Protein Alignment Myo10A and MYO1B

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_047300366.1
• Gene: MYO1B / 4430
• HGNCID: 7596
• Length: 1156
• Species: Homo sapiens
• Alignment Length: 825
• Identity: 301/825 - (36%)
• Similarity: 456/825 - (55%)
• Gaps: 69/825 - (8%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            ||.||.||:.|:|.:.:.||:.|:|...|||:.||::|:||||:..| .|..|..::|..|....
Human    36 GVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLP-IYSPEKVEEYRNRNFYE 99

  Fly   221 LPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            |.||:||:...|:.:|   ...|.::|:||||:||||::||||.|:|||. |.|:....:.||:|
Human   100 LSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVC-GKGAEVNQVKEQLL 163

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ::.|:|||||||:|.|||||||||||:::.|. .|..:|..|:.|||||||:|.|..||||:|||
Human   164 QSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVF 228

  Fly   347 YELLGGLSETERSKYGLLEAD--KYFYLN------QGATDCASGRVDWESLQGAMQVLGVSEGER 403
            |:||.|.||...:|. .||.|  :|.||:      .|..|.|:.|    :::.|||::|..:.|.
Human   229 YQLLSGASEELLNKL-KLERDFSRYNYLSLDSAKVNGVDDAANFR----TVRNAMQIVGFMDHEA 288

  Fly   404 EGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARA 468
            |.::.|:||||.|||:.|......:|.:..::....|:|....|..|....|.||.:.||.||:.
Human   289 ESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQ 353

  Fly   469 ERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRI-SILDIFGFEDLAEN 532
            |::.|.|.:.||..||||.||.||:.||:|||:|||..: |..|....:: .:|||:|||...:|
Human   354 EKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESI-KAQTKVRKKVMGVLDIYGFEIFEDN 417

  Fly   533 SFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDD 597
            ||||..|||.||.||..|.:...|.||.||.||.:|||.:.:.:|..:..|:.....||..:||:
Human   418 SFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDE 482

  Fly   598 ESNFP-RATDLSFLEKCH-----YNHALSELYARPR------IGAQEFGVTHYAGQVWYCVDGFL 650
            |...| ..||.:||||.:     :.|..|.:....|      :....|.:.||||:|.|.|:||:
Human   483 ECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFV 547

  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADS 715
            |||.|.|..|:.:.:..:...|:..|             .|:|:..: :.:| |.||..::|..|
Human   548 DKNNDLLYRDLSQAMWKASHALIKSL-------------FPEGNPAK-INLK-RPPTAGSQFKAS 597

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            :..|::::...:|.::||||||.:|.|...:...|..|:||||:|:.:::|:.||..|..::..:
Human   598 VATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCL 662

  Fly   781 ERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EALHRALESGRTE 841
            |||:.|...  |..:| |.|.....|...:.   :...:|..|.:::|:|  ..|.: ||..|.:
Human   663 ERYKMLCKQTWPHWKG-PARSGVEVLFNELE---IPVEEYSFGRSKIFIRNPRTLFK-LEDLRKQ 722

  Fly   842 RLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQAR 906
            ||...|..:|:..||...|......:.:...:.|.:|....|:||::.:..||..|...||.:||
Human   723 RLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKAR 787

  Fly   907 RRVQQLRSDHRRRQ------------EAREAAQRAREAREAKQAV 939
            :.:::|:...|.::            :||...:|.:|....|.|:
Human   788 KILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAI 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	261/685 (38%)
		PTZ00121	<828..>943	CDD:173412	32/126 (25%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
MYO1B	XP_047300366.1	MYSc_Myo1	49..708	CDD:276829	261/685 (38%)
		IQ	769..791	CDD:197470	7/21 (33%)
		Myosin_TH1	961..1138	CDD:461801