Protein Alignment Myo10A and MYH6

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_002462.2
• Gene: MYH6 / 4624
• HGNCID: 7576
• Length: 1939
• Species: Homo sapiens
• Alignment Length: 2015
• Identity: 497/2015 - (24%)
• Similarity: 823/2015 - (40%)
• Gaps: 422/2015 - (20%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Human    87 IEDMAMLTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG-----GSASA--- 275
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|::...|     .:|:|
Human   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGKKDNANANKG 215

  Fly   276 VITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPG 339
            .:.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|...
Human   216 TLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKA 280

  Fly   340 ERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAMQ 394
            |||||:||::|      ...|..||:       ...|.:::||....|| ..|.|.|   ..|..
Human   281 ERNYHIFYQIL------SNKKPELLDMLLVTNNPYDYAFVSQGEVSVAS-IDDSEELMATDSAFD 338

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            |||.:..|:.|:.::..|::|.||:.|.::|   .:|..|.....:...:|:|:.:::..|.:.|
Human   339 VLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQ---REEQAEPDGTEDADKSAYLMGLNSADLLKGL 400

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|...:..|.|||:|..:|||:|:|||:.::...... :.|.:|||.
Human   401 CHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATLETKQPRQ-YFIGVLDIA 464

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|||||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|.:||:
Human   465 GFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPM 529

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|||::|..|.:.|| ..|..:.:||  .|.||  |.:.||||.|.|.:.|:
Human   530 GIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAHFSLIHYAGTVDYNILGW 594

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRA--QRDAGKTLPKGSNGRFVTMKPRTPTVAARF 712
            |:||:|.|...|:.|...|.|.|:..|......  ..|:||:  ||...:..:.:    ||:|..
Human   595 LEKNKDPLNETVVALYQKSSLKLMATLFSSYATADTGDSGKS--KGGKKKGSSFQ----TVSALH 653

  Fly   713 ADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQ 777
            .::|.:|:.::...||.|||||.||:.|....||.|.|:.|||..|:|:.|:|.::|:|.|:.:.
Human   654 RENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 718

  Fly   778 HFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT 840
            .|.:|||.|.|..:..|  ...|:....||.::   .::...|:.|.|:||.:..|...||..|.
Human   719 DFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSL---DIDHNQYKFGHTKVFFKAGLLGLLEEMRD 780

  Fly   841 ERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGA 893
            |||.|....:|...||.|:|   :::..|:.|...:|         ..|...:...:.:.|.|.|
Human   781 ERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSA 845

  Fly   894 LTAQRLWRGRQARRRVQQL--RSDHRRRQ------------------------------------ 920
            .|.:.:...::...|:::.  :|:.||::
Human   846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQL 910

  Fly   921 ---------EAREAAQRAREARE------AKQAVLERSQLSYL--DIPAELAFIYSKLQGWSPPH 968
                     :.:|..:|..:..|      ||:..|| .:.|.|  ||. :|....:|::  ...|
Human   911 IKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLE-DECSELKKDID-DLELTLAKVE--KEKH 971

  Fly   969 GDRHLVKVLGTVPGPPSSAV---------------QLPEDLGQFSFGKFSSVYCNGLRLQPRREP 1018
            ...:.||.|..........:               |..:|| |....|.:|:..:.::|:.:.:.
Human   972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-QVEEDKVNSLSKSKVKLEQQVDD 1035

  Fly  1019 ITAPL---------LTRAASRDQDFQDALAVFKLILRWSNDKAL--EGAKEKLLADYIVHKALSS 1072
            :...|         |.||..:.:.  |.....:.|:...|||..  |..|:|   ::.:::..|.
Human  1036 LEGSLEQEKKVRMDLERAKRKLEG--DLKLTQESIMDLENDKLQLEEKLKKK---EFDINQQNSK 1095

  Fly  1073 RGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLL 1137
              :.||.::.|..| ..|..|......|.:.|.      ....|.:|.          |.||..|
Human  1096 --IEDEQVLALQLQ-KKLKENQARIEELEEELE------AERTARAKV----------EKLRSDL 1141

