Protein Alignment Myo10A and LOC4577508

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_061511173.1
• Gene: LOC4577508 / 4577508
• VectorBaseID: AGAMI1_001064
• Length: 1934
• Species: Anopheles gambiae
• Alignment Length: 2087
• Identity: 525/2087 - (25%)
• Similarity: 790/2087 - (37%)
• Gaps: 623/2087 - (29%)

  Fly    86 SLEDFEDLPNLSAKHPALPSSRLRR---LKCRYPQVVKRLSTLCSDVIAR--------------- 132
            ::|..|..|.|...||.....::.|   .|..:|:   :.|::.||.|:.
Mosquito   265 AIELAEGDPPLCELHPMRALFQIPRNPPPKLSHPE---QYSSMLSDFISECLVKDLEQRPFSKEL 326

  Fly   133 --HPQTFALQPGEGSLR-------ARQ---------------------DLGSSG----VEDMTLL 163
              ||...::.|....:|       |||                     |..|..    ::|:..|
Mosquito   327 VTHPFLKSVGPYVDQIRQELRAEIARQREDGRAPSQAIATTKYGKLKSDRKSKPQKMYMDDLAAL 391

  Fly   164 DDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAI 228
            |.|.|.:::..|:.||:...|||:.|.|||||||:... ..|..:..::|.|:.....|||:|||
Mosquito   392 DVLTEDAIVEQLQKRYETNQIYTYIGDILIAVNPFSQV-GLYTTQHQRKYTGQARSDNPPHIFAI 455

  Fly   229 GAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEA 290
            ..|||.||   ...|.:|||||||||||||..|:::.|..:   |.:.:..:.|:||:..|::||
Mosquito   456 ADAAHQALVHQRQNQAIVISGESGSGKTESANLLLKQLVYL---GKAVTKNLEERILQVNPIMEA 517

  Fly   291 FGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGL- 353
            ||||||..|.||||||||||:.. :||.:.||:|..||||:||:|.||.||.|:||||.:..||
Mosquito   518 FGNARTGINANSSRFGKYLELTMARSGKVNGARIFVYLLEQSRVVKQAEGEGNFHVFYYMYDGLQ 582

  Fly   354 SETERSKYGLLEADK--YFYLNQGATDCASGRVD-WESLQGAMQVLGVSEGEREGIVRVLAAVLH 415
            :|....:|.|..:.:  :.||.:.|| .....|| |:.|..:.:|||..:.|.:.:.|||||:|:
Mosquito   583 AEGRLEEYYLHPSYRKTHRYLQETAT-LPKTNVDRWKQLLASFRVLGFKDDEVDMVNRVLAAILN 646

  Fly   416 LGNVYFHRRQLRHGQEG-VEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQ 479
            ||::.|.........:. ..|...|.:...:.||.:.:..|..||:|.:...|.|.:.....:.:
Mosquito   647 LGDIEFGEMDSNDNTDSRARVIDVAPMHRVSKLLGVDSADLLEALSSNSVVTRGETITRHNNVAE 711

  Fly   480 ALDARDAFAKALYAGLFNWLVSRINSIV---QKGGTHDAHRISILDIFGFEDLAENSFEQLCINY 541
            |..||||.||.||..||:|:|::||.::   :...:.:...:.:|||||||:.::|||||||||.
Mosquito   712 ACTARDAMAKGLYGRLFDWMVNQINLLLVHNRNSNSSEQLAVGLLDIFGFENFSKNSFEQLCINI 776

  Fly   542 ANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATD 606
            |||.:|.|||:|:|..||.||..|.:....:.:.||.||:.:|..:|:|:..|||:||.|||:||
Mosquito   777 ANEQIQYYFNQHIFTWEQQEYMAEGIPVDLVEFADNRPVLDMLLSRPLGLLALLDEESRFPRSTD 841

  Fly   607 LSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLP 671
            .|.:||.| |:..|:.|.||:..|..|.:.|:||:|.|..||||:|||:.|..::::|:..|:..
Mosquito   842 RSLIEKFH-NNVKSKFYQRPKSDAVCFAIHHFAGRVVYQADGFLEKNRNFLPAEIIQLIRQSQYD 905

  Fly   672 LVG-----ELTKQ---LRAQRDAG--KTLP--------KGSNGRFVTMKPRT-PTVAARFADSLQ 717
            ::.     .:||.   ..|.:|.|  :.:|        :..|.|.:..:.|. .|||..|..||.
Mosquito   906 MIRFLFQCPITKTGNLYSAIQDTGSRQNVPSFIKVDTKEKFNSRGLASQSRAQQTVATYFRYSLM 970

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            .|||.|....|.|:||||||:.|.|...|...||:||||.|:|:||:|||.|:..|..|..|:.:
Mosquito   971 DLLQKMVTGTPQFIRCIKPNELKAAKSFDAAKVLKQLRYTGVLETIRIRQHGFSHRFTFADFLRK 1035

  Fly   783 YRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFL-------------------- 827
            |..|..|...|....||.||.||..:...|     :.||.::|||
Mosquito  1036 YCFLAYSFEERVVSNRESCRLLLVRLKMDG-----WALGKSKVFLKYYHVEYLSKLYEEHVRKIV 1095

  Fly   828 ------REALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRY 886
                  |..|.:||.....:|:..:||::|:||||.|.||::
Mosquito  1096 LVQACVRRWLAKALYKREKQRVALSAVTLQKHVRGWLTRRRM----------------------- 1137

  Fly   887 ERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRA-REAREAKQAVLERS---QLSY 947
                       |:.:.:|.|.|::|.|.:..|..:.|.|.::. .|..:||||:.:..   |||.
Mosquito  1138 -----------RILKEKQERERLEQERLEKERLAKERLAKEKKNNEQNKAKQALAKAKLIHQLSS 1191

