Protein Alignment Myo10A and MYO1F

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001427538.1
• Gene: MYO1F / 4542
• HGNCID: 7600
• Length: 1119
• Species: Homo sapiens
• Alignment Length: 1312
• Identity: 374/1312 - (28%)
• Similarity: 545/1312 - (41%)
• Gaps: 370/1312 - (28%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFP-------DAYGLEVAKQ 212
            |||:||.||..:.|.::..|||.|:....|:|:.||:||:|||:|..|       |.|  :.|.|
Human    17 SGVDDMVLLPQITEDAIAANLRKRFMDDYIFTYIGSVLISVNPFKQMPYFTDREIDLY--QGAAQ 79

  Fly   213 YAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSAS 274
            |..      |||::|:....:..:   ...|.|:||||||:|||.:.|.:|.|::. |.|||...
Human    80 YEN------PPHIYALTDNMYRNMLIDCENQCVIISGESGAGKTVAAKYIMGYISK-VSGGGEKV 137

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:.||::.|||||||||:|.||:||||||||.|:.| :.|...|.||:.:||||||:|.|..
Human   138 QHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNE 202

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSE 400
            .|||:|::|:||.|.|:.:|...||:..|.|:||||..|   |....|.|:.....||||:|:..
Human   203 NERNFHIYYQLLEGASQEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPP 267

  Fly   401 GEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRAL 459
            ..::.:::::|.:|||||:.|           .|.|:.|.::      :.|:||.|.:..|...|
Human   268 SIQQLVLQLVAGILHLGNISF-----------CEDGNYARVESVDLLAFPAYLLGIDSGRLQEKL 321

  Fly   460 TSRTTEA----RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISI 520
            |||..::    |:|.::..|.::||...|||.||.|||.||::||..||..:||  ..:.:.|.:
Human   322 TSRKMDSRWGGRSESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQK--PQEEYSIGV 384

  Fly   521 LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLA 585
            |||:|||...:|.|||.|||:.||.||..|.:...|.||.||.:|.:.|||:.:.:|..|..|:.
Human   385 LDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIE 449

  Fly   586 KK--PVGICHLLDDESNFPRAT----DLSFLEKCHYNHALSELYARPRIGAQE--------FGVT 636
            .|  |.||..:|||......||    |.:.|:|           .:..:|..|        |.:.
Human   450 NKLSPPGIMSVLDDVCATMHATGGGADQTLLQK-----------LQAAVGTHEHFNSWSAGFVIH 503

  Fly   637 HYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTM 701
            ||||:|.|.|.||.::|||.|..|::||:.:|....:..|             .|:..:|   ..
Human   504 HYAGKVSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRML-------------FPEKLDG---DK 552

  Fly   702 KPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHAL------------RMDMPCVLQQL 754
            |.|..|..::.......|:.::.||.|.::||||||:.|...            |.|......|.
Human   553 KGRPSTAGSKIKKQANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRTGDSPPRGDSAYPPHQS 617

  Fly   755 RYLGMLDTIQIRQRGYPVRLRFQHFVE---------RYRHLLPS--PLARGTPYRELCRALLEAM 808
            :..|.:...:...:|...|||....|.         ||..|.|.  |..||.. |:..:.||.|:
Human   618 QAPGGIPGPEGEHQGAQSRLRLPPPVRQIPAEPSALRYAILTPETWPRWRGDE-RQGVQHLLRAV 681

  Fly   809 PRTGVEGPDYQLGATRVFLR--EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAAT 871
               .:|...||:|:|:||::  |:|. .||..|           :|...|.            |.
Human   682 ---NMEPDQYQMGSTKVFVKNPESLF-LLEEVR-----------ERKFDGF------------AR 719

  Fly   872 RLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAK 936
            .:|..||...|.::||.:|:                                ||:......:|.:
Human   720 TIQKAWRRHVAVRKYEEMRE--------------------------------EASNILLNKKERR 752

  Fly   937 QAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGK 1001
            :..:.|:            |:           ||     .||....|         :|.|| .||
Human   753 RNSINRN------------FV-----------GD-----YLGLEERP---------ELRQF-LGK 779

  Fly  1002 FSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIV 1066
                          ||.:             ||.|::..:        |:..:..|
Human   780 --------------RERV-------------DFADSVTKY--------DRRFKPIK--------- 800

  Fly  1067 HKALSSRGLRDEILVQLCNQVHGLP-----PNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVD 1126
                     ||.||...|..|.|..     |..|:           :|         :.|.:.||
Human   801 ---------RDLILTPKCVYVIGREKVKKGPEKGQ-----------VC---------EVLKKKVD 836

  Fly  1127 DEAPESLRPLLL--RQ----LLRQQGGGTSSGAV-----GAGACRSFVPAWLEWRAWTRGCDMAL 1180
            .:|   ||.:.|  ||    :|::....:...:|     .:..|:.|..|       ||   ..|
Human   837 IQA---LRGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLCKRFEEA-------TR---RPL 888

  Fly  1181 PLTLPDEASQTVAVDSW--------TSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSC----- 1232
            |||..|.....|..:.|        |.......|||..:|    |.||.:..|..|..|.
Human   889 PLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGDLAVLKVG----GRTLTVSVGDGLPKSSKPTRK 949

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAV-----------PPPAPP-T 1285
            |:.......:.:....|.|||...:.|:|..      |.|...|..           ||..|| |
Human   950 GMAKGKPRRSSQAPTRAAPAPPRGMDRNGVP------PSARGGPLPLEIMSGGGTHRPPRGPPST 1008

  Fly  1286 SSGKEDVPRERRSSR---ELLS----------RSSALNERYFEREPSPGPGQGSSTGQAKS---R 1334
            |.|....||.|..|.   |.|:          |..::.:|       |.||.|....|.::   |
Human  1009 SLGASRRPRARPPSEHNTEFLNVPDQGMAGMQRKRSVGQR-------PVPGVGRPKPQPRTHGPR 1066

  Fly  1335 SKSLDDLLAGDI 1346
            .::|...:..|:
Human  1067 CRALYQYVGQDV 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	252/719 (35%)
		PTZ00121	<828..>943	CDD:173412	18/116 (16%)
		MyTH4	1014..1171	CDD:470587	31/172 (18%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	19/79 (24%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1F	NP_001427538.1	None