  Fly  1138 LRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSW 1197
            .|:|..     ::.||.:|..:.....|.     .|::...|..:.|   ||..||:
Human  1142 SRELEEISERLEEAGGATSVQIEMNKKRE-----AEFQKMRRDLEEA---TLQHEAT-------- 1190

  Fly  1198 TSCEEAAAL------AVSSLG--------------VASRGWTLVLDDGQQLTDSCGLDYVMDLIA 1242
                 ||||      :|:.||              .....:.|.|||   :|.:  ::.::...|
Human  1191 -----AAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDD---VTSN--MEQIIKAKA 1245

  Fly  1243 EKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSS 1307
            ..|........:::..|...:.|:.:|.|...:.|    ...|.:|  ::.|:......|:|:.:
Human  1246 NLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA----KLQTENG--ELARQLEEKEALISQLT 1304

  Fly  1308 ALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD------LLAGDIVPVPTDCD------------ 1354
            .              |:.|.|.|.:...:.|::      .||..:.....|||
Human  1305 R--------------GKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEA 1355

  Fly  1355 SQEPLHTLGLSESRL--------NDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSK 1411
            ..|....|..:.|.:        .|.....|.|....|....|.|.::.|....:|.......:|
Human  1356 KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420

  Fly  1412 YADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLA 1476
            :..:.|.   ...|.|...:.:.|:     .:..:..:.|:.|.: :....:.|..||..::..|
Human  1421 HRLQNEI---EDLMVDVERSNAAAA-----ALDKKQRNFDKILAE-WKQKYEESQSELESSQKEA 1476

  Fly  1477 ASIRGGSYEQENEAESEIDDLDDY----------INDIFQPI----PLVQNLEKLTSK------- 1520
            .|:....::.:|..|..::.|:.:          |:|:.:.:    ..|..|||:..:
Human  1477 RSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLE 1541

  Fly  1521 --------------------------DQLAAIIKGGGVASKPEERDEESE---------IEDLDD 1550
                                      :|:.|.|:     .|..|:|||.|         ::.|.
Human  1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE-----RKLAEKDEEMEQAKRNHQRVVDSLQ- 1600

  Fly  1551 YINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETES-----GPALY 1610
                        ..||..|...:..:.::.....|.|..:..|....::..|.:.     ...|.
Human  1601 ------------TSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLK 1653

  Fly  1611 QQQVQRAFLQSAMAQNLQIQQQLL---AQNQALQTLLSQQAAAA---------AANNSTSPPPAP 1663
            ..|:|   |..|:..|..:::.:.   .:|..||..|.:..|..         |...........
Human  1654 DTQIQ---LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERV 1715

  Fly  1664 PILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRA 1728
            .:|.|.:.|....:..|....|:....|.|::|              ||::..|         :|
Human  1716 QLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQ--------------ECRNAEE---------KA 1757

  Fly  1729 KTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQH-----HQMTSNGGMMESGPG 1786
            |     |..........:.:.|:|..|.  :|:::..:|....||     .|:...||..:
Human  1758 K-----KAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ---- 1813

  Fly  1787 ARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQS 1850
            .:...|...|.| |.|.|..........:.:|..|::..|..|.....|..|   .||:...:|
Human  1814 LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLR---LQDLVDKLQ- 1874

  Fly  1851 VVTTKLAKKSFEIGADRPPPGSVGKL-KLSSEMRQRLEQVTAGHSVRSTVSTKSEQ-RAPAKLED 1913
             :..|..|:..| .|:.....::.|. |:..|:.:..|:.....|..:.:..||.. .|..|:.|
Human  1875 -LKVKAYKRQAE-EAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHD 1937

  Fly  1914  1913
            Human  1938  1937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	253/689 (37%)
		PTZ00121	<828..>943	CDD:173412	32/179 (18%)
		MyTH4	1014..1171	CDD:470587	34/172 (20%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	18/86 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYH6	NP_002462.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..768	CDD:276951	253/689 (37%)
		Actin-binding	657..679		10/21 (48%)
		Actin-binding	759..773		5/13 (38%)
		Myosin_tail_1	848..1925	CDD:460256	211/1219 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1826..1849		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1909..1939		7/29 (24%)