Protein Alignment Myo10A and Myo3b

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001380706.1
• Gene: Myo3b / 366069
• RGDID: 1560313
• Length: 1333
• Species: Rattus norvegicus
• Alignment Length: 1023
• Identity: 350/1023 - (34%)
• Similarity: 523/1023 - (51%)
• Gaps: 177/1023 - (17%)

  Fly    67 QSPSLALLSP--------HVLRRQRPASLEDFEDLPNLS--AKHPALPSSRLRRLKCRYPQVVKR 121
            ::|...||.|        |.:.:   ..::|||..|:::  ..||.:..::.:.|..:     |:
  Rat   266 RNPPPTLLHPDNWCEEFNHFISQ---CLIKDFEKRPSVTHLLDHPFIKGTQGKVLFLQ-----KQ 322

  Fly   122 LSTLCSDVIARHPQTFALQPGEGSLRAR----QDLGSSGVE-DMTLLDDLHEASLLWNLRLRYDK 181
            |:.:..|  .:|....|....|.....|    :|.|...:| |:..|:.|.|.::::.|:.||..
  Rat   323 LAKVLWD--QKHQNPVAKTRHERMHTGRPHHVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYAD 385

  Fly   182 GLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVV 243
            .||||:.|.||||:||::.. ..|..:.::.|.|....|.|||:||....|:..|   ...|.:|
  Rat   386 ALIYTYVGDILIALNPFQNL-SIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIV 449

  Fly   244 ISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKY 308
            |||||||||||:..|::|:|..:   |.:.:..:.::||:...|:|||||||||.||||||||||
  Rat   450 ISGESGSGKTENAHLIVQHLTFL---GKANNQTLRQKILQVNSLVEAFGNARTAINDNSSRFGKY 511

  Fly   309 LEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGG-----------LSETERSKY 361
            ||:.| .:||::||:|::|||||||::.||.||:|:|:||.:..|           |.|.:..:|
  Rat   512 LEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRY 576

  Fly   362 GLLEADKYFYLNQGATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQL 426
            ...|.::   :.|..|...|.|..::.:|...:::|.::.|...:.|:||.:|::||:.|.....
  Rat   577 IAAETER---VTQDITSKESYRRQFDVIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISS 638

  Fly   427 RHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKAL 491
            :|..:..||.:...::.||.:|.|:::.|..||||.....|.|.:.....:|:|.|.|||.:|||
  Rat   639 QHQTDKSEVPNPEALENAASVLCINSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKAL 703

  Fly   492 YAGLFNWLVSRINSIVQKG----GTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNK 552
            |..||:|:|:|||:::|..    ...|...:.|||||||||...|||||||||.|||.:|.|||:
  Rat   704 YGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQVQFYFNQ 768

  Fly   553 HVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH 617
            |||.|||.||.:|.::...:.::||.|::.:..:||:|:..|||:||.||:.||.:.::|...|
  Rat   769 HVFALEQMEYKKEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDN- 832

  Fly   618 ALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGE-----LT 677
            ...:.:.||:.....||:.||||.|.|...|.|:||||.|..||:.:|.:|...|:.:     ||
  Rat   833 LRCKFFWRPKGVELSFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLT 897

  Fly   678 K-----QLRAQRDA-GKTLPKG-SNGRF------------VTMKPRTPTVAARFADSLQQLLQSM 723
            |     |.||:..| .::||.. |.||.            .|...:..|:|:.|..||..||..|
  Rat   898 KTGNLAQTRARITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKM 962

  Fly   724 GRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP 788
            ....|.||||||||.::.||:.....||.|||..|:|:|:.||::||..|:.|:.||.||.:|
  Rat   963 VVGQPHFVRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRILFEEFVRRYYYL-- 1025

  Fly   789 SPLARGTP--YRELCRALLEAMPRTGVEGPDYQLGATRVFLR----EALHRALESGRTERLRRAA 847
            :..|..||  .:|.|.|:||   ::.::  .:.||.|:|||:    |.|:..|
  Rat  1026 AFRAHQTPPANKESCVAILE---KSRLD--HWVLGKTKVFLKYYHIEQLNLLL------------ 1073

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLR----KGALTAQRLWRGRQARRR 908
                |.|.|.:|            .|||..:|....:||:|.:    |.|:|.|..|||...||:
  Rat  1074 ----REVMGRVV------------MLQAYTKGWLGARRYKRAKEKREKSAITIQSAWRGYDTRRK 1122

  Fly   909 VQQLRSDHRRRQEAREAAQRAREAREAKQAVLE-----------------RSQLSYLDIPAELAF 956
            .:|.|  |||.:.|...           ||||:                 |.:.:..:.|||..
  Rat  1123 FKQTR--HRRNESAAHT-----------QAVLQTTPDEKRFPDSGVESNSRHEETSRNCPAEAD- 1173

  Fly   957 IYSKLQGWSPP-------------HGDRHL------VKVLGTVPGPPS 985
                 ..|.|.             |.|:..      :.|.|| .|.||
  Rat  1174 -----TDWHPQTQSSPASSDVTSGHADKEAGNAVAELSVAGT-DGSPS 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	276/703 (39%)
		PTZ00121	<828..>943	CDD:173412	33/139 (24%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo3b	NP_001380706.1	Protein Kinases, catalytic domain	20..310	CDD:473864	11/46 (24%)
		MYSc_Myo3	373..1062	CDD:276830	276/703 (39%)
		IQ	1102..1124	CDD:197470	9/21 (43%)