DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myh4

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001001244.1 Gene:myh4 / 407946 XenbaseID:XB-GENE-989283 Length:1935 Species:Xenopus tropicalis


Alignment Length:2533 Identity:552/2533 - (21%)
Similarity:919/2533 - (36%) Gaps:804/2533 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|||:|:||:.||...:|||::|.....|||||..| .|..||...|.|:.....
 Frog    87 IEDMAMMTHLNEASVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYNPEVVAGYRGKKRMEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG-------GSASAV 276
            |||:|::...|:.|:.:.   |.|:|:||||:|||.:||.|:||.|.:...|       .|....
 Frog   151 PPHIFSLSDNAYQAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDKKKESSNSLQGN 215

  Fly   277 ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGE 340
            :.:||::|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|...|
 Frog   216 LEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQLSAE 280

  Fly   341 RNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWESL---QGAMQVLGVSE 400
            |:||:||::|.. .:.|..:..||..:.|.|  ::||.....|.. |.|.|   ..|:.|||.::
 Frog   281 RSYHIFYQILTN-KKPEIVEMLLLTTNPYDYPSISQGELVVKSIN-DEEELMATDSAIDVLGFNQ 343

  Fly   401 GEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTE 465
            .|:.||.::..||:|.||:.|.::|   .:|..|..|.......|:||.:::..|.:.|.....:
 Frog   344 EEKMGIYKMTGAVMHHGNLKFKQKQ---REEQAEPDSTEVADKIAYLLGLNSADLLKGLCYPRVK 405

  Fly   466 ARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFED 528
            ...|.:.....:.|..::..|..|:::..||.|:|:|||   |:..|....:  |.:|||.|||.
 Frog   406 VGNEFVTKGQTVPQVYNSVGALCKSVFEKLFLWMVTRIN---QQLDTKQPRQFFIGVLDIAGFEI 467

  Fly   529 LAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICH 593
            ...||.||||||:.||.||.:||.|:|.|||.||.:|.::|..:.:..:|.....|.:||:||..
 Frog   468 FDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPLGIFS 532

  Fly   594 LLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRIG----AQEFGVTHYAGQVWYCVDGFLDKN 653
            :|::|..||:|||.||..|.:..| ...:.:.:|:.|    ...|.:.||||.|.|.:.|:|:||
 Frog   533 ILEEECMFPKATDTSFKNKLYEQHLGKCKNFEKPKPGKGKAEAHFSLVHYAGTVDYNISGWLEKN 597

  Fly   654 RDALRGDVLELLASSRLPLVGELTKQLRA-QRDA---GKTLPKGSNGRFVTMKPRTPTVAARFAD 714
            :|.|...|::|...|.:.|:..|.....| ..||   |....|||:.:         ||:..|.:
 Frog   598 KDPLNESVVQLYQKSSVKLLSLLYSSYAATDGDAGGKGGKKKKGSSFQ---------TVSGLFRE 653

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            :|.:|:.::...||.||||:.||:.|....||...::.|||..|:|:.|:|.::|:|.|:.:..|
 Frog   654 NLNKLMTNLRSTHPHFVRCLIPNETKTPGIMDNHLLIHQLRCNGVLEGIRICRKGFPSRILYGDF 718

  Fly   780 VERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTER 842
            .:||:.|..|.:..|  ...::.|..||.::   .|:...|:.|.|:||.:..|...||..|.|:
 Frog   719 KQRYKVLNASAIPEGQFIDSKKACEKLLGSI---DVDHTQYKFGHTKVFFKAGLLGTLEEMRDEK 780

  Fly   843 LRRAAVSVQRHVRGMLVR----RQLARRQAAAT---RLQA-----RWRGQRAQQRYERLRKGALT 895
            |.:.....|...||.|:|    :.:.||:|...   .|::     .|...:...:.:.|.|.|  
 Frog   781 LAQLITRTQALCRGYLMRLEFTKMMERREAIYVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSA-- 843

