DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and Myo3b

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_001380706.1	Gene:	Myo3b / 366069	RGDID:	1560313	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1023	Identity:	350/1023 - (34%)
Similarity:	523/1023 - (51%)	Gaps:	177/1023 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QSPSLALLSP--------HVLRRQRPASLEDFEDLPNLS--AKHPALPSSRLRRLKCRYPQVVKR 121
            ::|...||.|        |.:.:   ..::|||..|:::  ..||.:..::.:.|..:     |:
  Rat   266 RNPPPTLLHPDNWCEEFNHFISQ---CLIKDFEKRPSVTHLLDHPFIKGTQGKVLFLQ-----KQ 322

  Fly   122 LSTLCSDVIARHPQTFALQPGEGSLRAR----QDLGSSGVE-DMTLLDDLHEASLLWNLRLRYDK 181
            |:.:..|  .:|....|....|.....|    :|.|...:| |:..|:.|.|.::::.|:.||..
  Rat   323 LAKVLWD--QKHQNPVAKTRHERMHTGRPHHVEDAGKCCLEDDLVNLEVLDEDTIIYWLQKRYAD 385

  Fly   182 GLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVV 243
            .||||:.|.||||:||::.. ..|..:.::.|.|....|.|||:||....|:..|   ...|.:|
  Rat   386 ALIYTYVGDILIALNPFQNL-SIYSPQFSRLYHGVKRSSNPPHIFASADNAYQCLVTFSKDQCIV 449

  Fly   244 ISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKY 308
            |||||||||||:..|::|:|..:   |.:.:..:.::||:...|:|||||||||.||||||||||
  Rat   450 ISGESGSGKTENAHLIVQHLTFL---GKANNQTLRQKILQVNSLVEAFGNARTAINDNSSRFGKY 511

  Fly   309 LEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGG-----------LSETERSKY 361
            ||:.| .:||::||:|::|||||||::.||.||:|:|:||.:..|           |.|.:..:|
  Rat   512 LEMMFTPTGAVMGARISEYLLEKSRVIQQAAGEKNFHIFYYIYAGLYHQKKLAEFRLPEEKPPRY 576

  Fly   362 GLLEADKYFYLNQGATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQL 426
            ...|.::   :.|..|...|.|..::.:|...:::|.::.|...:.|:||.:|::||:.|.....
  Rat   577 IAAETER---VTQDITSKESYRRQFDVIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISS 638

  Fly   427 RHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKAL 491
            :|..:..||.:...::.||.:|.|:::.|..||||.....|.|.:.....:|:|.|.|||.:|||
  Rat   639 QHQTDKSEVPNPEALENAASVLCINSEELQEALTSHCVVTRGETIVRANTVDRAEDVRDAMSKAL 703

  Fly   492 YAGLFNWLVSRINSIVQKG----GTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNK 552
            |..||:|:|:|||:::|..    ...|...:.|||||||||...|||||||||.|||.:|.|||:
  Rat   704 YGRLFSWIVNRINTLLQPDKNICSAEDRMNVGILDIFGFEDFQRNSFEQLCINIANEQVQFYFNQ 768

  Fly   553 HVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH 617
            |||.|||.||.:|.::...:.::||.|::.:..:||:|:..|||:||.||:.||.:.::|...|
  Rat   769 HVFALEQMEYKKEGVDAVLVQYEDNRPLLDMFLQKPLGLLALLDEESRFPQGTDQTLVDKFEDN- 832

  Fly   618 ALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGE-----LT 677
            ...:.:.||:.....||:.||||.|.|...|.|:||||.|..||:.:|.:|...|:.:     ||
  Rat   833 LRCKFFWRPKGVELSFGIQHYAGPVLYDASGVLEKNRDTLPADVVVVLRTSENKLLQQLFSIPLT 897

  Fly   678 K-----QLRAQRDA-GKTLPKG-SNGRF------------VTMKPRTPTVAARFADSLQQLLQSM 723
            |     |.||:..| .::||.. |.||.            .|...:..|:|:.|..||..||..|
  Rat   898 KTGNLAQTRARITASSRSLPPHFSAGRAKVDTLEVIRHPEETTNMKRQTMASYFRYSLMDLLSKM 962

  Fly   724 GRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP 788
            ....|.||||||||.::.||:.....||.|||..|:|:|:.||::||..|:.|:.||.||.:|
  Rat   963 VVGQPHFVRCIKPNDDRKALQFSQDRVLAQLRSTGILETVSIRRQGYSHRILFEEFVRRYYYL-- 1025

  Fly   789 SPLARGTP--YRELCRALLEAMPRTGVEGPDYQLGATRVFLR----EALHRALESGRTERLRRAA 847
            :..|..||  .:|.|.|:||   ::.::  .:.||.|:|||:    |.|:..|
  Rat  1026 AFRAHQTPPANKESCVAILE---KSRLD--HWVLGKTKVFLKYYHIEQLNLLL------------ 1073

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLR----KGALTAQRLWRGRQARRR 908
                |.|.|.:|            .|||..:|....:||:|.:    |.|:|.|..|||...||:
  Rat  1074 ----REVMGRVV------------MLQAYTKGWLGARRYKRAKEKREKSAITIQSAWRGYDTRRK 1122

  Fly   909 VQQLRSDHRRRQEAREAAQRAREAREAKQAVLE-----------------RSQLSYLDIPAELAF 956
            .:|.|  |||.:.|...           ||||:                 |.:.:..:.|||..
  Rat  1123 FKQTR--HRRNESAAHT-----------QAVLQTTPDEKRFPDSGVESNSRHEETSRNCPAEAD- 1173

  Fly   957 IYSKLQGWSPP-------------HGDRHL------VKVLGTVPGPPS 985
                 ..|.|.             |.|:..      :.|.|| .|.||
  Rat  1174 -----TDWHPQTQSSPASSDVTSGHADKEAGNAVAELSVAGT-DGSPS 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	284/729 (39%)
		MYSc_Myo15	169..828	CDD:276838	276/703 (39%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo3b	NP_001380706.1	MYSc_Myo3	373..1062	CDD:276830	276/703 (39%)
		IQ	1102..1124	CDD:197470	9/21 (43%)
		PKc_like	20..310	CDD:419665	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910