DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and didum

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_724569.1 Gene:didum / 35680 FlyBaseID:FBgn0261397 Length:1800 Species:Drosophila melanogaster


Alignment Length:1692 Identity:449/1692 - (26%)
Similarity:717/1692 - (42%) Gaps:339/1692 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||..:|.|||:|: ::.:|||:.|.||:|:|||...| .||..:.:.|.|..:|
  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMG 134

  Fly   220 SLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .|.||:||:...|:..|.....   :::|||||:|||.|.|..|:|.|||  ||..:...:..::
  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV--GGSESETQVERKV 197

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA----IVGAKITQYLLEKSRIVTQAPGERN 342
            |.::|::||||||:|.||||||||||:.::.|::..    :.||.:..|||||||:|.||.||||
  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262

  Fly   343 YHVFYELLGGLSETERSKYGLL---EADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEG 401
            ||:||:|...     ||||..|   ..||:.:||.|..   :..|....:.....||.|||.|..
  Fly   263 YHIFYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322

  Fly   402 EREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGS------DAEIKWAAHLLHISADGLHRALT 460
            :...||::||.:|||||:...:: ...|.|..:..|      |..::..|.||.:|||.|.|.|.
  Fly   323 QIADIVKILAGILHLGNIQVSKK-FNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFG 525
            .|..|:..|.:..|..|:.|..||||.||.:||.||.::|..:|..: ..|:.....|.:|||:|
  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL-NNGSKQCSFIGVLDIYG 450

  Fly   526 FEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVG 590
            ||....|||||.|||||||.||..||:|||||||.||.:|.:.||.:.:.||.|.|.|:..: :|
  Fly   451 FETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LG 514

  Fly   591 ICHLLDDESNFPRATDLSF----LEKCH-YNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFL 650
            :..|||:|...|:.:|.|:    :.||: :.|     :.:||.|...|.:.|::..|.|.|:|||
  Fly   515 VLDLLDEECRMPKGSDESWAGKLIGKCNKFPH-----FEKPRFGTTSFFIKHFSDTVEYDVNGFL 574

  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQLRAQR-------DAGKTLPKG--------------- 693
            :||||.:..::.::|:.|.:    .|.||:....       |:.|:...|               
  Fly   575 EKNRDTVSKELTQVLSESNM----SLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGND 635

  Fly   694 SNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLG 758
            :..|.|..|....||.::|.:||..|:.::....|.:|||||||.:|.|.:.:...::||||..|
  Fly   636 TRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700

  Fly   759 MLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD-YQLGA 822
            :|:|::|...|:|.|..:..|..||:.|:..........:..||.::    ...::..| |:.|.
  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIV----MKWIQDEDKYRFGN 761

  Fly   823 TRVFLREALHRALESGRTE-----------------------RLRRAAVSVQRHVRGMLVRRQLA 864
            |::|.|......||..|..                       |:::....:|:|.||.|.|.:..
  Fly   762 TQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQ 826

  Fly   865 R-RQAAATRLQARW-RGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQE------ 921
            : |:|.|..:.::: ||...::||.|||......|...||..||.:...:| ||.|..:      
  Fly   827 KMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMR-DHYRAVQIQRFVR 890

  Fly   922 ---AREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGP 983
               ||.|.|:.|......||.:.|    :|   |...|...|.:..:..|.:...:.:...:...
  Fly   891 GALARRAYQKRRRNIIICQAAIRR----FL---ARRKFKRMKAEAKTISHMENKYMGLENKIISM 948

  Fly   984 PSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLI---- 1044
            .....:|..|...... |.|.:....::|:.::.........:||.:|:|        |||    
  Fly   949 QQRIDELNRDNSNLKH-KTSEISVLKMKLELKKTLEAEFKNVKAACQDKD--------KLIEALN 1004

  Fly  1045 --LRWSNDKALE------GAKEKLLA----------------DYIVHKA----LSSRGLRDEILV 1081
              |....|:.::      .|:|:.::                |.|:..|    ::.|...|.:|.
  Fly  1005 KQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLA 1069