  Fly   896 AQRLWRGRQARRRVQQLRSDHRRRQEAR-EAAQRAREAREAKQAVLERSQLSYLDIPAE---LAF 956
                    :..:.:..::.:..:.:||. :|..|.:|..|...|:|:......|.:.:|   ||.
 Frog   844 --------ETEKEMANMKEEFEKTKEALVKAEARKKELEEKMVAMLQEKNDLVLQVQSESETLAD 900

  Fly   957 IYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITA 1021
            ...:.:|         |:||                                .::|:.:.:.:|.
 Frog   901 SEERCEG---------LIKV--------------------------------KIQLESKIKELTE 924

  Fly  1022 PLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQ 1086
            .|      .|::..:|....|                             .|.|.||     |::
 Frog   925 RL------EDEEESNAELTAK-----------------------------KRKLEDE-----CSE 949

  Fly  1087 VHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSS 1151
                                              |.:.:||                        
 Frog   950 ----------------------------------LKKDIDD------------------------ 956

  Fly  1152 GAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAAL--AVSSLG 1212
                                        |.|||.....:..|.::...  .||.|.|  .:|.|.
 Frog   957 ----------------------------LELTLAKVEKEKHATENKVKNLTEEMAVLDENISKLS 993

  Fly  1213 VASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPA 1277
            ...:    .|.:..|.|    ||   ||.||:           |.:.|.:| |:|.|...|    
 Frog   994 KEKK----ALQEAHQQT----LD---DLQAEE-----------DKVSSLSK-AKTKLEQQV---- 1031

  Fly  1278 VPPPAPPTSSGKEDVPRERRSSREL---LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLD 1339
                        :|:.......::|   |.|:    :|..|             |..|...:::.
 Frog  1032 ------------DDLEGSLEQEKKLRLDLERA----KRKLE-------------GDLKLTQETVM 1067

  Fly  1340 DLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAAS 1404
            ||                           .||:..:.|:|..  ||    ::.||..|:.....|
 Frog  1068 DL---------------------------ENDKQQTEEKLKK--KD----FEISQLQGKIEDEQS 1099

  Fly  1405 HGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDEL 1469
            .|:...|..  .|...|...:.:..||...|    |.:|..|.:|            |...|:|:
 Frog  1100 LGTQLQKKI--KELQARIEEVEEEIEAERAA----RAKVEKQRAD------------LSRELEEI 1146

  Fly  1470 SDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVAS 1534
            |:....|........|...:.|:|           ||  .|.::||:.|.:.:..|    |.:..
 Frog  1147 SERLEEAGGATSAQIEMNKKREAE-----------FQ--KLRRDLEEATLQHEATA----GALRK 1194

  Fly  1535 KPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQL 1599
            |     ....:.:|.:.|:.|..   |.:.|:|  .|..|.:.|           |.|...|   
 Frog  1195 K-----HADSVAELGEQIDNLQR---VKQKLEK--EKSELKMEI-----------DDLASNL--- 1235

  Fly  1600 PGETESGPALYQQQVQRAFLQSAMAQNLQIQQQL---LAQNQALQTLLSQQAAAAAANNSTSPPP 1661
              |..|......::|.|.           |:.||   .|::...|.||:..:...|...:.:   
 Frog  1236 --ENVSKSKANLEKVNRV-----------IEDQLSEVKAKDDEHQRLLNDLSTQKARLQTET--- 1284

  Fly  1662 APPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYG 1726
                 ..||          |....|.||:...|.                               
 Frog  1285 -----GELS----------RQLEERESLISQLSR------------------------------- 1303

  Fly  1727 RAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGAS 1791
                   ||..:....:|.:.|.||:..|.....|..::   |:|.                   
 Frog  1304 -------GKQGFTQQVEELKRQLEEETKAKNALAHALQS---ARHD------------------- 1339

  Fly  1792 ATAIEWEEFEIESPTPPPMSGQLMRSSIRL-ETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTK 1855
             ..:..|:||.|......:...|.:::..: :..|...|.|:   .|..|.::            
 Frog  1340 -CDLLREQFEEEQEAKAELQRSLSKANGEVSQWRTKYETDAI---QRTEELEE------------ 1388

