DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and MYH2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001093582.1 Gene:MYH2 / 4620 HGNCID:7572 Length:1941 Species:Homo sapiens


Alignment Length:2216 Identity:507/2216 - (22%)
Similarity:855/2216 - (38%) Gaps:587/2216 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Human    88 IEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYKPEVVTAYRGKKRQEA 151

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:...|         |...
Human   152 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEITSGKIQ 216

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:|.|..
Human   217 GTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLK 281

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLE-----ADKYFY--LNQGATDCASGRVDWESL---QGAM 393
            .||:||:||::      |...|..|:|     .:.|.|  ::||....|| ..|.|.|   ..|:
Human   282 AERSYHIFYQI------TSNKKPELIEMLLITTNPYDYPFVSQGEISVAS-IDDQEELMATDSAI 339

  Fly   394 QVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLH 456
            .:||.:..|:..|.::..||:|.||:.|.::|.....|  |.||...     ||:|..:::..|.
Human   340 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADK-----AAYLQSLNSADLL 399

  Fly   457 RALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--IS 519
            :||.....:...|.:.....::|..:|..|.|||:|..:|.|:|:|||   |:..|....:  |.
Human   400 KALCYPRVKVGNEYVTKGQTVEQVSNAVGALAKAVYEKMFLWMVARIN---QQLDTKQPRQYFIG 461

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLL 584
            :|||.|||....||.||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|
Human   462 VLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIEL 526

  Fly   585 AKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWY 644
            .:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|::  |..|  |.:.||||.|.|
Human   527 IEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFALIHYAGVVDY 591

  Fly   645 CVDGFLDKNRDALRGDVLELLASSRLPLVGELTK--QLRAQRDAGKTLPKGSNGRFVTMKPRTPT 707
            .:.|:|:||:|.|...|:.|...|.:..:.:|..  |......||....||...:..:.:    |
Human   592 NITGWLEKNKDPLNETVVGLYQKSAMKTLAQLFSGAQTAEGEGAGGGAKKGGKKKGSSFQ----T 652

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            |:|.|.::|.:|:.::...||.|||||.||:.|....|:...||.|||..|:|:.|:|.::|:|.
Human   653 VSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPS 717

  Fly   773 RLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALES 837
            |:.:..|.:||:.|..|.:..| .:.:..:|..:.:....::...|:.|.|:||.:..|...||.
Human   718 RILYADFKQRYKVLNASAIPEG-QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFKAGLLGLLEE 781

  Fly   838 GRTERLRRAAVSVQRHVRGMLVR----RQLARRQAA-ATRLQAR-------WRGQRAQQRYERLR 890
            .|.::|.:.....|...||.|.|    |.:.||:|. ..:...|       |...:...:.:.|.
Human   782 MRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVKHWPWMKLFFKIKPLL 846

  Fly   891 KGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELA 955
            |.|.|.:.:...::..::::    |...:.||:      |:..|.|...|.:.:           
Human   847 KSAETEKEMATMKEEFQKIK----DELAKSEAK------RKELEEKMVTLLKEK----------- 890

  Fly   956 FIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPIT 1020
                                                                |.|:||.:.|   
Human   891 ----------------------------------------------------NDLQLQVQAE--- 900

  Fly  1021 APLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA--KEKLLADYIVHKALSSRGLRDEILVQL 1083
            |..|..|..|    .|.|...|:.|.....:..|.|  :|::.|:....|    |.|.||     
Human   901 AEGLADAEER----CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK----RKLEDE----- 952

  Fly  1084 CNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDD--------EAPESLRPLLLRQ 1140
            |::                                  |.:.:||        |..:......::.
Human   953 CSE----------------------------------LKKDIDDLELTLAKVEKEKHATENKVKN 983

  Fly  1141 LLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAA 1205
            |..:.          ||...:......|.:|    ...|...||.|..::...|::.|..:    
Human   984 LTEEM----------AGLDETIAKLTKEKKA----LQEAHQQTLDDLQAEEDKVNTLTKAK---- 1030

  Fly  1206 LAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKF------ 1264
                          :.|:  ||:.|..|     .|..||:|       |.||.|:..|.      
Human  1031 --------------IKLE--QQVDDLEG-----SLEQEKKL-------RMDLERAKRKLEGDLKL 1067

  Fly  1265 ----------ARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPS 1319
                      .:..|.:.:|:...     ..|:.:..:..|:....:|..:...|..|..|.|..
Human  1068 AQESIMDIENEKQQLDEKLKKKEF-----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEE 1127

  Fly  1320 PGPGQGSSTGQAKSR---SKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAP 1381
            ....:.|.....|.|   |:.|:::                        ..||.:...:......
Human  1128 IEAERASRAKAEKQRSDLSRELEEI------------------------SERLEEAGGATSAQIE 1168

