Protein Alignment Myo10A and MYH1

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_005954.3
• Gene: MYH1 / 4619
• HGNCID: 7567
• Length: 1939
• Species: Homo sapiens
• Alignment Length: 2192
• Identity: 488/2192 - (22%)
• Similarity: 839/2192 - (38%)
• Gaps: 536/2192 - (24%)

  Fly   129 VIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILI 193
            |..:..|.|.:.|.:          ...:|||.::..|||.::|:||:.||...:|||::|...:
Human    70 VTVKDDQVFPMNPPK----------YDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCV 124

  Fly   194 AVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTES 255
            .|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:
Human   125 TVNPYKWLP-VYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVN 188

  Fly   256 TKLVMQYLAAVVPGG---------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV 311
            ||.|:||.|.:...|         |.....:.:||:.|.|||||||||:|.||||||||||::.:
Human   189 TKRVIQYFATIAVTGEKKKEEVTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRI 253

  Fly   312 YF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE-------ADK 368
            :| .:|.:..|.|..|||||||:..|...||:||:||:::      ...|..|:|       ...
Human   254 HFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIM------SNKKPDLIEMLLITTNPYD 312

  Fly   369 YFYLNQGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQ 430
            |.:::||.....| ..|.|.|   ..|:::||.:..||..|.::..||:|.||:.|.::|.....
Human   313 YAFVSQGEITVPS-IDDQEELMATDSAIEILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQA 376

  Fly   431 E--GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYA 493
            |  |.||...     ||:|.::::..|.:||.....:...|.:.....:.|..:|..|.|||:|.
Human   377 EPDGTEVADK-----AAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGALAKAVYD 436

  Fly   494 GLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFK 556
            .:|.|:|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||.:||.|:|.
Human   437 KMFLWMVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFV 498

  Fly   557 LEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALS 620
            |||.||.:|.:|||.:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|
Human   499 LEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKS 563

  Fly   621 ELYARPR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL---TK 678
            ..:.:|:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.:..:..|   ..
Human   564 NNFQKPKPAKGKPEAHFSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLALLFVGAT 628

  Fly   679 QLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHAL 743
            ...|:...||...|.....|       .||:|.|.::|.:|:.::...||.|||||.||:.|...
Human   629 GAEAEAGGGKKGGKKKGSSF-------QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPG 686

  Fly   744 RMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAM 808
            .|:...||.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:
Human   687 AMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG-QFIDSKKASEKLL 750

  Fly   809 PRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAA 870
            ....::...|:.|.|:||.:..|...||..|.|:|.:.....|...||.|.|   :::..|:.:.
Human   751 GSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESI 815

  Fly   871 TRLQ---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAA 926
            ..:|         ..|...:...:.:.|.|.|          :..:.:..::.:..:.:|.....
Human   816 FCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSA----------ETEKEMANMKEEFEKTKEELAKT 870

  Fly   927 QRAREAREAKQAVL--ERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQ 989
            :..|:..|.|...|  |::.|. |.:.||                              ..|...
Human   871 EAKRKELEEKMVTLMQEKNDLQ-LQVQAE------------------------------ADSLAD 904

  Fly   990 LPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALE 1054
            ..|...|....|        ::|:.:.:.:|        .|.:|.::..|......|...|:..|
Human   905 AEERCDQLIKTK--------IQLEAKIKEVT--------ERAEDEEEINAELTAKKRKLEDECSE 953

  Fly  1055 GAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK 1119
            ..|:....:..:.|....:...:..:..|..::.||.....:.|:             ...|..:
Human   954 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK-------------EKKALQE 1005

  Fly  1120 YLMRFVDD-EAPE-SLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPL 1182
            ...:.:|| :|.| .:..|...::..:|......|::
Human  1006 AHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSL---------------------------- 1042

  Fly  1183 TLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELC 1247
                |..:.:.:|    .|.|.......|.:|......:.:|.|||.:.         :.:||
Human  1043 ----EQEKKIRMD----LERAKRKLEGDLKLAQESTMDIENDKQQLDEK---------LKKKE-- 1088

  Fly  1248 PAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNER 1312
                            |..:.|...:                ||   |:....:|..:...|..|
Human  1089 ----------------FEMSGLQSKI----------------ED---EQALGMQLQKKIKELQAR 1118

