Protein Alignment Myo10A and didum

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_724569.1
• Gene: didum / 35680
• FlyBaseID: FBgn0261397
• Length: 1800
• Species: Drosophila melanogaster
• Alignment Length: 1692
• Identity: 449/1692 - (26%)
• Similarity: 717/1692 - (42%)
• Gaps: 339/1692 - (20%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||..:|.|||:|: ::.:|||:.|.||:|:|||...| .||..:.:.|.|..:|
  Fly    71 GQNDLTTLSYLHEPGVLHNLRVRFCERQIIYTYCGIILVAINPYAEMP-LYGPSIIRAYRGHAMG 134

  Fly   220 SLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .|.||:||:...|:..|.....   :::|||||:|||.|.|..|:|.|||  ||..:...:..::
  Fly   135 DLEPHIFALAEEAYTKLERENCNLSIIVSGESGAGKTVSAKYAMRYFAAV--GGSESETQVERKV 197

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGA----IVGAKITQYLLEKSRIVTQAPGERN 342
            |.::|::||||||:|.||||||||||:.::.|::..    :.||.:..|||||||:|.||.||||
  Fly   198 LASSPIMEAFGNAKTTRNDNSSRFGKFTKLLFRNQMGVMFLQGATMHTYLLEKSRVVYQAQGERN 262

  Fly   343 YHVFYELLGGLSETERSKYGLL---EADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEG 401
            ||:||:|...     ||||..|   ..||:.:||.|..   :..|....:.....||.|||.|..
  Fly   263 YHIFYQLCAA-----RSKYPELVLDHQDKFQFLNMGGAPEIERVSDAEQFNETVQAMTVLGFSIQ 322

  Fly   402 EREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGS------DAEIKWAAHLLHISADGLHRALT 460
            :...||::||.:|||||:...:: ...|.|..:..|      |..::..|.||.:|||.|.|.|.
  Fly   323 QIADIVKILAGILHLGNIQVSKK-FNEGSEEEDSDSCDIFHNDIHLQITADLLRVSADDLRRWLL 386

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFG 525
            .|..|:..|.:..|..|:.|..||||.||.:||.||.::|..:|..: ..|:.....|.:|||:|
  Fly   387 MRKIESVNEYVLIPNSIEAAQAARDALAKHIYAKLFQYIVGVLNKSL-NNGSKQCSFIGVLDIYG 450

  Fly   526 FEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVG 590
            ||....|||||.|||||||.||..||:|||||||.||.:|.:.||.:.:.||.|.|.|:..: :|
  Fly   451 FETFEVNSFEQFCINYANEKLQQQFNQHVFKLEQEEYLKEGITWTMIDFYDNQPCIDLIESR-LG 514

  Fly   591 ICHLLDDESNFPRATDLSF----LEKCH-YNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFL 650
            :..|||:|...|:.:|.|:    :.||: :.|     :.:||.|...|.:.|::..|.|.|:|||
  Fly   515 VLDLLDEECRMPKGSDESWAGKLIGKCNKFPH-----FEKPRFGTTSFFIKHFSDTVEYDVNGFL 574

  Fly   651 DKNRDALRGDVLELLASSRLPLVGELTKQLRAQR-------DAGKTLPKG--------------- 693
            :||||.:..::.::|:.|.:    .|.||:....       |:.|:...|
  Fly   575 EKNRDTVSKELTQVLSESNM----SLAKQVMTLEEIDTLCVDSAKSSTLGGRVVISAGRKQQGND 635

  Fly   694 SNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLG 758
            :..|.|..|....||.::|.:||..|:.::....|.:|||||||.:|.|.:.:...::||||..|
  Fly   636 TRRRVVPSKQHRKTVGSQFQESLASLISTLHATTPHYVRCIKPNDDKVAFKWETAKIIQQLRACG 700

  Fly   759 MLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD-YQLGA 822
            :|:|::|...|:|.|..:..|..||:.|:..........:..||.::    ...::..| |:.|.
  Fly   701 VLETVRISAAGFPSRWLYPDFYMRYQLLVYRSKLDKNDMKLSCRNIV----MKWIQDEDKYRFGN 761

  Fly   823 TRVFLREALHRALESGRTE-----------------------RLRRAAVSVQRHVRGMLVRRQLA 864
            |::|.|......||..|..                       |:::....:|:|.||.|.|.:..
  Fly   762 TQIFFRAGQVAFLEQVRANLRKKYITIVQSVVRRFVYRRQFLRIQKVINGIQKHARGYLARERTQ 826

  Fly   865 R-RQAAATRLQARW-RGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQE------ 921
            : |:|.|..:.::: ||...::||.|||......|...||..||.:...:| ||.|..:
  Fly   827 KMREARAGLILSKYARGWLCRRRYLRLRHSISGIQTYARGMLARNKFHAMR-DHYRAVQIQRFVR 890

  Fly   922 ---AREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGP 983
               ||.|.|:.|......||.:.|    :|   |...|...|.:..:..|.:...:.:...:...
  Fly   891 GALARRAYQKRRRNIIICQAAIRR----FL---ARRKFKRMKAEAKTISHMENKYMGLENKIISM 948

