DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myh4

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_062198.1 Gene:Myh4 / 360543 RGDID:3139 Length:1939 Species:Rattus norvegicus


Alignment Length:1777 Identity:452/1777 - (25%)
Similarity:745/1777 - (41%) Gaps:376/1777 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 VIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILI 193
            |..:..|.|::.|.:          ...:|||.::..|||.::|:||:.||...:|||::|...:
  Rat    70 VTVKEDQVFSMNPPK----------YDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCV 124

  Fly   194 AVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTES 255
            .|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.::|:||||:|||.:
  Rat   125 TVNPYKWLP-VYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVN 188

  Fly   256 TKLVMQYLAAVVPGG---------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV 311
            ||.|:||.|.:...|         |.....:.:||:.|.|||||||||:|.||||||||||::.:
  Rat   189 TKRVIQYFATIAVTGDKKKEEAPSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRI 253

  Fly   312 YF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKY--FYLN 373
            :| .:|.:..|.|..|||||||:..|...||:||:||:::.. .:.|..:..|:..:.|  .|::
  Rat   254 HFGATGKLASADIETYLLEKSRVTFQLKAERSYHIFYQVMSN-KKPELIEMLLITTNPYDFAYVS 317

  Fly   374 QGATDCASGRVDWESLQG---AMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GV 433
            ||.....| ..|.|.|..   |:.:||.:..|:..|.::..||:|.||:.|.::|.....|  |.
  Rat   318 QGEITVPS-IDDQEELMATDTAVDILGFTADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGT 381

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            ||...     ||:|..:::..|.:||.....:...|.:.....:.|..::..|.|||:|..:|.|
  Rat   382 EVADK-----AAYLTSLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALAKAMYEKMFLW 441

  Fly   499 LVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAE 561
            :|:|||   |:..|....:  |.:|||.|||....|:.||||||:.||.||.:||.|:|.|||.|
  Rat   442 MVTRIN---QQLDTKQPRQYFIGVLDIAGFEIFDFNTLEQLCINFTNEKLQQFFNHHMFVLEQEE 503

  Fly   562 YARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYAR 625
            |.:|.:||..:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:.:
  Rat   504 YKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQK 568

  Fly   626 PR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL---TKQLRAQ 683
            |:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|:.|...|.|..:..|   .:...|:
  Rat   569 PKPAKGKAEAHFSLVHYAGTVDYNIIGWLDKNKDPLNETVVGLYQKSGLKTLAFLFSGGQAAEAE 633

  Fly   684 RDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMP 748
            ...||...|.....|       .||:|.|.::|.:|:.::...||.||||:.||:.|....|:..
  Rat   634 GGGGKKGGKKKGSSF-------QTVSALFRENLNKLMTNLKSTHPHFVRCLIPNETKTPGAMEHE 691

  Fly   749 CVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGV 813
            .||.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:....:
  Rat   692 LVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG-QFIDSKKASEKLLGSIDI 755

  Fly   814 EGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ- 874
            :...|:.|.|:||.:..|...||..|.|:|.:.....|...||.|:|   |::..|:.:...:| 
  Rat   756 DHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQAVCRGYLMRVEFRKMMERRESIFCIQY 820

  Fly   875 --------ARWRGQRAQQRYERLRKGALTAQRLWRGR-------------QARRR--------VQ 910
                    ..|...:...:.:.|.|.|.|.:.:...:             :|:|:        :.
  Rat   821 NVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMATMKEDFEKAKEDLAKSEAKRKELEEKMVALM 885

  Fly   911 QLRSDHRRRQEA--------------------------REAAQRAREARE------AKQAVLERS 943
            |.::|.:.:.:|                          :|..:||.:..|      ||:..|| .
  Rat   886 QEKNDLQLQVQAEADGLADAEERCDQLIKTKIQLEAKIKELTERAEDEEEINAELTAKKRKLE-D 949

  Fly   944 QLSYL--DIPAELAFIYSKLQGWSPPHGDRHLVKVL-GTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            :.|.|  ||. :|....:|::  ...|...:.||.| ..:.|...:.|:|.::..........::
  Rat   950 ECSELKKDID-DLELTLAKVE--KEKHATENKVKNLTEEMAGLDENIVKLTKEKKALQEAHQQTL 1011

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASR-DQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKA 1069
            .    .||...:.:..  ||:|.:: :|...|.....:...:...|  ||.||.||..|.     
  Rat  1012 D----DLQAEEDKVNT--LTKAKTKLEQQVDDLEGSLEQEKKLRMD--LERAKRKLEGDL----- 1063

