DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo10A and Plekhh3

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_006247425.1	Gene:	Plekhh3 / 360634	RGDID:	1304854	Length:	871	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	152/620 - (24%)
Similarity:	225/620 - (36%)	Gaps:	175/620 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2604 LQD-ESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPL 2667
            |:| :.:||.|.:|        |:.:.||..|        ||.|:|  .||            ||
  Rat   289 LRDIQESGGDPEAV--------ALIYRRNPIL--------RHTSSA--LYA------------PL 323

  Fly  2668 LRLPNDL-------APLALECFDCIL--------RYCGDIPLDPDLTEVKCVYTVLMHCHKYLAL 2717
            |.||.::       |||..|.....|        |..|  ||         :..||..|....||
  Rat   324 LPLPYEVSAPGPGYAPLREEAVRLFLALQALEGARRPG--PL---------MQGVLQTCRDLPAL 377

  Fly  2718 RDEVYCQLMKQTTANRSP--CP----DSSQRAWRLLSILAAYFGCSDALRPYLMEHL---TSAAS 2773
            :||::.||.|||:....|  .|    .::.|.|:||:.::..|....|:|.:|:.||   ..|..
  Rat   378 QDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERTEQALP 442

  Fly  2774 DRRRSCHGTAAVCLTNLRKT-ARCGGRKNVPSVEEVTAVSAGRSARRQ----IYRLPGGAERVVN 2833
            |      ...|.....:||. .|..||:.|||:.|::|:|     |||    ....||.....|:
  Rat   443 D------SELAEYARFIRKALGRTRGRELVPSLAEISALS-----RRQELLCTVHCPGAGACPVS 496

  Fly  2834 TRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTT--ELLKSGQP 2896
            ....|...:|..||...||:  ...:..|:||  .|..|....||....:.||.|  |.|.|.:.
  Rat   497 IDSHTTAGEVARELVGRLGL--ARSRNAFALY--EQRGAQERALAGGTLVADVLTRFENLTSEEV 557

  Fly  2897 FYLIFCRSVWHFALKREPAPMPLYVE----------VLFNQVAPDYLEGLLLELPGNGVPVPEMV 2951
            .......|.|...|:...   ||:.|          .||.|.     ..|||.  |...|..:.:
  Rat   558 GLEDSPDSGWRLCLRLHG---PLHPEGLSPEGHELPFLFEQA-----HALLLR--GRPPPPDDTL 612

  Fly  2952 RDMARI-AALLHRAADLSHVPAMKEIKFLLPKPA----------------------------LGI 2987
            |.:|.: ...|||  |.|....:..:..|:|.||                            |..
  Rat   613 RALAALRLQSLHR--DFSPRGPLPLLDRLMPPPAPPREQPSRPARRPPPSAALLAGALWSPGLAK 675

  Fly  2988 REIRPAQWVG---------------------LVQSAWPQVANLSPGQVKAQFLNVLATWPLFGSS 3031
            |....|:.:|                     .|...|.::..:...:..|.:|.:.|..|.||::
  Rat   676 RRAERARRIGTGRSTESTAQVGGGGGGSTTAAVLGGWKRLRGMGQAEAMAAYLALAAQCPGFGAA 740

  Fly  3032 FFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEVISTRKVRSEDG 3096
            .:.|..:..|.|     ..:|  :.|.|.|..:.:....|...|.:...|:..|.:.:.:    |
  Rat   741 RYDVLELSTEPG-----GGAP--QKLCLGLGAKAMSLSRPGESEPIHSVSYGHVAACQLI----G 794

  Fly  3097 ALFLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYI 3131
            ...|.::||:..    :.:|:.|..||..||..|:
  Rat   795 PHTLALRVGDSQ----LLLQSPQVEEIMELVNAYL 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580
		MYSc_Myo15	169..828	CDD:276838
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165	36/115 (31%)
		B41	2823..3033	CDD:214604	59/271 (22%)
		FERM_B-lobe	2920..3025	CDD:271216	29/164 (18%)
		FERM_C_MyoXV	3029..3138	CDD:270022	23/103 (22%)
Plekhh3	XP_006247425.1	PH3_MyoX-like	161..285	CDD:270109
		PH	173..276	CDD:278594
		MyTH4	365..474	CDD:279165	36/114 (32%)
		UBQ	486..>536	CDD:294102	14/53 (26%)
		FERM_B-lobe	591..>630	CDD:298919	15/47 (32%)
		PH-like	738..825	CDD:302622	22/101 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4229
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810