DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Mhcl

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster


Alignment Length:2017 Identity:405/2017 - (20%)
Similarity:706/2017 - (35%) Gaps:589/2017 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFP-DAYGLEVAKQYAGRPLGS 220
            |||:..|..|:|||:|..||.||...||:|.||..|:.|||  |.| ..|..:|...:.|.....
  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNP--MAPLSLYSEKVVSMFRGCKTED 625

  Fly   221 LPPHLFAIGAAAHAALPS---PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQIL 282
            :|||::::...|:.:|..   .|.::..|.|||||:.|.|..:.|||  :..|...:.:..|::.
  Fly   626 MPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLA--LAAGAYNNFINAEKVN 688

  Fly   283 EAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVF 346
            ....:||||||.:|..|.|::|..:.|.:.| ::|.|..|.:...|.|:.|...:...|.::|:.
  Fly   689 ALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIM 753

  Fly   347 YELLGGLSETERSKYGLLEAD------------KYFYLNQGATDCASGRVDWESLQGAMQVLGVS 399
            ..||.|.:       |||:.:            .:..|:|...|......|:.....|.:.|.:.
  Fly   754 TRLLAGAA-------GLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTVQAFETLNID 811

  Fly   400 EGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW--------AAHLLHISADGLH 456
            .....||..:|||:.|||..         |...:..||.|..::        |:.||.::.:.|.
  Fly   812 AKAVRGIWSILAAIYHLGIA---------GVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867

  Fly   457 RALTSRT---------TEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT 512
            .|....|         :.:::....|  |.:.|.:..:|....||:.....:|:.||..:.. .:
  Fly   868 SAAFGLTQPNAPNGGLSPSKSPTSDT--GHEWAWECLEALVIGLYSEALAAVVALINRQICT-SS 929

  Fly   513 HDAHRISILDIFGFEDLAE------NSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLE-WT 570
            |....|.::|..||::.|.      .:...|..||..|.||:.|:.......:..||:|.:| ..
  Fly   930 HTIASIMLIDTPGFQNPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEM 994

  Fly   571 PLAWDDNL-PVIHLLAKKPV-----------------GICHLLDDESNFPRATDLSFLEK--CHY 615
            .||.:.:. |:|.|:.|.|.                 |:..|||:|:.:|.:.|.:|||:  .||
  Fly   995 DLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHY 1059

  Fly   616 ----NHALSELYARPRIGAQEFGVTHYAG--QVWYCVDGFLDKNRD--ALRGDVLELLASSRLPL 672
                :|:|....|.||    :|.:.|..|  .|.|.|||::..:|:  .:|..|..|..|||..:
  Fly  1060 GDREHHSLLRKCAGPR----QFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEI 1120

  Fly   673 ----VGELTKQLRAQRDAG--------KTLPKGSNGR--FVTMKPRTPTVAARFADSLQQLLQSM 723
                :|.||:...|....|        ::|.:.|:.|  |.|...:..::..:...::..::.::
  Fly  1121 NRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTL 1185

  Fly   724 GRCHPWFVRC--IKPNQEKHAL-------------------RMDMPCVLQQLRYLGMLDTIQIRQ 767
            .|....||.|  ::.|..||..                   .:::|.:..|||...:|:..::.:
  Fly  1186 RRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHR 1250

  Fly   768 RGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALH 832
            .|:|..:....||.|: .||...||.....     ::.:.:....::...|::|.:::..|..:.
  Fly  1251 LGFPESVPLLEFVRRF-GLLAGDLASNKDV-----SVEQILAVNELDVASYRIGPSQILFRSGVL 1309

  Fly   833 RALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ 897
            ..||:.|...|....:.:|...||.|.|:::::|:.....::...|..:           |..|.
  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVK-----------AFLAV 1363

  Fly   898 RLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQ 962
            |.|...:...||..|.:.||..::.:.|.:.....|    |.||:.:....::.||...:.:||.
  Fly  1364 RDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLR----AKLEKIECDRSEVKAENQKLEAKLS 1424

  Fly   963 GWSPPHGDRHLVKVLGT--VPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLR-LQPRREPITAPLL 1024
            ..:....:......:.|  :....:..::|.::||.         ..|.:: ||...|.:...|:
  Fly  1425 ELTVDLAEERSTAHIATERLEAETAERLKLEKELGD---------QTNKVKNLQETTEKLEMELI 1480

  Fly  1025 -----TRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK-ALSSRGLRDEILVQL 1083
                 ....|.|:|.:             |:..:.|...||..:.:..: ..:.|.|..:     
  Fly  1481 CAKSDLNGISEDEDAE-------------NEDGVGGGVYKLKYERVARELEFTKRRLHTQ----- 1527

