Gene: MYH7 / 4625
• HGNCID: 7577
• Length: 1935
• Species: Homo sapiens
• Alignment Length: 2226
• Identity: 532/2226 - (23%)
• Similarity: 873/2226 - (39%)
• Gaps: 594/2226 - (26%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Human    87 IEDMAMLTFLHEPAVLYNLKDRYGSWMIYTYSGLFCVTVNPYKWLP-VYTPEVVAAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVV-----------PGGGS 272
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:.           ||.|:
Human   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQSPGKGT 215

  Fly   273 ASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQ 336
                :.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|
Human   216 ----LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ 276

  Fly   337 APGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWESL---QGAMQVL 396
            ...||:||:||::|.. .:.|.....|:..:.|.|  ::||.|..|| ..|.|.|   ..|..||
Human   277 LKAERDYHIFYQILSN-KKPELLDMLLITNNPYDYAFISQGETTVAS-IDDAEELMATDNAFDVL 339

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            |.:..|:..:.::..|::|.||:.|   :|:..:|..|.....|...:|:|:.:::..|.:.|..
Human   340 GFTSEEKNSMYKLTGAIMHFGNMKF---KLKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCH 401

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGF 526
            ...:...|.:.....:.|.:.|..|.|||:|..:|||:|:|||:.::...... :.|.:|||.||
Human   402 PRVKVGNEYVTKGQNVQQVIYATGALAKAVYERMFNWMVTRINATLETKQPRQ-YFIGVLDIAGF 465

  Fly   527 EDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGI 591
            |....|||||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|.:||:||
Human   466 EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGI 530

  Fly   592 CHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGFLD 651
            ..:|::|..||:|||::|..|...|| ..|..:.:||  .|..|  |.:.||||.|.|.:.|:|.
Human   531 MSILEEECMFPKATDMTFKAKLFDNHLGKSANFQKPRNIKGKPEAHFSLIHYAGIVDYNIIGWLQ 595

  Fly   652 KNRDALRGDVLELLASSRLPLVGELTKQLRA-----QRDAGKTLPKGSNGRFVTMKPRTPTVAAR 711
            ||:|.|...|:.|...|.|.|:..|......     ::..||. .|||:.:         ||:|.
Human   596 KNKDPLNETVVGLYQKSSLKLLSTLFANYAGADAPIEKGKGKA-KKGSSFQ---------TVSAL 650

  Fly   712 FADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRF 776
            ..::|.:|:.::...||.|||||.||:.|....||.|.|:.|||..|:|:.|:|.::|:|.|:.:
Human   651 HRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILY 715

  Fly   777 QHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGR 839
            ..|.:|||.|.|:.:..|  ...|:....||.::   .::...|:.|.|:||.:..|...||..|
Human   716 GDFRQRYRILNPAAIPEGQFIDSRKGAEKLLSSL---DIDHNQYKFGHTKVFFKAGLLGLLEEMR 777

  Fly   840 TERLRRAAVSVQRHVRGMLVRRQ----LARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLW 900
            .|||.|....:|...||:|.|.:    |.||.:.   |..:|          .:|  |....:.|
Human   778 DERLSRIITRIQAQSRGVLARMEYKKLLERRDSL---LVIQW----------NIR--AFMGVKNW 827

  Fly   901 RGRQARRRVQQLRSDHRRRQE---AREAAQRAREA---REAKQAVLERSQLSYLDIPAELAFIYS 959
            ...:...:::.|.....|.:|   .:|...|.:||   .||::..||...:|.|....:|
Human   828 PWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDL----- 887

  Fly   960 KLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLL 1024
            :||                         ||..:|....:..:...:..|.::|:
Human   888 QLQ-------------------------VQAEQDNLADAEERCDQLIKNKIQLE----------- 916

  Fly  1025 TRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHG 1089
            .:....::..:|                    :|::.|:....|    |.|.||     |::
Human   917 AKVKEMNERLED--------------------EEEMNAELTAKK----RKLEDE-----CSE--- 949

  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAV 1154
                                           |.|.:||      ..|.|.::.:::
Human   950 -------------------------------LKRDIDD------LELTLAKVEKEK--------- 968

  Fly  1155 GAGACRSFVPAWLEWRAWTRGCD-MALPLTLPDEASQTV---AVDSWTSCEEAAALAVSSLGVAS 1215
              .|..:.|....|..|   |.| :...||...:|.|..   |:|...:.|:    .|::|..|.
Human   969 --HATENKVKNLTEEMA---GLDEIIAKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKAK 1024

  Fly  1216 RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPP 1280
                :.|:  ||:.|..|     .|..||::       |.||.|     |:..|...:|.
Human  1025 ----VKLE--QQVDDLEG-----SLEQEKKV-------RMDLER-----AKRKLEGDLKL----- 1061