  Fly   948 LDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV---YCNG 1009
            ..:.|:              |...|..:.:               |:......:.:.|   |..|
Mosquito  1192 NQLEAK--------------HNHHHEKRAM---------------DMNNKENERAAIVIQSYYRG 1227

  Fly  1010 -----LRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKA 1069
                 :|:.|..|                                      ||.|    ||:
Mosquito  1228 YTIRKMRMTPEIE--------------------------------------AKTK----YIL--- 1247

  Fly  1070 LSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLR 1134
                               |:..|..||.|:.|..|                  |..::|..
Mosquito  1248 -------------------GIAKNRVEAQRMMQKEG------------------FAKEDAAR--- 1272

  Fly  1135 PLLLRQLLRQQGGGTSSG----AVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVD 1195
              ::::..|.|....:|.    |...||..:...|   .|..........|||..|:....:|..
Mosquito  1273 --IIQRYYRTQKSKHNSNRDAMAAAVGAASAVAAA---GRKGPAPQPQPKPLTTKDQQMDLIAFS 1332

  Fly  1196 S---WTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAF------- 1250
            .   ..:.|....|.|:..||.                   ||.:..|.::....|.|
Mosquito  1333 QNVHMLNQEVHKNLRVNKAGVP-------------------LDAIEKLPSDYRRPPGFVLVPGLL 1378

  Fly  1251 -PAPRSDLLRSGAKFARTTLPD--------AVKRPAVPPPA------PPTSSGKEDVPRERRSSR 1300
             ..|..|.    ||::.....|        .::|  .||||      .|......:|.|..||.|
Mosquito  1379 GTVPGGDC----AKYSSLRSVDCDHEMTKEVIQR--TPPPAADFDDISPWDMPFYEVERNLRSQR 1437

  Fly  1301 EL----------LSRSSALNERYFE---REPSPG-----PGQGSSTGQAKSRSKSLDDLLAGDIV 1347
            :.          ::|:..|.:|..|   |:.|..     .|...:|.|.|.:
Mosquito  1438 QRNMQQPPQRIDINRNDILGDRKMELSDRKLSSNWHQAFQGTDGTTPQDKFK------------- 1489

  Fly  1348 PVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGP------RYQKSQHAGRRSHAASHG 1406
                           ||:.|..|....:..|..|......|      ||..:||
Mosquito  1490 ---------------GLARSPQNQNEPAHIRSIPAFSYLNPNNQQILRYSPNQH----------- 1528

  Fly  1407 SHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSD 1471
                          |.::...|...||          |.:.|.|:|...:..:|          .
Mosquito  1529 --------------RDASGEPTPPHPS----------PVRQSPVEQPTREASTP----------P 1559

  Fly  1472 ARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKP 1536
            .|.....:.||....:..|::|:...:.            :|.|:                  |.
Mosquito  1560 TRLGLLGLGGGGGAGKKAAKAELKAREK------------ENKER------------------KK 1594

  Fly  1537 EERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPG 1601
            .|:..:.|.|.            ..|.||...::..       .|||..|:||.....|..:..|
Mosquito  1595 REKKAKKEKEK------------AAANGLTASSTSS-------SGGSAASSGASSGEKQRKEPAG 1640

  Fly  1602 ETESGPALYQQQVQRAFLQSA---------MAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNST 1657
            ..:......|||.|:...:.|         ..|..|.|||.:.|.:.::....|..:.....:|.
Mosquito  1641 RKKRSEQKEQQQQQQIVSRFAGVDDQSLHEYHQQYQQQQQQVPQKRLIEHHEYQNISEETKIDSK 1705

  Fly  1658 SPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFL 1722
            ||                   .|||....:.||                            .|
Mosquito  1706 SP-------------------VMRMFGDTNFLV----------------------------NH-- 1721

  Fly  1723 DPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGA 1787
                |.|... .|.:....|...|:..::.....|.||.|::   |.|||.. .|||    .||
Mosquito  1722 ----RRKAAE-QKQQLAQLQQVQQYHKQQQQQQQKARQQQQQ---QQQHHHQ-GNGG----PPG- 1772

  Fly  1788 RGASATAIEWEEFEIESPTPPPMSGQ----LMRSSIRLETTTTT----TTSAVNNRDRDRETQDV 1844
                     |.:.|:.       .||    |:....|.....|:    .:.:.::...||.|.|
Mosquito  1773 ---------WRQQELN-------CGQGVCELLNGVYRFSPHVTSFAQLDSKSASSLSDDRSTLD- 1820

  Fly  1845 GQPMQSVVTTKL----AKKSFEIGADRPPPGSVGKLKLSSEM------RQRLEQVTAGHSVRSTV 1899
             :..|:...:|.    .|.......||.....|.:..:||..      ...:..:.:..||...:
Mosquito  1821 -KDYQNFNVSKYLNIDVKGPLHHQRDRARDSGVHERDISSNSSSLSTGSSGMNSLNSFDSVEQAI 1884

  Fly  1900 STKSEQRAPAKLE--DTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPP- 1961
            ..:.::.|.:.|.  :.|:|:...|             ||           |:..|....::||
Mosquito  1885 IFQKDRNADSYLGPFNFRQLLRPTQ-------------GP-----------TESLRKRKGINPPS 1925

  Fly  1962 PAPPSGG 1968
            |.||..|
Mosquito  1926 PPPPQRG 1932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	276/715 (39%)
		PTZ00121	<828..>943	CDD:173412	29/115 (25%)
		MyTH4	1014..1171	CDD:470587	23/160 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	13/69 (19%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC4577508	XP_061511173.1	None