DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myh2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001006805.1 Gene:myh2 / 448514 XenbaseID:XB-GENE-5760121 Length:1939 Species:Xenopus tropicalis


Alignment Length:2213 Identity:491/2213 - (22%)
Similarity:843/2213 - (38%) Gaps:624/2213 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|||:|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
 Frog    87 IEDMAMMTHLNEASVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNPEVVAGYRGKKRQEA 150

  Fly   222 PPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|:|...|:..:   ...|.|:|:||||:|||.:||.|:||.|.:...|         .|..
 Frog   151 PPHIFSISDNAYQFMLQDRENQSVLITGESGAGKTVNTKRVIQYFATIAAIGDSNKKKEMSNSMQ 215

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||::|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|..
 Frog   216 GTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLS 280

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWE----SLQGAMQVLG 397
            .||:||:||::|.. .:.|..:..||..:.|.|  ::||  :.|...:|.|    :...|:.:||
 Frog   281 AERSYHIFYQILTN-KKPEIVEMLLLTTNPYDYAFISQG--EIAVKSIDDEEELMATDSAIDILG 342

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALT 460
            .:..|:.||.::..:|:|.||:.|.::|.....|  |.||...     ..:|:.:::..|.:||.
 Frog   343 FTAEEKMGIYKMTGSVMHKGNMKFKQKQREEQAEPDGTEVADK-----IGYLMGLNSADLLKALC 402

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTH--DAHRISILDI 523
            ....:...|.:.....:.|..:|..|.:|:::..||.|:|:|||   |:..|.  ..:.|.:|||
 Frog   403 YPRVKVGNEFVTKGQTVQQVYNAIGALSKSVFEKLFLWMVTRIN---QQLDTKLPRQYFIGVLDI 464

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKP 588
            .|||....||.||||||:.||.||.:||.|:|.|||.||.:|.::|..:.:..:|.....|.:||
 Frog   465 AGFEIFDLNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKP 529

  Fly   589 VGICHLLDDESNFPRATDLSFLEKCHYNHALSEL----YARPRIGAQE--FGVTHYAGQVWYCVD 647
            :||..:|::|..||:|||.||..|.:..| |.:.    ..:|..|..|  |.:.||||.|.|.:.
 Frog   530 MGILSILEEECMFPKATDTSFKNKLYDQH-LGKCKNFEKPKPAKGKAEAHFSLVHYAGTVDYNIC 593

  Fly   648 GFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARF 712
            |:||||:|.|...|:.|...|.|.|:..|.........||.....|...:..:.:    ||:|.|
 Frog   594 GWLDKNKDPLNETVVGLYQKSSLKLLSFLYSSYAGTDGAGDGAKSGKKKKGSSFQ----TVSALF 654

  Fly   713 ADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQ 777
            .::|.:|:.::...||.||||:.||:.|....|:...::.|||..|:|:.|:|.::|:|.|:.:.
 Frog   655 RENLNKLMTNLRSTHPHFVRCLIPNESKTPGIMENHLIIHQLRCNGVLEGIRICRKGFPSRILYG 719

  Fly   778 HFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT 840
            .|.:||:.|..|.:..|  ...::.|..||.::   .::...|:.|.|:||.:..|...||..|.
 Frog   720 DFKQRYKILNASAIPDGQFIDSKKACEKLLGSI---DIDHTQYRFGHTKVFFKAGLLGTLEEMRD 781

  Fly   841 ERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGA 893
            ::|.:.....|...||.|:|   :::..|:.|...:|         ..|...:...:.:.|.|.|
 Frog   782 DKLAQLITRTQALCRGFLMRVEFKKMIERRDAIFVIQYNVRSFMNVKHWPWMKLYFKIKPLLKSA 846

  Fly   894 LTAQRLWRGRQARRRVQQLRSDHRRRQEA-REAAQRAREAREAKQAVLERSQLSYLDIPAE---L 954
                      :..:.:..::.:..:.:|| .::..|.:|..|...|:|:......|...:|   |
 Frog   847 ----------ETEKEMANMKEEFEKTKEALTKSDARRKELEEKMVALLQEKNDLMLQCQSENESL 901

  Fly   955 AFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPI 1019
            |....:.:|         |:|                                |.:.|:.:.:.:
 Frog   902 ADAEERCEG---------LIK--------------------------------NKINLEAKIKEL 925

  Fly  1020 TAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLC 1084
            |..|      .|::..:|....|                             .|.|.||     |
 Frog   926 TERL------EDEEESNAELTAK-----------------------------KRKLEDE-----C 950

  Fly  1085 NQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGT 1149
            ::                                  |.:.:||                      
 Frog   951 SE----------------------------------LKKDIDD---------------------- 959

  Fly  1150 SSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAAL--AVSS 1210
                                          |.|||.....:..|.::...  .||.|.|  .:|.
 Frog   960 ------------------------------LELTLAKVEKEKHATENKVKNLTEEMAGLDETISK 994

  Fly  1211 LGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKR 1275
            :....:    .|.:..|.|    ||   ||.||:           |.:.|.:| |:|.|...|  
 Frog   995 ISKEKK----ALQEAHQQT----LD---DLQAEE-----------DKVSSLSK-AKTKLEQQV-- 1034

  Fly  1276 PAVPPPAPPTSSGKEDVPRERRSSREL---LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKS 1337
                          :|:.......::|   |.|:    :|..|             |..|...::
 Frog  1035 --------------DDLEGSLEQEKKLRLDLERA----KRKLE-------------GDLKLAQET 1068