  Fly  1281 PAPPTSSGKEDVPRERRSSRELLSRS----SALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL 1341
                |.....|:..:::...|.|.:.    :|||.| .|.|.:.|........:.::|.:.|::.
Human  1062 ----TQESIMDLENDKQQLDERLKKKDFELNALNAR-IEDEQALGSQLQKKLKELQARIEELEEE 1121

  Fly  1342 LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHG 1406
            |..:..       ::..:..|....||  :....:|||...|..|..:.:.::..
Human  1122 LEAERT-------ARAKVEKLRSDLSR--ELEEISERLEEAGGATSVQIEMNKKR---------- 1167

  Fly  1407 SHSSKYADKAEY-ATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELS 1470
                    :||: ..|......|.:..:.|:.:|:....|.|.             |...:|.|.
Human  1168 --------EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE-------------LGEQIDNLQ 1211

  Fly  1471 DARSLAASIRGGSYEQENEAESEID-DLDDYINDIFQPIPLVQNLEKL--TSKDQLAAIIKGGGV 1532
            ..:.        ..|:|   :||.. :|||..:::.|.|....||||:  |.:||:
Human  1212 RVKQ--------KLEKE---KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM--------- 1256

  Fly  1533 ASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLM 1597
                  .:..|:.|:....:|:             |||:.....:..|..|...:..:.|:.||.
Human  1257 ------NEHRSKAEETQRSVND-------------LTSQRAKLQTENGELSRQLDEKEALISQLT 1302

  Fly  1598 QLPGETESGPALYQQQV--------QRAFLQSAMAQNLQ--------IQQQLLAQNQA---LQTL 1643
            :       |...|.||:        :....::|:|..||        :::|...:.:|   ||.:
Human  1303 R-------GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1360

  Fly  1644 LSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPP 1708
            ||:..:..|...:.....|  |..:..:.....:...|::....::..:.:
Human  1361 LSKANSEVAQWRTKYETDA--IQRTEELEEAKKKLAQRLQEAEEAVEAVNA-------------- 1409

  Fly  1709 PLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTE-EDFFAFKMRQHQRKTTPQAQHH 1772
              :|....:|:|                         :.|.| ||......|
Human  1410 --KCSSLEKTKH-------------------------RLQNEIEDLMVDVER------------- 1434

  Fly  1773 QMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRS-SIRL--------ETTTTTT 1828
               ||..........|.......||::...||.:....|.:..|| |..|        |:.....
Human  1435 ---SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLE 1496

  Fly  1829 TSAVNNRDRDRETQDVGQPMQSVVTT--KLAKKSFEIGADRPPPGSVGKLKLSSE---------- 1881
            |....|::...|..|:.:.:.|...|  :|.|...::.|:        |::|.|.
Human  1497 TFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE--------KMELQSALEEAEASLEH 1553

  Fly  1882 -----MRQRLE--QVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGG 1939
                 :|.:||  |:.|  .:...::.|.|:...||....|
Human  1554 EEGKILRAQLEFNQIKA--EIERKLAEKDEEMEQAKRNHLR------------------------ 1592

  Fly  1940 VVDS-----HATVRTQIE------RMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMA 1993
            ||||     .|..|::.|      :|||.|:......|                     ....||
Human  1593 VVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLS---------------------HANRMA 1636

  Fly  1994 PPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQ------ERDTFGAV--------- 2043
            ..|...........:..:.:.|....::..:||:: |.::|:      |.:...||
Human  1637 AEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI-AIVERRNNLLQAELEELRAVVEQTERSRK 1700

  Fly  2044 -RQQQMISSHH----LHLEDHS-----------------------------------ASSSPAVA 2068
             .:|::|.:..    ||.::.|                                   |.:..|:.
Human  1701 LAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMM 1765

  Fly  2069 AWEQAERERSRSRSRSRDREDYSESV------WDRAEVEGPASGSGSEKEREKRERERERLYEIR 2127
            | |:.::|:..|....|.:::..:::      .|.||......|....::.|.|.||.|...|..
Human  1766 A-EELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829

  Fly  2128 QVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGL----------ATFRTHMAQKYEHERK 2182
            | :|..||.|..:.:..|:.:.:..|     .|||...|          ...:.:..|..|.|.:
Human  1830 Q-KRNAESVKGMRKSERRIKELTYQT-----EEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888

  Fly  2183 RKSSASS--GMREELD 2196
            ..::.|.  .::.|||
Human  1889 ANTNLSKFRKVQHELD 1904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	253/690 (37%)
		PTZ00121	<828..>943	CDD:173412	32/124 (26%)
		MyTH4	1014..1171	CDD:470587	18/156 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	17/69 (25%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYH7	NP_000248.2	COG5022	37..1432	CDD:227355	433/1673 (26%)
		MYSc_Myh7	99..766	CDD:276881	253/690 (37%)
		Actin-binding	655..677		10/21 (48%)
		Actin-binding	757..771		5/13 (38%)
		SMC_prok_B	1173..1930	CDD:274008	160/913 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1907..1935