  Fly  1856 LAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
             |||                 ||:..::...|||.|.:|..:::. |::||..:::||       
 Frog  1389 -AKK-----------------KLAQRLQDAEEQVEAVNSKCASLE-KTKQRLQSEVED------- 1427

  Fly  1921 QQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPP 1985
                 |...|...||.        |....:.:|...|              ||:           
 Frog  1428 -----LMVDVERANSA--------AAALDKKQRNFDK--------------VLV----------- 1454

  Fly  1986 PIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMIS 2050
                                     |.:..|....:::.                .|:::.:.:|
 Frog  1455 -------------------------EWKQKYEEGQAELE----------------AALKESRSLS 1478

  Fly  2051 SHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK 2115
            :....:::          |:|:|   .....:..|:.::..:.:.|..|..|.:..|..|.|:.|
 Frog  1479 TEIFKMKN----------AYEEA---LEHVETLKRENKNLQQEISDLTEQIGESGKSVVELEKAK 1530

  Fly  2116 RERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYE-- 2178
            ::.|:|: .:::....|.|....::.|  ::::..::........||         .:|:|.|  
 Frog  1531 KQVEQEK-NDLQAALEEAEGSLEHEEA--KILRIQLELNQVKSEVDR---------KIAEKDEEI 1583

  Fly  2179 HERKRKSSAS-SGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLT 2242
            .:.||.|..| ..|:..|||                                             
 Frog  1584 EQLKRNSQRSIDTMQSTLDS--------------------------------------------- 1603

  Fly  2243 YNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVS 2307
                  ::|.|.:..:             |..::.||:               :.|.:..||   
 Frog  1604 ------EIRSRNDALR-------------LKKKMEGDL---------------NELEIQLGH--- 1631

  Fly  2308 VDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQG----APLYPDVSIMGVS 2368
                :||..|.|.                           .:|..|||    ..|..|.:|.   
 Frog  1632 ----ANRQASEAQ---------------------------KQLRNVQGQFKETQLQLDEAIR--- 1662

  Fly  2369 HSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGK----HLALHAARAAAIQSMV 2429
                  |:.|....:.|........|:.:...| |.|:...|:.|    .|...:.|...:.|..
 Frog  1663 ------AQEDLKEQVAVTERRNNLFQAEIEENR-AGLEQTERSRKIAEQELLDASERLQLLHSQN 1720

  Fly  2430 TTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELH 2494
            |:.:...:|.:|....|.:.|..|.|         |:|.|..:..:...|......|..::.:..
 Frog  1721 TSLINSKKKLESDICQLQNEAEEAVQ---------EARNAEEKAKKAITDAALMAEELKKEQDTS 1776

  Fly  2495 HHLQQQQQQQQQQ----QHHQQQQQQ----------QQLEDAMEEQHMATDHQQQQQQQLGQQQG 2545
            .||::.::..:|.    ||...:.:|          |:||..:.|.....|::|:...:..:...
 Frog  1777 AHLERMKKNLEQTVKDLQHRLDEAEQLAMKGGKKQLQKLESRVRELENELDNEQKHGVEAVKGVR 1841

  Fly  2546 QQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPH--------HDLD 2600
            :.:|.:|:.:|.....|.|..:....:...|...:....|.::.:.|:..|        |:|:
 Frog  1842 KYERRVKELTYQTEEDKKNILRLQDLVDKLQSKVKAYKRQAEEAEEQANTHLGRFRKVQHELE 1904

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 255/707 (36%)
MYSc_Myo15 169..828 CDD:276838 249/687 (36%)
MyTH4 1014..1171 CDD:295320 13/156 (8%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh4NP_001001244.1 Myosin_N 34..72 CDD:397036
MYSc_class_II 99..766 CDD:276951 249/687 (36%)
Myosin_tail_1 846..1923 CDD:396244 279/1743 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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