DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and MYH4

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_060003.2 Gene:MYH4 / 4622 HGNCID:7574 Length:1939 Species:Homo sapiens


Alignment Length:2219 Identity:508/2219 - (22%)
Similarity:872/2219 - (39%) Gaps:584/2219 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 VIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILI 193
            |..:..|.|::.|.:          ...:|||.::..|||.::|:||:.||...:|||::|...:
Human    70 VTVKEDQVFSMNPPK----------YDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCV 124

  Fly   194 AVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTES 255
            .|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:
Human   125 TVNPYKWLP-VYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVN 188

  Fly   256 TKLVMQYLAAVV---------PGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV 311
            ||.|:||.|.:.         |..|.....:.:||:.|.|||||||||:|.||||||||||::.:
Human   189 TKRVIQYFATIAVTGEKKKEEPASGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRI 253

  Fly   312 YF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKY--FYLN 373
            :| .:|.:..|.|..|||||||:..|...||:||:||::|.. .:.|..:..|:..:.|  .:::
Human   254 HFGATGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIEMLLITTNPYDFAFVS 317

  Fly   374 QGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GV 433
            ||.....| ..|.|.|   ..|:.:||.:..|:..|.::..||:|.||:.|.::|.....|  |.
Human   318 QGEITVPS-IDDQEELMATDSAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGT 381

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            ||...     ||:|..:::..|.::|.....:...|.:.....:.|..:|..|.|||:|..:|.|
Human   382 EVADK-----AAYLTSLNSADLLKSLCYPRVKVGNEFVTKGQTVQQVYNAVGALAKAIYEKMFLW 441

  Fly   499 LVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAE 561
            :|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||.:||.|:|.|||.|
Human   442 MVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEE 503

  Fly   562 YARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYAR 625
            |.:|.:||..:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:
Human   504 YKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQK 568

  Fly   626 PR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL---TKQLRAQ 683
            |:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.:..:..|   .:...|:
Human   569 PKPAKGKPEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLAFLFSGAQTAEAE 633

  Fly   684 RDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748
            ...||...|.....|       .||:|.|.::|.:|:.::...||.|||||.||:.|....|:..
Human   634 GGGGKKGGKKKGSSF-------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHE 691

  Fly   749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGV 813
            .||.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:....:
Human   692 LVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG-QFIDSKKASEKLLGSIEI 755

  Fly   814 EGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ- 874
            :...|:.|.|:||.:..|...||..|.|:|.:.....|...||.|:|   |::..|:.:...:| 
Human   756 DHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAICRGFLMRVEFRKMMERRESIFCIQY 820

  Fly   875 --------ARWRGQRAQQRYERLRKGALTAQRLWRGR-------------QARRR--------VQ 910
                    ..|...:...:.:.|.|.|.|.:.:...:             :|:|:        :.
Human   821 NIRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLM 885

  Fly   911 QLRSDHRRRQEA--------------------------REAAQRAREARE------AKQAVLERS 943
            |.::|.:.:.:|                          :|..:||.:..|      ||:..|| .
Human   886 QEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE-D 949

  Fly   944 QLSYL--DIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK--FSS 1004
            :.|.|  ||. :|....:|::  ...|...:.||.|      ......|.|.:.:.:..|  ...
Human   950 ECSELKKDID-DLELTLAKVE--KEKHATENKVKNL------TEEMAGLDETIAKLTKEKKALQE 1005

  Fly  1005 VYCNGL-RLQPRREPITAPLLTRAASR-DQDFQDALAVFKLILRWSNDKALEGAKEKL------- 1060
            .:...| .||...:.:..  ||:|.:: :|...|.....:...:...|  ||.||.||       
Human  1006 AHQQTLDDLQMEEDKVNT--LTKAKTKLEQQVDDLEGSLEQEKKLCMD--LERAKRKLEGDLKLA 1066

  Fly  1061 -------------LADYIVHKALSSRGLRDEI------LVQLCNQVHGLPPNSGEATRLWQLLGQ 1106
                         |.:.:..|......|:.:|      .:||..::..|.....|       |.:
Human  1067 QESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEE-------LEE 1124

  Fly  1107 CLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAW 1166
            .:...:.|.|            ..|..|..|.|:|..     ::.||.:|..:.....|.     
Human  1125 EIEAERASRA------------KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE----- 1172

  Fly  1167 LEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL------AVSSLGVASRGWTLVLDDG 1225
            .|::...|..:.:   ||..||:             ||||      :|:.||..       :|..
Human  1173 AEFQKMRRDLEES---TLQHEAT-------------AAALRKKHADSVAELGEQ-------IDSL 1214

  Fly  1226 QQLTDSCGLD------YVMDLIAEKELCPAFPAPRSDLLRSGAKFAR--TTLPDAVKRPAVPPPA 1282
            |::......:      .:.||.:..|          .:.::.|.|.:  .||.|.:         
Human  1215 QRVKQKLEKEKSELKMEINDLASNME----------TVSKAKANFEKMCRTLEDQL--------- 1260