  Fly  1070 LSSRGLRDEILVQLCNQV----HGLPPNSGEATRLW------QLLGQCLCCFQPSAAFSKYLMRF 1124
                .|..|..:.:.|..    ..|.....|.:.|.      |.||..|   |......:..:..
  Rat  1064 ----KLAQESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQL---QKKIKELQARIEE 1121

  Fly  1125 VDDE---------APESLRPLLLRQLLR-----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRG 1175
            :::|         ..|..|..|.|:|..     ::.||.:|..:.....|.     .|::...|.
  Rat  1122 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKRE-----AEFQKMRRD 1181

  Fly  1176 CDMALPLTLPDEASQTVAVDSWTSCEEAAAL------AVSSLGVASRGWTLVLDDGQQLTDSCGL 1234
            .:.|   ||..||:             ||||      :|:.||..       :|:.|::......
  Rat  1182 LEEA---TLQHEAT-------------AAALRKKHADSVAELGEQ-------IDNLQRVKQKLEK 1223

  Fly  1235 D------YVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVP 1293
            :      .:.||.:..|...........:.|        ||.|.:            |..|....
  Rat  1224 EKSELKMEIDDLASNMETVSKAKGNLEKMCR--------TLEDQL------------SEVKTKEE 1268

  Fly  1294 RERRSSRELLSRSSALNER--YFERE--------PSPGPGQGSSTGQAKSRSKSLDD------LL 1342
            .::|...||.::.:.|:..  .|.|:        .....|:.:.|.|.:...:.|::      .|
  Rat  1269 EQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEESKAKNAL 1333

  Fly  1343 AGDIVPVPTDCD--------SQEPLHTLGLSESRLN------------DRYHSAERLAPVGKDTG 1387
            |..:.....|||        .||....|..:.|:.|            |.....|.|....|...
  Rat  1334 AHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1398

  Fly  1388 PRYQKS-QHAG---------------------------RRSHAASHG-SHSSKYADK--AEY--- 1418
            .|.|.: :|..                           .||:||... ....:..||  ||:   
  Rat  1399 QRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACAALDKKQRNFDKVLAEWKQK 1463

  Fly  1419 --ATRSSAMSDTSEAPSLASHVRRVR------------VPSQASDVDQFLDDLFSPVLDGS--LD 1467
              .|::...:...|:.||::.:.:|:            :..:..::.|.:.||...:.:|.  :.
  Rat  1464 YEETQAELEASQKESRSLSTELFKVKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKHIH 1528

  Fly  1468 EL--------SDARSLAASIR--GGSYEQE-----------NEAESEID----DLDDYINDIFQ- 1506
            ||        .:...|.||:.  ..|.|.|           |:.:||||    :.|:.|:.:.: 
  Rat  1529 ELEKIKKQIDQEKSELQASLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRN 1593

  Fly  1507 PIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYIN-------ELFEPIPVAEG 1564
            .:.:|::::     ..|.|.|:....|.:.::: .|.::.:::..:|       |....:...:|
  Rat  1594 HLRVVESMQ-----STLDAEIRSRNDALRIKKK-MEGDLNEMEIQLNHANRQAAEAIRNLRNTQG 1652

  Fly  1565 LDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQ--RAFLQSAMAQNL 1627
            :.|.| :.||..::|        |.|.|..||..:    |....|.|.:::  ||.|:.......
  Rat  1653 MLKDT-QLHLDDALR--------GQDDLKEQLAMV----ERRANLMQAEIEELRASLEQTERSRR 1704

  Fly  1628 QIQQQLLAQNQALQTLLSQQAA 1649
            ..:|:||..::.:|.|.:|..:
  Rat  1705 VAEQELLDASERVQLLHTQNTS 1726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 253/709 (36%)
MYSc_Myo15 169..828 CDD:276838 246/688 (36%)
MyTH4 1014..1171 CDD:295320 35/181 (19%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh4NP_062198.1 Myosin_N 36..73 CDD:280832 1/2 (50%)
Myosin_head 88..770 CDD:278492 252/700 (36%)
MYSc_Myh4 100..770 CDD:276879 246/688 (36%)
Actin-binding. /evidence=ECO:0000250 659..681 9/21 (43%)
Actin-binding. /evidence=ECO:0000250 761..775 5/13 (38%)
Myosin_tail_1 850..1927 CDD:279860 177/968 (18%)
RILP-like <994..1098 CDD:304877 23/120 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1128..1147 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1172 3/18 (17%)
MIT_CorA-like <1299..>1411 CDD:294313 21/111 (19%)
COG6 1376..>1511 CDD:303003 20/134 (15%)
DUF342 <1506..1582 CDD:302792 17/75 (23%)
DUF342 <1670..1767 CDD:302792 15/61 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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