  Fly  1382 VGKDTGPRYQKSQ---HAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRV-- 1441
            :.|.....:||.:   ......|.|:..:...|:||            ..:|......:::||  
Human  1169 MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD------------SVAELGEQIDNLQRVKQ 1221

  Fly  1442 RVPSQASDVDQFLDDLFSPV-----LDGSL--------DELSDARS-----------LAASIRGG 1482
            ::..:.|::...:|||.|.|     ..|:|        |:||:.:|           |.|. ||.
Human  1222 KLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ-RGR 1285

  Fly  1483 SYEQENEAESEIDDLDDYINDIFQ-PIPLVQNLEKLTSKDQLAAIIKGGGVAS------------ 1534
            ...:..|...::|:.:..::.:.: .....|.:|:|  |.||...||.....:            
Human  1286 LQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL--KRQLEEEIKAKNALAHALQSSRHDCDL 1348

  Fly  1535 --KPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVS-IRGGGSTDSNGADPLLHQL 1596
              :..|.::||:.|                  |.:..||.:..|: .|....||:          
Human  1349 LREQYEEEQESKAE------------------LQRALSKANTEVAQWRTKYETDA---------- 1385

  Fly  1597 MQLPGETESGPALYQQQVQRA----FLQSAMAQNLQIQQQLLAQNQALQTLLS-QQAAAAAANNS 1656
            :|...|.|.......|::|.|    ...:|...:|:..:|.| ||:....:|. ::..||.|...
Human  1386 IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL-QNEVEDLMLDVERTNAACAALD 1449

  Fly  1657 TSPPPAPPIL-----------SSLSISPPPPQS----PMRMK-ATRSSLVVMESLQPPPPPPPPP 1705
            ........||           :.|..|....:|    ..::| |...||..:|:|:         
Human  1450 KKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK--------- 1505

  Fly  1706 MPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQ 1770
                      .|.::.                    |.|....||:.....|......|...|.:
Human  1506 ----------RENKNL--------------------QQEISDLTEQIAEGGKRIHELEKIKKQVE 1540

  Fly  1771 HHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNR 1835
            ..:......:.|        :..::|.||            |:::|..:.|....:.....:..:
Human  1541 QEKCELQAALEE--------AEASLEHEE------------GKILRIQLELNQVKSEVDRKIAEK 1585

  Fly  1836 DRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRL--------- 1886
            |.:     |....:.:.|||.:..::..::..|...:...|.:.::::......|:         
Human  1586 DEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYR 1650

  Fly  1887 --------EQVTAGHSVRSTVSTKS-----EQRA---PAKLEDTR---------KLMLQQQLGGL 1926
                    .|:....::||....|.     |:||   .|::|:.|         :.:.:|:|...
Human  1651 NTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1715

  Fly  1927 FASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPS 1991
            ...|...::....::::...:.|.|.:|:|::.           .:|                  
Human  1716 SERVQLLHTQNTSLINTKKKLETDISQMQGEME-----------DIL------------------ 1751

  Fly  1992 MAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQ-----QQMISS 2051
                         ..||:.|.:.....:.:.::.|.:     ::|:||...:.:     :|.:..
Human  1752 -------------QEARNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNMEQTVKD 1798

  Fly  2052 HHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKR 2116
            ..|.|::...      .|.:..:::..:..:|.|:.|...||...|          .:|..:..|
Human  1799 LQLRLDEAEQ------LALKGGKKQIQKLEARVRELEGEVESEQKR----------NAEAVKGLR 1847

  Fly  2117 ERERERLYEIR-QVERERESHKVYQPAPPRVIQASMDTTGGHRR------EDRTGGLATFRTHMA 2174
            :.|| |:.|:. |.|.:|::....|....: :||.:.:   ::|      |.....||.||    
Human  1848 KHER-RVKELTYQTEEDRKNILRLQDLVDK-LQAKVKS---YKRQAEEAEEQSNTNLAKFR---- 1903

  Fly  2175 QKYEHE 2180
             |.:||
Human  1904 -KLQHE 1908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 259/712 (36%)
MYSc_Myo15 169..828 CDD:276838 252/692 (36%)
MyTH4 1014..1171 CDD:295320 27/166 (16%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYH2NP_001093582.1 Myosin_N 36..73 CDD:280832
Myosin_head 88..772 CDD:278492 258/704 (37%)
MYSc_Myh2_mammals 100..772 CDD:276877 252/692 (36%)
Actin-binding. /evidence=ECO:0000250 661..683 10/21 (48%)
Actin-binding. /evidence=ECO:0000250 763..777 5/13 (38%)
Myosin_tail_1 852..1929 CDD:279860 229/1431 (16%)
RILP-like 967..1100 CDD:304877 29/183 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1149 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1155..1174 3/18 (17%)
DUF342 <1672..1769 CDD:302792 18/138 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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