  Fly  1283 PPTSSGKEDVPRERRSSRELLSRSSALNER--YFERE--------PSPGPGQGSSTGQAKSRSKS 1337
               |..|.....::|...||.::.:.|:..  .|.|:        .....|:.:.|.|.:...:.
Human  1261 ---SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ 1322

  Fly  1338 LDD------LLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHA 1396
            |::      .||..:.....|||             .|.::|.. |:.|......|.....|:.|
Human  1323 LEEETKAKSTLAHALQSARHDCD-------------LLREQYEE-EQEAKAELQRGMSKANSEVA 1373

  Fly  1397 GRRSHAASHGSHSSKYADKAEYATRSSA--MSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFS 1459
            ..|:   .:.:.:.:..::.|.|.:..|  :.|..|      ||..|.  |:.:.:::....|.:
Human  1374 QWRT---KYETDAIQRTEELEEAKKKLAQRLQDAEE------HVEAVN--SKCASLEKTKQRLQN 1427

  Fly  1460 PVLDGSLD-ELSDARSLAASIRGGSYE----------QENEAESEIDDLD--DYINDIFQPIPLV 1511
            .|.|..:| |.|:|..:|...:..:::          :|.:||.|....:  ....::|:    |
Human  1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK----V 1488

  Fly  1512 QNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEG------LDKLTS 1570
            :|..: .|.|.|..:        |.|.::.:.||.||.:.|         |||      |:|:..
Human  1489 KNAYE-ESLDHLETL--------KRENKNLQQEISDLTEQI---------AEGGKHIHELEKVKK 1535

  Fly  1571 KEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQ---VQRAFLQSAMAQNLQIQQQ 1632
            :                    |.|:..:|....|...|..:.:   :.|..|:....:: :|.::
Human  1536 Q--------------------LDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKS-EIDRK 1579

  Fly  1633 LLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQP 1697
            :..:::.|..|                                         .|:.|.|:||:|.
Human  1580 IAEKDEELDQL-----------------------------------------KRNHLRVVESMQS 1603

  Fly  1698 PPPPPPPPMPPPLECKDPSETRHFLDPYGRAK--TVRIGKWRWPPPQDEPQFQTEEDFFAFKMR- 1759
            .                       ||...|::  .:||.|            :.|.|....::: 
Human  1604 T-----------------------LDAEIRSRNDALRIKK------------KMEGDLNEMEIQL 1633

  Fly  1760 QHQRKTTPQAQHHQMTSNGGMMES----GPGARGAS------------ATAIEWEEFEIESPTPP 1808
            .|..:...:|..:...:.|.:.::    ....||..            |..::.|..|:.:....
Human  1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLER 1698

  Fly  1809 PMSG------QLMRSSIRLETTTTTTTSAVNNRDR-DRETQDVGQPMQSVV-----TTKLAKKSF 1861
            ...|      :|:.:|.|::...|..||.:|.:.: :.:...:...|:.:|     ..:.|||:.
Human  1699 TERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAI 1763

  Fly  1862 EIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRK-LMLQ----Q 1921
            ...|           .::.|:::  ||.|:.|.          :|....:|.|.| |.|:    :
Human  1764 TDAA-----------MMAEELKK--EQDTSAHL----------ERMKKNMEQTVKDLQLRLDEAE 1805

  Fly  1922 QLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPP 1986
            ||     ::.||              :.||:::|.::.                           
Human  1806 QL-----ALKGG--------------KKQIQKLEARVR--------------------------- 1824

  Fly  1987 IRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEH---VPAFIQRQERDTFGAVRQQQM 2048
                              ......|.|..:...:.:.:::|   |.....:.|.|....:|.|.:
Human  1825 ------------------ELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL 1871

  Fly  2049 ISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKER 2113
            :......::.:...:       |:||.:.:.:.::.|..:...|...:||::        :|.:.
Human  1872 VDKLQTKVKAYKRQA-------EEAEEQSNVNLAKFRKLQHELEEAKERADI--------AESQV 1921

  Fly  2114 EK-RERERE 2121
            .| |.:.||
Human  1922 NKLRVKSRE 1930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 254/709 (36%)
MYSc_Myo15 169..828 CDD:276838 247/688 (36%)
MyTH4 1014..1171 CDD:295320 33/188 (18%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYH4NP_060003.2 Myosin_N 36..73 CDD:280832 1/2 (50%)
Myosin_head 88..770 CDD:278492 253/700 (36%)
MYSc_Myh4 100..770 CDD:276879 247/688 (36%)
Actin-binding. /evidence=ECO:0000250 659..681 10/21 (48%)
Actin-binding. /evidence=ECO:0000250 761..775 5/13 (38%)
Myosin_tail_1 850..1927 CDD:279860 230/1405 (16%)
RILP-like 965..1098 CDD:304877 26/144 (18%)
MIT_CorA-like <1299..>1411 CDD:294313 24/134 (18%)
COG6 1376..>1511 CDD:303003 30/158 (19%)
DUF342 <1670..1767 CDD:302792 16/96 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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