  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQG 1146
            ::.|:      ...||                      |.....|.|..|:...:|..:|.|...
  Fly  1070 EIDNR------ELNEA----------------------YQRAIKDKEVIENENFMLKEELSRLTA 1106

  Fly  1147 GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSL 1211
            |..|..|..|....|.....:.:.:.....|:..|   ||..|:..:.:..|           ||
  Fly  1107 GSFSLHARKASNASSQNEDDVGYASAKNTLDINRP---PDLLSKNYSYNDST-----------SL 1157

  Fly  1212 GVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAP----RSDLLRSGAKFARTTLPDA 1272
            .|..|.   :|::.:|........|:......|....:|...    .::.|||.....||::...
  Fly  1158 VVKLRS---ILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHG 1219

  Fly  1273 VKRPAVPPPAPPTSSGKEDVPRERRSSRE----LLSRSSALNERYFEREPSPGPGQGSSTG---- 1329
            |:   :.......::.:|:|.|.|....:    ||.:|.::.    ..||.....:|:...    
  Fly  1220 VE---INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMR----SLEPESLQMRGNDVNELME 1277

  Fly  1330 ----------QAKSRSKSLDDLLAGDIVPVPTDC---------------DSQEPLHTLGLSESRL 1369
                      |.:|..|::.:.....:|.:..:.               :|.:......:...|.
  Fly  1278 AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQ 1342

  Fly  1370 NDRYHSAE--------------------RLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYAD 1414
            ||||...|                    :|....:|.|....|.:....|:  .|:|:.    ||
  Fly  1343 NDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRN--KSNGTS----AD 1401

  Fly  1415 KAEYATRSSAMSDTSEAPS--LASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDEL---SDARS 1474
            .....|:..     |:.|.  :..|         :||:|:.|..|.|.:...::..|   ..|..
  Fly  1402 VGANVTKQK-----SQNPQGLMKFH---------SSDLDKILQRLLSALTPRTVVGLLPGFPAYL 1452

  Fly  1475 LAASIRGGSYEQENEAESEIDD-LDDYINDIFQ----PIPLVQNLEKLTSKDQLAAIIKGGGVAS 1534
            :...||   |.....|:.::.: |..::..|.:    |.|:...:..|.:...|..::|..|...
  Fly  1453 IFMCIR---YTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514

  Fly  1535 K----PEERDEESEIE--DLDDY------------------INELFEP--IPVAEGLDKLT---- 1569
            :    ..|:..:.:::  :|.:|                  |..|.:|  :|.....|::.    
  Fly  1515 EYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQ 1579

  Fly  1570 --SKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQ 1632
              .....|.|| |..|:..:|..|...||:   |:.|.    :.:|.|...|.:..|:  ||..|
  Fly  1580 AHGMRSRATSI-GASSSPEHGGGPAWKQLI---GQLEH----FYKQFQHFGLDNCYAE--QIFHQ 1634

  Fly  1633 LL 1634
            ||
  Fly  1635 LL 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 267/727 (37%)
MYSc_Myo15 169..828 CDD:276838 259/706 (37%)
MyTH4 1014..1171 CDD:295320 32/188 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
didumNP_724569.1 MYSc 65..778 CDD:214580 269/730 (37%)
MYSc_Myo5 84..767 CDD:276831 259/706 (37%)
IQ 900..922 CDD:197470 6/28 (21%)
GBP_C <971..1086 CDD:303769 22/150 (15%)
coiled coil 1049..1068 CDD:293879 4/18 (22%)
coiled coil 1077..1086 CDD:293879 3/30 (10%)
JAKMIP_CC3 <1190..1299 CDD:292653 20/115 (17%)
Myo5_CBD 1424..1792 CDD:271254 47/226 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466255
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1389at50557
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100101
Panther 1 1.100 - - P PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
65.850

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