  Fly  1313 YFEREPSPGPGQGSSTGQAKSR---SKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYH 1374
            ..|.|......:.|.....|.|   |:.|:::                        ..||.:...
Human  1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEI------------------------SERLEEAGG 1159

  Fly  1375 SAERLAPVGKDTGPRYQKSQ---HAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLAS 1436
            :......:.|.....:||.:   ......|.|:..:...|:||            ..:|......
Human  1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD------------SVAELGEQID 1212

  Fly  1437 HVRRV--RVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDD 1499
            :::||  ::..:.|::...:|||.|     :::.:|.|:.....:.....:|.:|.:::.::...
Human  1213 NLQRVKQKLEKEKSEMKMEIDDLAS-----NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272

  Fly  1500 YINDIFQPIPLVQN-----LEKLTSKDQLAAIIKGGGVASKPE----ERDEESEIEDLD------ 1549
            .|||:......:|.     ..:|..||.|.:.:..|..|...:    :|..|.||:...
Human  1273 LINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL 1337

  Fly  1550 -------DYINELFEPIPVAEG-LDKLTSKEHLAVS-IRGGGSTDSNGADPLLHQLMQLPGETES 1605
                   |.:.|.:|....|:. |.:..||.:..|: .|....||:          :|...|.|.
Human  1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDA----------IQRTEELEE 1392

  Fly  1606 GPALYQQQVQRA----FLQSAMAQNLQIQQQLLAQNQALQTLLS-QQAAAAAANNSTSPPPAPPI 1665
            ......|::|.|    ...:|...:|:..:|.| ||:....::. ::..||.|...........|
Human  1393 AKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRL-QNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456

  Fly  1666 L-----------SSLSISPPPPQS----PMRMK-ATRSSLVVMESLQPPPPPPPPPMPPPLECKD 1714
            |           :.|..|....:|    ..::| |...||..:|:|:
Human  1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLK------------------ 1503

  Fly  1715 PSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGG 1779
             .|.::.                    |.|....||:.....|......|...|.:..:......
Human  1504 -RENKNL--------------------QQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA 1547

  Fly  1780 MMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRD-----R 1839
            :.|        :..::|.||            |:::|..:.|....:.....:..:|.:     |
Human  1548 LEE--------AEASLEHEE------------GKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592

  Fly  1840 ETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSE 1904
            ....:.:.|||.:..::..::..|...:...|.:.::::......|:    |..::|:..:|:
Human  1593 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRM----AAEALRNYRNTQ-- 1651

  Fly  1905 QRAPAKLEDTRKLM---------LQQQLGGLFASVSGGNSGPGGVVDSHAT-VRTQIERMEGKLS 1959
                |.|:||:..:         |::||               .:|:..|. ::.:||.:...|.
Human  1652 ----AILKDTQLHLDDALRSQEDLKEQL---------------AMVERRANLLQAEIEELRATLE 1697

  Fly  1960 PPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPE-PEPDYRTSSSQV 2023
                                                         .|.||.: .|.:...:|.:|
Human  1698 ---------------------------------------------QTERSRKIAEQELLDASERV 1717

  Fly  2024 VKEHVP---------------AFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQA 2073
            ...|..               :.||.:..|.....|..:         |....:.:.|....|:.
Human  1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAE---------EKAKKAITDAAMMAEEL 1773

  Fly  2074 ERERSRSRSRSRDREDYSESVWD---RAEVEGPASGSGSEKEREKRERERERLYEIRQVERERES 2135
            ::|:..|....|.:::..::|.|   |.:.....:..|.:|:.:|.|.      .:|::|.|.||
Human  1774 KKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEA------RVRELEGEVES 1832

  Fly  2136 HKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERK 2182
            .:          :.:::...|.|:.:|.....|::|      |.:||
Human  1833 EQ----------KRNVEAVKGLRKHERKVKELTYQT------EEDRK 1863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	250/693 (36%)
		PTZ00121	<828..>943	CDD:173412	23/128 (18%)
		MyTH4	1014..1171	CDD:470587	21/158 (13%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	10/66 (15%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYH1	NP_005954.3	Myosin_N	33..77	CDD:460670	1/6 (17%)
		MYSc_Myh1_mammals	100..770	CDD:276875	250/693 (36%)
		Actin-binding. /evidence=ECO:0000250	659..681		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	761..775		5/13 (38%)
		Myosin_tail_1	850..1927	CDD:460256	211/1368 (15%)