  Fly  1084 CNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGG 1148
              ..|.|.          ||:           |..|:|...:.|...|.:..   ||::.|    
  Fly  1528 --HEHDLE----------QLV-----------ALKKHLEMKLSDAYEEVVEQ---RQVVGQ---- 1562

  Fly  1149 TSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV 1213
                                   |.|                                       
  Fly  1563 -----------------------WKR--------------------------------------- 1565

  Fly  1214 ASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLL-RSGAKFAR--TTLPDAVKR 1275
                      ..|::|:.  ::.:..|:.|:.       .|::|| :...||..  .:|.|||::
  Fly  1566 ----------KAQKMTNE--MNDLRMLLEEQN-------ARNNLLEKKQRKFDAECQSLQDAVRQ 1611

  Fly  1276 PAVPPPAPPTSSGKEDVPRER-----------------RSSRELLSRSSALNERYFEREPSPGPG 1323
                     ....||...||:                 |...|......|..:|..| |.:.|.|
  Fly  1612 ---------ERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELE-EMTFGGG 1666

  Fly  1324 -----------QGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLH-TLGLSESRLNDRYHSA 1376
                       :..:..:||.:.:.||: :||.|..:     .|..|. .:.|...|...|..|.
  Fly  1667 TEEEFAQLRRSKNETERRAKEQEEELDE-MAGQIQLL-----EQAKLRLEMTLETMRKEARRESQ 1725

  Fly  1377 ERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA-----PSLAS 1436
            :|...:.:..|..|:|.: |........|...:....:|.|...|.|:|.|....     .:|..
  Fly  1726 QRDEELEEVRGNGYKKIK-ALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQ 1789

  Fly  1437 HVRR--VRVPSQASDVDQFLDDLFSPV--------LDGSLDELSDARSLAASIRGGSYEQENEAE 1491
            .:||  .:..:...|....|:.|.:..        |...|::...|||||...|..:..:..|.:
  Fly  1790 KLRRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQ 1854

  Fly  1492 SEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELF 1556
            :..|:.....||          .|:..:             |:..:..:.:::||:.::.:.||.
  Fly  1855 AMFDESHRARND----------AEERAN-------------AAHRDRAELQAQIEENEEELGELM 1896

  Fly  1557 ------------EPIPVAEGLDKLTS--------KEHLAVSIRGGGSTDSNGADP---LLHQLMQ 1598
                        |.|.|:|...||..        ||.:| .::.......|..||   ::.:.::
  Fly  1897 KKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVA-ELQHRLDNVENLGDPSMAMMSKRLE 1960

  Fly  1599 L-PGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPA 1662
            | ..|.||  .|..:|..||.|:..:.::.:..::|  ||:..|:                    
  Fly  1961 LRTKELES--RLELEQATRARLEVQVNRHKEALEKL--QNEVTQS-------------------- 2001

  Fly  1663 PPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGR 1727
                              :|:..::..|:.:|                                 
  Fly  2002 ------------------KMREMQAQDVIKKS--------------------------------- 2015

  Fly  1728 AKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASA 1792
            .|::|               ...|:|.|...|:.:..|    :...:......|||         
  Fly  2016 QKSLR---------------DMREEFHAVSSREQESLT----RRKDLEKKVEQMES--------- 2052

  Fly  1793 TAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLA 1857
                              .|..:::.:||..............:.:.|..:..:.:.||      
  Fly  2053 ------------------EGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSV------ 2093

  Fly  1858 KKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQ 1922
                         ||:      |::..||..|   |..||:                     ||.
  Fly  2094 -------------GSI------SDLEDRLRPV---HVKRSS---------------------QQS 2115

  Fly  1923 LGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPI 1987
            |.|   |:.||.   |.||.|..||  ..|:.:.........||......|...|.::||..|..
  Fly  2116 LNG---SIGGGG---GSVVSSTRTV--VFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANKPDT 2172

  Fly  1988 RP 1989
            :|
  Fly  2173 KP 2174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 195/782 (25%)
MYSc_Myo15 169..828 CDD:276838 188/762 (25%)
MyTH4 1014..1171 CDD:295320 23/162 (14%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 197/786 (25%)
MYSc_Myo18 575..1305 CDD:276837 188/762 (25%)
GBP_C <1540..1750 CDD:303769 52/314 (17%)
COG1340 1565..1833 CDD:224259 59/342 (17%)
coiled coil 1723..1734 CDD:293879 2/10 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466245
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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