DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and MYH3

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens


Alignment Length:1828 Identity:458/1828 - (25%)
Similarity:731/1828 - (39%) Gaps:423/1828 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 DVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSIL 192
            ||.|.:|..|                 ..:|||.:|..|:|.::|:||:.||...:|||::|...
Human    76 DVYAMNPPKF-----------------DRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFC 123

  Fly   193 IAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTE 254
            :.|||||..| .|..||.:.|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.
Human   124 VTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTV 187

  Fly   255 STKLVMQYLAAVVPGGGSA-------SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVY 312
            :||.|:||.|.:...|..|       ...:.:||:.|.|||||||||:|.||||||||||::.::
Human   188 NTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIH 252

  Fly   313 F-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQ 374
            | .:|.:..|.|..|||||||:..|...||:||:||::|.. .:.|..:..|:..:.|.|  ::|
Human   253 FGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYPFISQ 316

  Fly   375 GATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVE 434
            |....|| ..|.|.|   ..|:.:||.:..|:.|:.::..||:|.||:.|.::|.....|  |.|
Human   317 GEILVAS-IDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTE 380

  Fly   435 VGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499
            |...     .|:|:.:::..|.:||.....:...|.:.....:||...|.:|.:|::|..||.|:
Human   381 VADK-----TAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWM 440

  Fly   500 VSRINSIVQKGGTH--DAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEY 562
            |:|||   |:..|.  ..|.|.:|||.|||....||.||||||:.||.||.:||.|:|.|||.||
Human   441 VTRIN---QQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEY 502

  Fly   563 ARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARP 626
            .:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|
Human   503 KKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKP 567

  Fly   627 RI--GAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQL-RAQRDA 686
            ::  |..|  |.:.||||.|.|.|.|:|:||:|.|...|:.|...|...|:..|.... .|..|:
Human   568 KVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADS 632

  Fly   687 GK---TLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748
            ||   ...|||:.:         ||:|.|.::|.:|:.::...||.|||||.||:.|....|:..
Human   633 GKKKVAKKKGSSFQ---------TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHS 688

  Fly   749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRT 811
            .||.|||..|:|:.|:|.::|:|.|:.:..|.:|||.|..|.:..|  ...::.|..||.::   
Human   689 LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDSKKACEKLLASI--- 750

  Fly   812 GVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRL 873
            .::...|:.|.|:||.:..|...||..|.:||.:.....|...||.|:|   :::.:|:.:...:
Human   751 DIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCI 815

  Fly   874 Q---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQ------------------------- 904
            |         ..|...:...:.:.|.|.|.|.:.:...::                         
Human   816 QYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVT 880

  Fly   905 ---------------------ARRRVQQL-RSDHRRRQEAREAAQRAREARE------------- 934
                                 |..|..|| ::..:...:.:|..:||.:..|             
Human   881 LVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE 945

  Fly   935 --------------------------------------------------AKQAVLERSQLSYLD 949
                                                              .|:|:.|..|.:..|
Human   946 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDD 1010

  Fly   950 IPAE-----------------LAFIYSKLQGWSPPHGD--RHLVKVLGTVPGPPSSAVQLPEDLG 995
            :.||                 :..:.|.|:.......|  |:..|:.|.:.....|.:.|..|..
Human  1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075

  Fly   996 QFS--FGKFSSVYCN-----------GLRLQPR-----------REPITAPLLTRAASRDQDFQD 1036
            |..  ..|....||.           ||:.|.:           .|.|.|...|||.:..|....
Human  1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDY 1140

  Fly  1037 ALAVFKLILRWSNDKALEGA----------KEKLLADYI-VHKALSSRGLRDEILVQLCNQVHG- 1089
            |..:.:|      .:.||.|          .:|..|::: :.:.|....|:.|.:|....:.|. 
Human  1141 ARELEEL------SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHAD 1199

  Fly  1090 LPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAV 1154
            .....||.....|.:.|.|                   |..:|...|.:..|.......:.|.|.
Human  1200 SVAELGEQIDNLQRVKQKL-------------------EKEKSEFKLEIDDLSSSMESVSKSKAN 1245

  Fly  1155 GAGACRSFVPAWLEWRAWTRGCDMAL-PLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGW 1218
            ....||:......|.|........:| .||......||.|.:.....||..:: ||.|..:.:.:
Human  1246 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI-VSQLSRSKQAF 1309

  Fly  1219 TLVLDD-GQQLTD-----------------SCGL---DYVMDLIAEKELCPAFPAPRSDLLRSGA 1262
            |...:: .:||.:                 .|.|   .|..:...:.||..|.....|::.:...
Human  1310 TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374

  Fly  1263 KFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQG-- 1325
            |:.    .||::|      .......|:.:.:..:.|.|   :..|:|.:....|.:....||  
Human  1375 KYE----TDAIQR------TEELEEAKKKLAQRLQDSEE---QVEAVNAKCASLEKTKQRLQGEV 1426

  Fly  1326 -----------SSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESR--------LND 1371
                       |.......:.::.|.:||    ...|.|:..:......|.|||        |.:
Human  1427 EDLMVDVERANSLAAALDKKQRNFDKVLA----EWKTKCEESQAELEASLKESRSLSTELFKLKN 1487

  Fly  1372 RYHSA-ERLAPVGKDTGPRYQKSQHAGRRSHAASHG--------SHSSKYADKAEY---ATRSSA 1424
            .|..| ::|..|.::.  :..:.:.|......|.:|        |......:||:.   ...:.|
Human  1488 AYEEALDQLETVKREN--KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550

  Fly  1425 MSDTSEAPSLASHVRRVRVPSQ----ASDVDQFLDDL----------FSPVLDGSLDELSDARSL 1475
            ..:..||..|...:...:|.|:    .::.|:.::.|          ....||..:...::|..|
Human  1551 ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615

  Fly  1476 AASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTS-------------KDQLAAII 1527
            ...:.|    ..||.|.::...:....:..:.:..||...|.|.             |:|||.:.
Human  1616 KKKMEG----DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676

  Fly  1528 KGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPL 1592
            :...:.        ::|:|:|...:.:       .|...||..:|.|          |||....|
Human  1677 RRANLL--------QAEVEELRATLEQ-------TERARKLAEQELL----------DSNERVQL 1716

  Fly  1593 LH---------------QLMQLPGETESG---PALYQQQVQRAFLQSA-MAQNLQIQQQLLAQNQ 1638
            ||               .||||..|.|..   ....:::.::|...:| ||:.|:.:|...|..:
Human  1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781

  Fly  1639 ALQTLLSQ 1646
            .::..|.|
Human  1782 RMKKNLEQ 1789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 264/710 (37%)
MYSc_Myo15 169..828 CDD:276838 257/689 (37%)
MyTH4 1014..1171 CDD:295320 33/179 (18%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYH3NP_002461.2 Myosin_N 36..73 CDD:280832
Myosin_head 88..767 CDD:278492 263/701 (38%)
MYSc_Myh3 100..767 CDD:276878 257/689 (37%)
Actin-binding 656..678 10/21 (48%)
Actin-binding 758..772 5/13 (38%)
GrpE 843..>962 CDD:295646 10/118 (8%)
Myosin_tail_1 847..1924 CDD:279860 172/1017 (17%)
BAR <956..1063 CDD:299863 13/106 (12%)
MIT_CorA-like <1296..>1408 CDD:294313 20/125 (16%)
COG6 1373..>1506 CDD:303003 27/151 (18%)
TMPIT 1739..>1850 CDD:285135 11/51 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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