  Fly  1338 LDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHA 1402
            :.||                           .||:..:.|:|..  ||    ::.||..|:....
 Frog  1069 IMDL---------------------------ENDKQQTEEKLKK--KD----FELSQLQGKIEDE 1100

  Fly  1403 ASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLD 1467
            .|.|....|..  .|...|...:.:..||...|    |.:|..|.:|            |...|:
 Frog  1101 QSVGCQLQKKI--KELQARIEEVEEEIEAERAA----RAKVEKQRAD------------LSRELE 1147

  Fly  1468 ELSDARSLAASIRGGSYEQENEAESEID----DLD------------------DYINDIFQPIP- 1509
            |:|:....|........|...:.|:|..    ||:                  |.:.::.:.|. 
 Frog  1148 EISERLEEAGGATSAQIEMNKKREAEFQKLRRDLEESTLQHEATSAALRKKHADSVAELGEQIDN 1212

  Fly  1510 ---LVQNLEKLTSK-----DQLAAIIKGGGVASKPEER------DEESEIEDLDDYINELFEPIP 1560
               :.|.|||..|:     |.||:.::....:....|:      |:.|||:..||....:...:.
 Frog  1213 LQRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEKLSRVLEDQLSEIKSRDDEHQRIINDLT 1277

  Fly  1561 V---------AEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPAL------- 1609
            .         .|...:|..||.|...:..|....:...:.|..||.:   ||::..||       
 Frog  1278 AQKARLQTENGELSRQLEEKESLVSQLTRGKQGFTQQTEELKRQLEE---ETKAKNALAHALQSS 1339

  Fly  1610 -----------YQQQVQRAFLQSAMAQ-NLQIQQQLL---------------AQNQALQTLLSQQ 1647
                       .::|..:|.||.:::: |.::.|...               |:.:..|.|...:
 Frog  1340 RHDCDLLREQYEEEQEAKAELQRSLSKANTEVSQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404

  Fly  1648 AAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLEC 1712
            ....|.|:.         .:||.      ::..|::|....|:|                   :.
 Frog  1405 EQVEAVNSK---------CASLE------KTKQRLQAEVEDLMV-------------------DV 1435

  Fly  1713 KDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEE------DFFAFKMR-------QHQRK 1764
            :..:.....||...|.....:.:|:....:.:.:.:..:      ....|||:       :|...
 Frog  1436 ERANSAAAALDKKQRNFDKVLVEWKQKYEESQAELEASQKESRSLSTEIFKMKNAYEEALEHLET 1500

  Fly  1765 TTPQAQHHQMTSNGGMMESGPGA----------------RGASATAIEWEEFEIESPTPPPMSGQ 1813
            ...:.::.|...:....:.|..|                ||....|:|..|..:|..     ..:
 Frog  1501 MKRENKNLQQEISDLSEQIGESAKTTMELEKAKKQVEQERGDLQAALEEAEGSLEHE-----EAK 1560

  Fly  1814 LMRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSV 1873
            ::|..:.|....:.....:..:|.:     |.:|.|...|||.:.:::..::..:...:...|.:
 Frog  1561 ILRIQLELNQVKSEVDRKIAEKDEEIEQLKRNSQRVIDTMQSTLDSEIRSRNDALRLKKKMEGDL 1625

  Fly  1874 GKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQR-APAKLEDTRKLM---------LQQQLGGLFA 1928
            .:|           ::..||:.|.....:.:.| ..|:|:||:..:         |::||     
 Frog  1626 NEL-----------EIQLGHANRQAGEAQKQLRNVQAQLKDTQIHLDDSVRAQEDLKEQL----- 1674

  Fly  1929 SVSGGNSGPGGVVDSHATV-RTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSM 1992
                      .|||...|: :.:||.|...|.                                 
 Frog  1675 ----------AVVDRRTTLQQAEIEEMRVALE--------------------------------- 1696

  Fly  1993 APPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQER-DTFGAVRQQQM----ISSH 2052
                     |:..:.:..|.|....:...|::.....:.|..::: :|.....|.:|    ..:.
 Frog  1697 ---------QTERSRKMAEQELLDASERVQLLHSQNTSLINTKKKLETDAGTLQNEMEEAVQEAR 1752

  Fly  2053 HLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWD---RAEVEGPASGSGSEKERE 2114
            :...:...|.:..|:.| |:.::|:..|....|.:::..::|.|   |.:.....:..|.:|:.:
 Frog  1753 NAEEKAKKAITDAALMA-EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQ 1816

  Fly  2115 KRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEH 2179
            |.|.      .:|::|.|.::.:          :.|::...|.|:.:|.....|:::      |.
 Frog  1817 KLES------RVRELENELDNEQ----------KRSVEAVKGVRKYERRVKELTYQS------EE 1859

  Fly  2180 ERK 2182
            :||
 Frog  1860 DRK 1862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 252/709 (36%)
MYSc_Myo15 169..828 CDD:276838 246/689 (36%)
MyTH4 1014..1171 CDD:295320 13/156 (8%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh2NP_001006805.1 Myosin_N 37..72 CDD:280832
Myosin_head 87..769 CDD:278492 251/701 (36%)
MYSc_class_II 99..769 CDD:276951 246/689 (36%)
Myosin_tail_1 849..1926 CDD:279860 223/1421 (16%)
RILP-like 964..1097 CDD:304877 42/221 (19%)
DUF342 <1155..1254 CDD:302792 17/98 (17%)
MIT_CorA-like <1298..>1410 CDD:294313 19/114 (17%)
COG6 1375..>1510 CDD:303003 19/168 (11%)
TMPIT 1741..>1837 CDD:285135 19/112 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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