  Fly   984 PSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLI---- 1044
            .....:|..|...... |.|.:....::|:.::.........:||.:|:|        |||
  Fly   949 QQRIDELNRDNSNLKH-KTSEISVLKMKLELKKTLEAEFKNVKAACQDKD--------KLIEALN 1004

  Fly  1045 --LRWSNDKALE------GAKEKLLA----------------DYIVHKA----LSSRGLRDEILV 1081
              |....|:.::      .|:|:.::                |.|:..|    ::.|...|.:|.
  Fly  1005 KQLEAERDEKMQLLEENGHAQEEWISQKQTWRQENEELRRQIDEIIDMAKNAEVNQRNQEDRMLA 1069

  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQG 1146
            ::.|:      ...||                      |.....|.|..|:...:|..:|.|...
  Fly  1070 EIDNR------ELNEA----------------------YQRAIKDKEVIENENFMLKEELSRLTA 1106

  Fly  1147 GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSL 1211
            |..|..|..|....|.....:.:.:.....|:..|   ||..|:..:.:..|           ||
  Fly  1107 GSFSLHARKASNASSQNEDDVGYASAKNTLDINRP---PDLLSKNYSYNDST-----------SL 1157

  Fly  1212 GVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAP----RSDLLRSGAKFARTTLPDA 1272
            .|..|.   :|::.:|........|:......|....:|...    .::.|||.....||::...
  Fly  1158 VVKLRS---ILEEEKQKHKVLQEQYIKLSSRHKPTEDSFRVSELEVENEKLRSEYDQLRTSIKHG 1219

  Fly  1273 VKRPAVPPPAPPTSSGKEDVPRERRSSRE----LLSRSSALNERYFEREPSPGPGQGSSTG---- 1329
            |:   :.......::.:|:|.|.|....:    ||.:|.::.    ..||.....:|:...
  Fly  1220 VE---INELNAQHAALQEEVRRRREECIQLKAVLLQQSQSMR----SLEPESLQMRGNDVNELME 1277

  Fly  1330 ----------QAKSRSKSLDDLLAGDIVPVPTDC---------------DSQEPLHTLGLSESRL 1369
                      |.:|..|::.:.....:|.:..:.               :|.:......:...|.
  Fly  1278 AFHSQKLINRQLESELKAITEEHNSKLVEMTQEIERLNNEKDELQKVMFESIDEFEDSNVDTLRQ 1342

  Fly  1370 NDRYHSAE--------------------RLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYAD 1414
            ||||...|                    :|....:|.|....|.:....|:  .|:|:.    ||
  Fly  1343 NDRYLRRELQKAVAQFLLVQEELKLANAKLKAYRQDGGQLEHKIEEEMIRN--KSNGTS----AD 1401

  Fly  1415 KAEYATRSSAMSDTSEAPS--LASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDEL---SDARS 1474
            .....|:..     |:.|.  :..|         :||:|:.|..|.|.:...::..|   ..|..
  Fly  1402 VGANVTKQK-----SQNPQGLMKFH---------SSDLDKILQRLLSALTPRTVVGLLPGFPAYL 1452

  Fly  1475 LAASIRGGSYEQENEAESEIDD-LDDYINDIFQ----PIPLVQNLEKLTSKDQLAAIIKGGGVAS 1534
            :...||   |.....|:.::.: |..::..|.:    |.|:...:..|.:...|..::|..|...
  Fly  1453 IFMCIR---YTDLTNADDDVRELLSKFVIQIKKMHRTPHPIENRVIWLVNSITLLNLMKQYGDVD 1514

  Fly  1535 K----PEERDEESEIE--DLDDY------------------INELFEP--IPVAEGLDKLT---- 1569
            :    ..|:..:.:::  :|.:|                  |..|.:|  :|.....|::.
  Fly  1515 EYVKFNTEKQNQQQLKNFNLFEYRRVILDLIVNLYQALIMQIQGLLDPKIVPAILNNDEIQRGRQ 1579

  Fly  1570 --SKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQ 1632
              .....|.|| |..|:..:|..|...||:   |:.|.    :.:|.|...|.:..|:  ||..|
  Fly  1580 AHGMRSRATSI-GASSSPEHGGGPAWKQLI---GQLEH----FYKQFQHFGLDNCYAE--QIFHQ 1634

  Fly  1633 LL 1634
            ||
  Fly  1635 LL 1636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	259/706 (37%)
		PTZ00121	<828..>943	CDD:173412	37/148 (25%)
		MyTH4	1014..1171	CDD:470587	32/188 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	12/66 (18%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
didum	NP_724569.1	MYSc_Myo5	84..767	CDD:276831	259/706 (37%)
		IQ	900..922	CDD:197470	6/28 (21%)
		SMC_prok_B	<942..1365	CDD:274008	79/483 (16%)
		Myo5_CBD	1424..1792	CDD:271254	47/226 (21%)